Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, NyQuil, Sudafed Nasal Decongestant, Claritin-D, Mucinex D, Actifed, Allegra-D 24 Hour, Zyrtec-D, Resperal-DM, Sudafed 12-Hour, Show all 1024 »SudoGest, Vicks Dayquil Daytime Cold/Flu, Conex, Advil Cold and Sinus, Zutripro, Dimetapp Elixir, Allegra-D 12 Hour, Entex, Vanacof, Claritin-D 24 Hour, Semprex-D, Cheratussin DAC, Robitussin Cold Cough and Flu, Aprodine, Tusnel, Tylenol Cold, Drixoral, Nyquil Cold Medicine, Zephrex, AllerClear D-24 Hour, Loratadine-D 24 Hour, Lodrane, Rescon, Alka-Seltzer Cold and Sinus, Benadryl Children's Allergy And Sinus, Alavert D-12 Hour Allergy and Sinus, Lodrane D, Dimetane DX, Sudafed 24-Hour, Kolephrin, Zyrtec-D 12 Hour, Anamine, Sinus Relief, Brotapp, Stahist, Chlor-Trimeton Allergy Decongestant, Nucodine, Aleve-D Sinus & Cold, Contac Cold and Flu Maximum Strength, Theraflu Flu, Cold and Cough Powder, Stahist AD, Sinarest, Advil Allergy Sinus, Dristan Sinus, Pseudovent, M-End WC, Maldec-DM, Triaminic-D Multi-Symptom Cold, Maldec, Dimetapp DM, Simplet, Duralex, Deltuss DMX, Capmist DM, Deltuss DP, Lodrane 24D, Cold Medicine Plus, Wal-Zyr D, Tylenol Sinus Maximum Strength, Vanatab DX, Atridine, DryMax, Cetiri D, Endacof HC, Bromanate DX Cough, Ru-Tuss, Bromadine-DM, Brotapp-DM, Bromaline, Bromfed PD, Q-Tapp, M-End DMX, Profen II, Nomuc-PE, Benadryl Allergy Sinus, Decongestant Cold Formula, PanMist DM, Dimacol, ExeFen, Rezira, Aphedrid, Atrogen, Sudafed Children's Nasal Decongestant, Suphedrin, Advil Cold and Sinus Liqui-Gels, SuTan, DuraHist D, Time-Hist QD, Isophen-DF, Xiral SR, Esocor P, M-End DM, Atuss DS, Brexin LA, Mintex, Clarinex-D 12 Hour, Dixaphedrine, Neo AC, Guaifenesin DAC Liquid, Ambifed CD, NasOpen, M-End Max D, Tylenol Allergy Sinus, Tylenol Sinus NightTime, Ornex, Sinarest Sinus, Genacol Maximum Strength, Ridafed, Pancof HC, Novahistine DMX, Dicel, Afrinol, Pannaz, Actifed Allergy Day/Night, Donatussin DM Syrup, Sinus Maximum Strength, Allerest No Drowsiness, Ephed Plus, Elixsure Decongestant, Contac Cold, AlleRx Dose Pack, Sudafed Sinus Nighttime Plus Pain, Tussafed, Histex HC, M-END, Bromplex HD, SudoGest 12 Hour, Medent DM, Nexafed, Nacon, SudaTex-DM, Tekral, Tricom, Sinutab Ex-Strength, Alka-Seltzer Plus Flu/Body, Contac Severe Cold and Flu Non Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Sinutab Maximum Strength Caplets, Motrin Sinus Headache, De-Congestine, Atrohist Pediatric Capsule, Deconamine SR, LoHist-D, Qdall, Drituss HD, J-TanD PD, Respi-Tann, Dimaphen, Lodrane LD, Shellcap, Tavist Allergy/Sinus/Headache, Allegra-D 12 Hour Allergy & Congestion, Su-Tuss HD Elixir, Biotussin DAC, Tussadur-HD, Decotuss-HD, Entex PSE, Dorcol Childrens Cough, Detuss, JayCof-HC, Hydro-Tussin EXP, Nucofed, Tanafed DMX, Welltuss HC, Zephrex LA, Mucus Relief D, ProHist DM, Robitussin Allergy & Cough, Brometane DX, Abatuss DMX, Tannate DMP-DEX, Disophrol, Dexophed, Actifed Cold and Sinus, Drexophed SR, 12 Hour Cold, Tylenol Cold Severe Congestion Daytime, Pseudodine C, Dexatrex D, Tussin Pediatric Cold and Cough, Coldcough Syrup, Maxifed, Bromdex D, Sudal SR, Maxifed-G, Sinutab Non Drying, Kidcare Cough and Cold, NyQuil Multi-Symptom, Pseudo GG, Viravan-P, Profen Forte, Dynex, Eudal SR, Biotuss