Isosorbide Mononitrate Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Angina Pectoris Prophylaxis

30-60 mg (Imdur) orally once a day or
20 mg (ISMO) orally twice a day or
10-20 mg (Monoket) orally twice a day.

Usual Adult Dose for Congestive Heart Failure

30-60 mg (Imdur) orally once a day or
20 mg (ISMO) orally twice a day or
10-20 mg (Monoket) orally twice a day.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

After several days, the dose of Imdur may be increased to 120 mg.
An initial 5 mg dose for Monoket might be appropriate for persons of a small stature. This dose should be increased to at least 10 mg by the second or third day.

Precautions

Severe hypotension can occur following administration of isosorbide mononitrate, even in small doses.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Usual twice a day dosing (for ISMO and Monoket) is administered upon arising and 7 hours later. The Imdur dose should be taken once a day upon arising each morning. The maximum recommended dose of Imdur is 240 mg/day.

The presence of food does not significantly alter the absorption or bioavailability of Monoket.

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