Naloxone

Pronunciation

Generic Name: naloxone (nal-OX-one)
Brand Name: Narcan

Naloxone is used for:

Completely or partially reversing the effects of narcotics. It may also be used to diagnose overdose of narcotics. It may also be used for other conditions as determined by your doctor.

Naloxone is a narcotic antagonist. It works by blocking opiate receptor sites, which reverses or prevents toxic effects of narcotic (opioid) analgesics.

Do NOT use naloxone if:

  • you are allergic to any ingredient in naloxone

Contact your doctor or health care provider right away if any of these apply to you.

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Before using naloxone:

Some medical conditions may interact with naloxone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart disease or a history of substance abuse

Some MEDICINES MAY INTERACT with naloxone. However, no specific interactions are known at this time.

Ask your health care provider if naloxone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use naloxone:

Use naloxone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Naloxone is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use naloxone if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of naloxone, contact your doctor right away.

Ask your health care provider any questions you may have about how to use naloxone.

Important safety information:

  • Naloxone may cause dizziness, drowsiness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use naloxone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If you experience a return of symptoms (such as drowsiness or difficulty breathing), contact your doctor immediately.
  • Naloxone should be used with extreme caution in NEWBORNS of women who may have had dependency on narcotics; opioid withdrawal may occur.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using naloxone while you are pregnant. It is not known if naloxone is found in breast milk. If you are or will be breast-feeding while you use naloxone, check with your doctor. Discuss any possible risks to your baby.

If you are addicted to narcotics and are given naloxone, you may experience WITHDRAWAL symptoms, including abnormal skin sensations; anxiety; diarrhea; fever; goose bumps; nausea; pain; rapid heartbeat; rigid muscles; runny nose; seeing, hearing, or feeling things that are not there; shivering or tremors; sneezing; sweating; trouble sleeping; and vomiting.

Possible side effects of naloxone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in mood; increased sweating; nausea; nervousness; restlessness; trembling; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dizziness; fainting; fast or irregular pulse; flushing; headache; heart rhythm changes; seizures; sudden chest pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of naloxone:

Naloxone is usually handled and stored by a health care provider. If you are using naloxone at home, store naloxone as directed by your pharmacist or health care provider. Keep naloxone out of the reach of children and away from pets.

General information:

  • If you have any questions about naloxone, please talk with your doctor, pharmacist, or other health care provider.
  • Naloxone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take naloxone or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about naloxone. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to naloxone. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using naloxone.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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