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Zofran solution

Pronunciation

Generic Name: ondansetron (on-DAN-se-tron)
Brand Name: Zofran

Zofran solution is used for:

Preventing nausea and vomiting associated with cancer chemotherapy, radiation treatment, or surgery. It may also be used for other conditions as determined by your doctor.

Zofran solution is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (eg, chemotherapy).

Do NOT use Zofran solution if:

  • you are allergic to any ingredient in Zofran solution
  • you have a certain type of irregular heartbeat (congenital long QT syndrome)
  • you are taking apomorphine, arsenic, dronedarone, halofantrine, nilotinib, toremifene, or vandetanib

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Zofran solution:

Some medical conditions may interact with Zofran solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to another serotonin 5-HT3 receptor blocker (eg, dolasetron, granisetron)
  • if you have liver problems, heart problems (eg, congestive heart failure, slow or irregular heartbeat), or electrolyte problems (eg, low potassium or magnesium levels)
  • if a member of your family has a history of congenital long QT syndrome
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Zofran solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, dofetilide, dronedarone), arsenic, asenapine, bepridil, chloroquine, cisapride, citalopram, clozapine, crizotinib, dasatinib, diuretics (eg, furosemide, hydrochlorothiazide), dolasetron, domperidone, doxepin, droperidol, halofantrine, haloperidol, lapatinib, macrolide antibiotics (eg, clarithromycin, erythromycin), maprotiline, methadone, nilotinib, nortriptyline, paliperidone, pentamidine, phenothiazines (eg, chlorpromazine, thioridazine), pimozide, quetiapine, quinolone antibiotics (eg, levofloxacin), sunitinib, tacrolimus, telithromycin, tetrabenazine, toremifene, vandetanib, vemurafenib, or ziprasidone because the risk of serious and sometimes fatal irregular heartbeat (prolonged QT interval) may be increased
  • Apomorphine because the risk of its side effects may be increased by Zofran solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zofran solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zofran solution:

Use Zofran solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Zofran solution by mouth with or without food.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • It is important to take Zofran solution as directed to prevent nausea and vomiting. If you forget to take a dose of Zofran solution, take it when you remember as directed by your doctor. If you are not sure what to do, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Zofran solution.

Important safety information:

  • Zofran solution may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zofran solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Zofran solution should be used with extreme caution in CHILDREN younger than 4 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zofran solution while you are pregnant. It is not known if Zofran solution is found in breast milk. If you are or will be breast-feeding while you use Zofran solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zofran solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; drowsiness; headache; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; wheezing; unusual hoarseness); chest pain; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; fever; seizures; skin tingling or numbness; stomach pain; trouble urinating; uncontrollable or involuntary muscle movements; vision changes (including sudden temporary blindness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe constipation; severe dizziness; slow or irregular heartbeat; sudden, temporary blindness.

Proper storage of Zofran solution:

Store Zofran solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store the bottle upright. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zofran solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Zofran solution, please talk with your doctor, pharmacist, or other health care provider.
  • Zofran solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Zofran solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zofran solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zofran solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Zofran solution.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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