PE, Actagen, Triptifed, Histafed, Congestac, Triacin, Rymed, Actedril, Rescon-DM, Allerfrim, Touro LA, Maxiflu CDX, Balminil DM + Decongestant, Welltuss EXP, Vicks 44D, Benylin DM-D, Actifed Cold & Sinus, Tavist NightTime Allergy, Respa SA, Benylin Multi-Symptom, Uni-Cof Expectorant, Pancof EXP, Benaphen Plus, Lortuss LQ, Viravan-PDM, Maxiflu CD, Allegra-D 24 Hour Allergy & Congestion, DiHydro-GP, Pedia Relief Infant, Entex HC, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Nalex CR, Allerest Headache Strength, Sinarest Extra Strength, Pseudatex HC, Allergy Sinus Maximum Strength, Triaminicin, Mardrops-EX, Poly-Vent IR, Fenex-PSE, Nalex, Syn-Rx, Anatuss LA, Guaimax-D, Medent-LDI, Despec-Tab, Entex T, Drixoral Cough & Congestion Liquid Caps, Dynex HD, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, SRC Expectorant, Tussgen Expectorant, Vanex Expectorant, Tussend Expectorant, Detussin Expectorant, Entuss-D, Hydrotussin HD, Tussafin Liquid, Hytussin Expectorant, Hydro-Tuss XP, Vanacon, Spantuss HD, KG-Tuss HD, Medtuss HD, Entuss-D JR, Aldex GS DM, Z-Cof 8DM, Complete Sinus Relief, Entex Pac, Entre-Cough, Poly-Vent DM, Sinadrin Plus, Drixoral Allergy Sinus, Hexafed, Nalfrx, Lortuss DM, Drixoral Cold and Flu, Medent-DMI, Mardrops-DX, Ambi 80/780/40, Benylin DM-D-E, Calmylin 4, Ambi 60/580/30, Ambifed DM, Ambi 600/1000/30, TL-Dex DM, Maxifed DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, AllerDur, Tanafed DP, All-Nite Cold, Pharmadrine, C-Phed DPD Tann, DuraTan Forte, Bromatan Plus, Drixoral Cold and Allergy, Drixomed, Desihist SA, Duomine, Disobrom, Dexaphen SA, Dur-Tann Forte, TanDur DM, Contac Day and Night Cold and Flu, Hexaflu, Drixoral Sinus, Duotan PD, Histatab D, D-Hist D, SuTan-DM, Tannate PD-DM, TanaCof DM, Polaramine Expectorant, Tenar DM, Novahistine DM Expectorant with Decongestant, Tusnel Pediatric, Ambifed-G DM, Touro CC-LD, Relacon-DM NR, Despec Drops, Z-Cof DM(obs), Altarussin CF, Ru-Tuss DM, Respaire-60 SR, Relacon-DM, Coldmist DM, Despec DM, Pseudo Cough, Pseudo DM GG, Trikof-D, Pseudo Max DMX, P-Tuss DM, Drixoral Cold/Flu, Z-Cof 12DM, Maxifed DMX, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, S-Pak DM, ExeClear-DM, Suda-Tussin DM, Guaifenex DM RX, Pseudogest-DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Syn-Rx DM, Rhinosyn-X, Z-COF 12, Anatuss DM, Ambenyl-D, Ru-Tuss Expectorant, Daytime Liquicap, Multi Symptom Cough and Cold, Profen Forte DM, Profen II DM, ExeFen-DMX, Profen II DM Liquid, Robitussin Cough & Cold D, Touro CC, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Buckley's DM Decongestant, Guaifenex PSE 60, Extendryl PSE, Amdry-D, Respivent-D, Allerx-D, Sinus & Cold D, AlleRx Dose Pack (AM Dose), Sudatrate, Claritin-D 12 Hour, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache, Childrens Tylenol Cold Plus Cough, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Liquid, nasofed, Silfedrine, Allpanto-S, Co-Apap, Quadra-Hist D Pediatric, Quadra-Hist D, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D, Clear-Atadine-D, Comtrex Sinus and Nasal, Entuss-D Liquid, Histinex D, H-C Tussive D, ColdCough HCM, SymTan, Iotussin D Liquid, Hytussin, Allerest Sinus, Procof D, Tussafin, Tussgen, P-V-Tussin, Liquituss HD, Detussin, Motrin Cold and