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Acetaminophen / diphenhydramine for Pain User Reviews

Brand names: Tylenol PM, Percogesic Original Strength, Midol PM, Pain Reliever PM, Headache Relief PM, Unisom PM Pain, Non-Aspirin PM Extra Strength, Percogesic Extra Strength, Bayer Select Max Strength Night Time Pain, ConRx PM, Acetadryl, Night Time Pain, Genapap PM, Mapap PM, Counteract PM Extra Strength, Wal-Nadol PM Extra Strength, Excedrin PM, Headache Formula PM, Legatrin PM, Tylenol Sore Throat Nighttime, Pharbetol PM Acetaminophen PM Extra Strength Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime Anacin PM Aspirin Free …show all brand names

Acetaminophen / diphenhydramine has an average rating of 8.4 out of 10 from a total of 17 reviews for the treatment of Pain. 82% of reviewers reported a positive experience, while 12% reported a negative experience.

Acetaminophen/diphenhydramine rating summary

8.4/10 average rating

17 ratings from 17 user reviews.

Compare all 1448 medications used in the treatment of Pain.

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Reviews for Acetaminophen / diphenhydramine

  • Shayd...
  • February 10, 2015

Tylenol PM (acetaminophen / diphenhydramine) "I was very surprised when I took this medicine. I took it at 9pm and by 9:30 I was in bed sleep. It a high power pill and I rested all night. It a good pill besides the fact that I woke up the next morning and barely could get up and get dressed for work because I was still sleepy for the pill. It finally wore off at about 10am. It helped me a lot. I was told by a friend to take it for pain and I'm glad I got it."

9 / 10
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40 Report
  • Helene
  • Taken for 6 months to 1 year
  • August 15, 2021

Tylenol PM (acetaminophen / diphenhydramine) "Initially started taking Tylenol PM for ongoing knee & foot pain (I’m a dancer) 6 months ago. Very quickly became a nightly ritual to take one (occasionally 2) and fall asleep within 20 mins and stay asleep for 8+ hrs. The downside - blurred vision (especially in the morning), troubling memory loss (my kids were growing concerned about me not remembering conversations), anxiety and depression (bursting into tears frequently and for no reason). I went ‘cold turkey’ 6 days ago and am already starting to feel better after a couple of sleepless nights. I will NEVER touch this stuff again. It’s easy to see how this drug has been linked to dementia. Please don’t be tempted to use it."

1 / 10
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8 Report
  • tazen
  • Taken for 10 years or more
  • December 19, 2012

Percogesic Original Strength (acetaminophen / diphenhydramine) "I was told about this medicine about 10 years ago. At the time I could only find the original strength, and quickly found out that I could not take during the day because it knocks me out and I will be sleeping. It is the only medicine that will take away the pain I am having. I had knee surgery twice in a year and the prescription pain medicine I had took away some pain, but with the Percogesic, the rest of the pain went away and I got to sleep. I tried the maximum strength last year for the first time and discovered that it didn't make me sleep. ...actually hyped me up. I discovered it was different than the original strength by having an antihistamine in which I am sensitive too. So now I can take during the day. its the best!"

10 / 10
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21 Report
  • Anonymous
  • November 11, 2008

Percogesic Original Strength (acetaminophen / diphenhydramine) "I had a very painful tooth abscess that was not relieved with the popular OTC medicines. A pharmacy technician recommended Percogesic and I felt relief within 30 minutes. Pain relief lasted longer as well so I had to take it less often. The only negative was a minor side effect: dry mouth."

9 / 10
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19 Report
  • Lyght...
  • Taken for 6 months to 1 year
  • September 21, 2013

Midol PM (acetaminophen / diphenhydramine) "This product is not well known. I had to introduced it to my sister. She was taking Advil PM and it made her angry, anxious. I took her off Advil PM it and got her on Midol PM. Few days later, she called me and shared the same thing I experienced. Calm, well rested, relax and not as angry as before. I love this product. I hate the fact that it took me so long to find it. It needs to be marketed more. Black women like me have issues with our periods. Bad cramps and insomnia plague us. A product that focus on treating these problems without the side effect is God sent. I take just two pills at night when I am PMSing and during my period and I wake up like a new woman."

