Robinul Side Effects

Generic Name: glycopyrrolate

Please note - some side effects for Robinul may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Robinul - for the Consumer

Robinul Forte

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Robinul Forte:

Bloated feeling; blurred vision; constipation; decreased milk production;decreased sweating; dizziness; drowsiness; dry mouth; dry skin; enlarged pupils; headache; loss of taste; nausea; nervousness; sleeplessness; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; diarrhea; difficulty focusing the eyes; difficulty urinating; excitement; fainting; fast or irregular heartbeat; impotence (erectile dysfunction);pounding in the chest; seizures; unusual weakness; vomiting.

Robinul

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Robinul:

Bloated feeling; blurred vision; constipation; decreased milk production; decreased sweating; dizziness; drowsiness; dry mouth; dry skin; enlarged pupils; headache; loss of taste; nausea; nervousness; pain, swelling, or redness at the injection site; sleeplessness; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; diarrhea; difficulty focusing the eyes; difficulty urinating; excessive excitement; fainting; fast or irregular heartbeat; fever; impotence (erectile dysfunction); pounding in the chest; seizures; shortness of breath; unusual weakness; vomiting.

Robinul Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Robinul Tablets:

Bloated feeling; blurred vision; constipation; decreased milk production;decreased sweating; dizziness; drowsiness; dry mouth; dry skin; enlarged pupils; headache; loss of taste; nausea; nervousness; sleeplessness; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; diarrhea; difficulty focusing the eyes; difficulty urinating; excitement; fainting; fast or irregular heartbeat; impotence (erectile dysfunction);pounding in the chest; seizures; unusual weakness; vomiting.

Robinul Side Effects - for the Professional

Robinul

Anticholinergics produce certain effects, most of which are extensions of their fundamental pharmacological actions.  Adverse reactions to anticholinergics in general may include xerostomia; decreased sweating; urinary hesitancy and retention; blurred vision; tachycardia; palpitations; dilation of the pupil; cycloplegia; increased ocular tension; loss of taste; headaches; nervousness; mental confusion; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; constipation; bloated feeling; impotence; suppression of lactation; severe allergic reaction or drug idiosyncrasies including anaphylaxis, urticaria and other dermal manifestations.
 
Robinul (glycopyrrolate) is chemically a quaternary ammonium compound; hence, its passage across lipid membranes, such as the blood-brain barrier, is limited in contrast to atropine sulfate and scopolamine hydrobromide.  For this reason the occurrence of CNS related side effects is lower, in comparison to their incidence following administration of anticholinergics which are chemically tertiary amines that can cross this barrier readily.

Side Effects by Body System

Nervous system

Nervous system side effects have included headache, nervousness, drowsiness, dizziness, insomnia, and mental confusion. The elderly appear to be more prone to the anticholinergic effects of glycopyrrolate on the CNS. Seizures have been reported from postmarketing experience.

Cardiovascular

Cardiovascular side effects have included tachycardia and palpitations. In addition, cardiac arrhythmias, cardiac arrest, hypertension, and hypotension have been reported from postmarketing experience.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, nausea, vomiting, constipation, and feeling bloated.

Genitourinary

Genitourinary side effects have included urinary hesitancy, urinary retention, and impotence.

Ocular

Ocular side effects have included blurred vision, increased ocular tension, cycloplegia, and dilatation of the pupil.

Endocrine

Endocrine side effects have included suppression of lactation.

Dermatologic

Dermatologic side effects have included dry mucous membranes and decreased sweating.

General

General side effects have included weakness, hyperpyrexia, and a loss of taste.

Hypersensitivity

Hypersensitivity side effects have included urticaria and other dermal manifestations.

Immunologic

Immunologic side effects have included anaphylaxis.

Local

Local side effects have included pruritus, edema, erythema, and pain at the injection site.

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