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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, NyQuil, Sudafed Nasal Decongestant, Claritin-D, Mucinex D, Actifed, Resperal-DM, Zyrtec-D, Vicks Dayquil Daytime Cold/Flu, Sudafed 12-Hour, Show all 1024 »Allegra-D 24 Hour, SudoGest, Zutripro, Cheratussin DAC, Conex, Aprodine, Allegra-D 12 Hour, Entex, Dimetapp Elixir, Vanacof, Advil Cold and Sinus, Tylenol Cold, Tusnel, Robitussin Cold Cough and Flu, Semprex-D, Claritin-D 24 Hour, Drixoral, Rescon, Loratadine-D 24 Hour, AllerClear D-24 Hour, Sinarest, Zephrex, Theraflu Flu, Cold and Cough Powder, Zyrtec-D 12 Hour, Nyquil Cold Medicine, Lodrane, Sudafed 24-Hour, Lodrane D, Dimetane DX, Benadryl Children's Allergy And Sinus, Kolephrin, Maxifed, Anamine, Alavert D-12 Hour Allergy and Sinus, Aleve-D Sinus & Cold, Clarinex-D 24 Hour, M-End DMX, Alka-Seltzer Plus Flu/Body, Novafed, Tylenol Cold Severe Congestion Daytime, Rynex PSE, Dristan Sinus, Rescon-DM, Contac Cold and Flu Maximum Strength, Tusnel Pediatric, Deltuss DP, Pseudovent, Vanatab DX, Lodrane 24D, Tylenol Sinus Maximum Strength, Guaifenesin DAC Liquid, DryMax, Dixaphedrine, Capmist DM, Cold Medicine Plus, Stahist, Advil Cold and Sinus Liqui-Gels, Actifed Cold and Sinus, Dimetapp DM, Robitussin Allergy & Cough, Maldec, Endacof HC, Atrogen, Brotapp, Q-Tapp, Maldec-DM, Brotapp-DM, Bromanate DX Cough, Atridine, Bromfed PD, Bromaline, Chlor-Trimeton Nasal Decongestant, Deltuss DMX, Disophrol, Suphedrin, Neo AC, Decongestant Cold Formula, Profen II, Motrin Cold and Flu, Rezira, ExeFen, Nomuc-PE, Children's Dimetapp Decongestant Infant, Qdall, Stahist AD, NasOpen, Unifed, Wal-Zyr D, Esocor P, Triaminic-D Multi-Symptom Cold, Brexin LA, Advil Allergy Sinus, Sudafed Children's Nasal Decongestant, Aphedrid, M-End Max D, Alka-Seltzer Cold and Sinus, Sinarest Sinus, Ornex, Tylenol Allergy Sinus, Contac Severe Cold and Flu Non Drowsy, Tylenol Sinus NightTime, Genacol Maximum Strength, Simplet, LoHist-12D, J-TanD PD, Bromfenex, Lodrane LD, Bromfed SR, Shellcap, Sinutab Ex-Strength, Cetiri D, Nucofed Pediatric Expectorant, Tricode GF, Biotussin DAC, Triaminicin, Sudafed Sinus Nighttime Plus Pain, Disobrom, Codimal, Afrinol, Sinus Maximum Strength, Elixsure Decongestant, Contac Cold, Nexafed, SudoGest 12 Hour, Ridafed, Silfedrine, Coldcough Syrup, Singlet, Hydro-Tussin EXP, Rhinaclear, Theraflu (pseudoephedrine) Daytime Severe Cold, Comtrex Non-Drowsy, Deconamine, Allegra-D 12 Hour Allergy & Congestion, Carbodex DM Drops, Tussafin, Pancof HC, Tussadur-HD, Decotuss-HD, Tussafed, Carbodec, Tussin Pediatric Cold and Cough, Histex HC, Dexatrex D, Benadryl Allergy Sinus, Pannaz, Su-Tuss HD Elixir, Respi-Tann, Suphenamine-SR, Isophen-DF, Orlenta, Fedahist, Deconamine SR, Motrin Sinus Headache, Cophene No 2, Anaplex, LoHist-D, Drituss HD, Dicel, Mintex, Chlor-Trimeton Allergy Decongestant, Tavist Allergy/Sinus/Headache, Drexophed SR, ProHist DM, Carbodex DM Syrup, Bromadine-DM, Brometane DX, Sinus Relief, Ephed Plus, Dynex, Biotuss PE, Actagen, Maxichlor PSE DM, Histafed, Triacin, Guaifenex PSE 120, SuTan, Phenapap, Pseudoephedrine Sinus, Tannate DMP-DEX, Abatuss