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Duloxetine for Generalized Anxiety Disorder User Reviews (Page 3)

Brand names: Cymbalta, Drizalma Sprinkle, Irenka

Duloxetine has an average rating of 6.5 out of 10 from a total of 157 reviews for the treatment of Generalized Anxiety Disorder. 55% of reviewers reported a positive experience, while 29% reported a negative experience.

Reviews for Duloxetine

  • Less...
  • September 18, 2011

Cymbalta (duloxetine) "I have been on 120 mg of Cymbalta daily for 8 months, as well as another year and a half at 60 mg. I take it for anxiety, MDD, OCD, panic disorder, PTSD, etc. In addition to 10 mg of Abilify and a benzo I am feeling almost back to normal. This happens to be one medicine that helps me, and I have tried many SSRI's over the years."

9 / 10
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81 Report
  • Anonymous
  • Taken for 2 to 5 years
  • May 3, 2017

Cymbalta (duloxetine) "My thoughts on Cymbalta: Cymbalta has left me in a fog. I have no feelings- NONE. Driving is a chore as my eyes are excessively shifty. God forbid you ever forget to take your medication as you will be stricken with these obnoxious little shocks (which I've recently learned were called 'brain zaps'.) My heart beat is erratic. My brain is unable to form the right words when I talk which causes me to pause when I speak. I zone out regularly. I've been trying to taper off of this medication and am on day 9. The withdrawals are debilitating. I cannot focus. My chest and my jaw are tense. My fog has worsened significantly. Driving is dangerous as my vision is blurred. I am angry and easily agitated. I feel like crying but I can't. JUST SAY NO!!"

1 / 10
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51 Report
  • Danie
  • Taken for 1 to 6 months
  • April 16, 2021

Cymbalta (duloxetine) "I was on the edge of taking my life again. I was on Lexapro for almost a year but it stopped working. I switched to so many different things, Paxil, ability , Prozac, nothing helped I was still not sleeping and had major depression and anxiety. Then I got on Cymbalta . My anxiety and stuff isn’t full gone but I’m so much better. I’m FINALLY sleeping through the entire night without anything !! Give this med a try and wait a few weeks the transition period is tough especially if your switching meds ."

9 / 10
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27 Report

Frequently asked questions

  • Madcar
  • Taken for less than 1 month
  • November 28, 2015

Cymbalta (duloxetine) "I've been taking Cymbalta for about 3 weeks now. I started with 30mg for the first week. I found it worked but not quite there for me so I asked my Doctor to increase it for me. I'm on 60mg a day now which I take in the morning. I feel much better on this dose. I feel happier, much more calm, relaxed, less worry, and I even find myself being more friendly to people in general. I also take 300mg of Wellbutrin in the morning for my depression. This combo seems to be really working for depression and general anxiety. Side effects: frequent headaches (I just take Advil when needed) a little bit of increased body temperature and I'm up later in the evening and wake up earlier in the morn. When I wake I'm super wide awake and very clear headed."

8 / 10
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57 Report
  • Finally...
  • May 9, 2015

Cymbalta (duloxetine) "I have been taking Cymbalta for over 3 weeks now. I have to say it has helped with my depression. I have been suffering with depression for 2 years now and decided to get help. I am starting to feel like myself again except for some minor side effects. Constipation, nausea and headaches. Hopefully these side effects will disappear in time."

9 / 10
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59 Report

Are you taking this medicine?

  • jacki...
  • August 13, 2010

Cymbalta (duloxetine) "I have been taking Cymbalta (60 mg) for 7 weeks and it has been of great help with the anxiety, depression and chronic abdominal pain. I have some minor nausea and fatigue most days but nothing really bad. The most serious side effects I have is the sexual one - lost libido and inability to reach orgasm. After 7 weeks I fear it will be a permanent side effect, which is hard to deal with. Thank you."

8 / 10
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79 Report
  • Libby
  • Taken for 1 to 6 months
  • May 26, 2023

Cymbalta (duloxetine) "I have panic disorder and agoraphobia as well as spondylolisthesis. I took Lexapro for about 5 years and thought it was doing a good job...Until I built up a tolerance to it and started having withdrawal symptoms halfway through the day every day. My doc switched me to Cymbalta and it was a real eyesopener. I had NO IDEA how poorly Lexapro was affecting me until Cymbalta changed things for me. I had been sluggish, unmotivated, tired, gained a lot of weight, and was still in pain all through my years with Lexapro and, since I was just so darned happy to not be suffering from random crippling panic attacks constantly, I figured that was "good enough". Not true. Now I know better. With Cymbalta, I have far more energy, my mood is boosted, my pain is reduced, I've lost weight and I'm just generally more "chipper" as well as being able to focus better at work and not suffering from panic attacks. Total life changer."

10 / 10
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10 Report

More FAQ

  • Angel
  • December 23, 2016

Cymbalta (duloxetine) "Cymbalta has made a huge difference. I was in constant pain and emotionally distraught 24/7. Now, taking 60mg a day I feel alive again. The only thing i dont like is my inability to deep sleep but i will take it over constant pain and distress any day."

