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Semaglutide User Reviews & Ratings (Page 5)

Brand names: Ozempic, Wegovy, Rybelsus

Semaglutide has an average rating of 6.6 out of 10 from a total of 1,987 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 25% reported a negative experience.

Reviews for Semaglutide

  • Nw272...
  • Taken for 1 to 6 months
  • June 20, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "Started April 1, 2021, on Ozempic low dose. 3-week intervals it was increased. Side effects were constipation (went on laxatives to help), pain in my back (severe), bloating. Week 11 increased to 1mg, the side effects were major bloating, diarrhea, sounds in my stomach (crazy), nauseous, feeling under the weather. My appetite has decreased to the point that I only eat 2 meals a day that are small. My sugar levels have decreased from 7.1 to 5.2 A1C. I’ve noticed that I have been kept awake some nights like I’m nervous for some reason. In the first 3 weeks, I’ve lost 15 pounds. Haven’t checked since I want to wait but can feel a difference. The pains in the stomach are really uncomfortable, and the bloating I will try gas-x for relief. When I try to eat more than I should, my body tells me that I’m full. If I go beyond that point, I get severe pains in the stomach for hours. But depends on what I eat. Going to stay with smaller portions/healthier foods."

8 / 10
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  • Lala...
  • Taken for 1 to 6 months
  • June 10, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I started 3 weeks ago and every Monday I inject myself with a .25 mg dose. I started this medication because at age 47 even though I tried so hard to exercise and diet my weight was a roller coaster ride and I would bounce back to my heaviest weight. My weight when I started was 170 lbs which was 3 weeks ago. After a week I am down to 159 lbs, then second week 157 lbs, I weigh myself yesterday and I am down 155 lbs that's 15 lbs less. The first week I had a little heartburn, and the second week was a little dizzy because you can go a day without being hungry at all. End of the second week I had no side effects at all. I am surprised that again I can go a day without being hungry at all but of course, I force myself to eat something even with food I will eat but will be so full easily. I take protein shakes daily as my meal replacement. I'm taking fiber (gummies) so I can go to the bathroom with no problem and it helps a lot. Overall I am pretty happy with the result."

8 / 10
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  • Alli
  • Taken for 6 months to 1 year
  • August 23, 2020

Rybelsus (semaglutide) "I was put on this medication by my internist at the beginning of 2020 for weight loss. I have Polycystic Ovarian Syndrome which causes insulin resistance despite the fact that I'm not diabetic. It makes it extremely hard to lose weight. My doctor thought I would be a good candidate for Rybelsus and had seen success with others. I lost almost 30 pounds in two months while taking Rybelsus and going to the gym 3 times a week. However, I had to stop going to the gym during the pandemic and continued the medication. I started having severe gastrointestinal issues about a month ago. I had to have an EGD, HIDA scan, and ultrasound done to discover I have gallstones. My gallbladder is functioning perfectly though and my cholesterol is always good so all signs point to the fact that Rybelsus gave me gallstones. Gallstones are an 'infrequent yet severe side effect' listed by the drug manufacturer. BEWARE! I never had these issues until I started taking Rybelsus!"

1 / 10
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Frequently asked questions

  • eric
  • Taken for 1 to 6 months
  • December 20, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I tried everything, almost getting gastric sleeve surgery. Thanks to my cardiologist, even my heart is fine, he doesn't want to give me clearance for the operation. He recommended Wegovy. I think this is the best decision I ever made. I started on November 2nd, 2023, and until now, December 20th, I have lost an incredible 30 pounds. I now eat only two times a day. I used to eat lots of sweet stuff, but not anymore. No more late eating. I eat very small portions and I feel full all day. I love you, Wegovy, it's real. I am on a 1mg dosage. I was 331 pounds and now I am 301 pounds, with a goal to lose 40 more pounds by July. Good luck everyone, there's a chance because of Wegovy."

10 / 10
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  • Wegovme
  • Taken for 1 to 6 months
  • September 7, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Please do not let these reviews scare you like I almost did. I held off multiple weeks because of all these death-like reviews. Finally, when I did decide to just start—I hunkered down like the outside world was about to end. Did the world end? No. I was perfectly fine. Were there the occasional burp and heartburn? Yes. But nothing that wasn’t manageable. I’m over 14 weeks in now, and I barely have a side effect at all. My point—everyone’s body is different. Try it for yourself."

