Tbo-filgrastim

Generic Name: tbo-filgrastim (TBO-fil-GRA-stim)
Brand Name: Granix

Tbo-filgrastim is used for:

Decreasing the amount of time that the number of certain white blood cells (neutrophils) are very low. It is used in certain cancer patients who are receiving chemotherapy. It may also be used for other conditions as determined by your doctor.

Tbo-filgrastim is a hematopoietic agent. It works by stimulating the production of neutrophils by bone marrow.

Do NOT use tbo-filgrastim if:

  • you are allergic to any ingredient in tbo-filgrastim, to filgrastim, or to pegfilgrastim

Contact your doctor or health care provider right away if any of these apply to you.

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Before using tbo-filgrastim:

Some medical conditions may interact with tbo-filgrastim. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are receiving radiation therapy
  • if you have leukemia, sickle cell anemia, or other blood disorders (eg, myelodysplastic syndrome)
  • if you have kidney or liver problems, spleen problems, lung or breathing problems, or a blood or tissue infection

Some MEDICINES MAY INTERACT with tbo-filgrastim. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Lithium because it may increase the risk of tbo-filgrastim's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if tbo-filgrastim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use tbo-filgrastim:

Use tbo-filgrastim as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with tbo-filgrastim. Talk to your pharmacist if you have questions about this information.
  • Tbo-filgrastim is given as an injection under your skin at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Your first dose of tbo-filgrastim will be given at least 24 hours after you receive your chemotherapy. Do not use tbo-filgrastim within 24 hours before any chemotherapy treatment.
  • Do not use tbo-filgrastim if it contains particles, is cloudy or discolored, or if the vial or syringe is cracked or damaged.
  • Continue to use tbo-filgrastim for the full course of treatment. Do not miss any doses.
  • Tbo-filgrastim works best if it is used at the same time each day.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of tbo-filgrastim, contact your doctor right away.

Ask your health care provider any questions you may have about how to use tbo-filgrastim.

Important safety information:

  • Tbo-filgrastim may reduce the chance of infection, but it does not prevent all infections. Contact your doctor right away if you develop signs of an infection (eg, fever; chills; sore throat; diarrhea; pain, redness, or swelling around a cut or sore).
  • You may experience bone aches while you use tbo-filgrastim. These symptoms can usually be relieved by a non-aspirin pain reliever (eg, acetaminophen; nonsteroidal anti-inflammatory drugs [NSAIDs] such as ibuprofen) as directed by your doctor.
  • Serious and sometimes fatal spleen problems (including spleen rupture) have been reported in patients using tbo-filgrastim. Contact your doctor right away if pain occurs in the stomach (especially in the left upper stomach area) or left shoulder area.
  • A serious lung problem called acute respiratory distress syndrome (ARDS) has been reported in patients who use tbo-filgrastim. Contact your doctor if you have shortness of breath or trouble breathing after receiving tbo-filgrastim.
  • Tell your doctor or dentist that you take tbo-filgrastim before you receive any medical or dental care, emergency care, or surgery.
  • Tbo-filgrastim may interfere with certain lab tests, including certain bone scans or tests. Be sure your doctor and lab personnel know you are taking tbo-filgrastim.
  • Lab tests, including complete blood cell counts, may be performed while you use tbo-filgrastim. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Tbo-filgrastim should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Tbo-filgrastim may cause harm to the fetus. Do not become pregnant while you are using tbo-filgrastim. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using tbo-filgrastim while you are pregnant. It is not known if tbo-filgrastim is found in breast milk. If you are or will be breast-feeding while you use tbo-filgrastim, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of tbo-filgrastim:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild bone pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, eyes, or tongue; dizziness; fast heartbeat; sudden increased sweating); fainting; fast breathing; fever; left shoulder pain; severe or persistent bone pain; shortness of breath; stomach pain (especially in the left upper stomach area); swelling; trouble breathing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of tbo-filgrastim:

Tbo-filgrastim is usually handled and stored by a health care provider. If you are using tbo-filgrastim at home, store tbo-filgrastim as directed by your pharmacist or health care provider. Keep tbo-filgrastim out of the reach of children and away from pets.

General information:

  • If you have any questions about tbo-filgrastim, please talk with your doctor, pharmacist, or other health care provider.
  • Tbo-filgrastim is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take tbo-filgrastim or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about tbo-filgrastim. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to tbo-filgrastim. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using tbo-filgrastim.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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