Nizoral (ketoconazole) Disease Interactions

There are 2 disease interactions with Nizoral (ketoconazole):

The use of oral ketoconazole has been associated with occasional cases of hepatotoxicity. The injuries are typically hepatocellular in nature and reversible upon discontinuation of therapy, although fatalities have been reported rarely. Several cases of hepatitis have been reported in children. Liver function tests should be performed prior to initiation of therapy and regularly during treatment in patients receiving prolonged therapy with ketoconazole, particularly those with a current or past history of liver disease. Therapy should be withdrawn if persistent elevations or worsening of liver enzyme levels occur, or if the abnormalities are accompanied by symptoms of possible liver injury. Since ketoconazole is primarily metabolized by the liver, empirically reducing the dosage may also be appropriate in patients with existing liver disease.

Nizoral (brand of ketoconazole) tablets require acidity for proper dissolution and absorption. Therefore, the drug may not be effective in patients with achlorhydria. Taking the medication with an acidic beverage such as orange or cranberry juice may help, but an alternative antifungal agent should be considered.

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Nizoral (ketoconazole) drug Interactions

There are 415 drug interactions with Nizoral (ketoconazole)

Nizoral (ketoconazole) food/lifestyle Interactions

There is 1 food/lifestyle interaction with Nizoral (ketoconazole)

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