Generic Name: antihemophilic factor (recombinant) (AN-tye-HEE-moe-FIL-ik FAK-tor)
Brand Name: Advate
Advate is used for:
Preventing and controlling bleeding in patients with hemophilia A (factor VIII deficiency), including in surgical settings. It may also be used for certain other bleeding conditions.
Advate is a manmade clotting factor. It works by increasing the amount of clotting factor VIII in the body, which helps the blood clot normally.
Do NOT use Advate if:
- you are allergic to any ingredient in Advate or to mice or hamsters
Contact your doctor or health care provider right away if any of these apply to you.
Before using Advate:
Some medical conditions may interact with Advate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have been told that you have inhibitors to factor VIII
Some MEDICINES MAY INTERACT with Advate. However, no specific interactions with Advate are known at this time.
Ask your health care provider if Advate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Advate:
Use Advate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Advate. Talk to your pharmacist if you have questions about this information.
- Advate is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Advate at home, a health care provider will teach you how to use it. Be sure you understand how to use Advate. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Wash your hands before and after use.
- If Advate was stored in the refrigerator, let it reach room temperature before mixing. Do not heat it.
- Mix by gently swirling. Do not shake.
- After mixing, Advate must be used within 3 hours. Throw away any unused portion.
- This product should be clear and colorless after mixing. Do not use Advate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- When drawing a dose into a syringe, be sure to follow the procedure demonstrated to you by your doctor to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers.
- Carefully check that you have drawn the correct dose before administration.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of Advate, call your doctor to find out what to do.
Ask your health care provider any questions you may have about how to use Advate.
Important safety information:
- Patients receiving clotting factors sometimes develop antibodies or inhibitors to the medicine. This makes it less effective. If Advate stops working or does not work as well as it has before, contact your doctor immediately for instructions.
- Tell your doctor or dentist that you take Advate before you receive any medical or dental care, emergency care, or surgery.
- Talk with your doctor before you travel while you are using Advate. Be sure to take along enough of Advate for your treatment while you are traveling
- Lab tests may be performed while you take Advate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- PREGNANCY and BREAST-FEEDING: It is not known if Advate can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Advate while you are pregnant. It is not known if Advate is found in breast milk. If you are or will be breast-feeding while you are using Advate, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Advate:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Cough; diarrhea; headache; joint pain; nose or throat irritation; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning, numbness, or tingling; dizziness or light-headedness; fainting; flushing; nausea; shortness of breath.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Advate:
Store Advate in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. You may also store Advate at room temperature, below 86 degrees F (30 degrees C), for up to 6 months. If stored at room temperature, make note of the date the product was placed at room temperature. Do not use Advate if the expiration date on the product has passed. Do not place it back in the refrigerator after storage at room temperature or after mixing it. Discard any medicine remaining in the vial after you use it. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Advate out of the reach of children and away from pets.
- If you have any questions about Advate, please talk with your doctor, pharmacist, or other health care provider.
- Advate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Advate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Advate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Advate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Advate.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.