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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Claritin-D, Allegra-D 24 Hour, Zyrtec-D, Actifed, Mucinex D, Sudafed 12-Hour, Vicks Dayquil Daytime Cold/Flu, Allegra-D 12 Hour, Vanacof, Show all 1032 »Advil Cold and Sinus, SudoGest, Resperal-DM, Conex, Entex, Zyrtec-D 12 Hour, Drixoral, Dimetapp Elixir, Tylenol Cold, Loratadine-D 24 Hour, Aprodine, Sudafed 24-Hour, Cheratussin DAC, Sinarest, Duomine, Semprex-D, Sinutab Ex-Strength, Theraflu Flu, Cold and Cough Powder, Claritin-D 24 Hour, Allergy & Congestion Relief, Claritin-D 12 Hour, Suphedrine, Rescon, Alka-Seltzer Cold and Sinus, Decofed, Robitussin Cold Cough and Flu, Sudafed Congestion, Allegra-D 24 Hour Allergy & Congestion, Stahist, Advil Allergy Sinus, Clorfed, Virtussin DAC, Bromatane DX, Sudafed Children's Nasal Decongestant, Actifed Cold and Sinus, SudoGest Sinus & Allergy, Aleve-D Sinus & Cold, Contac Cold, Sinus Relief, Polyhist NC, Allergy Relief D, Capmist DM, Cold Medicine Plus, Lodrane D, Codimal, Zutripro, Despec DM, Pseudovent, Maldec, NasOpen, Decongestant Cold Formula, AllerClear D-24 Hour, M-End DMX, Klerist-D, Allegra-D 12 Hour Allergy & Congestion, Deconamine SR, Stahist AD, Deconamine, Dimetane DX, Dristan Sinus, Aleve-D Sinus & Headache, Hycofenix, Detuss, Sudafed 12 Hour Pressure+Pain, Afrinol, Q-Tapp DM, Brotapp-DM, Ursinus, Silfedrine, Suphedrin, Coldcough Syrup, Children's Dimetapp Decongestant Infant, Mytussin DAC, Abatuss DMX, Allerfrin, Lodrane 24D, Bromfenex, Disophrol, Maxifed, LoHist-12D, Orlenta, Complete Sinus Relief, Clarinex-D 24 Hour, Contact Cold and Sore Throat, Daytime Cold, Clarinex-D 12 Hour, Brofed, Pseudo GG, Phenylhistine DH, Congestac, Entex PSE, Entex T, Deltuss DMX, Profen Forte, Sinufed, Wal-Zyr D, Allerest Maximum Strength, Brexin LA, Novafed A, Tusnel Pediatric, Maxifed DM, Corzall, Tusnel, Alavert D-12 Hour Allergy and Sinus, Ambenyl-D, Pseudogest-DM, Coldamine, Hytussin, Histussin D, Mintex HC, Lortuss LQ, Hyphed, Benadryl Children's Allergy And Sinus, Atuss HD, Cordron-HC, M-END, Tekral, Dihydro-CP, Pancof, Benaphen Plus, VisRx Dose Pack, LoHist-D, Suclor, Xiral SR, Q-Tapp, Lodrane, Lodrane Liquid, Bromaline, Mintex, Allerx-D, Kidcare Cough and Cold, Kidkare Cough/Cold, Ornex, Defen-LA, Tripohist D, Drixoral Cold and Allergy, Esocor P, Nexafed, Unifed, Tylenol Cold Severe Congestion Daytime, Tussar SF, Dexaphen SA, Atrogen, Mucus Relief D, Theraflu (pseudoephedrine) Daytime Severe Cold, Allerphed, Alka-Seltzer Plus Flu/Body, Aphedrid, Actedril, Triafed, Biotuss PE, Maxifed-G, Touro LA-LD, Benadryl Severe Allergy & Sinus Headache, Dynex, Myfedrine, Duraflu, Bromdex D, Cycofed, Notuss-NXD, Vanacof DX, Dimetapp DM, Disobrom, Allerest Sinus, M-End WC, Singlet, Zephrex, Drixoral Cold/Flu, Versacaps, Comtrex Day and Night, Biclora-D, Robitussin Allergy & Cough, All-Nite Multi-Symptom Cold/Flu Relief, Medent-LDI, SuTan, Maxifed DMX, Z-Cof 12DM, Liquicough DM, Pedia Relief Infant, Benylin DM-D, Trikof-D, Dynex HD, Dexatrex D, P-Tuss DM, SudaTex-DM, Viravan-PDM, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Balminil DM + Decongestant, Tussin Pediatric Cold and Cough, Vicks 44D, Pseudo Max DMX, Pseudo DM GG, Pancof EXP, KG-Tuss HD, Vanex Expectorant, Tussadur-HD, Decotuss-HD, Entuss-D JR, Spantuss HD, Medtuss HD, Tussend Expectorant, Detussin Expectorant, Deconamine CX, Nalex Expectorant, Ambi 40 /400 /20, Poly-Tussin XP, Entuss-D, Tussgen Expectorant, Hydrotussin HD, Allpanto-S, Co-Apap, Welltuss EXP, Hydro-Tuss XP, Benylin Multi-Symptom, SRC Expectorant, Hydro-Tussin EXP, DiHydro-GP, Uni-Cof Expectorant, Actifed Allergy Day/Night, Drituss HD, Benadryl Allergy Sinus, Respa SA, Vanacon, Su-Tuss HD Elixir, Tavist NightTime Allergy, Hytussin Expectorant, Tussafin Liquid, Pediatex TDM, Syn-Rx DM, Tanafed DMX, TanaCof DM, Polaramine Expectorant, D-Hist D, DuraHist D, Tannate PD-DM, SuTan-DM, DuraTan Forte, C-Phed DPD Tann, Bromatan Plus, Dur-Tann Forte, TanDur DM, Histatab D, Duotan PD, Entex Pac, Z-Cof 8DM, Entre-Cough, Poly-Vent DM, Medent-DMI, Lortuss DM, Nalfrx, Tanafed DP, AllerDur, Deltuss DP, Hexafed, Tannate DMP-DEX, Dixaphedrine, KG-Fed, Notuss-DC, Nucodine, Neo AC, Triacin C, EndaCof-DC, Nucofed, Suttar-2, Codafed, Codafed Pediatric, Zodryl DEC, Codar D, Allerfrin with Codeine, Triafed & Codeine, Dexophed, Desihist SA, 12 Hour Cold, Drixomed, Pharmadrine, Drexophed SR, Alka-Seltzer Plus-D, Trifed C, Pseudodine C, Deka, Triaminic Flu, Cough & Fever, Mardrops-DX, PanMist DM, Profen II DM, Profen Forte DM, ExeFen-DMX, Profen II DM Liquid, ExeClear-DM, Robitussin Cough & Cold D, Touro CC, Tussin Cough and Cold, Multi Symptom Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, S-Pak DM, Ru-Tuss DM, Relacon-DM NR, Touro CC-LD, Despec Drops, Pseudo Cough, Relasin DM, Ambifed-G DM, Z-Cof DM(obs), Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Daytime Liquicap, Medent DM, Ambi 60/580/30, Calmylin 4, Ambifed DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Ambi 80/780/40, Benylin DM-D-E, Sudafed Cough Syrup, Sudafed Cough, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Z-COF 12, Donatussin DM Syrup, Guaifenex DM RX, Entex HC, Suda-Tussin DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Dorcol Childrens Cough, Rhinosyn-X, Anatuss DM, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Z-Cof DM, Guaibid D Pediatric, Motrin Childrens Cold, Motrin Cold and Flu, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Advil Children's Cold, Sine-Aid IB, Motrin IB Sinus, Liquituss HD, SymTan, Detussin, Zymine HC, Contac Cold and Flu Maximum Strength, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Respivent-D, Extendryl PSE, Sinus & Cold D, Quadra-Hist D Pediatric, Quadra-Hist D, Amdry-D, AlleRx Dose Pack (AM Dose), Allergy Relief D12, Clear-Atadine-D, Leader Allergy Relief D-24, Allergy Relief D 24 Hour, Sudatrate, Pancof HC, ColdCough HCM, Pseudo GG TR, Nomuc-PE, Ru-Tuss Jr., ExeFen, Ambi 60/1000, Poly-Vent, Jr., Poly-Vent, Pseudatex, Medent, Aldex GS, Despec-SR, Guaifenex PSE 85, Ambi 60/580, Ambi 80/780, Iotussin D Liquid, P-V-Tussin, Histinex D, Entuss-D Liquid, H-C Tussive D, Tussgen, Tussafin, Aquatab D Dose Pack, Mucinex D Maximum Strength, Protuss-D, Procof