Skip to main content

Duloxetine for Generalized Anxiety Disorder User Reviews (Page 2)

Brand names: Cymbalta, Drizalma Sprinkle, Irenka

Duloxetine has an average rating of 6.5 out of 10 from a total of 157 reviews for the treatment of Generalized Anxiety Disorder. 55% of reviewers reported a positive experience, while 29% reported a negative experience.

Reviews for Duloxetine

  • Chelso
  • Taken for 1 to 2 years
  • December 18, 2019

Cymbalta (duloxetine) "I have panic disorder, GAD, and intermittent depressive episodes. After trying numerous SSRI's (Wellbutrin, Prozac, Lexapro, etc.) my GP thought we should try an SNRI. I have had excellent results on this one called Cymbalta. No sexual side effects, no weight gain (in fact, some slight weight loss), no brain "zaps". I have been on 90mg per day, but my Psychiatrist just increased me to 120mg/day. I do have some fatigue but not sure if it's related to the med or not and I'd rather be a little tired than suffer constantly. This has been a lifesaver."

9 / 10
Was this helpful?YesNo
65 Report
  • will...
  • Taken for 5 to 10 years
  • May 11, 2013

Cymbalta (duloxetine) "Under the supervision of a psychiatrist I ran the gambit of SSRIs from Prozac to Zoloft with only mild improvements. Cymbalta proved at 120mgs to be wonderful. My insurance was a buzzkill by limiting me to 60mgs but we tried Celexa as an adjunct with similar but not total benefit. Taken with breakfast the change within an hour is dramatic, and missing a dose or two is traumatic. My only anxiety now is God forbid I am ever to go without my Cymbalta. It helped me through 10 chemo sessions, especially with the resulting neuropathy. Perhaps it will fall to a tier 1 med and I can resume 120mgs... There is hope."

10 / 10
Was this helpful?YesNo
126 Report
  • Anonymous
  • Taken for 2 to 5 years
  • November 9, 2015

Cymbalta (duloxetine) "Cymbalta saved my life from severe anxiety and panic disorder, as well as Reflex Sympathetic Dystrophy (intense nerve pain). I am 22 and have been on it for a few years. A year ago, I stopped taking it because I wasn't sure I still needed it. Within a week, I was living in hell. Crippled by my emetophobia, anxiety, and pain, I couldn't leave my apartment. I was having up to 10 panic attacks a day, sick to the point of throwing up all the time, stuck in bed. I got back on Cymbalta and in six weeks everything was better again. I can live my life now. Thank you Cymbalta! If I have to be on this med for the rest of my life, that is fine with me."

10 / 10
Was this helpful?YesNo
101 Report

Frequently asked questions

  • Bells
  • Taken for less than 1 month
  • January 24, 2021

Cymbalta (duloxetine) "This is my first time taking cymbalta. Today was my day one. Let me say. I took it with food. And within two to three hours, I started experiencing severe nausea. Within another hour I became very jittery and it felt like my skin was humming with electricity. Fast forward an hour and I can only compare this feeling to doing a tab of acid minus the hallucinations.. Or what I assume people feel like doing speed because I bounced on a yoga ball for two hours while feeling very manic. Crazy. Edgy. Like I was pumped full of adrenaline and needed to jump out of my skin while laughing and humming. I kept twitching and kicking my legs. Do hand snaps and rubbing my hands up and down my jeans to the point where I have rubbed my palms raw. I took ONE pill. The ONLY upside, is that my sciatic pain is basically gone. Which is heaven. I'm about 9 hours in and I'm finally sitting down but I cant stop fidgeting or bring myself to eat anything despite my stomach gnawing at me. Will update in a week"

1 / 10
Was this helpful?YesNo
49 Report
  • a per...
  • Taken for 1 to 6 months
  • February 12, 2020

Cymbalta (duloxetine) "I have been diagnosed with Bipolar 2 as well as anxiety, OCD, ADD, depression etc. I decided to start going down off my 900 mg of lithium due to the fact that I felt it was not helping much anymore. So my psych prescribed me 20 mg dose of Cymbalta to start to help with my severe anxiety. For the first month I noticed a small change in the way I felt. So we decided to go up to 30 mg. One week after starting the new dose, my life changed. I remember waking up one morning and just being happy. Everything seemed lighter and my anxiety as well as depression lifted. Unfortunately two months into that, my bipolar mania symptoms started coming back. So we are trying to figure out how to safely manage all symptoms. All in all, Cymbalta has made the biggest difference in my life."

