Metaxalone Disease Interactions

There are 2 disease interactions with metaxalone:

Metaxalone (Includes Metaxalone) ↔ Anemia

Severe Potential Hazard, Moderate plausibility

Applies to: Anemia

The manufacturer considers the use of metaxalone to be contraindicated in patients with or predisposed to drug-induced, hemolytic, or other anemias. Rare incidences of hemolytic anemia have been associated with the administration of metaxalone.

References

  1. "Product Information. Skelaxin (metaxalone)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

Metaxalone (Includes Metaxalone) ↔ Renal/Liver Disease

Severe Potential Hazard, High plausibility

Applies to: Liver Disease, Renal Dysfunction

The manufacturer considers the use of metaxalone to be contraindicated in patients with severely impaired hepatic and/or renal function. Metaxalone is metabolized by the liver and subsequently eliminated by the kidney, thus both parent drug and metabolites may accumulate in such patients. Additionally, metaxalone may be hepatotoxic. Jaundice as well as abnormalities in liver function tests, including elevations in serum AST, ALT, alkaline phosphatase and bilirubin, have been reported. Nephrotoxicity and proteinuria have also occurred rarely. Therapy with metaxalone should be administered cautiously in patients with mild to moderate hepatic and/or renal impairment.

References

  1. "Product Information. Skelaxin (metaxalone)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

You should also know about...

metaxalone drug Interactions

There are 581 drug interactions with metaxalone

metaxalone alcohol/food Interactions

There is 1 alcohol/food interaction with metaxalone

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2014 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web5)