Epoprostenol Disease Interactions
There are 2 disease interactions with epoprostenol.
Epoprostenol (applies to epoprostenol) CHF
Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure
The use of epoprostenol is contraindicated in patients with heart failure due to reduced severe left ventricular systolic dysfunction. A large study involving such patients was terminated after an interim analysis revealed a higher mortality in the group receiving epoprostenol plus standard therapy than in the group receiving standard therapy alone.
References
- Bugiardini R, Galvani M, Ferrini D, Gridelli C, Tollemeto D, Macri N, Puddu P, Lenzi S (1987) "Myocardial ischemia during intravenous prostacyclin administration: hemodynamic findings and precautionary measures." Am Heart J, 113, p. 234-40
- Bugiardini R, Galvani M, Ferrini D, Gridelli C, Tollemeto D, Mari L, Puddu P, Lenzi S (1985) "Myocardial ischemia induced by prostacyclin and iloprost." Clin Pharmacol Ther, 38, p. 101-8
- Pickles H, O'Grady J (1982) "Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man." Br J Clin Pharmacol, 14, p. 177-85
- (2001) "Product Information. Flolan (epoprostenol)." Glaxo Wellcome
- (1996) "Epoprostenol for primary pulmonary hypertension." Med Lett Drugs Ther, 38, p. 14-5
Epoprostenol (applies to epoprostenol) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cerebral Thrombosis/Embolism
Epoprostenol is a potent inhibitor of platelet aggregation. Therefore, expect an increased risk for hemorrhagic complications, particularly for patients with other risk factors for bleeding. Caution and close monitoring is advised.
References
- (2001) "Product Information. Flolan (epoprostenol)." Glaxo Wellcome
Epoprostenol drug interactions
There are 295 drug interactions with epoprostenol.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.