Zidovudine Syrup

Zidovudine Syrup is used for:

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Treating HIV infection when used along with other medicines. It is also used with other medicines to help prevent women from passing the HIV virus to the fetus during pregnancy.

Zidovudine Syrup is an antiviral. It works by blocking the reproduction of the HIV virus.

Do NOT use Zidovudine Syrup if:

• you are allergic to any ingredient in Zidovudine Syrup
• you have an enlarged liver, high lactic acid levels in the blood, or abnormal liver function tests
• you are taking doxorubicin, ribavirin, stavudine, or any medicine that contains zidovudine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zidovudine Syrup:

Some medical conditions may interact with Zidovudine Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have bone marrow problems, low white blood cell levels, or liver or kidney problems
• if you are very overweight

Some MEDICINES MAY INTERACT with Zidovudine Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Zalcitabine because severe pancreas problems may occur
• Fluconazole, ganciclovir, interferon alfa, probenecid, valproic acid, or any medicine that contains zidovudine because they may increase the risk of Zidovudine Syrup's side effects
• Doxorubicin, ribavirin, or stavudine because they may decrease Zidovudine Syrup's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zidovudine Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zidovudine Syrup:

Use Zidovudine Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zidovudine Syrup may be taken with or without food.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Use Zidovudine Syrup on a regular schedule around the clock, unless otherwise directed by your doctor.
• Continue to take Zidovudine Syrup even if you feel well. Do not miss any doses.
• It is important not to miss doses of Zidovudine Syrup. If you miss a dose of Zidovudine Syrup, take it as soon as your remember. If it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zidovudine Syrup.

Important safety information:

• Zidovudine Syrup may lower your body's ability to fight infection. Avoid contact with people who have colds or other infections. Contact your doctor if any signs of infection occur, such as fever, sore throat, rash, or chills.
• Do not take more of Zidovudine Syrup than directed without checking with your doctor. Do not take Zidovudine Syrup for longer than directed without checking with your doctor.
• Zidovudine Syrup is not a cure for HIV infection. You may also still have infections or other illnesses that occur along with HIV. Remain under the care of your doctor.
• Zidovudine Syrup does not prevent you from giving HIV to other people through contact with blood or through sex. Use a barrier form of birth control (eg, condoms) if you have HIV. Do not share needles, other injection supplies, or personal items (eg, toothbrush, razor).
• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Zidovudine Syrup. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
• Lab tests, including liver function, kidney function, and complete blood count, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANT WOMEN: Zidovudine Syrup may not always prevent you from passing the HIV virus to the fetus. It is unknown how Zidovudine Syrup may affect the baby later in life. Discuss any questions or concerns with your doctor.
• PREGNANCY AND BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Zidovudine Syrup during pregnancy. Zidovudine Syrup is excreted in breast milk. Do not breast-feed while taking Zidovudine Syrup. HIV-infected mothers should not breast-feed their infants because of the risk of transmitting the HIV infection or Zidovudine Syrup.

Possible side effects of Zidovudine Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; loss of appetite; nausea; tiredness; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chills; dark urine; drowsiness; fast breathing; fever; muscle pain or aches; red, swollen, or blistered skin; seizures; shortness of breath; sore throat; stomach pain; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include severe or persistent headache; tiredness; vomiting.

Store Zidovudine Syrup at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zidovudine Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Zidovudine Syrup, please talk with your doctor, pharmacist, or other health care provider.
• Zidovudine Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zidovudine Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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