Medication Guide App

Methylergonovine

Generic Name: methylergonovine (METH-il-ER-goe-NOE-veen)
Brand Name: Methergine

Methylergonovine is used for:

Treating bleeding during and after delivery of a baby. It may also be used for other conditions as determined by your doctor.

Methylergonovine is an ergot alkaloid uterine stimulant. It works by increasing uterine contractions, which helps reduce blood loss after the baby is delivered.

Do NOT use methylergonovine if:

  • you are allergic to any ingredient in methylergonovine
  • you are pregnant
  • you have high blood pressure, especially high blood pressure caused by pregnancy (toxemia or preeclampsia)
  • you are taking certain azole antifungals (eg, itraconazole, ketoconazole, voriconazole), cobicistat, a ketolide antibiotic (eg, telithromycin), certain macrolide antibiotics (eg, clarithromycin, erythromycin), certain protease inhibitors (eg, indinavir, ritonavir, telaprevir), or certain reverse transcriptase inhibitors (eg, delavirdine, efavirenz)
  • you have taken or will be taking a triptan (eg, sumatriptan) within 24 hours before or after using methylergonovine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using methylergonovine:

Some medical conditions may interact with methylergonovine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a blood infection or a history of blood vessel problems (eg, in the brain or heart), stroke, liver problems, kidney problems, heart problems, or high blood pressure (especially high blood pressure caused by pregnancy)
  • if you have eclampsia (certain types of seizures in a pregnant woman)
  • if you smoke, are very overweight, or have diabetes or high cholesterol
  • if you are taking medicine for angina (chest pain), or if you are taking another ergot medicine (eg, dihydroergotamine)

Some MEDICINES MAY INTERACT with methylergonovine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, itraconazole, ketoconazole, voriconazole ), beta-blockers (eg, propranolol), clotrimazole, cobicistat, fluoxetine, fluvoxamine, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, protease inhibitors (eg, indinavir, ritonavir, telaprevir), reverse transcriptase inhibitors (eg, delavirdine, efavirenz), triptans (eg, sumatriptan), or zileuton because they may increase the risk of methylergonovine's side effects
  • Nevirapine or rifamycins (eg, rifampin) because they may decrease methylergonovine's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if methylergonovine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use methylergonovine:

Use methylergonovine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Methylergonovine is given as an injection at your doctor's office, hospital, or clinic.
  • Eating grapefruit or drinking grapefruit juice while you are taking methylergonovine may increase the amount of methylergonovine in your blood, which may increase your risk for serious side effects. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
  • If you miss a dose of methylergonovine, contact your doctor right away.

Ask your health care provider any questions you may have about how to use methylergonovine.

Important safety information:

  • Methylergonovine tightens the muscles of the uterus. You may experience some uterine cramping. Check with you doctor if cramps are persistent or severe.
  • Tell your doctor or dentist that you take methylergonovine before you receive any medical or dental care, emergency care, or surgery.
  • Methylergonovine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use methylergonovine if you are pregnant. It may cause harm to the fetus. If you think you may be pregnant, contact your doctor right away. Methylergonovine is found in breast milk. Do not breast-feed while you are using methylergonovine and for 12 hours after your last dose.

Possible side effects of methylergonovine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; burning, tingling, numbness, or unusually pale skin of the fingers or toes; chest, jaw, or arm pain; confusion; dizziness; fainting; fast, slow, or irregular heartbeat; hallucinations; leg cramps; mental or mood changes; one-sided weakness; ringing in the ears; seizure; severe or persistent headache, nausea, vomiting, or stomach pain; shortness of breath; slurred speech; sudden, unusual sweating or weakness; vision problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; decreased urination; difficulty breathing; fainting; feeling of being very cold; nausea; seizures; severe headache or dizziness; stomach pain; tingling or numbness of the hands or feet; vomiting.

Proper storage of methylergonovine:

Methylergonovine is usually handled and stored by a health care provider. If you are using methylergonovine at home, store methylergonovine as directed by your pharmacist or health care provider. Keep methylergonovine out of the reach of children and away from pets.

General information:

  • If you have any questions about methylergonovine, please talk with your doctor, pharmacist, or other health care provider.
  • Methylergonovine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take methylergonovine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about methylergonovine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to methylergonovine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using methylergonovine.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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