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Hydrochlorothiazide and metoprolol

Generic name: hydrochlorothiazide and metoprolol [ HYE-droe-klor-oh-THYE-a-zide-and-me-TOE-proe-lole ]
Brand names: Lopressor HCT, Dutoprol
Dosage form: oral tablet (25 mg-100 mg; 25 mg-50 mg; 50 mg-100 mg)
Drug class: Beta blockers with thiazides

Medically reviewed by Drugs.com on Aug 4, 2023. Written by Cerner Multum.

What is hydrochlorothiazide and metoprolol?

Hydrochlorothiazide is a thiazide diuretic (water pill). Metoprolol is a beta-blocker.

Hydrochlorothiazide and metoprolol is a combination medicine used to treat high blood pressure (hypertension).

Hydrochlorothiazide and metoprolol may also be used for purposes not listed in this medication guide.

Hydrochlorothiazide and metoprolol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Hydrochlorothiazide and metoprolol may cause serious side effects. Call your doctor at once if you have:

Common side effects of hydrochlorothiazide and metoprolol may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use hydrochlorothiazide and metoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly.

You should not use hydrochlorothiazide and metoprolol if you are unable to urinate.

Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose.

Before taking this medicine

You should not use this medicine if you are allergic to hydrochlorothiazide or metoprolol, or if you have:

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

Hydrochlorothiazide and metoprolol is not approved for use by anyone younger than 18 years old.

How should I take hydrochlorothiazide and metoprolol?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take hydrochlorothiazide and metoprolol with (or immediately after food) or without food.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea.

Your blood pressure will need to be checked often. You may also need frequent blood tests.

If you are diabetic, check your blood sugar carefully. Taking hydrochlorothiazide and metoprolol can make it harder for you to tell when you have low blood sugar. Do not change your medication dose or schedule without your doctor's advice.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and metoprolol.

Keep using hydrochlorothiazide and metoprolol as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Do not stop using hydrochlorothiazide and metoprolol suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Hydrochlorothiazide and metoprolol dosing information

Usual Adult Dose for Hypertension:

Immediate-release:
-Hydrochlorothiazide 25 to 50 mg-Metoprolol 100 to 200 mg orally per day in single or divided doses

Extended-release:
-Initial dose: Hydrochlorothiazide 12.5 mg-Metoprolol 25 mg orally once a day
-Maximum dose: Hydrochlorothiazide 25 mg-Metoprolol 200 mg orally once a day

Comments:
-Hydrochlorothiazide doses greater than 50 mg per day are not recommended.
-Immediate-release metoprolol (tartrate) may be administered once a day, but lower doses (100 mg) may not maintain a full effect for 24 hours; measure blood pressure near the end of the dosing interval to determine adequate control; larger or more frequent doses may be required.
-Extended-release metoprolol (succinate) may be titrated after 2 weeks.
-Beta-1 selectivity decreases as the metoprolol dose is increased.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heart rate, trouble breathing, or fainting.

What should I avoid while taking hydrochlorothiazide and metoprolol?

Avoid driving or hazardous activity until you know how hydrochlorothiazide and metoprolol will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol with this medicine can cause side effects.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis.

What other drugs will affect hydrochlorothiazide and metoprolol?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect hydrochlorothiazide and metoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.