Anagrelide

Generic Name: anagrelide (an-AG-re-lide)
Brand Name: Agrylin

Anagrelide is used for:

Treating patients with high blood platelet levels (thrombocythemia) due to bone marrow problems. It may also be used for other conditions as determined by your doctor.

Anagrelide is a platelet-reducing agent. It works by decreasing the body's production of platelets, which helps to prevent blood clots.

Do NOT use anagrelide if:

  • you are allergic to any ingredient in anagrelide
  • you have severe liver problems or low blood potassium levels
  • you have a history of a certain type of irregular heartbeat (prolonged QT interval) or you are taking any medicines that can cause this type of irregular heartbeat. There are many medicines that can do this. Ask your doctor or pharmacist if you are not sure

Contact your doctor or health care provider right away if any of these apply to you.

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Before using anagrelide:

Some medical conditions may interact with anagrelide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, congestive heart failure; fast, slow, or irregular heartbeat, heart attack) or lung, liver, or kidney problems

Some MEDICINES MAY INTERACT with anagrelide. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fluvoxamine because it may increase the risk of anagrelide's side effects
  • Sucralfate because it may decrease anagrelide's effectiveness
  • Amrinone, aspirin, cilostazol, enoximone, milrinone, olprinone, or theophylline because their actions and the risk of their side effects may be increased by anagrelide

This may not be a complete list of all interactions that may occur. Ask your health care provider if anagrelide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use anagrelide:

Use anagrelide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take anagrelide by mouth with or without food.
  • Take anagrelide on a regular schedule to get the most benefit from it. It may take several weeks (4 to 12 weeks) before you get the full effect from anagrelide.
  • If you miss a dose of anagrelide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use anagrelide.

Important safety information:

  • Anagrelide may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use anagrelide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Anagrelide may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Anagrelide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to anagrelide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Anagrelide may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Severe lung problems (eg, interstitial pneumonitis) have been reported in some patients who take anagrelide. This may develop within 1 week to several years after starting the medicine. Tell your doctor right away if you develop new or worsening shortness of breath or trouble breathing. Talk with your doctor for more information.
  • Tell your doctor or dentist that you are using anagrelide before you have any medical or dental care, emergency care, or surgery.
  • You may need to have an ECG checked while taking this drug. Discuss any questions or concerns with your doctor.
  • Lab tests, including liver function, kidney function, blood pressure, and complete blood cell counts, may be performed while you use anagrelide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • If you may become pregnant, you must use an effective form of birth control while you take anagrelide. If you have questions about effective birth control, talk with your doctor.
  • PREGNANCY and BREAST-FEEDING: Anagrelide may cause harm to the fetus. Avoid becoming pregnant while taking anagrelide. If you think you may be pregnant, contact your doctor right away. It is not known if anagrelide is found in breast milk. Do not breast-feed while taking anagrelide.

Possible side effects of anagrelide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; cough; diarrhea; dizziness; gas; general body discomfort; headache; loss of appetite; nausea; stomach pain; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; bloody or dark urine; change in the amount of urine produced; changes in vision; chest pain; confusion; decreased urination; fainting; fast or irregular heartbeat; flu-like symptoms (eg, sore throat, fever, or chills); flushing; memory problems; mental or mood changes (eg, depression); one-sided weakness; pale stools; pounding in the chest; seizures; severe or persistent headache, vomiting, or dizziness; severe stomach pain; shortness of breath; slurred speech; swelling of the hands, legs, or feet; trouble urinating; unusual bruising or bleeding; unusual sweating; unusual tiredness; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of anagrelide:

Store anagrelide at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep anagrelide out of the reach of children and away from pets.

General information:

  • If you have any questions about anagrelide, please talk with your doctor, pharmacist, or other health care provider.
  • Anagrelide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take anagrelide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about anagrelide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to anagrelide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using anagrelide.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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