9 / 10
Was this helpful?YesNo
58 Report

Are you taking this medicine?

  • Sage
  • Taken for 1 to 6 months
  • August 12, 2017

Cymbalta (duloxetine) "Hey everyone trying cymbalta, This drug has calmed me down and lightened me up. When someone asks me how I'm doing, I can honestly say , good ! I use to be intense and I thought about suicide a lot and spent many hours in bed trying to escape from reality . I hated small talk and saw it as phoney and awkward and an act I put on just to come across as average ; like the average happy person . Nope . That was not me . I was tormented by anxiety and depression and dark thoughts. Cymbalta is a good drug. Hope it works for you. I started at approx 5 mg, then 10, 20 and now 30mg. Low dose I know but effective. I would open the capsule and measure a somewhat close enough dose to what I could handle . Give it a good 3 months to work!!"

Was this helpful?YesNo
82 Report
  • Kev
  • July 30, 2015

Cymbalta (duloxetine) "I initially took Cymbalta for distonia, which was involuntary movement in my hands caused by a type of Muscular Dystrophy. A combination of Cymbalta, Neurontin, and Tramadol are very effective in reducing my pain. After several months I noticed a great change in my personality. To make a long story short, I realize I've dealt with anxiety most of my life. Cymbalta has literally changed my life. If this medication had been available in the 1960's or 1970's my life would have been dramatically different. I can't imagine life without Cymbalta."

10 / 10
Was this helpful?YesNo
94 Report

More FAQ

  • Anonymous
  • Taken for 2 to 5 years
  • May 11, 2013

Cymbalta (duloxetine) "I've been on Cymbalta over 2 years and it has worked great for my anxiety and Irritable bowel syndrome. I sometimes add Vistaril at stressful times. I tried Topamax and Lexapro and neither gave me the relief I needed. I wish I would have had Cynbalta 30 years ago."

9 / 10
Was this helpful?YesNo
103 Report
  • Nativ...
  • March 14, 2013

Cymbalta (duloxetine) "I was prescribed Cymbalta after taking Zoloft for a few months. Zoloft was horrible but when my prescription was changed to Cymbalta, my anxiety and everything else seemed to lessen. I was more calm in handling situations and my husband seemed pleased with the change in my attitude. For the first week while on Cymbalta, the experience was horrible. I had all the side effects listed and more but I was determined to stay on it. It only lasted a week then things became more clear. The only thing I FEAR is the withdrawals. I've experienced it accidentally when the medication wasn't available to me. "

7 / 10
Was this helpful?YesNo
102 Report
  • 30yrs...
  • Taken for 1 to 6 months
  • November 22, 2016

Cymbalta (duloxetine) "Out of the blue I started experiencing anxiety, I was nervous for no reason and having anxiety about anxiety! I tried change my diet and so on. Then I had the mother of all panic attacks (I'd never had one). I quickly realized that I needed to talk to my doctor. I tried zoloft and celexa, both gave me terrible side effects. I stuck with zoloft for 2 months and wasnt feeling any better so I went off discouraged. Then I started on cymbalta. Its been about 5 months with zero side effects. I realized a few days ago that the meds must be working, on a particularly stressful day I felt a panic attack coming on but it just didn't materialize into anything. Then I realized I really haven't been nervous for sometime. It can get better :) 40mg"

8 / 10
Was this helpful?YesNo
75 Report
  • Kroita
  • October 9, 2011

Cymbalta (duloxetine) "For the last 2 years I have suffered massive panic and anxiety attacks. I thought my world as I knew it was over. Thanks to Cymbalta everything is almost back to normal and I am feeling myself again. I started taking it 2 months ago, the first 2 weeks I had a bit of nausea but now its gone. No other side effects."

10 / 10
Was this helpful?YesNo
109 Report
  • GenieP
  • August 15, 2017

Cymbalta (duloxetine) "To the gentleman whose doctor switched him from Klonopin to Cymbalta: The reason you are suffering from severe anxiety is that you were taken off a Benzodiazepine too quickly instead of having been TAPERED off the drug. Cymbalta is no substitute for Klonopin. Your doctor needs to go back to med school! I've been taking 60 mg of Cymbalta since 2009, after my husband committed suicide. It has helped me a lot with depression and anxiety, but I'm finding that my anxiety has recently increased because my new husband has lung cancer. I was put on 90 mg of Cymbalta recently, and I'm hoping that the higher dose will decrease, and not increase, my anxiety levels."