DMX, Ru-Tuss, Detuss, Deka, Clarinex-D 12 Hour, JayCof-HC, M-End WC, Nucofed, D-Hist D, Pseudo GG, Sudal SR, Mucus Relief D, Maxifed-G, Tusnel-A, NyQuil Multi-Symptom, Maxifed DM, Donatussin DM Syrup, Touro LA, Rymed, Lortuss DM, Eudal SR, Atuss DS, Novahistine DMX, SudaTex-DM, Congestac, Despec DM, Profen II DM, Dorcol Childrens Cough, Medent DM, Viravan-P, Ambenyl-D, Decongest II, M-End DM, Kidcare Cough and Cold, Benaphen Plus, Tekral, Respa SA, Vanacon, Spantuss HD, Lortuss LQ, Allegra-D 24 Hour Allergy & Congestion, Zephrex LA, Poly-Vent IR, Complete Sinus Relief, Sinadrin Plus, Tavist NightTime Allergy, Benylin Multi-Symptom, Welltuss EXP, Allergy Sinus Maximum Strength, Pancof EXP, Uni-Cof Expectorant, DiHydro-GP, Drixoral Allergy Sinus, Sinutab Maximum Strength Caplets, Medtuss HD, Tussafin Liquid, Hytussin Expectorant, Medent-LDI, Actifed Allergy Day/Night, Nalex CR, Deconamine CX, Despec-Tab, Guaimax-D, Entex T, Poly-Tussin XP, Nalex Expectorant, Detussin Expectorant, Hydro-Tuss XP, SRC Expectorant, Actifed Cold & Sinus, Dynex HD, Anatuss LA, Entex HC, Pseudatex HC, Maxiflu CD, Entuss-D JR, KG-Tuss HD, Entex PSE, Tussgen Expectorant, Vanex Expectorant, Tussend Expectorant, Drixoral Cold/Flu, Entuss-D, Hydrotussin HD, Maxiflu CDX, Mardrops-EX, S-Pak DM, Medent-DMI, Poly-Vent DM, Mardrops-DX, PanMist DM, Sudafed Cough, Entre-Cough, Entex Pac, Contac Day and Night Cold and Flu, Hexaflu, Drixoral Sinus, Z-Cof 8DM, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, Tenar DM, Ambifed DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Anatuss DM, Ambi 60/580/30, Calmylin 4, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Nalfrx, Hexafed, C-Phed DPD Tann, Tylenol Severe Cold & Flu Night Time, DuraTan Forte, Bromatan Plus, Dur-Tann Forte, Pharmadrine, Drixoral Cold and Allergy, Dexophed, 12 Hour Cold, Dexaphen SA, Drixomed, TanDur DM, SuTan-DM, All-Nite Cold, Duotan PD, Tanafed DP, AllerDur, Histatab D, DuraHist D, Tannate PD-DM, TanaCof DM, Tanafed DMX, Polaramine Expectorant, Dimacol, Ru-Tuss Expectorant, Z-Cof DM, Relasin DM, Ambi 40 /400 /20, Liquicough DM, Maxifed DMX, Pseudo Cough, Despec Drops, Z-Cof DM(obs), Ambifed-G DM, Touro CC-LD, Relacon-DM NR, Z-Cof 12DM, Trikof-D, Vicks 44D, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Drixoral Cough & Congestion Liquid Caps, Buckley's DM Decongestant, Pseudo DM GG, Pseudo Max DMX, P-Tuss DM, Drixoral Cold and Flu, Altarussin CF, Coldmist DM, Daytime Liquicap, Tusnel-DM Pediatric Drops, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Tusnel Ped-C, Pseudogest-DM, Rhinosyn-X, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Med-RX DM, Tussafed-LA, Fenex-PSE, Ru-Tuss DM, Aldex GS DM, Relacon-DM, ExeClear-DM, Profen II DM Liquid, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, ExeFen-DMX, Viravan-PDM, Guaifenex PSE 60, Sudatrate, Allergy Relief D 24 Hour, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Allergy & Congestion Relief, Leader Allergy Relief D-24, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Clear-Atadine-D, Allergy Relief D12, Claritin-D 12 Hour, Respivent-D, Allerx-D, Allpanto-S, Co-Apap, Theraflu Flu & Cough, Childrens