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Fulvestrant Disease Interactions

There are 2 disease interactions with fulvestrant.

Major

Fulvestrant (applies to fulvestrant) hepatic dysfunction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Fulvestrant is metabolized primarily in the liver. A dose of fulvestrant 250 mg is recommended in patients with moderate hepatic impairment (Child-Pugh class B). Care is recommended when using fulvestrant in patients with severe hepatic impairment (Child-Pugh class C) as the agent has not been studied in these patients.

References

  1. (2002) "Product Information. Faslodex (fulvestrant)." Astra-Zeneca Pharmaceuticals
Moderate

Fulvestrant (applies to fulvestrant) bleeding

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopenia

Fulvestrant injection is administered intramuscularly and site related events have been reported. It is recommended to use caution in patients with bleeding diatheses, thrombocytopenia, or anticoagulant use. In addition, caution should be taken while administering fulvestrant injection at the dorsogluteal injection site due to the proximity of the underlying sciatic nerve.

References

  1. (2002) "Product Information. Faslodex (fulvestrant)." Astra-Zeneca Pharmaceuticals

Fulvestrant drug interactions

There are 3 drug interactions with fulvestrant.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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