Flu, Sine-Aid IB, Motrin Childrens Cold, Advil Children's Cold, Comtrex Nighttime Flu Therapy, Motrin IB Sinus, Singlet, Histussin D, Zymine HC, Codimal, Comtrex Allergy Sinus, Suphedrine, Drixoral Non-Drowsy, Atrofed, A-Phedrin, Hista-Tabs, LA Nasal Decongestant, Ridifed, Triofed, Allerphed, Allercon, Pediatex TD, Genac, Triafed, Triposed, Tri-Sudo, Triphed, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Vi-Sudo, Allerfrin, Altafed, Biofed-PE, Zymine-D, Ed A-Hist PSE, Superfed, Sudrine, Chlor-Trimeton Nasal Decongestant, Decofed Liquid, Efidac, Seudotabs, Genaphed, Children's Dimetapp Decongestant Infant, ElixSure Congestion, Allermed, Novafed, Cenafed, Decofed, Kid Kare Drops, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Day and Night, Dristan Cold Maximum Strength, Hist-PSE, Seldane-D, Sudafed Congestion, Myfedrine, Sudodrin, Unifed, Drixoral Decongestant Non-Drowsy, Protuss-D, Aquatab D Dose Pack, Guai-Vent/PSE, Guiadrine PSE 120, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Abletex-PSE, Guaifed-PSE, Desal II, Decongest II, Deco-D, Tenar PSE, GP 500, Guai Sudo, Guaipax PSE, Guiatuss PE, Guaitab, Mastussin PE, Mytussin PE, Q-Tussin PE, Guaifenex RX, Ru-Tuss DE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Defen-LA, Guiadrine II SR, Guaivent PD, Versacaps, Guaibid D Pediatric, Pseudocot-G, Nasatab LA, Sinufed Timecelles, G-Phed- PD, Respaire-120 SR, G-Phed, Guaibid D, Guaifed, Nalex Jr, Sudal 60/500, Tuss-LA, Guiadrine II, Demibid II, Iosal II, Guiatex II, Ambifed, Tylenol Severe Cold & Flu Night Time, D-Feda II, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, Robichem PE, T-Tussin PE, Pseudo Max, Coldmist Jr, Pseudovent 400, Ambifed-G, Levall G, Coldmist LA, Panmist-S, SudaTex-G, We Mist LA, Coldmist, Drituss GP, We Mist II LA, Guaifenex PSE 80, Pseudatex, Ru-Tuss Jr., Pseudo GG TR, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Poly-Vent, Jr., Poly-Vent, Touro LA-LD, Aldex GS, Despec-SR, Guaifenex PSE 85, Guiatex II SR, Guiadrine PSE, Tusnel Pediatric Drops, Respaire-30, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Guaivent (Ethex), Robafen PE, Tussin PE, Tusscidin PE, Sinufed, Venbid TR, Degen II, Robitussin Severe Congestion, Uni Tussin PE, Guaifenex GP, Pseudovent Ped, ExeFen-IR, Durasal II, Miraphen PSE, H 9600 SR, Panmist JR, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Nasabid, Suttar-2, PSE Carb DM Drops, PSE Carbinoxamine DM, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, Mintex DM, Pseudo Carb DM, Carbofed DM Drops, Carbaxef-DM, Decahist-DM, Pediatex-DM, Cordron-DM NR, PSE Allergy DM, Cordron-12 DM, Coldec, Coldec D, Carbodec, Pediatex 12D, Carboxine 12D, Biohist LA, Tylenol Sinus Day/Night Convenience Pack, Tri-Vent HC, Pediatex 12 DM, Mintex HC, Pannaz S, Pseudox M, Cydec-DM Drops, Dura-Ron DM, Re-Tann, Exall-D, Respi-Tann Pd, Carb Pseudo-Tan, Corzall, LoHist-12D, LoHist-PD, Unit-Hist Drops, Unit-Tex 10/120 ER, Di-Bromm, Bromhist-NR, Brovex SR, Allres Pd, Allres D, Dynatuss, Cordron-DM, Biodec DM, Rondamine DM, Cydec-DM Syrup, Carbodex DM Drops, Andehist DM NR, Pseudacarb, Zotex-D, Corzall Plus, Tylenol Sinus Severe Congestion Daytime, Carbiset, Cydec, Clofera, Certuss-D, Notuss-NXD, Statuss Green, Daytime Cold, Vanacof DX, Benadryl