Spravato for Major Depressive Disorder User Reviews (Page 2)

• Good...
• Taken for less than 1 month
• November 5, 2021

"I complete week 4 Monday. 84 mg is super strong - can be trippy. Start with 56 mg. Do NOT drive for several hours. Do NOT move around much during the session as you could get nauseous. My depression is much improved so far. improved, but this is not a magic bullet."

• kenne...
• Taken for 6 months to 1 year
• September 20, 2022

"Who needs therapy when there’s Spravato ? Paradoxically my own reservations almost kept me from trying this drug that turned my entire life around. I went from sleeping on the floor at my moms & in an abusive long distance relationship , to getting my own place and finally having the courage to leave the relationship. At the twice a week regimen, I was even going to the gym after work- pretty much unheard of for me in the last decade . I was discouraged to find that when I tapered to once every other week my depression seemed to be making its way back, however I am very lucky to be treated at a place that allows me to go back to more frequent visits. I cannot say enough good things about Spravato, and I’m not sure what my life would be without it. Lexapro took me out of a completely mental state, and Spravato ensured I stay there."

• Ricky
• Taken for less than 1 month
• February 22, 2022

"I am using this for PTSD. The drug experience is horrible. After I spray it in my nose and it begins to take effect I pray it will end. The feeling is so horrible. I want to throw up, I can't physically move, I can't assess where I am, I can't "sense" anything but I am aware of how bad I feel and pray it ends. For 24 hours after each treatment I am a worthless dish rag. I feel my brain will never come back. No ability to think and want to vomit. I can't take many drugs. I have severe reactions. I opted to try Spravato because it is not every day. You won't want a soul near you when under the effects in office. I feel I am in prison. Trapped. Can't scream. Buried alive with no help. It is a bad trip. If it treats PTSD it is worth more the nightmare side effects that is the only reason I tried it. I have had allergic reaction to everything ever given to me. I am not allergic to spravato. I just am terrified of how it makes me feel. I dread treatment."

• Kay
• Taken for 1 to 6 months
• November 6, 2022

"My major depressive disorder is drug resistant. I used Sparvarto at a doctors office 3 times weekly for about 6 weeks. My first 2 weeks, were filled with sadness, followed by mad anger (PTSD Symptoms) for the following 2 and experienced deeper sadness and suicidal ideation for the last two. We then stopped treatment about a month ago and I am still struggling with deep sadness.I feel disappointed. I had been so hoping for lasting help. I've begun to lose hope that I'll never again experience life with more delight."

• Destiny...
• Taken for less than 1 month
• July 4, 2022

"Spravato ended up making me have suicidal thoughts and I think maybe go into a psychosis or something... I took it for a month. Twice in one week 34mg, and then the rest ones were 84mg once a week. You take it like a nasal spray and it burns a lot. I just couldn’t move and felt drunk like mucked up seeing tracers for about 45 minutes maybe. I didn’t like how I couldn’t move. I was completely numb, it helps pain for that time. But when it wore off I was still numb mentally. I would get angry when it wore off. It just has to be known, it made me worse. They told me it was impossible to feel worse. Which is so stupid. I also have PTSD, social anxiety and generalized. Spravato made me take a lot of steps back. I had worked so hard to the point to where I was and it tore it all down. Now I am a lot better and building it back up. But I just still don’t feel 100%. I hope I do. It made me aggressive, I wanted to fight people and harm myself. I used to be addicted to self harming."

• Dan...
• Taken for 1 to 2 years
• June 5, 2022

"I have struggled with treatment resistant depression (TRD) since, I was dx'd with MDD in 1988. Things really got bad around 2001, and I had to go on disability. I have been fortunate in that I have been treated by some of the best psychiatrist in the game. Prior to being allowed to access Spravato between 2019 and 2020, I had received every Pharmacological, and Psychological Treatment available, Including TMS (extensive), and ECT, including a 1 year outpatient course of intensive ECT. Despite all of this I pretty much remained in Depressive Hell..or as I heard One expert describe it, "The Anti-life." Spravato, combined with a comprehensive Bio-Psycho-Social Treatment Approach, allowed me to Attain Recovery and Remission for the first time in over 30 years. However, my Insurance quit covering it, at the end of 2020. I actually thought I could do ok without it, so I did not really pursue trying to stay on it at that time. I was ok for awhile, but the past year has been particularly rough, and I intend to try and resume."

