Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, NyQuil, Mucinex D, Sudafed Nasal Decongestant, Actifed, Claritin-D, Allegra-D 24 Hour, Zyrtec-D, Resperal-DM, Vicks Dayquil Daytime Cold/Flu, Show all 1030 »SudoGest, Allegra-D 12 Hour, Sudafed 12-Hour, Nyquil Cold Medicine, Advil Cold and Sinus, Cheratussin DAC, Aprodine, Vanacof, Entex, Conex, Theraflu Flu, Cold and Cough Powder, Tylenol Cold, Dimetapp Elixir, Alka-Seltzer Cold and Sinus, Sinarest, Zutripro, Semprex-D, Drixoral, Tusnel, Claritin-D 12 Hour, Sudafed 24-Hour, Robitussin Cold Cough and Flu, Zyrtec-D 12 Hour, Claritin-D 24 Hour, M-End DMX, Despec DM, Alka-Seltzer Plus Flu/Body, Rezira, Suphedrine, Sudafed Congestion, Sudafed Children's Nasal Decongestant, Actifed Cold and Sinus, Sinutab Ex-Strength, Sinus Relief, Dimetane DX, Brotapp-DM, Capmist DM, Clorfed, Sinufed, Rescon, Wal-Zyr D, Zephrex, Deconamine, Stahist, Contac Cold, Loratadine-D 24 Hour, Dristan Sinus, Daytime Cold, Aleve-D Sinus & Headache, SudoGest Sinus & Allergy, Mar-cof BP, Advil Allergy Sinus, Entex PSE, Disophrol, Decongestant Cold Formula, Benadryl Children's Allergy And Sinus, Benadryl Allergy Sinus, Clarinex-D 24 Hour, Duralex, Lodrane 24D, Lodrane D, Aleve-D Sinus & Cold, Allergy Relief D, Allegra-D 24 Hour Allergy & Congestion, Lodrane, M-End Max D, Silfedrine, Suphedrin, Levall G, Allerx-D, Flutabs, NyQuil Multi-Symptom, Corzall, Polyhist NC, Pseudovent, Robitussin Severe Congestion, Allerfrin, Stahist AD, Respi-Tann, Respa-AR, Phenylhistine DH, Guaifenex PSE 120, M-End WC, Codahistine-DH Elixir, Q-Tapp DM, Contact Cold and Sore Throat, Detuss, Sudafed 12 Hour Pressure+Pain, Clarinex-D 12 Hour, Welltuss HC, Dixaphedrine, Bromaline, Cold Medicine Plus, LoHist-12D, Deltuss DMX, Allergy & Congestion Relief, AllerClear D-24 Hour, Sinutab Maximum Strength, Alavert D-12 Hour Allergy and Sinus, Complete Sinus Relief, Pseudoephedrine Sinus, Tussafed, Tekral, Maldec, Tussend Expectorant, Rondamine, Carbiset, Nacon, Mintex HC, Benylin Multi-Symptom, Mooredec, Lortuss LQ, Qdall, Advil Cold and Sinus Liqui-Gels, Lodrane Liquid, Brotapp, J-TanD PD, Bromfenex, Ultrabrom PD, Codimal, Brofed, Bromfed PD, Novagest with Codeine, Guaifenesin DAC Liquid, Motrin Sinus Headache, Histinex D, Hytussin, Suclor, Deproist with Codeine, Tussar SF, Mytussin DAC, P-V-Tussin, Biclora-D, Desal II, Biotuss PE, Tussin PE, Robafen PE, Nalex, T-Tanna DM, M-End DM, Kidkare Cough/Cold, CPM-PSE DM Drops, Tusnel Pediatric Drops, Dynex, JayCof-HC, We Mist II LA, Maxifed, Coldcough Syrup, Tussin-V, Q-V Tussin, Atuss HD, Cordron-HC, P-V-Tussin Syrup, Kidcare Cough and Cold, Neotuss D, Tylenol Cold Severe Congestion Daytime, All Day Allergy-D, Coldamine, Vanacof DX, Fedahist, Kronofed-A-Jr, Klerist-D, Anaplex, Brexin LA, DuraHist, DryMax, Congestac, Medent-LDI, Entex T, Phenylhistine DH Expectorant, NasOpen, Clofera, Notuss-NXD, AlleRx Dose Pack, Sudogest Cold & Allergy, Pancof HC, Daytime Cold and Flu Relief, Lortuss DM, Poly-Vent DM, Benylin DM-D-E, BroveX PSE DM, Dimetapp DM, Viravan-P, Trinalin