Tylenol Cold Plus Cough, Comtrex Cold and Flu Maximum Strength Liquid, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Sudafed 12 Hour Pressure+Pain, Sinus & Cold D, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, Quadra-Hist D, Tricom, Comtrex Allergy Sinus, Histinex D, Iotussin D Liquid, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Hytussin, P-V-Tussin, Protuss-D, Aquatab D Dose Pack, Procof D, Sinarest Extra Strength, Tussgen, SymTan, Liquituss HD, Motrin IB Sinus, Allerest Sinus, Sine-Aid IB, Motrin Childrens Cold, Advil Children's Cold, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Detussin, Histussin D, Zymine HC, Allerest Headache Strength, nasofed, Suphedrine, Hista-Tabs, Atrofed, LA Nasal Decongestant, Ridifed, Tri-Sudo, Actedril, A-Phedrin, Triafed, Genac, Triposed, Allerphed, Triofed, Triphed, Vi-Sudo, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Triptifed, Allerfrin, Altafed, Biofed-PE, Allercon, Pediatex TD, Decofed Liquid, Superfed, Efidac, Decofed, Kid Kare Drops, Sudrine, Seudotabs, ElixSure Congestion, Drixoral Non-Drowsy, Allermed, Cenafed, Genaphed, Myfedrine, Sudodrin, Hist-PSE, Dristan Cold Maximum Strength, Ed A-Hist PSE, Allerfrim, Zymine-D, Comtrex Day and Night, Cough Formula M Multi-Symptom, Drixoral Decongestant Non-Drowsy, Sudafed Congestion, Seldane-D, Comtrex Cold and Flu Maximum Strength Tablet, Ambi 80/780, Ambi 60/580, Abletex-PSE, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Hi Tex PSE, GP 500, Tenar PSE, Guiadrine II SR, Ambifed, Defen-LA, Desal II, Deco-D, Guiatex PSE, Guai Sudo, Guiatuss PE, Guaitab, Mastussin PE, Mytussin PE, Q-Tussin PE, Guaifenex RX, Ru-Tuss DE, Iotex PSE, Guaipax PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Guiatex II, Iosal II, G-Phed- PD, Nalex Jr, Sinufed Timecelles, Versacaps, Guaivent PD, Guaifed, Guaibid D, Respaire-60 SR, Syn-Rx, Nasabid, G-Phed, Respaire-120 SR, Guaibid D Pediatric, Pseudocot-G, D-Feda II, Deconsal LA, Duomine, Demibid II, Guiadrine II, Duratuss GP (old formulation), V-Dec-M, Nasatab LA, Sudal 60/500, Tuss-LA, Stamoist E, Robichem PE, T-Tussin PE, Coldmist LA, Panmist-S, Coldmist Jr, Pseudo Max, Pseudovent 400, We Mist II LA, Drituss GP, Guiatex II SR, Guiadrine PSE, We Mist LA, SudaTex-G, Coldmist, Ambifed-G, Levall G, Poly-Vent, Jr., Poly-Vent, Pseudo GG TR, Ru-Tuss Jr., Ambi 60/1000, Guaifenex PSE 85, Despec-SR, Guaifenex PSE 80, Pseudatex, Touro LA-LD, Aldex GS, Miraphen PSE, Durasal II, Tusnel Pediatric Drops, Respaire-30, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Guaivent (Ethex), Robafen PE, Tussin PE, Tusscidin PE, Sinufed, Venbid TR, Degen II, Sinutab Non Drying, Robitussin Severe Congestion, Pseudovent Ped, H 9600 SR, Guaifenex GP, ExeFen-IR, Profen Forte, Panmist JR, Panmist LA, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Nalex, Novagest with Codeine, Pseudo Carb DM, Cordron-DM NR, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Pediatex-DM, Decahist-DM, Dura-Ron DM, Cydec-DM Syrup, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Carboxine DM, Carboxine 12 DM, Pseudox M, Pannaz S, Nacon, Contac Day and Night Allergy, Biohist LA, Mintex HC, Tri-Vent