Triptorelin Pregnancy and Breastfeeding Warnings

Triptorelin is also known as: Trelstar, Trelstar Depot, Trelstar LA

Triptorelin Pregnancy Warnings

A retrospective chart review evaluated the teratogenic and fetal risk of 28 pregnancies in which triptorelin was inadvertently administered in the 20 first weeks of pregnancy. The authors did not report any teratogenic or fetal toxic effects. Furthermore, no specific hazards were reported among the newborns. Another study has reported four pregnancies occurring during pituitary down-regulation with triptorelin acetate in 366 in vitro fertilization cycles resulting in three deliveries of four normal neonates at term and one first trimester abortion.

Triptorelin has been assigned to pregnancy category X by the FDA. Animal studies have revealed evidence of embryotoxicity and maternal toxicity. There are no controlled data in human pregnancy. Triptorelin is considered contraindicated in women who are or may become pregnant while receiving the drug. If the drug is used during pregnancy or if the patient becomes pregnant while taking the drug, she should be advised of the potential hazard to the fetus.

Triptorelin Breastfeeding Warnings

There are no data on the excretion of triptorelin into human milk. Use of triptorelin is not recommended in nursing mothers because many drugs are excreted in human milk and the effects of the drug on lactation and on the breast-fed child have not been determined.

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