10 / 10
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8 Report

Are you taking this medicine?

  • Lori
  • October 25, 2011

Percogesic Original Strength (acetaminophen / diphenhydramine) "Out of the vast amounts of different medicines I've taken over the years (most of which has been medicines prescribed by my physicians for severe pain, insomnia, and other chronic issues), this OTC medication is the very best for a number of conditions. I've had migraines for most of my life, but am allergic to prescription drugs for migraines. I've found that Percogesic is ideal for many problems. I have always had a high tolerance for medicines which could sedate a large farm animal, yet it is next to impossible to sedate me. Percogesic, however, has sedative properties, unlike so-called "migraine" medicines, like Excedrin Migraine. The active ingredient in Excedrin is caffeine, which is the last thing I want when I'm trying to escape pain."

9 / 10
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8 Report
  • Ang
  • Taken for less than 1 month
  • September 8, 2019

Legatrin PM (acetaminophen / diphenhydramine) "I have taken this medication for pain in my foot due to gout. Nothing else I bought over the counter worked. I read the bottle and decided to try it. It eased my pain more than I ever thought an over the counter medicine could. The only thing to be aware of is it makes you sleepy and drowsy. But it works!"

10 / 10
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3 Report
  • Tricia
  • Taken for less than 1 month
  • December 30, 2021

Tylenol PM (acetaminophen / diphenhydramine) "Hi my name is Tricia, I usually take aleve pm for my bruised rib. My friend, former nurse said to use Tylenol pm so you don't get stomach bleeding. So I brought some last night. Omg, I was scratching all night and in the morning I felted very dizzy and disoriented. Don't know why I reacted that way but I will never take it again. Thank you God, that I didn't fall."

1 / 10
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1 Report
  • Anonymous
  • September 12, 2008

Percogesic Original Strength (acetaminophen / diphenhydramine) "Great for back pain, muscle aches and menstrual cramps!"

10 / 10
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28 Report
  • Anonymous
  • February 20, 2010

Percogesic Original Strength (acetaminophen / diphenhydramine) "the best for back pain, cramps.. it does make you sleepy so don't drive.. helps you sleep when you're in pain.. I have been taking it for years.. LOVE IT!"

10 / 10
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23 Report
  • Anonymous
  • January 4, 2009

Tylenol PM (acetaminophen / diphenhydramine) "Great. Take 30 minutes before bed and it treats both pain and mild restlessness."

9 / 10
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14 Report
  • kaydeee
  • Taken for less than 1 month
  • December 23, 2014

Percogesic Original Strength (acetaminophen / diphenhydramine) "It's great for sleeping but I just recently found out on here! That extra strength you can take during the day. Yipppeee!"

10 / 10
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7 Report
  • Luano
  • Taken for 5 to 10 years
  • June 25, 2019

Percogesic Original Strength (acetaminophen / diphenhydramine) "It has worked for me for years! Why is it so hard to find? It’s great for sleep I have a lot of body pain just 1 is amazing! "

10 / 10
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4 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • June 30, 2019

Legatrin PM (acetaminophen / diphenhydramine) "When I am awakened with intense leg cramps I am able to take one capsule and wait about twenty minutes to experience a great relief and I am able to go back to sleep."

10 / 10
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4 Report
  • Anonymous
  • July 7, 2008

Midol PM (acetaminophen / diphenhydramine) "If you're not having severe cramps, it takes most of the edge off. Severe, go with a prescribed medicine made for this."

7 / 10
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1 Report
  • Anonymous
  • Taken for 5 to 10 years
  • April 30, 2022

Percogesic Extra Strength (acetaminophen / diphenhydramine) "I’ve had chronic back pain for years and this is has been my go to medication rather than taking prescribed prescriptions by my doctors."

10 / 10
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0 Report
  • AnIie
  • Taken for less than 1 month
  • August 20, 2017

Percogesic Original Strength (acetaminophen / diphenhydramine) "This is a good over the counter Pain drug but I have to watch for side effects."

8 / 10
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0 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.