D, Rezira, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Hista-Tabs, Atrofed, LA Nasal Decongestant, Ridifed, Tri-Sudo, Atridine, A-Phedrin, Allercon, Pediatex TD, Genac, Triposed, Triofed, Triphed, Vi-Sudo, Trisofed, Actacin, Pseudocot-T, Zymine DXR, Trip-PSE, Ritifed, Triacin, Actagen, Triptifed, Altafed, Biofed-PE, Histafed, Zymine-D, Allerfrim, Ridafed, Genaphed, Seudotabs, Sudrine, Superfed, Cenafed, Novafed, nasofed, Cough Formula M Multi-Symptom, Drixoral Non-Drowsy, ElixSure Congestion, Allermed, Chlor-Trimeton Nasal Decongestant, Decofed Liquid, Seldane-D, Viravan-P, Dristan Cold Maximum Strength, Hist-PSE, Ed A-Hist PSE, SudoGest 12 Hour, Drixoral Decongestant Non-Drowsy, Efidac, Kid Kare Drops, Sudodrin, Elixsure Decongestant, Guaifenex PSE 80, Levall G, Guiadrine II, Demibid II, Iosal II, Respa-1st, Guiatex II, Guaifenex PSE 60, D-Feda II, Stamoist E, Tuss-LA, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, Ambifed, Guiadrine II SR, Guai-Vent/PSE, Guiadrine PSE 120, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Abletex-PSE, Guaifed-PSE, Desal II, Decongest II, Deco-D, Tenar PSE, GP 500, Sudal 60/500, Eudal SR, Anatuss LA, Guaimax-D, Touro LA, Fenex-PSE, Nalex, Despec-Tab, Poly-Vent IR, Nalex CR, Theraflu Flu & Cough, Mardrops-EX, Zephrex LA, Pan-Mist LA, Syn-Rx, Respaire-60 SR, Guaivent PD, Sinufed Timecelles, Suttar SF, Pseudocot-G, Nasatab LA, G-Phed- PD, Nalex Jr, G-Phed, Nasabid, Respaire-120 SR, Guaibid D, Guaifed, Guai Sudo, Guaipax PSE, ExeFen-IR, Guaifenex GP, Profen II, Durasal II, Miraphen PSE, Pseudovent Ped, H 9600 SR, Med-RX, Humibid GC, Nasabid SR, Panmist LA, Panmist JR, Guiadrine PSE, Guiatex II SR, Sudal SR, Coldmist Jr, Pseudo Max, Pseudovent 400, Ambifed-G, Coldmist LA, Panmist-S, SudaTex-G, We Mist LA, Coldmist, Drituss GP, We Mist II LA, Uni Tussin PE, Robitussin Severe Congestion, Mastussin PE, Guiatuss PE, Mytussin PE, Q-Tussin PE, Robichem PE, Guaitab, Guaifenex RX, Ami-Tex PSE, Iotex PSE, Pseudo-G/PSI, Zaptec PSE, Ru-Tuss DE, T-Tussin PE, Tusscidin PE, Altarussin PE, Tusnel Pediatric Drops, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Respaire-30, Guaivent (Ethex), Tussin PE, Venbid TR, Degen II, Robafen PE, Pseudatex HC, Maxifed CD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Iofed PD, Respahist, Shellcap, Touro A&H, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Endafed, Ultrabrom PD, Pseubrom-PD, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Sildec, Bromhist Pediatric Drops, Nalfed, Pseubrom, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Iofed, BroveX PSE, Rynex PSE, P-Hist DM Drops, ProHist DM, Carbodex DM Syrup, Sildec DM, Drocon-CS, J-Cof DHC, Brom Tann, Histacol BD Drops, Pediahist DM Drops, Bromhist-DM Drops, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Anaplex HD, Bromplex HD, Bromfed PD, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, J-Tan D HC, SymTan A, Visvex, Bromph HD, Bromcomp HC, Endacof HC, Brovex HC, AccuHist Pediatric, Unit-Tex 10/120 ER, PSE Carb DM Drops, PSE Carbinoxamine DM, Carboxine DM, Carboxine 12 DM, PSE Allergy DM, Carb PSE 12 DM, Mintex DM, Pseudo Carb DM, Carbofed DM