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Allegra (fexofenadine) Disease Interactions

There is 1 disease interaction with Allegra (fexofenadine):


Fexofenadine (Includes Allegra) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Fexofenadine is primarily eliminated unchanged by the kidney. Patients with renal impairment may be at greater risk for adverse effects from fexofenadine due to decreased drug clearance. The manufacturer recommends an initial dosage of 60 mg once daily in patients with renal dysfunction (CrCl < 80 mL/min).


  1. Russell T, Stoltz M, Weir S "Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers." Clin Pharmacol Ther 64 (1998): 612-21
  2. "Product Information. Allegra (fexofenadine)." Hoechst Marion-Roussel Inc, Kansas City, MO.

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Allegra (fexofenadine) drug Interactions

There are 71 drug interactions with Allegra (fexofenadine)

Allegra (fexofenadine) alcohol/food Interactions

There is 1 alcohol/food interaction with Allegra (fexofenadine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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