8 / 10
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47 Report
  • GAD
  • Taken for 6 months to 1 year
  • November 6, 2017

Cymbalta (duloxetine) "I am 24 I was experiencing chronic anxiety ، severe muscle tension، fatigue and problem in concentration for about more than year. I did not know exactly the reason for these symptoms. At first I thought it could be a physical problem in my body. but after some medical tests my doctors suggested me to visit a psychiatric doctor. So my p doctor recognized my problem as General anxiety disorder and prescribed me cybmalta. first week only one 30 mg from second week، two 30 mg per day. after 2 weeks، it started to work . after 5week ، excellent...I was almost the man who I was before anxiety!!!but after a while its performance a little decreased for 2 month. again after the third month ، again it started to getting better slowly. after 6 month، I am really calm"

9 / 10
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  • Lexi
  • Taken for less than 1 month
  • February 3, 2020

Cymbalta (duloxetine) "I was scared to take this med after the reviews. An anxiety attack triggered me to finally try it. I took 1 tablet 30 mg yesterday afternoon with lunch and experienced nothing until night. I was having constant random visions all night, when I finally got up in the morning I began shaking, my skin felt like it was burning, I was on fire hot, and my mouth was so incredibly dry. Then I got the chills. Shaking, burning skin, chills, dizziness went all day. I was wiped out tired and could not eat. I was in bed all of this beautiful day until 4:30pm when I forced myself up. Honestly I felt poisoned. I drank 2 gallons of water waiting to flush this out of my body. It was about 28 hours from the time I took it until I felt somewhat back to normal."

1 / 10
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30 Report
  • Alezie
  • Taken for 1 to 2 years
  • March 17, 2017

Cymbalta (duloxetine) "I've tried prozac, effexor, welbutrin and buspar. Cymbalta is the only med that makes me feel normal and cures my anxiety with no noticeable side effects. There is a withdrawal if I miss a dose and it involves being very sleepy, vivid dreams and night sweats. It's not fun, but it's worth feeling normal again."

9 / 10
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42 Report
  • Panic...
  • May 3, 2016

Cymbalta (duloxetine) "I've been on Cymbalta for a few years now (on various doses) alongside clonazepam (0.5mg twice/day) and I have to say its been the worst experience of my life. I was put on it after Effexor XR basically stopped working after 4 yrs.At first cymbalta seemed to "take the edge off". I didnt notice many of the initial side effects because of my severe withdrawal from Effexor.But after about 9 months at 30mg Cymbalta just stopped working and actually started to make me experience anxiety and panic attacks that were insanely intense. I have moved up to 60mg and back down to 30, upped my clonazepam and its just gotten worse and worse. Weight gain (50lbs), severe panic attacks, gad, severe depression, ocd, stomachache, IBS, headache, ..."

1 / 10
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  • ItWor...
  • October 14, 2016

Cymbalta (duloxetine) "I have GAD and mild depression. I initially had side effects such as insomnia, no appetite, and nausea but they went away after a few days. This has helped my anxiety tremendously! It is not without side effects though. If I forget to take it I will get nausea, headaches and dizziness. I did gain weight and some diarrhea but it has had no bad sexual side effects. I have been taking this for a year now. I am finding that the depression is now increasing so maybe time for a dosage change. Just keep in mind everyone is different and sometimes the benefits outweigh the effects."

10 / 10
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  • heiven
  • May 15, 2010

Cymbalta (duloxetine) "I have GAD with mild depression which caused a lot of tension in my shoulders and confused, muddled thinking with poor memory. I tend to be really irritable and short tempered with mood swings. I've so far taken Cymbalta for about 4-5 months. My mood swings, irritability and temper have improved. I am able to think much more clearly and remember better. The bad, my social anxiety hasn't improved much and I gained about 5 pounds. Otherwise no side effects. It doesn't make me sleepy, spacey, numb, nor does it diminish my libido. It isn't a wonder drug but it's nice to have fewer side effects."

8 / 10
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67 Report
  • Dee
  • Taken for less than 1 month
  • June 27, 2018

Cymbalta (duloxetine) "Please DO NOT TAKE THIS MEDICATION!! I took my first tablet 30mg of Cymbalta yesterday at about 11 am all was fine until about 6pm that night while I was sitting at the dinner table about too eat dinner I felt very dizzy, my eyes went very blurry couldn’t see properly, couldn’t eat, couldn’t speak was vomiting constantly shaking had the worst headache didn’t sleep all night still feeling some of these symptoms today. This drug is terrible and I don’t know how doctors can prescribe this to anyone!!!"

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  • Dee
  • Taken for less than 1 month
  • May 13, 2018

Cymbalta (duloxetine) "I have only been on Cymbalta for 1 day. Took it later last night, think I slept okay but woke up foggy brained, zoning out, nauseous, blurry vision, slight increase in anxiety and a bit snappy... won’t be taking anymore of this. I will figure out a different way to handle my panic attacks. Letting the Dr. know ASAP! 30mg at night is my dosage. Anyone else have these experiences right away??"

