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Naloxone Pregnancy and Breastfeeding Warnings

Naloxone is also known as: Evzio, Narcan

Naloxone Pregnancy Warnings

Naloxone rapidly crosses the placenta. Fetal serum levels are lower than those of the mother.

Naloxone has been assigned to pregnancy category C by the FDA. Animal data failed to reveal evidence of impaired fertility or fetotoxicity at very high human doses. There are no controlled studies in human pregnancy. Naloxone crosses the placenta. Administration during human pregnancy to a woman who is opioid-dependent may precipitate withdrawal in the woman and the fetus. Naloxone is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

See references

Naloxone Breastfeeding Warnings

There are no data on the excretion of naloxone into human milk. The manufacturer recommends that caution be used when administering naloxone to nursing women.

See references

References for pregnancy information

  1. Chamberlain JM, Klein BL "A comprehensive review of naloxane for the emergency physician." Am J Emerg Med 12 (1994): 650-60
  2. "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.
  3. Hibbard BM, Rosen M, Davies D "Placental transfer of naloxone." Br J Anaesth 58 (1986): 45-8

References for breastfeeding information

  1. "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.
  2. Chamberlain JM, Klein BL "A comprehensive review of naloxane for the emergency physician." Am J Emerg Med 12 (1994): 650-60

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