Spravato for Major Depressive Disorder User Reviews

• Stacy
• Taken for 1 to 2 years
• March 31, 2021

"This is an update to a review I wrote 6 months ago. I have now been on Spravato for one year. I have had depression and suicidal thoughts nearly every day for the past 25 years. Except for the last year on Spravato. Every month I see a gradual improvement. The biggest improvement my first six months was the cessation of suicidal ideation. The last six months, not only has my general sadness gone away, but I can now bounce back when things are rough. I still have healing to do, but none of it would be possible without Spravato."

• Sano
• Taken for 1 to 6 months
• March 17, 2021

"I can only speak about my own experience. The medicine does the work it sets out to do. I am a person struggling with CPTSD and depression. Spravato has helped significantly reduce suicidal ideation, reduce depression, and overall increase my well-being. The post-nasal drip is similar to that of any allergy nasal spray. The onset lasts approximately two hours in which I meditate, listen to audiobooks, and practice mindfulness. This is the largest breakthrough in psychiatric medication since 1987. I am not paid for this review nor am I affiliated with the pharma industry in any way."

• Anonymous
• Taken for 1 to 2 years
• October 6, 2020

"The Spravato nasal spray literally saved my life and I did it for a year straight. I did end up overdosing by taking it with tramadol that I was given for pain from my third hip surgery that I had no idea it would interact with. I only got to the 2nd spray before I had to spray the other into the trash to act like I used it cause they refused to believe I had ODED. I stopped going back for that unless for emergencies. It was perfectly fine for a year and I felt as if I could live. I used to do acid when I was younger so tripping never scared me. It is a huge experience for anyone wanting to try it but if you're at wits end, I'd say go for it. It worked for me. Just remember that tramadol is a MAJOR interaction and both kratom and klonopin/xanax will make the Spravato less effective when using it. Hope this helps for anyone wanting to try."

• Gent
• Taken for 1 to 6 months
• December 15, 2020

"I’ve dealt with depression for over 40 years and have been on most medications. This is the first time I’ve felt on the path to the true me, free of the clouds. This has literally saved my life. While I chose MDD as the condition, I am more accurately Treatment Resistant Depression."

• Lee
• Taken for 6 months to 1 year
• January 4, 2021

"My first treatment was February 7, 2020 and my life has been completely changed thanks to this medication. For one thing it has given me hope that there are new treatments to fight depression. The best thing is it is working! I no longer stay in bed all the time. I have more energy and I enjoy living life again. As far as the treatments themselves I get a feeling of euphoria for the first 40 minutes. My face, lips and nose have a very numb feeling which goes away within about 2 hours. Some days after my treatment I feel fatigued and some days I have a good amount of energy. For me watching funny videos/comedians/movies on my iPad help me not to dwell on the results of my treatment when coming down from the "high". Personally this medication is a blessing and it has given me my life back."

• Makep...
• Taken for 1 to 6 months
• December 20, 2020

"Suicidal depression has plagued me since before I could even conceived of it — probably very much like gender. A panoply of medicines, always with Cylert or Ritalin, provided a substantial modicum of relief for decades. However, consciousness continued to be unbearably painful and a craving for self-annihilation became my default. One week of the higher-dose treatment (3 containers) remains and, while I am not elated, the constant suicide hunger is gone. I don’t yet know if it facilitates pleasure but it does stop the death default."

• Dog...
• Taken for 1 to 6 months
• June 22, 2021

"Dx: MDD, GAD, C-PTSD Current Medication Regimen: Prozac 60mg, Atarax 50mg, Seroquel 100mg, Prazosin 2mg, Trazodone 50mg, and Spravato 56mg weekly. 4 MONTH UPDATE: Less suicidal ideation, higher moods, increased energy, and increased motivation. While I do have mild/moderate symptoms from time to time, I can finally go out and do stuff for once in my life. This medication regimen is a game changer for me. If you've suffered from severe depression for years, this medication may just change your life."

• SLA
• Taken for 6 months to 1 year
• November 5, 2023

"I've been fighting MDD, TRD, and anxiety for almost 40 years (I'm almost 60). Spravato is the ONLY thing that has helped. Side effects for me last about 2 hours. I noticed an improvement after the third or fourth treatment. It's been a complete game changer for me."

• First...
• Taken for less than 1 month
• November 23, 2020

"Had my first Spravato treatment today. The high feeling lasted about 45 minutes. It felt like my legs were separated from my body. I felt really happy. Coming down was not very fun. I started to feel sad again. I’m not giving up though. Going to keep going."

