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Thymoglobulin

Generic Name: anti-thymocyte globulin (rabbit) (AN-tye THYE-moe-site GLOB-yoo-lin)
Brand Name: Thymoglobulin

Thymoglobulin should only be given by a doctor in a medical setting under the supervision of a doctor who is experienced in management of organ transplant patients.


Thymoglobulin is used for:

Treating acute kidney transplant rejection with other medicines used to suppress the immune system. It may also be used for other conditions as determined by your doctor.

Thymoglobulin is an immune globulin. It works by suppressing the body's immune response, but the way it does this is not fully understood.

Do NOT use Thymoglobulin if:

  • you are allergic to any ingredient in Thymoglobulin
  • you are allergic to rabbit products
  • you have an acute viral illness

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Thymoglobulin:

Some medical conditions may interact with Thymoglobulin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart failure, shortness of breath, or swelling in the legs
  • if you have low blood platelets or a low white blood cell count
  • if you have high blood sodium or potassium, or kidney or liver problems

Some MEDICINES MAY INTERACT with Thymoglobulin. However, no specific interactions with Thymoglobulin are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Thymoglobulin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Thymoglobulin:

Use Thymoglobulin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Thymoglobulin is only administered as an injection by health care providers in a medical setting.
  • If Thymoglobulin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • You may be given other medicines (eg, acetaminophen, corticosteroids, an antihistamine) to decrease the side effects of Thymoglobulin.
  • If you miss a dose of Thymoglobulin, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Thymoglobulin.

Important safety information:

  • Thymoglobulin may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Thymoglobulin. Using Thymoglobulin alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Thymoglobulin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Thymoglobulin may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. Notify your doctor of any signs of infection including fever, sore throat, rashes, or chills.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Thymoglobulin.
  • Thymoglobulin can affect the results of certain lab tests. Make sure lab personnel and your doctors know you use Thymoglobulin.
  • Check with your doctor before having vaccinations while you are using Thymoglobulin.
  • Carry an identification card at all times that says you taking this medication.
  • LAB TESTS, including blood tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Thymoglobulin with caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Thymoglobulin during pregnancy. It is unknown if Thymoglobulin is excreted in breast milk. If you are or will be breast-feeding while you are using Thymoglobulin, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Thymoglobulin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chills; diarrhea; dizziness; fever; general body discomfort; headache; nausea; swelling of the hands and feet; urinary tract infection; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; dizziness; easy bleeding or bruising; fast or irregular heartbeat; fever; infection; joint or muscle pain; persistent sore throat; stomach pain; unusual fatigue.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Thymoglobulin:

Thymoglobulin is usually handled and stored by a health care provider. If you are using Thymoglobulin at home, store Thymoglobulin as directed by your pharmacist or health care provider. Keep Thymoglobulin out of the reach of children and away from pets.

General information:

  • If you have any questions about Thymoglobulin, please talk with your doctor, pharmacist, or other health care provider.
  • Thymoglobulin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Thymoglobulin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Thymoglobulin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Thymoglobulin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Thymoglobulin.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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