10 / 10
Was this helpful?YesNo
67 Report
  • Anon
  • October 29, 2013

Cymbalta (duloxetine) "After having done fine w/alprazolam and citalopram for years, and wanting to slightly up my alprazolam for my GAD, Doc suggested I try cymbalta. I had a *horrible* experience with this drug (have never before experienced such bad side effects). I can't recall the dosage, but it was a sample, so I don't believe it was anything too high. First day I took it, I felt absolutely wiped out, like all the energy had been sucked from my body. I could barely make it to the bed to lay down. A few hours later the muscles in my jaw began spasm-ing involuntarily, I could feel them tightening and clamping my teeth together, then slightly relaxing. I didn't take the next pill, and it took a day for side effects to go away. I'll never take it again."

1 / 10
Was this helpful?YesNo
87 Report
  • Anonymous
  • November 13, 2012

Cymbalta (duloxetine) "Excellent for controlling anxiety that, for me, can spiral in to major depression I feel more like myself on Cymbalta than I did on Zoloft. It has been excellent at relieving chronic musculoskeletal pain. Cymbalta benefits do come at a cost, financially and physically. The most annoying physical symptom is profuse sweating. I never sweated much, even on hot days. With Cymbalta, it can be cold outside & I'm in my car A/C on, face dripping with sweat. I can easily tell this from a menopausal hot flash.The two sometimes occur together. Cymbalta can give me bad morning headaches & I can't use Motrin while on it. Once you're on Cymbalta you can't just stop it without getting severe withdrawal symptoms, especially dizziness. "

7 / 10
Was this helpful?YesNo
93 Report
  • tiffy...
  • October 6, 2014

Cymbalta (duloxetine) "Best out of many I tried. Helped the best with least side effects. Added Wellbutrin and combination is awesome. I'm a high functioning person. Abilify at night. All good. Been on over ten years, Abilify recently. "

10 / 10
Was this helpful?YesNo
81 Report
  • No...
  • September 29, 2018

Cymbalta (duloxetine) "20 MG reduced my stress, worries, & obsessive thoughts. I've never been able to relax because I thought I wasn't doing enough, but now I enjoy the moment. I'm better at work, chores, getting things done. I'm not at war with myself. I'm finally living in MY LIFE instead of being in MY HEAD. I started because GAD and PMDD were causing shingles and interstitial cystitis. All better, relationships too. I can also finally fall asleep, which was a part of my struggle. I also run better, fewer pains. After muscle tightness and insomnia disappeared, there are lasting, but manageable, side effects. Libido lower, appetite higher, orgasm slower, constipation common, but patience, coffee, and probiotics help. Alcohol causes headaches, but I don't crave it either."

Was this helpful?YesNo
53 Report
  • Good...
  • Taken for 2 to 5 years
  • August 20, 2013

Cymbalta (duloxetine) "I started on 30mg of Cymbalta for a week then up to 60mg. I've taken it for about 2 years and noticed it really helped. When I got pregnant, my doctor told me to wean off it by taking it every other day. That was hell! He should have prescribed me a lower dosage. The price of it doubled so I no longer take it. I weaned off it this time by going from 60mg to 30mg then to 20mg. What a difference. That was manageable. Another down side is when I was on 60mg, if I would workout in the evenings, I would be wide awake at 3am! That was not the case when I was taking 30mg."

8 / 10
Was this helpful?YesNo
86 Report
  • Windee
  • Taken for 1 to 6 months
  • August 22, 2017

Cymbalta (duloxetine) "Cymbalta seems to be working great for me. I had been on two others Lexapro and Zoloft just prior. One made me feel happy but had bad side effects and the other stopped the panic and anxiety but left me feeling depressed/unhappy. I was not real hopeful going on this as I thought I needed more serotonin in my body verses just levelling out what I had, I was happy to find out that it seems to help a lot. No panic and anxiety and I actually feel like getting up and doing something rather than laying around and I have lost 8 pounds! I take 20mg and that seems to be all I need. Overall I am happy with it."