Cold, Allergy Relief D, All Day Allergy-D, Biclora-D, Chlo Tuss (Reformulated), Contac Day and Night Allergy, Dihistine DH, Tricode AR, Ryna-C, Co-Histine DH, Codahistine-DH Elixir, Severe Cold Multi-Symptom, Daytime Non-Drowsy, Novadyne DH, Phenylhistine DH Expectorant, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Up and Up All Day Allergy Relief D, Tylenol Allergy Complete NightTime, Dura-Ron, Carbic-D, Ex-Dec-TR, Coldec-TR, Andehist, Andec-TR, Palgic-D, Andec, Palgic-DC, Mooredec, Rondamine, Cardec-S, Hydro-Tussin CBX, Carboxine-PSE, Mintex PSE, PSE Allergy, Palgic DS, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Carboxine-D, Pseudo Carb, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, AccuHist Pediatric, Bromhist Pediatric Drops, Myphetane DX, Dallergy DM, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Neo DM Syrup, BromTann/DM Tann/PSE Tann, BroveX PSE DM, BroveX PSE DM Tablets, PBM Allergy, BroveX PSB DM, Anaplex DMX, Liquiphed DM, Anaplex DM, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Carbofed DM Syrup, Bromaline DM, Andehist DM NR Syrup, Bromphenex DM, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, PediaHist DM, AccuHist DM Pediatric Drops, Dicel CD, Trinalin Repetabs, SymPak II, Sinutab Regular Strength, Mar-cof BP, Sta-D, Respa-AR, Phenapap, Sinutab Maximum Strength, Ursinus, Suphedrin Plus, Genapap Sinus, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Tavist Sinus, Benadryl Allergy Sinus Headache, EndaCof PD Drops, Dristan Cold Non-Drowsy, Contac Sinus, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Sine-Off Maximum Strength, Bromph DM, Uni-Hist PDX Drops, Respahist, Nalfed PD, Iofed PD, Ultrabrom PD, Pseubrom-PD, Shellcap PD, Allent, B-Vex PD, BroveX PSB, Bromhist Pediatric, Endafed, Touro A&H, Bromfenex, Bromfenex PD, Touro Allergy, Nalfed, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Lodrane Liquid, Pseubrom, Histex SR, M-Hist TD, Ultrabrom, Iofed, BroveX PD, BroveX PSE, Drocon-CS, Sudogest Sinus Maximum Strength, Anaplex HD, Bromph HD, Visvex, J-Cof DHC, Sildec DM, Histacol BD Drops, Allanhist PDX Drops, Brom Tann, P-Hist DM Drops, Carbodex DM Syrup, Bromcomp HC, Brovex HC, Bromfed SR, Brofed, Bidhist-D, Lodrane 12D, Rynex PSE, LoHist PSB, Sudafed Triple Action, SymTan A, J-Tan D HC, Ornex Maximum Strength, Suphedrin Sinus, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Flutabs, Duraflu, Theraflu Max-D Severe Cold & Flu, Lortuss EX, Tusnel C, Comtrex Acute Head Cold, Dynahist ER, SudaHist, Sudal-12 Tannate, AccuHist Drops (old formulation), Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Z-Tuss E, Tricode GF, Ryna-CX, Robitussin-DAC, Medent C, Novahistine Expectorant, Nucofed Expectorant, Maxifed-G CDX, Maxifed-G CD, Ambifed-G CD, Ambifed CDX, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Sudal-12 Chewable, C-Phed Tannate, Ryna Liquid, Neutrahist Drops, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Sudogest Plus, Aller-Chlor Decongestant, Clorfed II, Fedahist Gyrocaps, Curaler, Chlorafed, Histafed LA, Hayfebrol Liquid, Suphedrine Plus, Suclor, Histade, Re2+30, Sudal-12, Pediox Chewable, CP-Tannic, Dynahist-ER Pediatric, Allerest Maximum Strength, Histex, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Tussar-2, Deproist