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Nesiritide

Generic Name: nesiritide (ni-SIR-i-tide)
Brand Name: Natrecor

Nesiritide is used for:

Treating patients with worsened congestive heart failure who have difficulty breathing during rest or with minimal activity.

Nesiritide is a human B type natriuretic peptide (hBNP). It works by allowing blood vessels to relax, causing better blood flow for the heart.

Do NOT use nesiritide if:

  • you are allergic to any ingredient in nesiritide
  • you have persistently low blood pressure before treatment with nesiritide
  • you have certain heart problems or shock caused by serious heart problems

Contact your doctor or health care provider right away if any of these apply to you.

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Before using nesiritide:

Some medical conditions may interact with nesiritide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergy to other recombinant peptides
  • if you have heart problems or kidney problems
  • if you have a history of low blood pressure

Some MEDICINES MAY INTERACT with nesiritide. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), angiotensin receptor blockers (ARBs) (eg, losartan), or other medicines that lower blood pressure because the risk of low blood pressure may be increased. Check with your doctor or pharmacist if you are unsure if any of your medicines may lower blood pressure

This may not be a complete list of all interactions that may occur. Ask your health care provider if nesiritide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use nesiritide:

Use nesiritide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Nesiritide is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use nesiritide if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of nesiritide, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use nesiritide.

Important safety information:

  • Nesiritide may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use nesiritide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If your symptoms do not improve or if they become worse, tell your doctor immediately.
  • Lab tests, including blood pressure monitoring, electrocardiogram (ECG) readings, and kidney function, may be performed while you use nesiritide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use nesiritide with caution in the ELDERLY; they may be more sensitive to its effects.
  • Nesiritide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using nesiritide while you are pregnant. It is not known if nesiritide is found in breast milk. If you are or will be breast-feeding while you use nesiritide, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of nesiritide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; dizziness; headache; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; chest pain; confusion; coughing up blood; decreased urination; fainting; fast, slow, or irregular heartbeat; fever; interrupted breathing; pain, redness, or tenderness at the injection site; severe or persistent dizziness or light-headedness; tremors; unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or light-headedness.

Proper storage of nesiritide:

Nesiritide is handled and stored by a health care provider. Keep nesiritide out of the reach of children and away from pets.

General information:

  • If you have any questions about nesiritide, please talk with your doctor, pharmacist, or other health care provider.
  • Nesiritide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take nesiritide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about nesiritide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to nesiritide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using nesiritide.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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