atenolol and chlorthalidone (Oral route)Pronunciation
Commonly used brand name(s)
In the U.S.
- Tenoretic 100
- Tenoretic 50
Available Dosage Forms:
Therapeutic Class: Beta-Adrenergic Blocker, Cardioselective/Thiazide Combination
Pharmacologic Class: Beta-Adrenergic Blocker, Cardioselective
Chemical Class: Thiazide Related
Uses For atenolol and chlorthalidone
Atenolol and chlorthalidone combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .
Atenolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .
Chlorthalidone is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure .
atenolol and chlorthalidone is available only with your doctor's prescription .
Before Using atenolol and chlorthalidone
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For atenolol and chlorthalidone, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to atenolol and chlorthalidone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of atenolol and chlorthalidone combination in the pediatric population. Safety and efficacy have not been established .
Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of atenolol and chlorthalidone combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving atenolol and chlorthalidone combination .
|All Trimesters||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking atenolol and chlorthalidone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using atenolol and chlorthalidone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
Using atenolol and chlorthalidone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amtolmetin Guacil
- Choline Salicylate
- Enalapril Maleate
- Flufenamic Acid
- Guar Gum
- Ibuprofen Lysine
- Insulin Aspart, Recombinant
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Mefenamic Acid
- Niflumic Acid
- Salicylic Acid
- Sodium Salicylate
- St John's Wort
- Tiaprofenic Acid
- Tolfenamic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of atenolol and chlorthalidone. Make sure you tell your doctor if you have any other medical problems, especially:
- Angina (severe chest pain)—May provoke chest pain if stopped too quickly .
- Anuria (not able to form urine) or
- Bradycardia (slow heartbeat) or
- Heart block or
- Heart failure or
- Pheochromocytoma (adrenal gland tumor), untreated—Should not use in patients with these conditions .
- Blood vessel disease (circulation problems) or
- Gout or
- Hyperuricemia (high uric acid in the blood) or
- Hypochloremia (low chloride in the blood) or
- Hypokalemia (low potassium in the blood) or
- Hyponatremia (low sodium in the blood) or
- Systemic lupus erythematosus—Use with caution. atenolol and chlorthalidone may make these conditions worse .
- Diabetes or
- Hyperthyroidism (overactive thyroid) or
- Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .
- Kidney disease or
- Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .
- Lung disease (e.g., asthma, bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .
- Sympathectomy—Use with caution. The effects of atenolol and chlorthalidone may be increased .
Proper Use of atenolol and chlorthalidone
In addition to the use of atenolol and chlorthalidone, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .
Remember that atenolol and chlorthalidone will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .
Do not interrupt or stop taking atenolol and chlorthalidone without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous .
The dose of atenolol and chlorthalidone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of atenolol and chlorthalidone. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For high blood pressure:
- Adults—One tablet once a day.
- Children—Use and dose must be determined by your doctor .
- For high blood pressure:
If you miss a dose of atenolol and chlorthalidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using atenolol and chlorthalidone
It is very important that your doctor check your progress at regular visits to make sure atenolol and chlorthalidone is working properly and to check for unwanted effects .
Using atenolol and chlorthalidone while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away .
atenolol and chlorthalidone may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing .
atenolol and chlorthalidone may cause changes in your blood sugar levels. Also, atenolol and chlorthalidone may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests .
Make sure any doctor or dentist who treats you knows that you are using atenolol and chlorthalidone. You may need to stop using atenolol and chlorthalidone several days before having surgery or medical tests .
atenolol and chlorthalidone Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- Cold arms or legs
- difficult or labored breathing
- shortness of breath
- tightness in chest
- Chest pain or discomfort
- cold sweats
- dizziness, faintness, or lightheadedness when getting up from lying or sitting position
- leg pain
- lightheadedness, dizziness, or fainting
- slow or irregular heartbeat
- unusual tiredness or weakness
- Black, tarry stools
- bleeding gums
- blood in urine or stools
- feeling that others are watching you or controlling your behavior
- feeling that others can hear your thoughts
- general feeling of discomfort, illness, or weakness
- paleness or cold feeling in fingertips and toes
- pinpoint red spots on skin
- seeing, hearing, or feeling things that are not there
- severe mood or mental changes
- skin irritation or rash, including rash that looks like psoriasis
- tingling or pain in fingers or toes when exposed to cold
- unusual behavior
- unusual bleeding or bruising
Get emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdose
- Blurred vision
- decreased urination
- dry mouth
- increase in heart rate
- muscle cramps or pain
- numbness, tingling, pain, or weakness in hands or feet
- rapid breathing
- sunken eyes
- weakness and heaviness of legs
- wrinkled skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- feeling sad or empty
- lack of appetite
- loss of interest or pleasure
- trouble concentrating
- trouble sleeping
- feeling of constant movement of self or surroundings
- sensation of spinning
- unusual drowsiness, dullness, or feeling of sluggishness
- Decreased interest in sexual intercourse
- disturbed color perception
- double vision
- hair loss, thinning of hair
- halos around lights
- inability to have or keep an erection
- loss in sexual ability, desire, drive, or performance
- loss of vision
- night blindness
- overbright appearance of lights
- pain of penis on erection
- tunnel vision
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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