Generic Name: isosorbide mononitrate (eye-soe-SOR-bide mon-oh-NYE-trate)
Brand Name: Examples include ISMO and Monoket
ISMO is used for:
Preventing angina (chest pain) caused by heart disease.
ISMO is a nitrate vasodilator. It works by widening the blood vessels in the body. This reduces the workload of the heart and helps to relieve chest pain.
Do NOT use ISMO if:
- you are allergic to any ingredient in ISMO or to other nitrate medicines
- you are also taking a phosphodiesterase type 5 inhibitor (eg, sildenafil, tadalafil, vardenafil)
- you drink alcohol
Contact your doctor or health care provider right away if any of these apply to you.
Before using ISMO:
Some medical conditions may interact with ISMO. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have heart problems (eg, heart failure, heart attack, hypertrophic cardiomyopathy), low blood pressure, blood problems (eg, anemia), dehydration, bleeding the brain, an overactive thyroid, or have had a recent head injury
Some MEDICINES MAY INTERACT with ISMO. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Calcium channel blockers (eg, diltiazem, verapamil) or phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil, vardenafil) because the risk of severe low blood pressure may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if ISMO may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use ISMO:
Use ISMO as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take ISMO by mouth with or without food.
- This medication should be taken twice daily, with the doses 7 hours apart. The first dose should preferably be taken in the morning upon waking up, unless directed otherwise by your doctor.
- Do not suddenly stop taking ISMO. You may have an increased risk of side effects (eg, angina attacks). If you need to stop ISMO or add a new medicine, your doctor will gradually lower your dose.
- If you miss a dose of ISMO, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use ISMO.
Important safety information:
- ISMO may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use ISMO with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- ISMO may cause dizziness or lightheadedness; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not drink alcohol while you are taking ISMO.
- When you begin taking ISMO, headaches are likely to occur. Ask your doctor for instructions on ways to reduce this side effect.
- ISMO should not be used to stop an attack of angina; it is intended only for prevention of an attack.
- ISMO may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking ISMO.
- ISMO should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ISMO while you are pregnant. It is not known if ISMO is found in breast milk. If you are or will be breast-feeding while you use ISMO, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of ISMO:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; headache; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; fainting; numbness of an arm or leg; severe stomach pain; sharp or crushing chest pain; sudden leg pain; sudden, severe headache; sudden shortness of breath; vomiting.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include breathing problems; confusion; dizziness; fainting; fever; flushing; headache; increased pressure in the head; irregular heartbeat; loss of appetite; nausea; paralysis; sweating; visual disturbances; vomiting.Proper storage of ISMO:
Store ISMO at 59 to 86 degrees F (15 to 30 degrees C). Store away from heat, moisture, and light. Keep ISMO in the original container with the lid tightly closed. Do not store in the bathroom. Keep ISMO out of the reach of children and away from pets.
- If you have any questions about ISMO, please talk with your doctor, pharmacist, or other health care provider.
- ISMO is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take ISMO or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ISMO. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ISMO. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ISMO.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More ISMO resources
- Isosorbide Mononitrate Professional Patient Advice (Wolters Kluwer)
- Isosorbide Mononitrate Prescribing Information (FDA)
- Imdur Consumer Overview
- Imdur Prescribing Information (FDA)
- Ismo Prescribing Information (FDA)
- Ismo Advanced Consumer (Micromedex) - Includes Dosage Information
- Monoket Prescribing Information (FDA)