Generic Name: entacapone (en-TAK-a-pone)
Brand Name: Comtan
Comtan is used for:
Treating Parkinson disease in certain patients. Comtan must be taken along with levodopa/carbidopa.
Comtan is a catechol-O-methyltransferase (COMT) inhibitor. It works by increasing the levels of levodopa/carbidopa in the brain, enhancing its effectiveness.
Do NOT use Comtan if:
- you are allergic to any ingredient in Comtan
Contact your doctor or health care provider right away if any of these apply to you.
Before using Comtan:
Some medical conditions may interact with Comtan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver disease, mental or mood problems, sleep problems, or a history of a severe muscle problem called rhabdomyolysis
- if you have taken certain monoamine oxidase inhibitors (MAOIs) (eg, phenelzine, tranylcypromine) within the past 14 days
Some MEDICINES MAY INTERACT with Comtan. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Ampicillin, chloramphenicol, cholestyramine, erythromycin, MAOIs (eg, phenelzine, selegiline, tranylcypromine), probenecid, or rifampin because they may increase the risk of Comtan's side effects
- Apomorphine, bitolterol, dobutamine, dopamine, isoetharine, isoproterenol, methyldopa, sympathomimetics (eg, epinephrine), or warfarin because their actions and the risk of their side effects may be increased by Comtan
This may not be a complete list of all interactions that may occur. Ask your health care provider if Comtan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Comtan:
Use Comtan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Comtan by mouth with or without food.
- Comtan should be given each time a dose of levodopa/carbidopa is given.
- If you miss a dose of Comtan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Comtan.
Important safety information:
- Comtan may cause dizziness and drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Comtan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Comtan may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of dizziness, light-headedness, or weakness.
- Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Comtan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Comtan may cause diarrhea. It typically begins within 4 to 12 weeks of starting Comtan, but may occur during the first week or many months after starting it. Rare cases of prolonged diarrhea caused by colitis (inflammation of the large intestine) have occurred in patients taking Comtan. Contact your doctor if you have severe, persistent, or watery diarrhea.
- If diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Comtan. Symptoms may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your doctor at once if you have any of these symptoms.
- Some patients who take Comtan have reported suddenly falling asleep while performing daily activities (eg, driving, eating, talking). Some patients did not experience drowsiness and felt that they were alert immediately before suddenly falling asleep. Some of these events have been reported as late as 1 year after Comtan was started. Use caution when driving, operating machinery, or performing other activities that could be dangerous. Inform your doctor if you experience unusual drowsiness or sleepiness while using Comtan.
- Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Comtan. Tell your doctor right away if you notice such effects.
- Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Comtan also increases the risk of melanoma. You may need to have skin exams while you are using Comtan. Discuss any questions or concerns with your doctor.
- Comtan may color the urine a brownish orange. This is normal and is not a cause for concern.
- Do not stop taking Comtan suddenly. If therapy is stopped, it should be tapered gradually.
- Tell your doctor or dentist that you take Comtan before you receive any medical or dental care, emergency care, or surgery.
- Lab tests may be performed while you use Comtan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Comtan should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Comtan while you are pregnant. It is not known if Comtan is found in breast milk. If you are or will be breast-feeding while you use Comtan, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Comtan:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Changes in the color of urine (brownish orange); constipation; diarrhea; dizziness; drowsiness; dry mouth; nausea; stomach pain; tiredness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fainting; fever; hallucinations; mental, mood, or behavior changes; muscle pain, stiffness, or rigidity; new or increased involuntary movements; severe or persistent dizziness or nausea; severe, persistent, or watery diarrhea; shortness of breath; unusual skin growths or change in the appearance of a mole.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Comtan:
Store Comtan at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Comtan out of the reach of children and away from pets.
- If you have any questions about Comtan, please talk with your doctor, pharmacist, or other health care provider.
- Comtan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Comtan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Comtan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Comtan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Comtan.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.