Xenleta Disease Interactions
There are 4 disease interactions with Xenleta (lefamulin).
Antibiotics (applies to Xenleta) colitis
Major Potential Hazard, Moderate plausibility. Applicable conditions: Colitis/Enteritis (Noninfectious)
Clostridioides difficile-associated diarrhea (CDAD), formerly pseudomembranous colitis, has been reported with almost all antibacterial drugs and may range from mild diarrhea to fatal colitis. The most common culprits include clindamycin and lincomycin. Antibacterial therapy alters the normal flora of the colon, leading to overgrowth of C difficile, whose toxins A and B contribute to CDAD development. Morbidity and mortality are increased with hypertoxin-producing strains of C difficile; these infections can be resistant to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea after antibacterial use. Since CDAD has been reported to occur more than 2 months after antibacterial use, careful medical history is necessary. Therapy with broad-spectrum antibacterials and other agents with significant antibacterial activity should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis; pseudomembranous colitis (generally characterized by severe, persistent diarrhea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus), if it occurs, may be more severe in these patients and may be associated with flares in underlying disease activity. Antibacterial drugs not directed against C difficile may need to be stopped if CDAD is suspected or confirmed. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation should be started as clinically indicated.
References
- (2002) "Product Information. Omnipen (ampicillin)." Wyeth-Ayerst Laboratories
- (2002) "Product Information. Ceftin (cefuroxime)." Glaxo Wellcome
- (2002) "Product Information. Zinacef (cefuroxime)." Glaxo Wellcome
- (2002) "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn
- (2002) "Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals
- (2002) "Product Information. Macrodantin (nitrofurantoin)." Procter and Gamble Pharmaceuticals
- (2001) "Product Information. Amoxil (amoxicillin)." SmithKline Beecham
- (2001) "Product Information. Merrem (meropenem)." Astra-Zeneca Pharmaceuticals
- (2001) "Product Information. Coly-Mycin M Parenteral (colistimethate)." Parke-Davis
- (2001) "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn
- (2003) "Product Information. Cubicin (daptomycin)." Cubist Pharmaceuticals Inc
- (2004) "Product Information. Xifaxan (rifaximin)." Salix Pharmaceuticals
- (2007) "Product Information. Doribax (doripenem)." Ortho McNeil Pharmaceutical
- (2009) "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc
- (2009) "Product Information. Vibativ (telavancin)." Theravance Inc
- (2010) "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals
- (2022) "Product Information. Penicillin G Sodium (penicillin G sodium)." Sandoz Inc
- (2014) "Product Information. Dalvance (dalbavancin)." Durata Therapeutics, Inc.
- (2014) "Product Information. Orbactiv (oritavancin)." The Medicines Company
- (2017) "Product Information. Bicillin C-R (benzathine penicillin-procaine penicillin)." A-S Medication Solutions
- (2017) "Product Information. Baxdela (delafloxacin)." Melinta Therapeutics, Inc.
- (2022) "Product Information. Polymyxin B Sulfate (polymyxin B sulfate)." AuroMedics Pharma LLC
- (2018) "Product Information. Zemdri (plazomicin)." Achaogen
- (2018) "Product Information. Seysara (sarecycline)." Allergan Inc
- (2018) "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc.
- (2018) "Product Information. Aemcolo (rifamycin)." Aries Pharmaceuticals, Inc.
- (2019) "Product Information. Fetroja (cefiderocol)." Shionogi USA Inc
- (2019) "Product Information. Biaxin (clarithromycin)." AbbVie US LLC, SUPPL-61
- (2021) "Product Information. Zithromax (azithromycin)." Pfizer U.S. Pharmaceuticals Group, LAB-0372-7.0
- (2018) "Product Information. E.E.S.-400 Filmtab (erythromycin)." Arbor Pharmaceuticals, SUPPL-74
- (2020) "Product Information. Priftin (rifapentine)." sanofi-aventis, SUPPL-18
- (2021) "Product Information. Xerava (eravacycline)." Tetraphase Pharmaceuticals, Inc
- (2023) "Product Information. Xacduro (durlobactam-sulbactam)." La Jolla Pharmaceutical
- (2024) "Product Information. Exblifep (cefepime-enmetazobactam)." Allecra Therapeutics
- (2021) "Product Information. Maxipime (cefepime)." Hospira Inc, SUPPL-46
Lefamulin (applies to Xenleta) QT prolongation
Major Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias
The use of lefamulin should be avoided in patients with known QT prolongation, ventricular arrhythmias including torsades de pointes, and patients receiving drugs that prolong the QT interval such as antiarrhythmic agents. In patients predisposed to QT prolongation, or those receiving another drug that prolongs the QT interval, ECG monitoring is recommended during treatment.
References
- (2019) "Product Information. Xenleta (lefamulin)." Nabriva Therapeutics US, Inc.
Lefamulin (applies to Xenleta) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The half-life of lefamulin is prolonged in subjects with severe hepatic impairment. Lefamulin tablets have not been studied in patients with hepatic impairment. It is not recommended to use them in patients with moderate or severe hepatic impairment. The dosage of lefamulin injection should be reduced by extending the dosing interval for patients with severe hepatic impairment. In patients with mild, moderate, or severe hepatic impairment, metabolic disturbances associated with hepatic impairment may lead to QT prolongation. Caution is advised.
References
- (2019) "Product Information. Xenleta (lefamulin)." Nabriva Therapeutics US, Inc.
Lefamulin (applies to Xenleta) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
No dosage adjustment of lefamulin is warranted in patients with renal impairment, including those on hemodialysis. However, in patients with renal failure who require dialysis, metabolic disturbances associated with renal failure may lead to QT prolongation. Monitoring is advised.
References
- (2019) "Product Information. Xenleta (lefamulin)." Nabriva Therapeutics US, Inc.
Xenleta drug interactions
There are 533 drug interactions with Xenleta (lefamulin).
Xenleta alcohol/food interactions
There is 1 alcohol/food interaction with Xenleta (lefamulin).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.