Mesna tablets

Generic Name: mesna (MES-na)
Brand Name: Mesnex

Mesna tablets is used for:

Preventing or reducing the harmful effects of chemotherapy on the bladder.

Mesna tablets is an uroprotectant. It works by protecting the bladder wall from the harmful effects of chemotherapy.

Do NOT use mesna tablets if:

  • you are allergic to any ingredient in mesna tablets or other thiol compounds

Contact your doctor or health care provider right away if any of these apply to you.

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Before using mesna tablets:

Some medical conditions may interact with mesna tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an autoimmune disorder (eg, rheumatoid arthritis, lupus) or kidney problems (eg, nephritis)

Some MEDICINES MAY INTERACT with mesna tablets.

However, no specific interactions with mesna tablets are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if mesna tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use mesna tablets:

Use mesna tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Mesna tablets may be taken with or without food.
  • Drink at least 1 quart (4 cups/1 L) of liquid per day.
  • If you vomit within 2 hours of taking mesna tablets, contact your doctor right away.
  • If you miss a dose of mesna tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use mesna tablets.

Important safety information:

  • Mesna tablets may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to mesna tablets. Using mesna tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Tell your doctor if your urine turns a pink or red color.
  • Certain prescription medicines and foods, such as red beets, may also cause your urine to change colors. A lab test of your urine will show if the source of the color is due to one of these causes.
  • Diabetes patients - Mesna tablets may cause incorrect test results with some urine glucose tests. Check with your doctor before you adjust your dose of your diabetes medicine or change your diet.
  • LAB TESTS, including urine tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use mesna tablets with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking mesna tablets, discuss with your doctor the benefits and risks of using mesna tablets during pregnancy. It is unknown if mesna tablets is excreted in breast milk. Do not breast-feed while taking mesna tablets.

Possible side effects of mesna tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; cold symptoms (coughing, sore throat); constipation; diarrhea; dizziness; drowsiness; fever; fluid retention; flushing; headache; loss of appetite; nausea; pain in arms or legs; paleness; stomach pain; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, face, throat, or tongue); blood in the urine (pink or red urine); chest pain; difficulty swallowing; fast heartbeat; hoarseness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of mesna tablets:

Store mesna tablets between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep mesna tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about mesna tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Mesna tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take mesna tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mesna tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mesna tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mesna tablets.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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