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Nipent

Generic Name: pentostatin (PEN-toe-sta-tin)
Brand Name: Nipent

The use of doses higher than specified by the manufacturer of Nipent is not recommended. Severe kidney, liver, lung, and central nervous system problems (toxicities) have occurred in some studies when using higher than recommended doses. Nipent is not recommended for use with fludarabine. The use of pentostatin in combination with fludarabine has caused severe lung problems; in some cases, this has led to death. Ask your doctor or pharmacist for more information.


Nipent is used for:

Treating certain types of cancer.

Nipent is an antineoplastic. How it prevents growth of cancer cells is unknown.

Do NOT use Nipent if:

  • you are allergic to any ingredient in Nipent
  • you are taking fludarabine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Nipent:

Some medical conditions may interact with Nipent. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an infection, chickenpox, kidney problems, or blood problems

Some MEDICINES MAY INTERACT with Nipent. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carmustine, cyclophosphamide, etoposide, fludarabine, or vidarabine because the risk of side effects, including life-threatening lung toxicity, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nipent may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nipent:

Use Nipent as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Nipent is administered as an injection at your doctor's office, hospital, or clinic.
  • If Nipent accidentally spills on your skin, wash it off immediately with soap and water.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Nipent, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Nipent.

Important safety information:

  • Nipent may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Nipent may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
  • Check with your doctor before having vaccinations while you are using Nipent.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Nipent.
  • The use of birth control is recommended while you are using Nipent.
  • LAB TESTS, including liver function, kidney function, and complete blood cell count, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Nipent with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Nipent has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Nipent. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Nipent during pregnancy. It is unknown if Nipent is excreted in breast milk. Do not breast-feed while taking Nipent.

Possible side effects of Nipent:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; fatigue; headache; loss of appetite; muscle pain; nausea; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chills; cough; eye pain or changes in vision; fever; hoarseness; itching; pain, redness, or swelling at the injection site; sore throat; sores on the mouth or lips; unusual bruising or bleeding; unusual tiredness or weakness

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Nipent:

Nipent is usually handled and stored by a health care provider. If you are using Nipent at home, store Nipent as directed by your pharmacist or health care provider.

General information:

  • If you have any questions about Nipent, please talk with your doctor, pharmacist, or other health care provider.
  • Nipent is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Nipent or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Nipent. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Nipent. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Nipent.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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