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MetroLotion (metronidazole topical) Disease Interactions

Drug Interactions (10) Alcohol/Food Interactions (1) Disease Interactions (4)

There are 4 disease interactions with MetroLotion (metronidazole topical):

Topical Metronidazole (Includes MetroLotion) ↔ Alcoholism

Moderate Potential Hazard, Low plausibility

Applies to: Alcoholism

Metronidazole may be systemically absorbed when applied to the skin or mucosal membranes. A disulfiram-like reaction has been reported in patients who consume alcohol during treatment with oral metronidazole. Symptoms include nausea, vomiting, flushing, sweating, headache, abdominal cramps, and hypotension. Therapy with topical metronidazole should be administered cautiously in patients who might be prone to acute alcohol intake. Patients should be instructed to avoid alcohol-containing products during therapy and for at least 48 hours after the last dose.


Topical Metronidazole (Includes MetroLotion) ↔ Blood Dyscrasias

Moderate Potential Hazard, Low plausibility

Applies to: Bone Marrow Depression/Low Blood Counts, History - Blood Dyscrasias

Metronidazole may be systemically absorbed when applied to the skin or mucosal membranes. The use of metronidazole has rarely been associated with hematologic adverse effects such as mild, transient leukopenia, thrombocytopenia, and bone marrow aplasia. The manufacturers recommend that therapy with metronidazole be administered cautiously in patients with evidence of or a history of blood dyscrasias.


Topical Metronidazole (Includes MetroLotion) ↔ Liver Disease

Moderate Potential Hazard, Low plausibility

Applies to: Liver Disease

Metronidazole may be systemically absorbed when applied to the skin or mucosal membranes. Once absorbed, metronidazole is extensively metabolized by the liver to both pharmacologically active and inactive compounds. The plasma clearance of metronidazole may be decreased and the half-life prolonged in patients with impaired hepatic function. Therapy with topical metronidazole should be administered cautiously in patients with liver disease.


Topical Metronidazole (Includes MetroLotion) ↔ Neurologic Toxicity

Moderate Potential Hazard, Low plausibility

Applies to: CNS Disorder, Peripheral Neuropathy

Metronidazole may be systemically absorbed when applied to the skin or mucosal membranes. The use of oral and intravenous metronidazole has been associated with the development of nervous system toxicity including convulsive seizures and dose-related peripheral neuropathy, the latter characterized primarily by numbness or paresthesia of an extremity. Persistent peripheral neuropathy has been reported in some patients treated for prolonged periods. Other neurologic adverse effects include vertigo, incoordination, ataxia, confusion, agitation, hallucinations, and depression. Therapy with topical metronidazole should be administered cautiously in patients with or predisposed to seizures or other nervous system abnormalities. Metronidazole therapy should be discontinued promptly if neurologic disturbances occur.


You should also know about...

MetroLotion (metronidazole topical) drug Interactions

There are 10 drug interactions with MetroLotion (metronidazole topical)

MetroLotion (metronidazole topical) alcohol/food Interactions

There is 1 alcohol/food interaction with MetroLotion (metronidazole topical)

See also...

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.


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