Metaxalone Disease Interactions

There are 2 disease interactions with metaxalone:

The manufacturer considers the use of metaxalone to be contraindicated in patients with or predisposed to drug-induced, hemolytic, or other anemias. Rare incidences of hemolytic anemia have been associated with the administration of metaxalone.

The manufacturer considers the use of metaxalone to be contraindicated in patients with severely impaired hepatic and/or renal function. Metaxalone is metabolized by the liver and subsequently eliminated by the kidney, thus both parent drug and metabolites may accumulate in such patients. Additionally, metaxalone may be hepatotoxic. Jaundice as well as abnormalities in liver function tests, including elevations in serum AST, ALT, alkaline phosphatase and bilirubin, have been reported. Nephrotoxicity and proteinuria have also occurred rarely. Therapy with metaxalone should be administered cautiously in patients with mild to moderate hepatic and/or renal impairment.

You should also know about...

metaxalone drug Interactions

There are 493 drug interactions with metaxalone

metaxalone food/lifestyle Interactions

There is 1 food/lifestyle interaction with metaxalone

See also...

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.