Generic Name: antihemophilic factor (recombinant) (plasma/albumin free) (AN-tye-HEE-moe-FIL-ik)
Brand Name: Advate
Advate is used for:
Preventing and controlling bleeding in patients with hemophilia A (factor VIII deficiency), including in surgical settings.
Advate is a manmade clotting factor. It works by increasing the amount of clotting factor VIII in the body, which helps the blood clot normally.
Do NOT use Advate if:
- you are allergic to any ingredient in Advate, including mouse or hamster proteins
Contact your doctor or health care provider right away if any of these apply to you.
Before using Advate:
Some medical conditions may interact with Advate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have von Willebrand disease
- if you have been told that you have inhibitors to factor VIII
Some MEDICINES MAY INTERACT with Advate. However, no specific interactions with Advate are known at this time.
Ask your health care provider if Advate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Advate:
Use Advate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An additional patient leaflet is available with Advate. Talk to your pharmacist if you have questions about this information.
- Advate is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Advate at home, carefully follow the injection procedures taught to you by your health care provider.
- Your doctor or other health care provider will give you detailed instructions on how to mix and administer Advate if you will be using it at home. Instructions are also included in the patient leaflet that is available with Advate. Be sure you understand how to give Advate before you administer a dose. If you have any questions or concerns, contact your doctor or other health care provider.
- If Advate contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- When drawing a dose into a syringe, be sure to follow the procedure demonstrated to you by your doctor to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers.
- Carefully check that you have drawn the correct dose before administration.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of Advate, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Advate.
Important safety information:
- Tell your doctor right away if bleeding is not controlled after using Advate.
- Advate may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Advate with caution. Do not drive or perform any other possibly unsafe tasks until you know how you react to it.
- Patients receiving clotting factors sometimes develop antibodies or inhibitors to the medicine. This makes it less effective. If Advate stops working or does not work as well as it has before, contact your doctor immediately for instructions.
- Tell your doctor or dentist that you take Advate before you receive any medical or dental care, emergency care, or surgery.
- Talk with your doctor before you travel while you are using Advate. Be sure to take along enough of Advate for your treatment while you are traveling
- Lab tests, including factor VIII levels, may be performed while you take Advate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- PREGNANCY and BREAST-FEEDING: It is not known if Advate can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Advate while you are pregnant. It is not known if Advate is found in breast milk. If you are or will be breast-feeding while you are using Advate, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Advate:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Cough; diarrhea; headache; joint pain; sore throat; stuffy or runny nose; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning numbness, or tingling; chest pain; dizziness; fainting; fever or chills; hot flashes; light-headedness; nausea; pain, swelling, or redness at the injection site; severe headache; shortness of breath; swelling of the legs; unusual bruising.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Advate:
Store Advate in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. You may also store Advate at room temperature, below 86 degrees F (30 degrees C), for up to 6 months. Once Advate has been kept at room temperature, do not return it to the refrigerator. Do not use Advate if the expiration date on the product has passed. Once Advate has been mixed, it must be used within 3 hours. Do not refrigerate after mixing. Discard any medicine remaining in the vial after you use it. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Advate out of the reach of children and away from pets.
- If you have any questions about Advate, please talk with your doctor, pharmacist, or other health care provider.
- Advate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Advate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Advate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Advate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Advate.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More Advate resources
- Advate Consumer Overview
- Advate Prescribing Information (FDA)
- Advate Advanced Consumer (Micromedex) - Includes Dosage Information
- Antihemophilic Factor Professional Patient Advice (Wolters Kluwer)
- Antihemophilic Factor (Human) Monograph (AHFS DI)
- Antihemophilic Factor (Recombinant) Monograph (AHFS DI)
- Helixate FS Prescribing Information (FDA)
- Kogenate Consumer Overview
- Kogenate FS Prescribing Information (FDA)
- Monoclate-P Prescribing Information (FDA)
- Recombinate Prescribing Information (FDA)
- Xyntha Prescribing Information (FDA)
- Xyntha Consumer Overview