Was this helpful?YesNo
60 Report
  • beste...
  • Taken for less than 1 month
  • September 18, 2015

Cymbalta (duloxetine) "I took cymbalta for years before and always loved how good I felt. Because of life changing circumstances I had to get off of them about 3 years ago. I did well for a year then all my symptoms came back like a trainwreck! I have bipolar 2 now along with GAD. I was going crazy mad all the time ,anxious, depressed couldn't remember where I was or days at a time. I finally had enough. I hadn't felt this bad since I was in my 20s I'm now 40. I was put back on cymbalta starting at 20 mgs a day the side effects are minimal to how I felt before the worst thing is the stomach issues but you have to keep on them the future benefits are amazing it's been 9 days I already feel good!"

10 / 10
Was this helpful?YesNo
71 Report
  • choose...
  • August 15, 2015

Cymbalta (duloxetine) "I was on celexa for a few yrs.n when I started feeling "well" again decided to stop taking it. Within a yr. I was constantly crying n went back on it but it affected my ability to Fully enjoy intimacy so the mental health nurse told me ask my Dr.for pristine, which I did n he prescribed my cymbalta instead which I took a long with my celexa. When I went back to c him he said that he told me stop the celexa n prescribed me 60mg.of cymbalta a day which I now have been on for about a yr. To say it's a godsend is an understatement. I actually went to an outside concert with approx.5000 people in attendance. Although I was still a little anxious a couple drinks helped me to somewhat enjoy myself. Normally crowds cause me unbearable anxiety."

8 / 10
Was this helpful?YesNo
70 Report
  • Soup
  • April 1, 2014

Cymbalta (duloxetine) "My cymbalta experience was brutal. After a few days I felt weak and tired. So tired that I started missing work. One week in to it and I started to get these strange brain zaps that made me feel as if I was being electrocuted. Two weeks in and I would start to cry. Just out of the blue I would cry for no reason. It was the first time I had shed a tear in 10 years and it was awful. I stopped taking it and am now afraid to take anything for my panic other than Klonopin."

Was this helpful?YesNo
77 Report
  • lou
  • July 19, 2011

Cymbalta (duloxetine) "I had been taking Lexapro which worked very well. I had been having pains in my back and headaches for a while so my Doctor started me on Cymbalta. I must say that with the switch my pains are relieved, and my whole being is in a very good place. Thanks Cymbalta"

10 / 10
Was this helpful?YesNo
88 Report
  • Anonymous
  • February 2, 2012

Cymbalta (duloxetine) "I took Cymbalta 60mg for 4 months. It helped tremendously with general anxiety so I believed it to be a miracle, however, after about 4 weeks I noticed depression setting in. It had gotten so bad that I felt compelled to leave a review on here. My heart was cold, didnt care about co-workers, friends and family or myself. The depresson hit so quickly. I was angry at the world for my own issues, everyone walking around all happy and everything, I wanted that so badly. I was mean and angry. I'd yell at people for things and accused them of beng rude to me or not considerate enough for my standards. I got off Cymbalta and gained my life back. It did help my generalized anxiety disorder though."

Was this helpful?YesNo
85 Report
  • Anxio...
  • Taken for 1 to 6 months
  • December 15, 2015

Cymbalta (duloxetine) "I have experienced anxiety and mild depression for several years. I finally decided to get help. Cymbalta has really helped. I noticed a change in the first couple days. My anxiety has all but disappeared. Experienced dry mouth and interrupted sleep the first several days. I have experienced tiredness but that has lessened over this month and I hope will go away all together."

9 / 10
Was this helpful?YesNo
63 Report
  • Anonymous
  • January 18, 2012

Cymbalta (duloxetine) "I started Cymbalta in September 2011 for Depression and Anxiety. My doctor started me off on 30 mg a day for 2 weeks then switched me to 60 mg a day. The side effects I noticed right away were dry mouth and loss of hunger (not a bad thing - I lost 5lbs in 2 weeks). After being on 60 mg for about a month I started to have pretty bad night sweats, and I mean INTENSE night sweats - you wonder how your body can possibly hold that much water. But they have gotten few and far between now and my dry mouth has subsided as well. About 2 months ago my doctor switched me back to 30mg a day - the 60mg dose was causing my stomach to hurt and burn for about 3 hours after taking it despite taking it with or without food. It helps with GAD. Try it."

8 / 10
Was this helpful?YesNo
79 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.