Repetabs, Nexafed, Unifed, Actedril, Allerfrim, Ru-Tuss, Bromdex D, Dallergy DM, P-Hist DM Drops, Protuss DM, Calmylin 4, Tussin Cough and Cold, Dimacol, Multi Symptom Cough and Cold, Robitussin Allergy & Cough, Tusnel Pediatric, Brometane DX, Bromophed-DX, SudaTex-DM, Z-Cof DM, Bromadine-DM, Nucodine, Childrens Tylenol Cold Plus Cough, J-Cof DHC, Triacin C, Contac Cold and Flu Maximum Strength, Children's Dimetapp Decongestant Infant, Novafed, Abatuss DMX, Drixoral Cold/Flu, Ephed Plus, Phenapap, Sudogest Sinus Maximum Strength, Pseudodine C, Drixoral Cold and Flu, Decofed, Drexophed SR, Duomine, Pan-Mist LA, Poly-Tussin XP, Deconamine CX, Entuss-D, Nalex Expectorant, SRC Expectorant, Hydrotussin HD, Vanacon, Spantuss HD, Medtuss HD, KG-Tuss HD, Drixomed, DuraTan Forte, Su-Tuss HD Elixir, Pharmadrine, Vanex Expectorant, Tussadur-HD, Detussin Expectorant, Drixoral Cold and Allergy, Nalex CR, Tussgen Expectorant, C-Phed DPD Tann, Tannate DMP-DEX, Mardrops-EX, Zephrex LA, Hydro-Tuss XP, Comtrex Allergy Sinus, Tanafed DP, Duotan PD, AllerDur, TanDur DM, SuTan, Kolephrin, Maxiflu CD, Histatab D, Tanafed DMX, TanaCof DM, Polaramine Expectorant, D-Hist D, DuraHist D, SuTan-DM, Decotuss-HD, Deltuss DP, Allergy Sinus Maximum Strength, Dynex HD, Entex HC, Bromatan Plus, Tannate PD-DM, Hytussin Expectorant, Drituss HD, Actifed Cold & Sinus, Pseudatex HC, Nalfrx, Hexafed, Dur-Tann Forte, Allerest Sinus, Tylenol Allergy Sinus, Tavist Allergy/Sinus/Headache, Tussafin Liquid, Comtrex Allergy Sinus Night and Day, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, Med-RX DM, Daytime Liquicap, Pseudogest-DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Profen II DM, ExeFen-DMX, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Coldmist DM, S-Pak DM, ExeClear-DM, Profen II DM Liquid, Poly-Vent IR, Medent-DMI, Mardrops-DX, Maxifed DM, Donatussin DM Syrup, Z-COF 12, Novahistine DM Expectorant with Decongestant, Tenar DM, Anatuss DM, Syn-Rx DM, Ambenyl-D, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Ambifed DM, Ambi 60/580/30, Sudafed Cough, Guaifenex DM RX, Suda-Tussin DM, PanMist DM, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, Ambi 80/780/40, Ambi 600/1000/30, TL-Dex DM, Altarussin CF, Z-Cof DM(obs), DiHydro-GP, Uni-Cof Expectorant, Hydro-Tussin EXP, Pancof EXP, Pediatex TDM, Viravan-PDM, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Welltuss EXP, Triaminicin, Allerest Headache Strength, Novahistine DMX, Comtrex Allergy Sinus Maximum Strength, Allegra-D 12 Hour Allergy & Congestion, Benaphen Plus, Respa SA, Sinarest Extra Strength, Actifed Allergy Day/Night, Tavist NightTime Allergy, Vicks 44D, Drixoral Cough & Congestion Liquid Caps, Relasin DM, Ambi 40 /400 /20, Liquicough DM, Entre-Cough, Pseudo Cough, Despec Drops, Ambifed-G DM, Touro CC-LD, Relacon-DM NR, Entex Pac, Maxifed DMX, Sinutab Maximum Strength Caplets, Dexatrex D, Z-Cof 8DM, Buckley's DM Decongestant, P-Tuss DM, Pseudo Max DMX, Z-Cof 12DM, Trikof-D, Pseudo DM GG, Entuss-D JR, Guiadrine II, AlleRx Dose Pack (AM