podophyllum resin (Topical route)

pode-oh-FIL-um REZ-in

Commonly used brand name(s)

In Canada

  • Podofilm

Available Dosage Forms:

  • Solution

Uses For podophyllum resin

Podophyllum is used to remove benign (not cancer) growths, such as certain kinds of warts. It works by destroying the tissue of the growth.

A few hours after podophyllum is applied to a wart, the wart becomes blanched (loses all color). In 24 to 48 hours, the medicine causes death of the tissue. After about 72 hours, the wart begins to slough or come off and gradually disappears.

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Podophyllum is usually applied only in a doctor's office because it is a poison and can cause serious side effects if not used properly. However, your doctor may ask you to apply podophyllum resin at home. If you do apply it at home, be sure you understand exactly how to use it.

Podophyllum is available only with your doctor's prescription.

Before Using podophyllum resin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For podophyllum resin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to podophyllum resin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of topical podophyllum in children with use in other age groups, podophyllum resin is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of topical podophyllum in the elderly with use in other age groups, podophyllum resin is not expected to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of podophyllum resin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Crumbling or bleeding warts or warts that have recently had surgery on them—Using podophyllum on these warts may increase the chance of absorption of the medicine through the skin

Proper Use of podophyllum resin

Podophyllum is a poison. Keep it away from the mouth because it is harmful if swallowed.

Also, keep podophyllum away from the eyes and other mucous membranes, such as the inside of the nose, mouth, or vagina. podophyllum resin may cause severe irritation. If you get some in your eyes, immediately flush the eyes with water for 15 minutes. If you get some on your normal skin, thoroughly wash the skin with soap and water to remove the medicine. However, if podophyllum resin contains tincture of benzoin, it may be removed more easily from the skin by swabbing with rubbing alcohol.

podophyllum resin may contain alcohol and therefore may be flammable. Do not use near heat, near open flame, or while smoking.

Use podophyllum only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects.

Do not use podophyllum on moles or birthmarks. To do so may cause severe irritation.

Also, do not apply podophyllum resin to crumbling or bleeding warts or to warts that have recently had surgery on them. To do so may increase the chance of absorption through the skin.

To use:

  • Podophyllum can cause severe irritation of normal skin. Therefore, apply petrolatum around the affected area before you apply podophyllum, and/or apply talcum powder to the treated area immediately after you apply podophyllum. This is to prevent the medicine from spreading to the normal skin.
  • Use a toothpick or a cotton-tipped or glass applicator to apply podophyllum resin. Apply 1 drop at a time, allowing time for drying between drops, until the affected area is covered.
  • After podophyllum is applied, allow it to remain on the affected area for 1 to 6 hours as directed by your doctor. Then, remove the medicine by thoroughly washing the affected area with soap and water. If podophyllum resin contains tincture of benzoin, it may be removed more easily by swabbing the affected area with rubbing alcohol. However, this may be more irritating than washing with soap and water.
  • Immediately after applying podophyllum resin, wash your hands to remove any medicine that may be on them.

Dosing

The dose of podophyllum resin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of podophyllum resin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical solution dosage form:
    • For venereal warts:
      • Adults and children—Apply to the affected area(s) of the skin and leave on the skin for one to six hours. Treatment may be repeated every week for up to six weeks.
    • For other warts or benign growths:
      • Adults and children—Apply to the affected area(s) of the skin once a day.

Missed Dose

If you miss a dose of podophyllum resin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

podophyllum resin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Early symptoms of too much medicine being absorbed into the body
  • Abdominal or stomach pain
  • clumsiness or unsteadiness
  • confusion
  • decreased or loss of reflexes
  • diarrhea (may be severe and continuing)
  • excitement, irritability, or nervousness
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • muscle weakness
  • nausea or vomiting
  • sore throat and fever
  • unusual bleeding or bruising
Late symptoms of too much medicine being absorbed into the body
  • Constipation
  • convulsions (seizures)
  • difficult or painful urination
  • difficulty in breathing
  • dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • drowsiness
  • fast heartbeat
  • numbness, tingling, pain, or weakness in hands or feet (may not occur for about 2 weeks after medicine is used)
  • pain in upper abdomen or stomach (mild, dull, and continuing)

Check with your doctor as soon as possible if any of the following side effects occur:

  • Burning, redness, or other irritation of affected area
  • skin rash or itching

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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