Cabotegravir Disease Interactions
There are 3 disease interactions with cabotegravir.
Cabotegravir (applies to cabotegravir) depression
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Psychosis
Depressive disorders (including depressed mood, depression, altered mood, mood swings) have been reported with oral cabotegravir. Depressive disorders (including depressed mood, depression, major depression, altered mood, mood swings, dysphoria, negative thoughts, suicidal ideation/attempt) have been reported with IM cabotegravir-rilpivirine or the individual drug products. Patients with severe depressive symptoms should be evaluated promptly. Caution should be used in patients with a history of depression or other psychiatric conditions.
References
- (2021) "Product Information. Cabenuva (cabotegravir-rilpivirine)." ViiV Healthcare ULC
- (2021) "Product Information. Vocabria (cabotegravir)." ViiV Healthcare
Cabotegravir (applies to cabotegravir) liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Hepatotoxicity has been reported in patients taking cabotegravir with or without known preexisting hepatic disease or identifiable risk factors. Patients with underlying liver disease or marked transaminase elevations prior to therapy may be at increased risk for worsening or development of transaminase elevations. Monitoring of liver chemistries is recommended and cabotegravir should be discontinued if hepatotoxicity is suspected. Cabotegravir has not been studied in patients with severe liver dysfunction (Child-Pugh C); caution is recommended.
References
- (2021) "Product Information. Cabenuva (cabotegravir-rilpivirine)." ViiV Healthcare ULC
- (2021) "Product Information. Vocabria (cabotegravir)." ViiV Healthcare
Cabotegravir (applies to cabotegravir) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
No dose adjustment of IM or oral cabotegravir is required in patients with mild to moderate or mild to severe renal dysfunction, respectively. Cabotegravir has not been studied in patients with ESRD not on dialysis; caution is recommended. IM cabotegravir should be used with caution and with increased monitoring for side effects in patients with severe renal dysfunction or ESRD.
References
- (2021) "Product Information. Cabenuva (cabotegravir-rilpivirine)." ViiV Healthcare ULC
- (2021) "Product Information. Vocabria (cabotegravir)." ViiV Healthcare
Cabotegravir drug interactions
There are 61 drug interactions with cabotegravir.
Cabotegravir alcohol/food interactions
There is 1 alcohol/food interaction with cabotegravir.
More about cabotegravir
- cabotegravir consumer information
- Check interactions
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- Side effects
- Dosage information
- During pregnancy
- Drug class: integrase strand transfer inhibitor
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.