Dose), Sudatrate, Amdry-D, Extendryl PSE, Respivent-D, Allergy Relief D 24 Hour, Leader Allergy Relief D-24, Comtrex Nighttime Flu Therapy, Advil Children's Cold, Comtrex Sinus and Nasal, Clear-Atadine-D, Allergy Relief D12, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Cough Formula M Multi-Symptom, Comtrex Day and Night, nasofed, Genacol Maximum Strength, Theraflu Flu & Cough, Quadra-Hist D Pediatric, Sinus & Cold D, Quadra-Hist D, Co-Apap, Allpanto-S, Motrin Childrens Cold, Motrin Cold and Flu, Procof D, Protuss-D, Tricom, Tussafin, Tussgen, Aquatab D Dose Pack, Ambi 80/780, ExeFen, Ru-Tuss Jr., Mucus Relief D, Ambi 60/1000, Ambi 60/580, Iotussin D Liquid, Entuss-D Liquid, Simplet, Zymine HC, Singlet, Motrin IB Sinus, Sine-Aid IB, Histussin D, Detussin, H-C Tussive D, ColdCough HCM, SymTan, Liquituss HD, Drixoral Non-Drowsy, ElixSure Congestion, LA Nasal Decongestant, Hista-Tabs, Ridifed, Tri-Sudo, Triphed, Atrogen, Atrofed, Triofed, Allerphed, Aphedrid, A-Phedrin, Atridine, Vi-Sudo, Triptifed, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Actagen, Biofed-PE, Histafed, Triacin, Triposed, Triafed, Afrinol, Chlor-Trimeton Nasal Decongestant, Decofed Liquid, Efidac, Kid Kare Drops, Superfed, Sudrine, Cenafed, Allermed, Genaphed, Ridafed, Seudotabs, Myfedrine, Sudodrin, Zymine-D, Ed A-Hist PSE, Pediatex TD, Allercon, Genac, Hist-PSE, Dristan Cold Maximum Strength, Elixsure Decongestant, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, Seldane-D, Pseudo GG TR, Maxifed-G, Defen-LA, Guiadrine II SR, Decongest II, Deco-D, Tenar PSE, Ambifed, Guiatex II, Demibid II, Guaifenex PSE 60, Dexaphen SA, Iosal II, Respa-1st, GP 500, Guaifed-PSE, Ami-Tex PSE, Iotex PSE, Pseudo-G/PSI, Zaptec PSE, Ru-Tuss DE, Guaipax PSE, Guai Sudo, Guiadrine PSE 120, Abletex-PSE, Guai-Vent/PSE, Hi Tex PSE, Guiatex PSE, D-Feda II, Deconsal LA, Respaire-120 SR, G-Phed, Guaibid D, Guaifed, Nalex Jr, Nasabid, Respaire-60 SR, Anatuss LA, Guaimax-D, Touro LA, Fenex-PSE, Syn-Rx, G-Phed- PD, Sinufed Timecelles, Tuss-LA, Sudal 60/500, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Eudal SR, Nasatab LA, Versacaps, Guaivent PD, Guaibid D Pediatric, Pseudocot-G, Guaifenex RX, Guaitab, Panmist-S, Drituss GP, Pseudo GG, Coldmist LA, Coldmist Jr, Coldmist, SudaTex-G, Miraphen PSE, Durasal II, Guiadrine PSE, Guiatex II SR, We Mist LA, Sudal SR, Pseudo Max, Guaifenex PSE 85, Despec-SR, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Aldex GS, Touro LA-LD, Ambifed-G, Pseudovent 400, Guaifenex PSE 80, Medent, Pseudatex, Profen Forte, Profen II, Degen II, Venbid TR, Guaivent (Ethex), Respaire-30, Altarussin PE, Tusscidin PE, T-Tussin PE, Mastussin PE, Guiatuss PE, Mytussin PE, Q-Tussin PE, Robichem PE, S-Pack, Sudafed Non Drying Sinus, H 9600 SR, Panmist JR, Pseudovent Ped, Guaifenex GP, ExeFen-IR, Panmist LA, Nasabid SR, Sinutab Non Drying, Uni Tussin PE, Humibid GC, Med-RX, Despec-Tab, Nucodine Expectorant, Carb Pseudo-Tan, Respi-Tann Pd, Allres Pd, Allres D, Pseudacarb, Re-Tann, Exall-D, Bromhist-NR, Di-Bromm, Brovex