HC, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Rondamine DM, Biodec DM, Brovex SR, Bromhist-NR, Dimaphen, LoHist-PD, Exall-D, Di-Bromm, Unit-Hist Drops, Sildec, Bromaxefed RF Syrup, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Re-Tann, Respi-Tann Pd, Tylenol Allergy Complete NightTime, Corzall Plus, Andehist DM NR, Cordron-DM, Dynatuss, Zotex-D, Pseudacarb, Carb Pseudo-Tan, Corzall, Allres Pd, Allres D, Coldec D, Coldec, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Vanacof DX, Certuss-D, Clofera, Chlo Tuss (Reformulated), Biclora-D, Daytime Cold, Benadryl Cold, Up and Up All Day Allergy Relief D, All Day Allergy-D, Allergy Relief D, Notuss-NXD, Statuss Green, Codehist DH, Decohistine DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Phenylhistine DH, Zodryl DAC, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Dihistine DH, Tricode AR, Palgic DS, Mintex PSE, Cardec-S, Rondamine, Palgic-D, Andec-TR, Carbic-D, Mooredec, Andec, Carboxine 12D, Pediatex 12D, Carbiset, Cydec, Palgic-DC, Dura-Ron, Ex-Dec-TR, Cordron-12 D, Cordron-D NR, Pseudo Carb, Carboxine-D, PSE Allergy, Pediatex-D, Cordron-D, Coldec-TR, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Andehist NR Syrup, Touro Allergy, Bromdex D, BromTann/DM Tann/PSE Tann, Neo DM Syrup, Dallergy DM, Myphetane DX, Anaplex DMX, BroveX PSB DM, PediaHist DM, AccuHist DM Pediatric Drops, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, Bromatane DX, Myphetane DX Cough, PSE Brom DM, Bromaxefed DM RF Syrup, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromtapp-DM, Andehist DM NR Syrup, Bromophed-DX, Liquiphed DM, Anaplex DM, Bromphenex DM, EndaCof PD Drops, Suphedrin Sinus, Tavist Sinus, Sinutab Maximum Strength, Benadryl Allergy Sinus Headache, Ursinus, Sudogest Sinus Maximum Strength, Suphedrin Plus, Genapap Sinus, Dristan Cold Non-Drowsy, Bayer Select Sinus Pain Formula, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Respa-AR, Sta-D, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Allerest No Drowsiness, Ornex Maximum Strength, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Trinalin Repetabs, Dicel CD, SymPak II, Mar-cof BP, Bromplex DM, Bromhist-DM Drops, Endafed, Bromhist Pediatric, Touro A&H, Allent, Shellcap PD, B-Vex PD, BroveX PSB, Bidhist-D, Brofed, Lodrane 12D, BroveX PSE, BroveX PD, Nalfed PD, Respahist, Iofed, Ultrabrom, Pseubrom, Lodrane Liquid, Nalfed, M-Hist TD, Histex SR, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, LoHist PSB, Benadryl Severe Allergy & Sinus Headache, P-Hist DM Drops, Brom Tann, Sildec DM, J-Cof DHC, M-END, Histacol BD Drops, Allanhist PDX Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Drocon-CS, Anaplex HD, Sudafed Triple Action, J-Tan D HC, Tylenol Sinus Severe Congestion Daytime, Tylenol Sinus Day/Night Convenience Pack, Actifed Sinus Day and Night, SymTan A, Brovex HC, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Ryna-C, Codahistine-DH Elixir, Tusnel C, Lortuss EX, Z-Tuss E, Ambifed CD, Ambifed CDX, Flutabs, Duraflu, Triaminic Softchews Cold and Allergy, AccuHist Drops (old formulation), Pseudoephedrine Plus, Dynahist ER, Comtrex Acute Head