triptorelin (Intramuscular route)
Commonly used brand name(s)
In the U.S.
- Trelstar Depot
- Trelstar LA
Available Dosage Forms:
- Powder for Suspension
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Luteinizing Hormone Releasing Hormone Agonist
Uses For triptorelin
Triptorelin is used to treat advanced prostate cancer in men. It is a hormone that is similar to the one normally released from the hypothalamus gland in the brain. When given on a regular basis to men, triptorelin decreases testosterone levels which helps treat prostate cancer.
triptorelin is to be given only by or under the supervision of a doctor.
Before Using triptorelin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For triptorelin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to triptorelin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of triptorelin in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of triptorelin in the elderly.
|All Trimesters||X||Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving triptorelin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using triptorelin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using triptorelin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
- Perflutren Lipid Microsphere
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of triptorelin. Make sure you tell your doctor if you have any other medical problems, especially:
- Bladder blockage or
- Diabetes or
- Heart or blood vessel disease or
- Hyperglycemia (high blood sugar) or
- Spinal cord problems—Use with caution. May make these conditions worse.
- Congestive heart failure or
- Electrolyte imbalance or
- Heart rhythm problems (eg, congenital long QT syndrome)—May cause side effects to become worse.
- Kidney disease or
- Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of triptorelin
A nurse or other trained health professional will give you triptorelin. triptorelin is given as a shot into your muscle (usually in the buttocks). triptorelin needs to be given on a fixed schedule. Make sure you keep all of your appointments.
Precautions While Using triptorelin
It is very important that your doctor check your progress at regular visits to make sure that triptorelin is working properly. Blood and urine tests may be needed to check for unwanted effects.
triptorelin may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive the medicine.
When you first start using triptorelin, some of your symptoms might get worse or you might have new symptoms for a short time. Tell your doctor right away if you have bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
triptorelin may cause changes in your blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.
triptorelin may increase your risk of having a heart attack or stroke. Call your doctor right away if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, nausea, sweating, or vomiting.
Before you have any medical tests, tell the medical doctor in charge that you are using triptorelin. The results of some tests may be affected by triptorelin.
triptorelin Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Less common
- Bladder pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or cloudy urine
- blurred vision
- burning while urinating
- chest pain
- cough producing mucus
- decrease in urine volume or frequency of urination
- difficult or labored breathing
- difficult, burning, or painful urination
- difficulty in passing urine
- dry mouth
- flushed, dry skin
- frequent urge to urinate
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- loss of consciousness
- lower back or side pain
- pale skin
- pounding in the ears
- rapid weight gain
- slow or fast heartbeat
- tightness in the chest
- tingling of the hands or feet
- troubled breathing
- troubled breathing with exertion
- unexplained weight loss
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- changes in skin color
- changes in vision
- chest discomfort
- cold, clammy, or pale skin
- dizziness or lightheadedness
- inability to speak
- irregular heartbeats
- numbness or tingling in the face, arms, or legs
- pain or discomfort in the arms, jaw, back, or neck
- pain, redness, or swelling in the arm or leg
- severe or sudden headache
- slow heart rate
- slurred speech
- sudden shortness of breath or troubled breathing
- temporary blindness
- trouble speaking, thinking, or walking
- weakness in the arm or leg on one side of the body, sudden and severe
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Bone pain
- decrease in testicle size
- decreased interest in sexual intercourse
- feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
- general feeling of discomfort or illness
- inability to have or keep an erection
- joint pain
- leg pain
- loss in sexual ability, desire, drive, or performance
- loss of appetite
- muscle aches and pains
- redness of the face, neck, arms, and occasionally, upper chest
- runny nose
- sore throat
- sudden sweating
- trouble sleeping
- Acid or sour stomach
- back pain
- body aches or pain
- breast pain
- burning, dry, or itching eyes
- difficulty having a bowel movement (stool)
- difficulty with moving
- discharge or excessive tearing
- eye pain
- injection site pain
- itching or rash
- lack or loss of strength
- leg cramps
- loss of appetite
- muscle aching or cramping
- muscle pains or stiffness
- quick to react or overreact emotionally
- rapidly changing moods
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- runny nose
- stomach discomfort, upset, or pain
- swelling of the breasts or breast soreness in both females and males
- swollen joints
- tender, swollen glands in the neck
- trouble swallowing
- voice changes
- weight loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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