# Mesna Dosage

Applies to the following strength(s): 100 mg/mL ; 400 mg

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### Usual Adult Dose for:

### Usual Pediatric Dose for:

#### Additional dosage information:

## Usual Adult Dose for Hemorrhagic Cystitis Prophylaxis

**Prevention of ifosfamide-induced cystitis**:

Mesna may be given on a fractionated dosing schedule of either 3 bolus intravenous injections or a single injection followed by two oral doses. IV mesna is administered at 20% of the ifosfamide dose while oral mesna is administered at 40% of the ifosfamide dose.

IV: 20% of the ifosfamide dose once at the time of ifosfamide administration and 20% of the ifosfamide dose 4 and 8 hours after each dose of ifosfamide. Thus, if ifosfamide were given at 1.2 g/m2, the dose of mesna would be 240 mg/m2 given at 0, 4, and 8 hours after ifosfamide.

When given with a continuous infusion of ifosfamide, mesna may be dosed on a "mg per mg" basis (e.g., 1.2 g/m2 for a 1.2 g/m2 continuous infusion of ifosfamide). 10% of the dose should be given before the ifosfamide infusion and the remainder continued during and for 12 to 24 hours after the ifosfamide infusion has stopped.

Oral (to be given after one dose of IV mesna): 40% of the ifosfamide dose at 2 and 6 hours after each dose of ifosfamide. Thus, if ifosfamide were given at 1.2 g/m2, the dose of IV mesna would be 240 mg/m2 given at the time of ifosfamide administration and the dose of oral mesna would be 480 mg/m2 given at 2 and 6 hours after ifosfamide.

## Usual Pediatric Dose for Hemorrhagic Cystitis Prophylaxis

**Prevention of ifosfamide-induced cystitis**:

Mesna may be given on a fractionated dosing schedule of either 3 bolus intravenous injections or a single injection followed by two oral doses. IV mesna is administered at 20% of the ifosfamide dose while oral mesna is administered at 40% of the ifosfamide dose.

IV: 20% of the ifosfamide dose once at the time of ifosfamide administration and 20% of the ifosfamide dose 4 and 8 hours after each dose of ifosfamide. Thus, if ifosfamide were given at 1.2 g/m2, the dose of mesna would be 240 mg/m2 given at 0, 4, and 8 hours after ifosfamide.

When given with a continuous infusion of ifosfamide, mesna may be dosed on a "mg per mg" basis (e.g., 1.2 g/m2 for a 1.2 g/m2 continuous infusion of ifosfamide). 10% of the dose should be given before the ifosfamide infusion and the remainder continued during and for 12 to 24 hours after the ifosfamide infusion has stopped.

Oral (to be given after one dose of IV mesna): 40% of the ifosfamide dose at 2 and 6 hours after each dose of ifosfamide. Thus, if ifosfamide were given at 1.2 g/m2, the dose of IV mesna would be 240 mg/m2 given at the time of ifosfamide administration and the dose of oral mesna would be 480 mg/m2 given at 2 and 6 hours after ifosfamide.

## Dose Adjustments

In order to maintain adequate protection, the recommended dosage regimen should be repeated on each day that ifosfamide is administered. When the dosage of ifosfamide is adjusted (either increased or decreased), the dose of mesna should also be modified accordingly.

## More about mesna

### Consumer resources

*Other brands: Mesnex*