Cold, Ambifed-G CD, Ambifed-G CDX, Novahistine Expectorant, Medent C, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Ryna-CX, Robitussin-DAC, Maxifed CD, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, SudaHist, Sudal-12 Tannate, Hayfebrol Liquid, SudoGest Sinus & Allergy, Suphedrine Plus, Atrohist Pediatric Capsule, Allerest Maximum Strength, Genaphed Plus, Sudogest Cold & Allergy, Aller-Chlor Decongestant, Histafed LA, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Histex, Chlor-Trimeton Allergy Decongestant SR, Pediox Chewable, Sudal-12, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Re2+30, Suclor, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Co-Histine Expectorant, Decohistine Expectorant, EndaCof-DC, Codar D, Notuss-DC, KG-Fed, Cycofed, Zodryl DEC, Codafed Pediatric, Sinutab Maximum Strength Non Drowsy, Codahistine Expectorant, Suttar SF, Codafed, Suttar-2, Nucodine, Theraflu Max-D Severe Cold & Flu, Phlemgesic, Balminil Cough and Flu Sugar Free, All-Nite Multi-Symptom Cold/Flu Relief, NyCair, Multi-Symptom Nighttime, Pseudodine C, Trifed C, Polyhist NC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Gua PC, Dihistine, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucochem Pediatric Expectorant, Novadyne Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Nucodine Expectorant, Deconsal C Expectorant, Phenylhistine Expectorant, Tussar SF, Nuco-Tuss Expectorant, Nucochem, Guaifen DAC, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, Chlorafed, Curaler, Hexatussin, Welltuss HC, Hyphed, Tussin-V, Q-V Tussin, Tussend, Pediatex HC, Day Time Multi Symptom, Lemohist Plus, Notuss-Forte, Notuss, Histinex PV, A-G Tussin, KG-Tussin, Atuss HS, Atuss HD, Theraflu Flu Cold & Cough, Advil Children's Allergy Sinus, AlleRx Dose Pack, Cordron-HC NR, Cordron-HC, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Hydrocof-HC, Z-Tuss 2, Uni-Cof, Tanafed-DM, Children's Nyquil, C-Phed DM, Atuss-12 DM, Dicel DM, Creomulsion Pediatric, Creomulsion Cough/Cold/Allergy, Contact Cold and Sore Throat, Day Relief Cold and Flu, Non-Drowsy Super Strength Contac Complete, Rhinosyn-DM, Vicks 44M Pediatric, Entre-S, Kidkare Cough/Cold, Pancof, T-Tanna DM, Tricof, Hydro-Tussin DHC, Dihydro-CP, Duotan DM, Allres DS, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, DuraHist, Xiral SR, D-Amine-SR, Colfed-A, Deconomed SR, Pseudocot-C, Duralex, Chlorphedrin SR, Fedahist Timecaps, Chlorafed HS Timecelles, Tanafed, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Rinade-BID, Kronofed-A, Klerist-D, Pseudochlor, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Rescon-Ed, Chlorafed Timecelles, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Histalet, Clorfed, Time-Hist QD, Amdry-C, AllePak, Allergy DN, Pseudo CM TR, PCM-LA, Hista-Vent PSE, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Coldamine, ScopoHist, Durafed, Duotan, Biohist LA (old formulation), Novafed A, Duratuss DA, Chlor-Trimeton Decongestant, Histade CR, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Maxiflu DM, Desihist SA

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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