9 / 10
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Are you taking this medicine?

  • Kelly...
  • Taken for 1 to 6 months
  • May 4, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been on Wegovy for almost 7 weeks, and have lost over 22 lbs. From the moment I took the first injection the food noise was gone. At times it feels progress is slow, but in truth the progress has been steady. I have not started dieting or exercising, I am focusing on eating healthier and listening to my body for signs that I am full. I have heard of bad side effects, though I personally have not experienced any. Prior to this medication I have lost, gained and relost 50-100 lbs over and over again."

10 / 10
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  • LADw
  • Taken for 1 to 6 months
  • July 4, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I took Wegovy for a few month and did in fact lose some weight. The side effect are terrible as so many others have noted here. One thing that they don’t tell you is that the drug slows down the stomach ability to empty. This is why people feel full and experience reflux, nausea, etc. In my case the drug not only slowed down my stomach ability to empty it permanently paralyzed my stomach muscles, a condition called gastroparesis. The only remedy was to have a neurotransmitter implanted in my stomach which forces the muscles to move. Do NOT take or first this medication. You could end up like me with a lifetime medical issue. No weight loss is worth that."

1 / 10
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More FAQ

  • Janny
  • Taken for 1 to 6 months
  • March 15, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "My doctor gave me Ozempic 0.5 to start with. I always had upset stomach, diarrhea with most foods, and an overall sick feeling all the time. I was able to 'live' with it until now. She decided to up my dose to the 1.0 and my body went into total chaos. I am always nauseous, constipated, got reflux, feels like my food is stuck in my stomach and doesn't go anywhere. I'm constantly burping and feeling bloated. The sick feeling feels intensified and I cannot function at work. I took my last one this past Friday night and was miserable all weekend long. Today I am at work unable to function at my best because the nausea is bad. I would say it is effective in lowering your blood sugar numbers and helping you lose weight but not worth feeling horribly sick over. I will not be using this medication any longer."

5 / 10
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  • Mike
  • Taken for 1 to 6 months
  • March 21, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Drug has been life changing. When I began I was 6'3" 357 lbs. Today is exactly 4 months in and I'm down 60 lbs exactly. Blood pressure meds cut in half, discontinued lasix and potassium pills. Currently taking 2.4 mg / weekly. My side effects have been relatively non existent. Early on some gastro upset and heartburn but all went away with time."

10 / 10
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  • Me22
  • Taken for 1 to 6 months
  • March 31, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Just finished the last shot of 2.4 mg pack. I’ve lost 27 pounds and literally do not think about food. No cravings, and I eat normally (albeit smaller amounts). Some side effects at the beginning but nothing terrible and they all eventually stopped. If you can afford it - this is a life changer."

10 / 10
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  • ShellB
  • Taken for 6 months to 1 year
  • May 1, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I began Wegovy in late August '21. I had bariatric surgery (2000). Menopause, major life changes & COVID resulted in a 60 lb wgt gain over 5 years. It's May 1 & I've lost a total of 81 lbs. My BMI has gone from 38 to 25 & I never got to the 2.4 injection. I had slight nausea & 2 incidents of gastronomic uncertainty ("Sharts") the 1st 2 weeks, but nothing after that. I walked 1.5 - 2.0 miles 6 or 7 days weekly, ate a high protein, low carb diet, switched to 50/50 Stevia/Sugar as a sweetener & ceased eating after 8pm nightly. I feel great & because of my weight loss I can delay my other hip replacement. Wegovy gave me a 2nd chance at better health & I'll continue to use it for maintenance."

10 / 10
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  • jmm
  • September 27, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "For me it is a miracle drug! I have had no side effects and have been on it since December of 2021. I was doing other medications, that helped a little, but I was stuck teetering between 190-195 could not pass that. As soon as I started Wegovy the weight started to come off. I am now right around 160 and I am close to my goal. I am also 60 which makes weight loss even more difficult. I highly recommend this treatment!"