SR, Dimaphen, LoHist-PD, Zotex-D, Corzall Plus, Cydec-DM Syrup, Maldec-DM, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Rondamine DM, Biodec DM, Andehist DM NR, Carbodex DM Drops, Cordron-DM, Dynatuss, Unit-Hist Drops, Unit-Tex 10/120 ER, Respahist, Nalfed PD, Iofed PD, Pseubrom-PD, Bromfenex PD, Lodrane LD, Shellcap PD, Endafed, Bromhist Pediatric, Touro A&H, Shellcap, Allent, Histex SR, M-Hist TD, Sildec, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Andehist NR Syrup, Touro Allergy, Ultrabrom, Iofed, Pseubrom, Nalfed, Carbofed DM Drops, Decahist-DM, Carboxine-PSE, Hydro-Tussin CBX, Cordron-D, Pediatex-D, Cordron-D NR, Andehist, Coldec-TR, Andec-TR, Palgic-D, Carbic-D, Dura-Ron, Ex-Dec-TR, Cordron-12 D, Pseudo Carb, Cetiri D, Up and Up All Day Allergy Relief D, Chlo Tuss (Reformulated), Multi-Symptom Nighttime, Vanatab DX, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Cardec-S, Andec, Carb PSE 12 DM, Carboxine 12 DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Carboxine DM, PSE Carb DM Drops, Cordron-DM NR, Pediatex-DM, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, Tri-Vent HC, Histex HC, Pediatex 12D, Carbodec, Carboxine 12D, Cydec, Palgic-DC, Coldec, Coldec D, Pannaz S, Pseudox M, Pannaz, Biohist LA, B-Vex PD, BroveX PSB, Comtrex Non-Drowsy, Ursinus, Sta-D, Dicel CD, SymPak II, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Tylenol Sinus Maximum Strength, Sinutab Regular Strength, Genapap Sinus, Suphedrin Plus, Sinarest Sinus, Theraflu Flu Cold & Cough, Rydex, Maxiflu DM, Tusnel-A, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Sine-Off Maximum Strength, Contac Sinus, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Tylenol Allergy Complete NightTime, Sudafed Sinus Nighttime Plus Pain, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Benadryl Cold, Contac Day and Night Allergy, Sudafed Triple Action, Day Relief Cold and Flu, Ornex, Tavist Sinus, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Dristan Cold Non-Drowsy, Benadryl Allergy Sinus Headache, Allerest No Drowsiness, Non-Drowsy Super Strength Contac Complete, Sinus Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, BroveX PSE DM Tablets, PBM Allergy, Visvex, Bromph HD, Bromcomp HC, Endacof HC, Brovex HC, Bromplex HD, Anaplex HD, Carbodex DM Syrup, ProHist DM, Sildec DM, M-END, Drocon-CS, SymTan A, J-Tan D HC, Lodrane 12D, Bidhist-D, Rynex PSE, BroveX PSE, BroveX PD, Bromfed SR, LoHist PSB, Duraflu, Theraflu Max-D Severe Cold & Flu, Balminil Cough and Flu Sugar Free, Phlemgesic, Brom Tann, Histacol BD Drops, Myphetane DX Cough, Bromatane DX, Liquiphed DM, Anaplex DM, Bromphenex DM, Bromanate DX Cough, Myphetane DX, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Neo DM Syrup, Andehist DM NR Syrup, Bromtapp-DM, Pediahist DM Drops, Bromhist-DM Drops, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Certuss-D, Poly-Tussin D, Comtrex Acute Head Cold, Dynahist ER, Drixoral Allergy Sinus, Lortuss EX, Tusnel C, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, Sudal-12 