• Jackie
• Taken for 1 to 6 months
• March 27, 2022

"I just finished treatment #12 of Spravato today. I am 37 years old and am diagnosed with treatment resistant depression and Complex PTSD. I have been on at least 10 different types of anti-depressants over the past 15 years. I have also done TMS and IV ketamine treatments in the past 5 years. I would say that I am cautiously optimistic that the Sravato is starting to work. I have gone from sleeping 6 to 7 hours of the day + 8 to 9 hours at night bc I did not want to face life. Now I still sleep a full night but only take a 1 to 2 hour nap during the day. So I have increased energy and overall improved mood. I would say the biggest change has been in my suicidal ideation. I still have hard nights, but the intrusive thoughts are way less! As anyone who has been dealing with depression for years and years knows there is no one miracle cure. I would say overall though spravato is helping and thankfully, unlike IV ketamine treatments is covered by my insurance which is a huge blessing."

• DanDan
• April 4, 2023

"I’ve just had my 9th Spravato at 84mg. I have only today felt the effects on me. It was not a scary ‘trip’ but it wasn’t nice. I felt distressed and a bit ‘out of it’. For example, I have chronic lower back pain, I felt the pain but couldn’t feel my legs. I am trying to find the positive side of this in the fact that at least I did feel it. I was really worried that it wasn’t working at all. I now hope number 10 has an effect as well. They are talking about possibly moving me from the Spravato spray to Ketamine infusions. So I will update you as soon as I can. At the moment my mood is still desperately low and suicidal thoughts are paramount. I hope my next ‘review’ is a more positive one."

• OwlsG...
• Taken for 1 to 6 months
• June 9, 2021

"I did Spravato for six weeks and it had zero effect on my depression, but did have several negative side effects. I became very aggressive and hostile. The actual process of taking the drug was a miserable experience. The taste was horrible and made me horribly nauseated. The entire experience was not worth it. Add to that I'm now fighting with the pharmacy that supplied the drug. I qualified for Janssens assistance and my portion should have been $10, but Alliance RX/Walgreens is billing me $1000."

• Sadgurl
• Taken for 1 to 6 months
• December 29, 2021

"First dose was like a light switch flipped on and everything was in color again. Immediate end to all suicidal thoughts and ideations. Drastically improved sleep and I was able to reduce other medications as a result. The rest of the treatments were beneficial, as the dissociation helped me process trauma that I just couldn't do with therapy alone. No side effects except drowsiness the day of treatment"

• Emmer...
• Taken for less than 1 month
• October 16, 2022

"Ok so I have only done it twice- the first time was 56mg, the second was 84mgs or whatever. I want to start off by saying I have a very long history of substance abuse, so something like “tripping” or “dosing” was not something I hadn’t experienced. Being on Spravato - I’ve never been so messed up in my life. Seriously, what in the world… At one point I thought I melted into a pool of something on the floor, and I could hear the air twitching. For me, the initial “high” lasts about 2 hours where you trip the hell out, hallucinate and completely dissociate- but the extreme dizziness and nausea is enough to knock me on my ass for an entire 2 days afterwards. I’m trying to decide since I have not yet felt any relief- if I’m going to continue. My doc says to give her a month of trying it before I stop, but the entire day of and next day I’m sick as anything. Hope some of you find relief with this stuff"

• Hazel
• Taken for less than 1 month
• January 24, 2024

"I had my first Spravato session today, and it was terrifying. I took 56 mg. The room started spinning, I felt like I was going to throw up, everything turned into this loud noise and distorted visuals swirling around me. I had trouble keeping breathing. Suddenly I became afraid that this state would be permanent, that they had tricked me into taking the med. I became overwhelmingly sad because Spravato felt like my last chance and now I was dying from it. I felt lost, like I had ruined my brain and now was stuck with an unbearable situation. Finally, after maybe an hour and fifteen minutes, I started to come out of it. Now I'm really scared to have another session. Too soon to know if it's helping."

• Mercury
• Taken for less than 1 month
• October 5, 2022

"I was diagnosed with MDD before 23 years, since then, I have used several antidepressants. I started Spravato sessions before 6 months. My Dr. Recommended 8 sessions (two 28mg doses on each sessions). I stopped the medication after the 5th session as the medication didn't work at all (ZERO benefit) and my Dr. has agreed with this."

• pfxtc
• Taken for less than 1 month
• November 29, 2022

"31 y/o, I have been tried on 30 meds over the last 6 years, tried rTMS as well with no results. Only thing that's ever helped is tramadol (for MDD). I'm also on klonopin as needed. I had one Spravato treatment today. It was the exact opposite of IV ketamine, which really didn't like and quit after 4 infusions. IV was COLD, clinical, and felt mean. Spravato, on the other hand, felt good. It felt very pleasant and WARM. I took the 84mg. I did not "trip" at all. I didn't on max dose IV ketamine either. Both felt like a drop in the water compared to DXM or DMT, but I didn't want to "get high", I want to feel less depressed. I think the klonopin attenuates it a bit. The experience was like a total couch lock. It was very pleasing. It felt like I was doing personal therapy in my mind along with the music. I was feeling words like creativity, and peace, and acceptance, and seeing troubling issues in my mind, like grief and loss, and was able to breathe through them. I am excited to keep going with Spravato."

