Alphanate

Generic Name: antihemophilic factor (human) (AN-tye-HEE-moe-FIL-ik FAK-tor)
Brand Name: Examples include Alphanate and Hemofil M

Alphanate is used for:

Preventing and controlling bleeding in patients with factor VII deficiency, also known as hemophilia A, including in surgical settings.

Alphanate is a human clotting factor derived from pooled human plasma. It works by increasing the amount of clotting factor VII in the blood, helping the blood form clots and stop bleeding.

Do NOT use Alphanate if:

  • you are allergic to any ingredient in Alphanate or to mouse proteins

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Alphanate:

Some medical conditions may interact with Alphanate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances, including rubber or latex
  • if you have von Willebrand disease

Some MEDICINES MAY INTERACT with Alphanate. However, no specific interactions with Alphanate are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Alphanate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Alphanate:

Use Alphanate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Do not shake Alphanate.
  • Alphanate is given as an injection at your doctor's office, hospital, or clinic.
  • Do not use Alphanate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Alphanate, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Alphanate.

Important safety information:

  • Alphanate may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Alphanate. Using Alphanate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Patients receiving clotting factors sometimes develop antibodies or inhibitors to the medicine. This makes Alphanate less effective. If Alphanate stops working or does not work as well as it has before, contact your doctor immediately for instructions.
  • Alphanate contains albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used Alphanate.
  • Contact your doctor if you develop a fever, drowsiness, chills, or a runny nose followed by a rash and joint pain 2 weeks later.
  • Contact your doctor if you develop several days to weeks of poor appetite, tiredness, or low-grade fever followed by nausea, vomiting, and pain in the stomach; dark urine; or a yellowed complexion.
  • LAB TESTS, including factor VIII levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: It is not known if Alphanate can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Alphanate while you are pregnant. It is not known if Alphanate is found in breast milk. If you are or will be breast-feeding while you use Alphanate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Alphanate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in taste; dizziness; headache; irritation or swelling at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; flushing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing); chest pain; fainting; nausea; severe or persistent dizziness or light-headedness; shortness of breath.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Alphanate:

Alphanate is handled and stored by a health care provider. Keep Alphanate out of the reach of children and away from pets.

General information:

  • If you have any questions about Alphanate, please talk with your doctor, pharmacist, or other health care provider.
  • Alphanate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Alphanate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Alphanate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Alphanate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Alphanate.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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