Generic Name: colistimethate (koe-LIS-ti-METH-ate)
Brand Name: Coly-Mycin M
Colistimethate is used for:
Treating infections caused by certain bacteria.
Colistimethate is an antibiotic. It works by killing sensitive bacteria.
Do NOT use colistimethate if:
- you are allergic to any ingredient in colistimethate
- you are taking sodium cephalothin
Contact your doctor or health care provider right away if any of these apply to you.
Before using colistimethate:
Some medical conditions may interact with colistimethate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have kidney problems
Some MEDICINES MAY INTERACT with colistimethate. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Sodium cephalothin because the risk of kidney problems may be increased
- Aminoglycosides (eg, gentamicin), curariform muscle relaxants (eg, tubocurarine), decamethonium, nondepolarizing muscle relaxants (eg, gallamine), polymyxin, sodium citrate, or succinylcholine because their actions and the risk of their side effects, including difficulty breathing, may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if colistimethate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use colistimethate:
Use colistimethate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Colistimethate is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using colistimethate at home, a health care provider will teach you how to use it. Be sure you understand how to use colistimethate. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- To clear up your infection completely, use colistimethate for the full course of treatment. Keep using it even if you feel better in a few days.
- Do not use colistimethate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of colistimethate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use colistimethate.
Important safety information:
- Colistimethate may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use colistimethate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Colistimethate may cause temporary effects such as dizziness; slurred speech; itching; burning or numbness around the mouth; or numbness or tingling in the arms or legs. Contact your doctor if these effects occur. Your dose may need to be decreased.
- Colistimethate only works against bacteria; it does not treat viral infections (eg, the common cold).
- Be sure to use colistimethate for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of colistimethate may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Tell your doctor or dentist that you take colistimethate before you receive any medical or dental care, emergency care, or surgery.
- Use colistimethate with caution in the ELDERLY, especially patients with kidney problems; they may be more sensitive to its effects.
- Caution is advised when using colistimethate in CHILDREN; they may be more sensitive to its effects.
- Use colistimethate with extreme caution in CHILDREN younger than 10 years of age who have diarrhea or an infection of the stomach or bowel.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using colistimethate while you are pregnant. It is not known if colistimethate is found in breast milk. If you are or will be breast-feeding while you use colistimethate, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of colistimethate:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Abnormal skin sensations around the mouth; dizziness; itching; numbness or tingling of the fingers or toes; slurred speech; stomach upset.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; decreased urination; fever; severe diarrhea; shortness of breath; stomach pain or cramps.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; confusion; decreased urination; difficulty breathing; difficulty speaking or walking; muscle weakness; rapid eye movements; severe or persistent abnormal skin sensations; severe or persistent dizziness; severe or persistent numbness or tingling of the fingers or toes; unusual drowsiness or sluggishness; weakness.Proper storage of colistimethate:
Colistimethate is usually handled and stored by a health care provider. If you are using colistimethate at home, store colistimethate as directed by your pharmacist or health care provider.
- If you have any questions about colistimethate, please talk with your doctor, pharmacist, or other health care provider.
- Colistimethate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take colistimethate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about colistimethate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to colistimethate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using colistimethate.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.