1 / 10
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  • Astut...
  • August 20, 2011

Cymbalta (duloxetine) "I've used Lexapro for several years before starting on Cymbalta around 10 months ago. My anxiety is under much better control and the sexual side effects are significantly less pronounced. Take twice a day, 30mg in the morning and 60 mg at night."

10 / 10
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60 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • May 21, 2019

Cymbalta (duloxetine) "I was prescribed 30mg of Cymbalta to deal with anxiety and slight depression. The medication is supposed to be titrated up to 120mg and I hard a hard time even convincing my therapist to go to 60mg. Once I hit 60mg it went downhill. I lost all ability to focus, and found myself not enjoying much of anything. I was tired all the time and started nodding off all day even at work. I stopped taking it, which I know isn't the brightest idea but I've gotten some of my focus back."

5 / 10
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29 Report
  • Sally
  • Taken for less than 1 month
  • May 29, 2016

Cymbalta (duloxetine) "Be careful when taking this medication. I took my first tablet yesterday in the morning and started feeling unwell during the day. Was out at a restaurant for lunch and started feeling so nauseous and burst into tears, and had to leave before my food arrived. Went home and felt so sick I slept for a couple of hours. Woke up and had some food, thought I was starting to feel better but a couple hours after that I collapsed (luckily I was at home with family) and was vomiting and had a severe fever, can't put into words just how horrible I was feeling. Woke up still feeling sick, of course didn't take another tablet, and am starting to feel better now about 38 hours after taking the tablet."

1 / 10
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40 Report
  • cymba...
  • Taken for 1 to 6 months
  • July 15, 2021

Cymbalta (duloxetine) "I have been lucky and found the perfect med for me. I am not exaggerating when I say Duloxetine has saved my life. It has saved me from absolutely crippling, mind-numbing anxiety, just wish I had started earlier. Unfortunately this whole process is trial and error and I had some bad experience with other meds (looking at you Effexor), but I started to feel better after just a couple weeks on the Cymbalta. Was a little activating at first and made me feel a little on edge but after a bit that went away. No negative side effects, just have really vivid dreams now. Hopefully can stay on this forever."

10 / 10
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18 Report
  • Anonymous
  • January 16, 2011

Cymbalta (duloxetine) "I took the first 30mg dose of Cymbalta and had bad side effects almost immediately. I felt dizzy and felt like I was passing out. I only took the one dose but have had insomnia for the past 48 hours. Lying awake feeling agitated and anxious."

1 / 10
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56 Report
  • New...
  • Taken for less than 1 month
  • November 12, 2014

Cymbalta (duloxetine) "Problems are panic attacks, phobias and generalized anxiety disorder, as a result to early menopause. First I tried Effexor 75mg, horrible blood pressure sky rocket up 170/101... Then I tried Fetzima for 5 days and couldn't tolerate high heart rate. Resting Heart Rate 96 and while I was walking 110 to 125. Not good always felt like I was climbing a hill, otherwise no other side effects except goosebumps and feeling cold. So then I started Cymbalta 13 days ago, the first 3-4 days very anxious, unable to sleep major. My body was tired, but my mind was not. Every time I would try to sleep my jaw would clench and my body would jerk (myoclonis jerks) and wake me up. I took small dose of Ativan to help me sleep. Also the first 4 days became hypoglycemic."

6 / 10
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  • Meg
  • Taken for 1 to 6 months
  • April 7, 2020

"I have been on duloxetine twice in my life, it is the only anti-anxiety medication that has worked for me. When I had nerve pain burning in my arms, it helped it go away. I weaned myself off it with few side effects/withdrawals about a year ago. Recently, I decided I needed it again as my anxiety attacks increased due to certain triggers related to the state of the world. I feel way happier, more energy than I’ve had in a long time. My sex drive hasn’t decreased this time and I feel no adverse side effects. I would highly recommend this to anyone. You deserve to be happy."

10 / 10
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  • Angel
  • Taken for less than 1 month
  • April 24, 2020

"I have just started this and it has totally saved me. I was so anxious I couldn't leave my house and off work and near getting fired. Now I can leave my house without getting lots of panic attacks. I have had a few tiny side effects but totally worth it. I am sleeping a lot better and I'm much calmer and able to cope with life."

10 / 10
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21 Report
  • goodn...
  • May 2, 2016

Cymbalta (duloxetine) "I have severe anxiety depression. I've tried all the meds out, as my doctor would say. Cymblatla was suggested. And me needing to feel normal tried it. Worst experience of my life. Was on 40mg. Felt like I was having an out of body experience, like someone was pulling me, everywhere. Dr told to stick with it, and lower dose (I actually did, did not recommend talk to Dr first). Nothing changed. I was talking without thinking, having more and more panic attacks and higher anxiety. Absolutely zero libido, and I gained weight. I felt "happy", but a weird happy. So, finally I TELL my doctor for the third time in 9 months, I want off this medication. Withdrawl symptoms no joke. It's been a month and I still have w.d effects"

2 / 10
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35 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.