Octreotide

Pronunciation

Generic Name: octreotide (ok-TREE-oh-tide)
Brand Name: Sandostatin

Octreotide is used for:

Treating severe diarrhea and flushing caused by certain types of cancer. It is also used to treat acromegaly in certain patients. It may also be used for other conditions as determined by your doctor.

Octreotide is a somatostatic agent. It works by reducing blood levels of a variety of hormones (eg, growth hormone) and chemical messengers (eg, gastrin, vasoactive intestinal peptide) that cause disease symptoms.

Do NOT use octreotide if:

  • you are allergic to any ingredient in octreotide

Contact your doctor or health care provider right away if any of these apply to you.

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Before using octreotide:

Some medical conditions may interact with octreotide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of gallstones or gallbladder problems, kidney disease, diabetes, thyroid problems, heart problems (eg, slow or irregular heartbeat), pancreas problems, or poor health or nutrition
  • if you are on dialysis

Some MEDICINES MAY INTERACT with octreotide. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), bromocriptine, calcium channel blockers (eg, verapamil), quinidine, or terfenadine because the risk of their side effects may be increased by octreotide
  • Cyclosporine, insulin, or oral hypoglycemic medicines (eg, glyburide) because their effectiveness may be decreased by octreotide

This may not be a complete list of all interactions that may occur. Ask your health care provider if octreotide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use octreotide:

Use octreotide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Octreotide is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using octreotide at home, a health care provider will teach you how to use it. Be sure you understand how to use octreotide. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use octreotide if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Allow octreotide to come to room temperature before using. Do not warm or thaw octreotide with hot water or by placing in the microwave.
  • Rotate injection sites to avoid using the same injection site within several days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of octreotide, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use octreotide.

Important safety information:

  • Octreotide may cause dizziness, drowsiness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use octreotide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Diabetes patients - Octreotide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Octreotide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Octreotide may lower your blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Lab tests, including blood sugar levels, growth hormone levels, and thyroid function, may be performed while you use octreotide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use octreotide with caution in the ELDERLY; they may be more sensitive to its effects.
  • Octreotide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • Octreotide may restore fertility in some women with acromegaly who were unable to become pregnant. If you wish to avoid pregnancy, you should use effective birth control while you use octreotide.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using octreotide while you are pregnant. It is not known if octreotide is found in breast milk. If you are or will be breast-feeding while you use octreotide, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of octreotide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; mild to moderate pain at the injection site; nausea; stomach pain or discomfort; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent stomach pain or tenderness; severe or persistent vomiting or diarrhea; slow or irregular heartbeat; stomach bloating or swelling; swollen or enlarged glands; trouble swallowing; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; diarrhea; dizziness; flushing; irregular heartbeat; severe stomach pain or tenderness; trouble breathing; unusual tiredness or weakness; weight loss; yellowing of the skin or eyes.

Proper storage of octreotide:

Store octreotide in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Octreotide may also be stored at room temperature, between 70 and 86 degrees F (20 and 30 degrees C), for up to 14 days if protected from light. Throw away multiple-dose vials within 14 days after opening. Open single-dose vials just before use and throw away any unused portion. Store away from heat, moisture, and light. Do not store in the bathroom. Keep octreotide, as well as syringes and needles, out of the reach of children and away from pets.

General information:

  • If you have any questions about octreotide, please talk with your doctor, pharmacist, or other health care provider.
  • Octreotide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take octreotide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about octreotide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to octreotide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using octreotide.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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