10 / 10
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  • JMH
  • Taken for 1 to 2 years
  • March 22, 2024

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been on Wegovy for a year and 3 months and have lost 100 lbs. (started at 289 & 5'7"). I do deal with nausea, but it is controllable with Zofran so I keep that on me at all times. You are in control of how you feel by what you eat and the amount of water that you drink. Protein is key! I have dealt with a B12 deficiency since being on this med as well as hair loss. I deal with chronic pain so working out has never been easy for me. Wegovy has been a game changer and completely changed my life. I went from a 2X to a L in clothing and feel the best that I've ever felt despite the nausea."

9 / 10
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  • Fingers...
  • Taken for 1 to 6 months
  • July 5, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "57 yr old on this for 3 1/2 weeks. I'd like to tell you how much I lost (was 4 pounds at 3 weeks) but I am so constipated for 4 days I cannot be sure what my real weight is (it could be 6 pounds now). Get a telemedicine provider to send you a vial of semaglutide (not the pre loaded syringes) and use an insulin syringe to administer 1/2 the dose on one day with a ODT Zofran, then take the second half of the dose 24 hours later with another ODT Zofran. I administer in my outer thigh, like you would give insulin. The provider will tell you exactly how many "units" to administer per week, just cut it in half say Saturday and Sunday. Take a stool softener on Sunday, which I forgot to do this week! I have had zero gastrointestinal issues, no nausea, no vomiting. The Zofran may be causing some of the constipation and I don't consider this a real issue, just a minor side effect with an easy fix. I am a Nurse Practitioner, so I have been watching everything for real side effects. I'll update."

10 / 10
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  • Erica
  • Taken for 1 to 6 months
  • March 29, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I've been on Wegovy for a little over a month now. My first injection of the .5mg dose was Friday (3/24/23). The weight loss has been fairly slow, but steady. The main thing that I've noticed is that it makes me feel full after I eat. I know it sounds strange, but for some reason, I've never felt hungry or full-- I ate when people told me and didn't stop eating until my plate was clean since I was a kid. Now, after I eat a bit, I feel full and stop eating. I've learned to be choosier with what I eat, opting for healthy things, protein and fiber, and less fat, and carbs. No crazy fad diets or anything, just being more mindful. My injections are Fridays, and I've noticed that Sundays are the worst days, but after 2 weeks on a dose, the side effects are pretty minimal. Just started the .5mg dose and so this past Sunday was bad, but my doctor gave me a PRN script for Zofran to help with nausea. I hope this review helps someone."

8 / 10
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  • MRS
  • Taken for 1 to 6 months
  • January 10, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been taking Wegovy since August 2021. I am down 45 pounds. I did low carb with this which has really helped me to lose the weight I have wanted to lose. The side effects are very real, extreme constipation and nausea for two days after injection. The doctor prescribed zofran for the nausea and I have taken stool softener for the constipation. All things said it really helped curb my appetite. But you have to diet with it."

9 / 10
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  • ShyFox
  • Taken for 1 to 6 months
  • November 1, 2021

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Been on Wegovy for 7 weeks. Lost 14 pounds. 2nd week into .50mg. It’s a little rough on my stomach. Taking prescription for nausea which happens the day of the injection. Feel tired and occasionally get severe abdominal pains. I can’t eat much and have to really watch the types of food. No greasy foods or spicy or heavy. The intestinal pains were very severe after eating wrong foods. I’m happy with the weight loss but the side effects are rough."

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  • Highly...
  • Taken for 1 to 6 months
  • April 18, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I was worried about side effects with this medication but I have not had any. So far I have lost 16 lbs in two and a half months, with diet and exercise. I started with the .25 mg dose, and I am now on the 1 mg dose. I would recommend it to others that want to try it"

10 / 10
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  • Grate...
  • Taken for 6 months to 1 year
  • June 15, 2022

Ozempic (semaglutide) for Cardiovascular Risk Reduction "I went to my Doctor to talk about my weight at 59, 247 pounds, bra size 40J. Was going to get reduction. Start with .25 MG and I am up to 1mg and I have lost 60lb I am at 187. Still get cramps every now and then. Going to try giving it to me in my leg. Bra size 33G. Off 2 pills, have energy and self esteem again. It's a miracle."

