gallium nitrate (Intravenous route)
Concurrent use with other potentially nephrotoxic drugs may increase the risk for developing severe renal insufficiency in patients with cancer-related hypercalcemia. If use of another potentially nephrotoxic drug is indicated during gallium nitrate therapy, discontinue gallium nitrate and continue hydration for several days after administration of the potentially nephrotoxic drug. Monitor renal function during and subsequent to this period. Discontinue gallium nitrate therapy if the serum creatinine level exceeds 2.5 mg/dL.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Calcium Regulator
Uses For gallium nitrate
Gallium nitrate is used to treat hypercalcemia (too much calcium in the blood) that may occur with some types of cancer.
gallium nitrate is available only with your doctor's prescription.
Before Using gallium nitrate
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For gallium nitrate, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to gallium nitrate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on gallium nitrate have been done only in adult patients, and there is no specific information comparing use of gallium nitrate in children with use in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of gallium nitrate in the elderly with use in other age groups, gallium nitrate is not expected to cause different side effects or problems in older people than it does in younger adults.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking gallium nitrate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using gallium nitrate with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Rotavirus Vaccine, Live
Using gallium nitrate with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine Type 4, Live
- Adenovirus Vaccine Type 7, Live
- Bacillus of Calmette and Guerin Vaccine, Live
- Influenza Virus Vaccine, Live
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Varicella Virus Vaccine
- Yellow Fever Vaccine
Using gallium nitrate with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Gallium Citrate Ga 67
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of gallium nitrate. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease—Gallium nitrate may make this condition worse
Proper Use of gallium nitrate
Make certain your health care professional knows if your diet includes large amounts of calcium-containing foods and/or vitamin D, such as milk or other dairy products. Also let your health care professional know if you are on any special diet, such as a low-sodium or a low-sugar diet.
The dose of gallium nitrate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of gallium nitrate. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For injection dosage form:
- For treatment of too much calcium in the blood:
- Adults and teenagers—The dose is based on body size and must be determined by your doctor. Gallium nitrate is injected slowly into a vein over 24 hours, for five days. The dose may be repeated in two to four weeks.
- Children up to 12 years of age—Use and dose must be determined by your doctor.
- For treatment of too much calcium in the blood:
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using gallium nitrate
It is important that your doctor check your progress at regular visits while you are receiving gallium nitrate. If your condition has improved and you are no longer receiving gallium nitrate, your progress must still be checked. The results of laboratory tests or the occurrence of certain symptoms will tell your doctor if your condition is coming back.
gallium nitrate Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.More common
- Blood in urine
- bone pain
- greatly increased or decreased frequency of urination or amount of urine
- increased thirst
- loss of appetite
- muscle weakness
- nausea or vomiting
- Abdominal cramps
- muscle spasms
- Unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- metallic taste
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: gallium nitrate Intravenous side effects (in more detail)
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