• Sandy...
• Taken for 1 to 6 months
• February 19, 2022

"11 weeks in and I am happy, thinking positively, seeing life brighter! I’m driving, being social, etc. Been struggling for 25 years. Started feeling good at about 6 weeks but even better now. Just so you know, every time you have a treatment, the experience is different. So if for some reason something is unpleasant, it doesn’t mean it always will be. Try to relax, bring water, hard candy or cough drops for the short time the taste is bad in your throat and I recommend headphones with music you like. You should be able to bring a pillow and small throw to cover up with. All this can make you more comfortable. I’ve never gotten sick or had any bad effect afterward. Spravato is helping me to be myself prior to my depression."

• TMW
• Taken for less than 1 month
• March 25, 2024

"I have struggled with depression and anxiety for years. I have tried many different meds. In 2019, I lost my middle son. In 2021, I lost my youngest son, and in January 2023, I lost my partner. I ended up in this hopeless, anxiety-ridden depressive state along with PTSD from having to drive my son's car after he had been in there for 2 days after he passed away. I thought about suicide 24/7. I am on week 3 of the treatment. I am taking the 84 mg 2x per week. All I can say is I couldn't remember what it felt like to not be in this brutal pain, and this is the first time in such a long time that I feel hopeful that something will finally work. I am feeling better every day. This is not a cure-all, and I went into this treatment recognizing that. I still have a lot of work to do and therapy ahead of me, but this has been a game-changer so far."

• Dog...
• Taken for 1 to 6 months
• April 29, 2021

"I'm currently in week 11 of treatment with esketamine 56 mg once a week. I feel that it started to work around weeks 6-8. Less suicidal ideation, more energy, improved mood, etc. I have had some minor bladder problems, such as an urgent need to urinate. However, the benefits far outweigh the side effects. I'm hoping to start on 84 mg soon. Diagnosed with MDD, PTSD, & GAD."

• Marlo
• Taken for 6 months to 1 year
• April 26, 2021

"September 24 2020 started Spravato after dealing with self hate, suicidal thoughts, depression and rage for over 35 years. Being admitted to a mental facility and being prescribed several different medications which worsened the idea of suicide, I felt this was the last option. I am taking 3 sprays per month and it has helped me a great deal. I take a Zofran shot before treatment and also take 2 Phenergan when I wake up the morning of the treatment to help with nausea however I still vomit during the session. I have tried empty stomach and that doesn't help either. I am very sensitive to smells now as well. The smell of the doctors office now makes me sick to my stomach. Other than the side affects I do think it is a good drug for me. I do seem to loose my of train of thought and if speaking sometimes I can not complete sentences and can not think of words. I am a bit skeptical of the long term affect of using this drug."

• Katie
• Taken for 1 to 6 months
• June 1, 2022

"I started using ketamine in November of 2021 I had my doubts that it would work because I have tried so many other medications throughout the years and I suffer from major depressive disorder. After the first 3 weeks at two treatments per week I started feeling better. Currently I have been taking my second round of spavado. My suicidal thoughts are gone, my depressive state is incredibly unreal. No depression, no anxiety, and I just can't believe this drug works as well as it does. If you suffer from depression, anxiety, and it also had help my chronic pain from nerve damage, my advice to you is to try spavato. It's amazing! I have never, ever felt as mentally good as I do now with the help of spavado. It's a game changer."

• Vrod
• Taken for less than 1 month
• April 1, 2021

"I’ve had 3 sessions now, 2 sessions with 2 doses and 3rd session with 3 doses. After each time I go home and crawl into bed for the rest of the day. The following day I’m in a major depression funk. I’ve asked my doc administering and my psychiatrist and they say keep going. I’m going to give it 1 more try but will not continue if a major depression spell occurs the day after again."

• Cirrus
• Taken for 6 months to 1 year
• November 2, 2023

"I've been on Spravato for 6 months and it got me through a period I'm not sure I could have endured otherwise. I highly recommend it. I started EMDR therapy last month, and EMDR + Spravato has been so incredible. It's like I started all over again. Definitely recommend, but I super recommend it with EMDR if you can swing it. They're like two sides of the same coin. My brain is quiet some days, and that feels like a miracle."

• Lrf
• Taken for 1 to 6 months
• November 15, 2022

"Spravato is like the Great Value version of the IV ketamine. I completed the induction period after being on ket for a year. By the end of the induction period, I was suicidal 95% of the time, my BP rose from 100-120/60-80 to 160/100. I received no relief whatsoever from this drug. I’m going back to IV ket which dramatically helped my depression, severe anxiety, chronic pain, inflammatory numbers, and migraines and paying $150-500 a session … but that’s how much better ket is."

• sean
• Taken for 5 to 10 years
• October 23, 2023

"I've had nothing but a positive experience with Spravato. The key to getting the most effective treatment is to just relax and avoid any distractions, such as your cell phone. Close your eyes, lay back, and let the drug do its work. Then you will get the best experience. If you are distracted, it will not work as well as it can. I've been on Spravato for 6 years, and I can't say enough good things about it. It gives me a sense of normalcy if only for a while. Just relax and let it do its magic."