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  • Big...
  • Taken for 1 to 6 months
  • April 24, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been on Wegovy for over a month now, it has been a life changer for me. Very few side effects. I have way more energy, I can fit into clothes that were so tight I couldn't wear them, and I have fewer aches and pains. My mindset is so different. I am 5 11', started at 263 lbs. (Obese) I have lost almost 15 lbs. This stuff pretty much keeps those hunger cravings away. I have changed my eating habits as well, I only eat fruits, veggies, and salads, I do plan on going back to some of my other favs' but for now, I'm sticking to no pasta, pizza, bread, or desserts. I only eat between the hours of 6 am to 3 pm. I have been walking around a 1/2 mile per day on my lunch breaks. I do not eat much, seems like I get full very quickly. Another benefit, I have bitten my nails my entire life, since starting Wegovy, I have not touched them, it's quite unbelievable."

10 / 10
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  • TBH
  • Taken for less than 1 month
  • February 25, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Started 2/23/23. 0.25. 64 years old, H 5/6, W 217. Only side effect is dizziness when standing up and subsides with a minute or two. That seems to be hypoglycemia. As of today 2/26/23 it has definitely curbed my appetite. I will check back in a month to let you know my progress."

8 / 10
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  • usmc
  • Taken for 1 to 6 months
  • November 29, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "At this time, I’m on my 5th week of the maintenance dose. The only side effect I’ve had is occasional constipation, but as a 25-year medical professional, I know how to deal with it medically and in conjunction with my VA doctor and pharmacist. At times, I would get hypoglycemic, but again I knew how to combat that. At this dose I find myself somewhat more fatigued but I can deal with that. Cat naps usually do the trick. I started at 393 and 6’3”. I’m 56 years old. I’m down to 349 since I started, which for me is great. I have critical low testosterone and can’t take testosterone due to my history of pulmonary embolisms. So I don’t mind losing only 2 pounds a week. I can now walk so much better and farther. I’m 95% VA disability rated, and I’ll tell you, I feel and look so much better after starting to use Wegovy. The VA truly cares for us veterans no matter what you hear. Stay blessed and hang in there."

10 / 10
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  • kathyc
  • Taken for 6 months to 1 year
  • April 26, 2024

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been on Wegovy for about 8 months. My weight has dropped about 40 lbs. In the beginning, I did have upset stomach on occasion and found there are a few things I could not eat or drink anymore, but my blood pressure is a lot better. I feel good about myself. I don't need to lose any more weight. I am walking a mile a day, using my weights every morning, and I don't drink much alcohol anymore, not that I am saying I was an over drinker, but because of the calories and some of it doesn't taste good anymore. It has helped me eat better, rethink about how much I eat, and be healthier. My old clothes that didn't fit are now fitting, and I have a whole new wardrobe to go through."

10 / 10
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  • SooGirl
  • Taken for less than 1 month
  • July 8, 2021

Ozempic (semaglutide) for Cardiovascular Risk Reduction "I've been on Ozempic for just over a week now as part of a physician-run weight loss program. I was told to expect some GI upset but I had no idea it would be this bad. 7 days after taking I started with diarrhea. One day after injection #2 (2.5mg) I was up all night with diarrhea, nausea, severe reflux, belching and eventually vomiting. Meds like Pepto can't seem to touch it. I am going to talk to the doc next week and see what he thinks. I really don't think it is worth this kind of suffering."

2 / 10
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  • WagOn
  • Taken for less than 1 month
  • April 5, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I took my first shot of .25 5 days ago. I was extremely nervous about taking it due to all of the negative side effects that I read others have had. I decided to inject in my upper thigh late on a Friday afternoon, so that if I did feel sick I had the weekend to take it easy and deal with it. The injection was painless and very easy to administer myself. I honestly noticed no side effects after taking it, other than not thinking about food as much and wanting to eat a little less. I did push the boundaries on the third evening after taking it and I did have bad nausea (I actually vomited) and felt generally ill for about 16 hours (not bad enough to not work though). I pushed the boundaries by over eating air fried chicken wings (no sauce) that were a bit more greasy/oily than normal. Those really set me off and I realized that I: 1. can no longer eat any type of greasy food and 2. cannot eat too much. As long as I stick to my normal healthy, low carb diet, I feel just fine (so far)."

9 / 10
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60 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.