with Codeine, Zodryl DEC, Codafed Pediatric, Balminil Cough and Flu Sugar Free, Codar D, EndaCof-DC, Pseudoephedrine Sinus, Codafed, Gua PC, Dihistine, Codahistine Expectorant, Novagest with Codeine, Suttar SF, Notuss-DC, KG-Fed, Clarinex-D 24 Hour, Trifed C, Deka, All-Nite Multi-Symptom Cold/Flu Relief, NyCair, Triafed & Codeine, Allerfrin with Codeine, Cycofed, Phlemgesic, Polyhist NC, Triacin C, Guaifen DAC, Nucochem, Nucochem Expectorant, Nucochem Pediatric Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, Novadyne Expectorant, Halotussin DAC, Decohistine Expectorant, Co-Histine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Nucofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Tussar SF, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Cycofed Pediatric Expectorant, Guiatussin DAC, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Codimal-LA Half, Klerist-D, Q-V Tussin, Tussin-V, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hyphed, Hexatussin, Notuss, Notuss-Forte, Histinex PV, Pediatex HC, Tussend, Hydrotuss HC, Hydron PCS, Non-Drowsy Super Strength Contac Complete, Advil Children's Allergy Sinus, Day Time Multi Symptom, Comtrex Non-Drowsy, DuraHist, Contact Cold and Sore Throat, Atuss HS, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Day Relief Cold and Flu, Lemohist Plus, Dicel DM, Atuss-12 DM, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, C-Phed DM, Tanafed-DM, Vicks 44M Pediatric, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Children's Nyquil, Neutrahist PDX Drops, AccuHist PDX Drops, Hydro-Tussin DHC, Tricof, Dihydro-CP, Uni-Cof, Z-Tuss 2, Pancof, T-Tanna DM, CPM-PSE DM Drops, Mesehist DM, Allres DS, Duotan DM, RelCof DN PSE, Dallergy PSE, Chlorphedrin SR, Orlenta, Colfed-A, D-Amine-SR, Deconomed SR, Fedahist Timecaps, Dura-Tap/PD, Tanafed, Fedahist, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Pseudocot-C, Rinade-BID, Rescon-Ed, Chlorafed Timecelles, Pseudochlor, Cophene No 2, Anaplex, Time-Hist, Anamine TD, Suphenamine-SR, Kronofed-A, ND Clear, Chlordrine SR, Histalet, Clorfed, Pseudo CM TR, Allergy DN, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, Rhinaclear, AllePak, Mescolor, Relcof PSE, Hista-Vent PSE, PCM-LA, Amdry-C, VisRx Dose Pack, Histatab, Biohist LA (old formulation), Durafed, Deconamine, Novafed A, Duratuss DA, Duotan, Chlor-Trimeton Decongestant, Theraflu Flu Cold & Cough, Tusnel-A, Maxiflu DM, Histade CR, Multi-Symptom Nighttime

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause occasional irritability. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine.

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[1] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[2] After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose, and half-life in milk was 5.5 hours. A fully breastfed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[3]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[2]

Alternate Drugs to Consider

Oxymetazoline

References

1. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

2. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

3. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20130907

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