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Braftovi Disease Interactions

There are 3 disease interactions with Braftovi (encorafenib).

Moderate

Encorafenib (applies to Braftovi) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

A recommended dose of encorafenib has not been established for patients with moderate (Child-Pugh Class B) or severe (Child-Pugh Class C) hepatic impairment. Caution and monitoring is advised if used on these patients. Dose adjustment for is not recommended in patients with mild hepatic impairment (Child-Pugh Class A).

References

  1. (2018) "Product Information. Braftovi (encorafenib)." Array BioPharma Inc.
Moderate

Encorafenib (applies to Braftovi) QTc prolongation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Long QT Syndrome, Congestive Heart Failure, Hypokalemia, Magnesium Imbalance

Encorafenib is associated with dose-dependent QTc interval prolongation in some patients. Monitor patients who already have or who are at significant risk of developing QTc prolongation, including patients with known long QT syndromes, clinically significant bradyarrhythmias, severe or uncontrolled heart failure and those taking other medicinal products associated with QT prolongation. Correct hypokalemia and hypomagnesemia prior to and during therapy with encorafenib. Withhold, reduce dose, or permanently discontinue for QTc > 500 ms.

References

  1. (2018) "Product Information. Braftovi (encorafenib)." Array BioPharma Inc.
Moderate

Encorafenib (applies to Braftovi) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

A recommended dose of encorafenib has not been established for patients with severe renal impairment (CrCl < 30 mL/min). Caution and monitoring is advised if used on these patients. No dose adjustment is recommended for patients with mild to moderate renal impairment (CrCl 30 to < 90 mL/min).

References

  1. (2018) "Product Information. Braftovi (encorafenib)." Array BioPharma Inc.

Braftovi drug interactions

There are 485 drug interactions with Braftovi (encorafenib).

Braftovi alcohol/food interactions

There is 1 alcohol/food interaction with Braftovi (encorafenib).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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