• Bobby...
• Taken for 1 to 2 years
• April 25, 2021

"Been on spravato for over a year. Still have been on regimen of 84mg twice a week. It’s has not given me really any adverse effects, light equilibrium issues when on it. When I first started it was very helpful but weaning down to anything less than twice a week hasn’t been able to work for me. It’s helpful for a few days and goes away, wouldn’t call it a miracle drug. But it’s very helpful compared to the countless other medications I’ve been on. Definitely bring some Listerine patches or a strong mints to help with the nausea/bad taste. Have MDD, PTSD, and Anxiety disordered. Spravato is an effective medication but with the caveat that weaning down really makes the depression kick in. Advice, make a nice playlist of music and try and relax."

• forev...
• Taken for less than 1 month
• February 20, 2022

"For years(actually) decades I’ve fought the beast… have tried it all and still fighting. I finally agreed to try Spravato. I thought it would be like a chemical ECT. I hesitate to say this and jinx the results which have been stunning. I’m only in my third week of treatment but the impact has been dramatic. Where I could barely get out of bed in the morning I’m now up and moving. No negative side effects. No apparent issues with other meds I take. I only hope this impact will be long lasting…"

• JAS
• Taken for 6 months to 1 year
• June 29, 2022

"Spravato gave me a much needed boost with the first dose. It didn’t completely alleviate my depression but it definitely got me out of a hopeless state. I was sleeping 24 hours a day for 7-8 months with only breaks to eat and use the bathroom. After the first dose of Spravato, I was able to play with my dog outside. This drug will give you a kickstart but probably won’t bring you all the way out of the depression alone. I am on wellbutrin, pristiq and abilify. I see my psychiatrist once a month and a counselor weekly. The Spravato definitely gave me enough of a boost to be able to start to recover with the help of counseling and other antidepressants."

• Chris...
• Taken for 1 to 6 months
• July 19, 2022

"I have struggled with TRD most of my life. I did not respond well to other medications or therapies. My first treatment with Spravato at 56 was amazing, My second at 84mg was intense, unpleasant and also very beneficial in helping me address an issue. During treatment my service dog died and the grief was overwhelming. I went in crying and came out better able to cope. This is a game changer for me. The dissociative aspects help me to get out of my own way and address issues. I’m going to continue taking this weekly because each time it feels I’m dropping some sad heavy weights and leaving them behind."

• hki
• Taken for less than 1 month
• April 11, 2023

"Cannot speak to effectiveness just yet, but this is my experience. I was very nervous going into it. I do not have experience with substances other than alcohol and THC (which I respond very badly to), so I was pretty scared that Spravato would really mess me up and I'd have a bad time. I am also super prone to nausea. My first dose went just fine. Took a few minutes for me to feel the effects, but they were manageable. I was pretty lucid the entire time. My head felt a little swimmy, I sometimes couldn't feel parts of my body, and my perception of time was out of whack. But no nausea, paranoia, etc. I actually felt very pleasant the entire time. The next dose, I did have a few minor moments of panic (once because there was a loud noise, once because it was too quiet and that scared me for some reason) but they subsided quickly. I have felt pretty good in the days after my first doses, but no marked improvement yet."

• H2B
• Taken for 1 to 6 months
• September 30, 2021

"It’s working for me. The first month wasn’t pleasant. I tried to go in with an open mind, but when nothing had happened during the third week, I felt desperate. Then after the 6th session (third week) I was able to do some minor tasks that had seemed overwhelming. By the end of the 4th week I felt significantly less depressed—no suicidal thoughts at all, less hopelessness, more willing to engage with the outside world. Feeling some pleasure. I’d estimate that I’ve achieved a 70% lift from one of the darkest and longest passages I’ve ever experienced. I’m currently stabilized at a higher level than what I’ve achieved after adjusting meds until I’m on a combo that works for a while. I ruminate less. I get off the couch occasionally. Most important, my head is clear enough that I can do some work in therapy. Unfortunately Janssen’s long-term study was for maybe 8 months, so who knows how long it’ll work?"

• Dinky
• Taken for 1 to 6 months
• May 16, 2022

"Hello I have been using spravato for about 4 months now and I'm on the highest dose and I have to say that I am actually getting worse to the point I don't think I'm going to use it anymore. Right now at this moment writing this I'm in the most depressed state of mind I've ever been in. I'm so so tired of hurting. Nothing but darkness follows and overshadows me. I just can't take feeling the way that I'm feeling. I've tried many medications, tms, spravato and nothing has worked. I want to try ect but I can't find anyone to take my insurance. I can't eat, I can't sleep, I haven't bathed in over a year and my hair is falling out. Plus I have a lot of physical pain because of an autoimmune disease, I can't find anyone to prescribe me pain meds so I'm just one big ball of pain. I was hoping spravato would have worked but it hasn't."