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Clorpres

Generic Name: chlorthalidone/clonidine (klor-THAL-i-done/KLON-i-deen)
Brand Name: Clorpres

Clorpres is used for:

Treating high blood pressure. It may also be used for other conditions as determined by your doctor.

Clorpres is a combination alpha agonist and diuretic. The alpha agonist works by relaxing blood vessels and decreasing heart rate. The diuretic works by increasing elimination of sodium and water.

Do NOT use Clorpres if:

  • you are allergic to any ingredient in Clorpres or to sulfonamide medicines (eg, sulfamethoxazole)
  • you are unable to urinate

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update - First Time Brand-to-Generic Switches

Before using Clorpres:

Some medical conditions may interact with Clorpres. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a thiazide diuretic (eg, hydrochlorothiazide)
  • if you have had a skin reaction to the patch form of clonidine
  • if you have kidney problems, heart problems (eg, slow or irregular heartbeat), problems with blood vessels in your heart or brain, or you have had a stroke or recent heart attack
  • if you have gout or high blood uric acid levels, liver disease, low blood levels of potassium or sodium, the blood disease porphyria, lupus, or an adrenal gland tumor (pheochromocytoma)
  • if you are dehydrated or are on a low-salt (sodium) diet, drink alcohol, or have low blood volume or low blood pressure
  • if you have a history of allergies or asthma
  • if you will be in a hot environment for long periods of time
  • if you are scheduled for surgery
  • if you have never taken another medicine for high blood pressure

Some MEDICINES MAY INTERACT with Clorpres. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol) because severe and sometimes life-threatening increased blood pressure may occur if Clorpres is suddenly stopped
  • Diltiazem or verapamil because the risk of slow or irregular heartbeat may be increased
  • Cholestyramine, colestipol, or tricyclic antidepressants (eg, amitriptyline) because they may decrease Clorpres's effectiveness
  • Barbiturates (eg, phenobarbital), corticosteroids (eg, cortisone), narcotic pain medicines (eg, codeine), or tizanidine because they may increase the risk of Clorpres's side effects
  • Diazoxide, digoxin, ketanserin, lithium, or other medicines for high blood pressure because the risk of their side effects may be increased by Clorpres
  • Insulin or oral diabetes medicines (eg, glipizide) because their effectiveness may be decreased by Clorpres

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clorpres may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clorpres:

Use Clorpres as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Clorpres by mouth with or without food.
  • If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Clorpres.
  • Take Clorpres on a regular schedule to get the most benefit from it.
  • Continue to use Clorpres even if you feel well. Do not miss any doses.
  • Clorpres may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Clorpres, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Clorpres.

Important safety information:

  • Clorpres may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Clorpres with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Clorpres; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Clorpres may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • If you experience dry mouth, use sugarless candy or gum, or melt bits of ice in your mouth to help keep your mouth moist.
  • Patients who wear contact lenses may notice dry eyes while using Clorpres. If you experience eye dryness or irritation, talk with your doctor about ways to lessen this effect.
  • Do not suddenly stop taking Clorpres without talking to your doctor. Nervousness, agitation, tremor, and headache may occur. These may be followed by a rapid, severe rise in blood pressure. You may be at greater risk if you use high doses or if you also take a beta-blocker (eg, propranolol). If you need to stop taking Clorpres, follow your doctor's instructions for slowly decreasing your dose.
  • Clorpres may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Clorpres may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Clorpres. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Clorpres before you receive any medical or dental care, emergency care, or surgery.
  • Contact your doctor if you develop an illness that includes vomiting or if you vomit soon after you take Clorpres.
  • Clorpres may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Clorpres.
  • Lab tests, including blood pressure and blood electrolyte levels, may be performed while you use Clorpres. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Clorpres with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness.
  • Clorpres should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clorpres while you are pregnant. Clorpres is found in breast milk. Do not breast-feed while using Clorpres.

If you stop taking Clorpres suddenly, you may have WITHDRAWAL symptoms. These may include nervousness, agitation, headache, tremor, and rapid increase in blood pressure. Do not suddenly stop taking Clorpres without checking with your doctor.

Possible side effects of Clorpres:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; headache; nausea; tiredness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning, numbness, or tingling; chest pain; confusion; dark urine; decreased sexual desire or ability; decreased urination or difficulty urinating; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; increased thirst; joint pain (gout); mental or mood changes (eg, anxiety, agitation, depression, nervousness); muscle pain, weakness, or cramping; rapid breathing; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent headache, dizziness, drowsiness, or light-headedness; severe or persistent dry mouth or nausea; shortness of breath; sluggishness; stomach pain; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; unusual bruising or bleeding; unusual tiredness or weakness; vision changes (eg, blurred vision); vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; decreased body temperature (feeling very cold); decreased reflexes; difficult or slow breathing; fainting; irritability; pinpoint pupils; seizures; severe or persistent dizziness, light-headedness, drowsiness, or headache; slow or irregular heartbeat; symptoms of blood electrolyte problems (eg, confusion; mental or mood changes; muscle cramps, pain, or weakness; sluggishness); symptoms of dehydration (eg, dry eyes, fast heartbeat, nausea, restlessness, unusual thirst or tiredness, vomiting); weakness.

Proper storage of Clorpres:

Store Clorpres at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clorpres out of the reach of children and away from pets.

General information:

  • If you have any questions about Clorpres, please talk with your doctor, pharmacist, or other health care provider.
  • Clorpres is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Clorpres or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Clorpres. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Clorpres. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Clorpres.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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