Drops, Carbaxef-DM, Decahist-DM, Pediatex-DM, Cordron-DM NR, Cordron-12 DM, Pediatex 12 DM, Coldec, Coldec D, Carbodec, Pediatex 12D, Carboxine 12D, Biohist LA, Pannaz, Histex HC, Tri-Vent HC, Pannaz S, Pseudox M, Nacon, Cydec-DM Drops, Dura-Ron DM, Exall-D, J-TanD PD, Re-Tann, Respi-Tann Pd, Respi-Tann, Carb Pseudo-Tan, LoHist-PD, Dimaphen, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brotapp, Brovex SR, Allres Pd, Allres D, Biodec DM, Tussafed, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dynatuss, Cordron-DM, Zotex-D, Pseudacarb, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Day Time Multi Symptom, Contac Severe Cold and Flu Non Drowsy, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Comtrex Non-Drowsy, Theraflu Flu Cold & Cough, Flutabs, Theraflu Max-D Severe Cold & Flu, Maxiflu DM, Tusnel-A, Comtrex Sinus and Nasal, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Sudafed Triple Action, Tylenol Sinus Severe Congestion Daytime, Sinus Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus NightTime, Contac Day and Night Allergy, Benadryl Cold, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Balminil Cough and Flu Sugar Free, Phlemgesic, Sinarest Extra Strength, Allerest Headache Strength, Triaminicin, Sinutab Maximum Strength Caplets, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Tricom, Simplet, Comtrex Allergy Sinus, Kolephrin, Tylenol Allergy Sinus, Tavist Allergy/Sinus/Headache, Maxiflu CD, All-Nite Cold, Vicks Nyquil D Cold and Flu Nighttime Relief, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, NyCair, Contac Day and Night Cold and Flu, Hexaflu, Sinadrin Plus, Maxiflu CDX, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Anaplex DMX, BroveX PSB DM, BromTann/DM Tann/PSE Tann, Neo DM Syrup, Myphetane DX, Dallergy DM, PBM Allergy, BroveX PSE DM, EndaCof PD Drops, Histacol DM Pediatric Syrup, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, Bromanate DX Cough, Myphetane DX Cough, Bromaxefed DM RF Syrup, Bromtapp-DM, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Andehist DM NR Syrup, Bromphenex DM, Liquiphed DM, Bromophed-DX, Brometane DX, Bromadine-DM, Anaplex DM, Pediahist DM Syrup, Bromhist-DM, Sinutab Regular Strength, Sine-Off Maximum Strength, Tylenol Sinus Maximum Strength, Genapap Sinus, Phenapap, Suphedrin Plus, Contac Sinus, Dristan Cold Non-Drowsy, Tavist Sinus, Benadryl Allergy Sinus Headache, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Pseudoephedrine Sinus, Sinarest Sinus, Rydex, Mar-cof BP, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, SymPak II, Dicel CD, Ru-Tuss, Sinutab Maximum Strength, Respa-AR, Sta-D, Trinalin Repetabs, Carbiset, Cydec, Neutrahist Drops, Sudogest Plus, Ryna Liquid, Sudogest Cold & Allergy, Hayfebrol Liquid, Genaphed Plus, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Clorfed II, Fedahist Gyrocaps, Curaler, Chlorafed, Histafed LA, Suphedrine Plus, Atrohist Pediatric Capsule, C-Phed Tannate, Pediox Chewable, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12, Re2+30, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Dynahist-ER Pediatric, CP-Tannic, Histade, Codimal-LA