• CAdep...
• Taken for 6 months to 1 year
• May 11, 2022

"I’ve been on Spravato for a few months, after the initial cycle I’ve stayed at once a week for a while. Here’s my tips: Tilt your head back. Have hard candy, the taste is bad. Some days I have more intense effects than others, sometimes it is as mild as a glass of wine or nothing at all. As far as being dissociative, I use eyeshades & earphones listening to vibration sounds on Spotify or Apple Music and completely absorb myself into this… no out of body feelings, no walking around, no messing with vision. This method has helped to enjoy the experience because it’s not scary & allows me to be with my thoughts. As far as how it’s worked, it helps the day of treatment but the efficacy wanes until the next treatment, even on the first day it’s not a fix. I was hoping for more. My provider suggested infusions but between the cost and knowing now how the drug works: it won’t last and would be infinitely more costly to maintain."

• TLAS
• Taken for 6 months to 1 year
• October 5, 2023

"I am currently in the phase of getting the medication every two weeks. I am also taking Venlafaxine and Doxepin for sleep. Overall, I feel like the medication is helping, but I developed some vertigo symptoms like random dizziness, brain zaps, and brain fog. I am also in EMDR therapy as well. I don't see a 'regular' therapist. So my experience with the sessions is great because I meditate, then I fall asleep. It's like the medication is giving my brain a much-needed break. I do have varied dips between treatment sessions, especially now that they are farther apart. I feel like I got more of a benefit in the beginning because the treatment was more frequent. I feel at odds about this because I don't want to come off as an addicted person, but it does help me. I am too ashamed to admit this to my medical team. I have emotional blunting rather than down (to me, a plus). I wish I could do the treatments at home because I am more comfortable there. I am concerned about relapses."

• carto...
• Taken for less than 1 month
• September 28, 2022

"After many months of coordinating clinicians, paid leave for hubby, and 2 insurances I had my first Spravato treatment yesterday and it was great. The first time I have been able to truly relax since a stalking in 2008 from which I developed PTSD. I go to a wonderful clinic with calm, serene decor, and my therapist specializes in psychedelic guidance (hubby's union insurance pays for this, my medicare advantage pays for the Spravato). Also, I have experience with psychedelics from when I was a kid and I use medical marijuana so I understand altered states. As of today I feel the same...low mood and anxiety, with a bit of stomach upset. Tomorrow is my second session. I'm hoping this is going to help as I am unable to tolerate most psychotropic drugs due to a gene mutation affecting my liver. Good luck to everyone out there."

• Winte...
• Taken for less than 1 month
• October 4, 2022

"I only tried Spravato once but it was too bad to continue. A few minutes after the nasal sprays, I had a horrible taste in my mouth, then nausea, then crying, dissociation, sweating, etc. No I’m back home after a few hours with somewhat of a hangover feeling: headache, still nauseous, & now also a sore throat. I can’t accurately “rate” this drug since it needs to be taken for quite some time to get the results but the side effects were just too horrible to go on. *Side note: I have also done several ketamine infusions prior to this, w only a bit of nausea once."

• HOPEF...
• Taken for 1 to 6 months
• June 7, 2023

"Although I haven't seen any results yet, it's important to remember that everyone's response can be different. After undergoing eight sessions, I haven't experienced any improvements. However, if you delve into the research, you'll find that this treatment was originally used as a horse tranquilizer. Logically, it seems plausible that a tranquilizer could be effective for addressing both anxiety and depression."

• Traci
• Taken for 1 to 6 months
• October 6, 2022

"Spravato has done absolutely nothing for me. I’ve become worse than when I started and I didn’t think that was possible. I am trying very hard not to commit suicide"

• bob
• Taken for 1 to 6 months
• November 4, 2023

"Improvement in mood overall. Improvement in motivation. It has been very helpful. Only downside is having to go to the doctor's office once a week for the 2-hour session."

• John...
• Taken for 1 to 6 months
• December 15, 2020

"Once the sedative effects are no longer felt you go back to being able to suppress your thoughts that you don't want to think about. It worked until my body got used to it."

• Tara
• Taken for less than 1 month
• March 9, 2021

"My first time was yesterday and it was not a good experience. I want to ask if the 2nd time may be better?"

• Fly...
• Taken for 1 to 6 months
• February 1, 2023

"I have had 15 treatments and have not gotten any better. Don't know if it's worth continuing treatments, speaking with my DR today. 25+ years of Treatment Resistant depression, nothing yet."

• Shakes
• Taken for 1 to 6 months
• March 13, 2024

"I have had a very positive experience so far. It's been a rough road, but I now have some hope. I pray that this treatment will be the end of the nightmare of MDD."