Generic Name: glycopyrrolate (GLYE-koe-PIR-oh-late)
Brand Name: Robinul

Robinul is used for:

Reducing secretions in the mouth, throat, airway, and stomach before surgery. It is used before and during surgery to block certain reflexes and to protect against certain side effects of some medicines. It is also used along with other medicines to treat peptic ulcers. It may also be used for other conditions as determined by your doctor.

Robinul is an anticholinergic. It works by blocking the activity of a certain substance (acetylcholine) in the body, which decreases secretions and decreases side effects caused by medicines that may increase the action of acetylcholine in the body.

Do NOT use Robinul if:

  • you are allergic to any ingredient in Robinul
  • you are being treated for a peptic ulcer and you also have glaucoma, urinary blockage (eg, inability to urinate), certain stomach or bowel problems (eg, stomach or bowel blockage, bowel paralysis, severe ulcerative colitis, toxic megacolon), myasthenia gravis, or heart problems caused by bleeding
  • you are taking a solid oral doseform of potassium (eg, a tablet)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Robinul:

Some medical conditions may interact with Robinul. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nerve problems (eg, autonomic neuropathy), Down syndrome, prostate problems, trouble urinating, liver problems, kidney problems, or increased pressure in the eyes
  • if you have heart problems (eg, coronary heart disease, heart failure), a fast or irregular heartbeat, high blood pressure, or an overactive thyroid
  • if you have stomach or bowel problems (eg, ulcerative colitis), constipation or diarrhea, hiatal hernia along with reflux disease, or if you have an ileostomy or colostomy
  • if you have a personal or family history of glaucoma
  • if the patient is a child with spastic paralysis or brain damage
  • if you are in poor health

Some MEDICINES MAY INTERACT with Robinul. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Solid oral potassium products (eg, tablets) because the risk of stomach or bowel irritation may be increased by Robinul
  • Anticholinergics (eg, benztropine), phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Robinul's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Robinul may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Robinul:

Use Robinul as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Robinul is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Robinul at home, a health care provider will teach you how to use it. Be sure you understand how to use Robinul. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Robinul if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Robinul, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Robinul.

Important safety information:

  • Robinul may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Robinul with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Robinul; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Drinking fluids, maintaining good oral hygiene, and sucking on hard sugarless candy can help relieve dry mouth.
  • Do not become overheated in hot weather or while being active; heatstroke may occur.
  • Use Robinul with extreme caution if you have a fever because heatstroke caused by decreased sweating may occur.
  • Robinul may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Use Robinul with caution in the ELDERLY; they may be more sensitive to its effects.
  • Robinul has benzyl alcohol in it. Do not use it in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects.
  • Robinul should not be used in CHILDREN to treat peptic ulcer; safety and effectiveness in children have not been confirmed.
  • Caution is advised when using Robinul in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Robinul while you are pregnant. It is not known if Robinul is found in breast milk. Robinul may decrease milk production. If you are or will be breast-feeding while you use Robinul, check with your doctor. Discuss any possible risks to your baby, as well as any questions or concerns about this information.

Possible side effects of Robinul:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; dry skin; enlarged pupils; headache; loss of taste; nausea; nervousness; pain, swelling, or redness at the injection site; sleeplessness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decreased sexual ability; diarrhea; difficulty focusing the eyes; difficulty urinating; excitement; fainting; fast, slow, or irregular heartbeat; fever; seizures; severe or persistent dizziness, light-headedness, or headache; shortness of breath; unusual weakness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; convulsions; difficulty breathing; disorientation; dry mouth; enlarged pupils; excessive thirst; flushed, hot, dry skin; muscle weakness; nausea; restlessness; seizures; unusual dizziness or drowsiness; vomiting.

Proper storage of Robinul:

Robinul is usually handled and stored by a health care provider. If you are using Robinul at home, store Robinul as directed by your pharmacist or health care provider. Keep Robinul out of the reach of children and away from pets.

General information:

  • If you have any questions about Robinul, please talk with your doctor, pharmacist, or other health care provider.
  • Robinul is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Robinul or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Robinul. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Robinul. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Robinul.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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