Half, Anamine, Chlorphedrin SR, Fedahist Timecaps, Colfed-A, D-Amine-SR, Pseudocot-C, Deconomed SR, Dura-Tap/PD, Kronofed-A-Jr, Fedahist, Histalet, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Duralex, Rinade-BID, Rescon-Ed, Chlorafed Timecelles, Pseudochlor, Cophene No 2, Anaplex, Time-Hist, Anamine TD, Isophen-DF, Suphenamine-SR, Kronofed-A, ND Clear, Chlordrine SR, Sudal-12 Tannate, SudaHist, Cycofed Expectorant, Nucodine Pediatric, KG-Fed Expectorant, Nucodine Expectorant, Guaiatussin DAC, Deconsal C Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Phenhist Expectorant, Dihistine Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Guiatuss DAC, Guiatussin DAC, Dihistine, Guaifen DAC, Gua PC, Codahistine Expectorant, Guaifenesin DAC Liquid, Nucochem, Nuco-Tuss Expectorant, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Nucofed Pediatric Expectorant, Biotussin DAC, Phenylhistine Expectorant, Dihistine Expectorant with Codeine, Decohistine Expectorant, Tusnel C, Lortuss EX, Z-Tuss E, Tricode GF, Ambifed CDX, Ambifed CD, Comtrex Acute Head Cold, M-End Max D, Triaminic Softchews Cold and Allergy, AccuHist Drops (old formulation), Pseudoephedrine Plus, Qdall, Dynahist ER, Ambifed-G CD, Ambifed-G CDX, Nucofed Expectorant, Novahistine Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Medent C, Ryna-CX, Maxifed CDX, Comtrex Nighttime Flu Therapy, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Duratuss DA, Biohist LA (old formulation), Decohistine DH, Zodryl DAC, Codehist DH, Phenylhistine DH Expectorant, Co-Histine DH, Novadyne DH, Tricode AR, Dihistine DH, Certuss-D, Vanatab DX, Clofera, Poly-Tussin D, Statuss Green, Ryna-C, Codahistine-DH Elixir, C-Phed DM, Tanafed-DM, M-End DM, Atuss-12 DM, Dicel DM, Rescon-DM, Children's Nyquil, Rhinosyn-DM, Neotuss D, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Panatuss PED, Chlo Tuss (Reformulated), Dura-Ron, Carbic-D, Ex-Dec-TR, Coldec-TR, Hydro-Tussin CBX, Andehist, Andec-TR, Palgic-D, Andec, Palgic-DC, Mooredec, Rondamine, Cardec-S, Carboxine-PSE, Cordron-D, KS Aller-Tec D-12, Palgic DS, Up and Up All Day Allergy Relief D, All Day Allergy-D, Cetiri D, Mintex PSE, PSE Allergy, Cordron-D NR, Pediatex-D, Cordron-12 D, Pseudo Carb, Carboxine-D, Atuss DS, Entre-S, RelCof DN PSE, DuraHist, Dallergy PSE, Relcof PSE, Hista-Vent PSE, Mescolor, DryMax, AlleRx Dose Pack, Hydrocof-HC, Hydron PCS, Cordron-HC NR, Atuss HS, Advil Children's Allergy Sinus, PCM-LA, Amdry-C, Histade CR, Histatab, Chlor-Trimeton Decongestant, Duotan, Durafed, Allergy AM-PM Dose Pack, ScopoHist, AllePak, Time-Hist QD, Rhinaclear, Allergy DN, Pseudo CM TR, Hydrotuss HC, P-V-Tussin Syrup, T-Tanna DM, Duotan DM, Tricof, Hydro-Tussin DHC, Uni-Cof, Allres DS, Triaminic-D Multi-Symptom Cold, Neutrahist PDX Drops, Maxichlor PSE DM, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Z-Tuss 2, Lemohist Plus, Tussin-V, Hexatussin, Q-V Tussin, A-G Tussin, KG-Tussin, Welltuss HC, Tussend, Notuss, Notuss-Forte, Histinex PV, JayCof-HC, Pediatex HC, Novagest with Codeine

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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