Tannate, Dicel, SudaHist, AccuHist Drops (old formulation), LoHist-D, Z-Tuss E, Tricode GF, Maxifed-G CDX, Maxifed-G CD, Robitussin-DAC, Ryna-CX, Medent C, Maxifed CDX, Maxifed CD, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Sudal-12 Chewable, De-Congestine, Neutrahist Drops, Sudogest Plus, Ryna Liquid, Genaphed Plus, Hayfebrol Liquid, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Clorfed II, Fedahist Gyrocaps, Curaler, Chlorafed, Histafed LA, Suphedrine Plus, Atrohist Pediatric Capsule, Re2+30, Mintex, Sudal-12, Pediox Chewable, C-Phed Tannate, Histade, CP-Tannic, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, Novahistine Expectorant, Nucofed Expectorant, Zodryl DEC, Codafed Pediatric, Codar D, Nucofed, EndaCof-DC, Suttar-2, Codafed, Dihistine, Guaifen DAC, Gua PC, Codahistine Expectorant, Suttar SF, Notuss-DC, KG-Fed, Maxiflu CDX, Deka, Desihist SA, Dexophed, Disobrom, Sinadrin Plus, Trifed C, Cycofed, Neo AC, Allerfrin with Codeine, Triafed & Codeine, Nucochem, Nuco-Tuss Expectorant, Novadyne Expectorant, Halotussin DAC, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Phenhist Expectorant, Dihistine Expectorant, Tussar-2, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Nucofed Pediatric Expectorant, Biotussin DAC, Phenylhistine Expectorant, Guiatussin DAC, Guiatuss DAC, KG-Fed Expectorant, Tylenol Cold Non-Drowsy Gelcaps, Deconsal C Expectorant, Guaiatussin DAC, Codimal-LA Half, Anamine, Lemohist Plus, Z-Tuss 2, Tylenol Severe Cold & Flu Night Time, Notuss-Forte, Notuss, Uni-Cof, Dihydro-CP, Duotan DM, Allres DS, Pancof, Tricof, Hydro-Tussin DHC, Histinex PV, Pediatex HC, Hydrocof-HC, Hydron PCS, Cordron-HC NR, Atuss HS, All-Nite Cold, Hydrotuss HC, KG-Tussin, Tussend, Hexatussin, Hyphed, A-G Tussin, Triaminic-D Multi-Symptom Cold, Mesehist DM, Ryna-C, Co-Histine DH, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Novadyne DH, Codehist DH, Dihistine DH, Statuss Green, Tricode AR, Zodryl DAC, Decohistine DH, Creomulsion Pediatric, Children's Nyquil, Maxichlor PSE DM, Entre-S, Neutrahist PDX Drops, AccuHist PDX Drops, Esocor P, Atuss DS, Dicel DM, Rescon-DM, Tanafed-DM, C-Phed DM, Atuss-12 DM, Advil Children's Allergy Sinus, Xiral SR, Chlorphedrin SR, Orlenta, Colfed-A, D-Amine-SR, Deconomed SR, Fedahist Timecaps, Dura-Tap/PD, Histalet, Duratuss DA, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Pseudocot-C, Rinade-BID, Chlorafed Timecelles, Time-Hist, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine TD, Chlordrine SR, Suphenamine-SR, Isophen-DF, Kronofed-A, ND Clear, Novafed A, Deconamine SR, Time-Hist QD, Amdry-C, AllePak, Rhinaclear, Allergy DN, PCM-LA, Hista-Vent PSE, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Pseudo CM TR, ScopoHist, Chlor-Trimeton Decongestant, Histade CR, Duotan, Durafed, Biohist LA (old formulation), Drixoral Sinus, Hexaflu, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Contac Day and Night Cold and Flu, 12 Hour Cold

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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