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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Claritin-D, Vicks Dayquil Daytime Cold/Flu, Mucinex D, Actifed, SudoGest, Allegra-D 24 Hour, Sudafed 12-Hour, Virtussin DAC, Show all 1037 »Zyrtec-D, Vicks Nyquil D Cold and Flu Nighttime Relief, M-End DM, Allegra-D 12 Hour, Dimetapp Elixir, Theraflu Flu, Cold and Cough Powder, Advil Cold and Sinus, Cheratussin DAC, Resperal-DM, Aprodine, Tylenol Cold, Robitussin Cold Cough and Flu, Vanacof, Loratadine-D 24 Hour, Zyrtec-D 12 Hour, Dimetane DX, Conex, Entex, Drixoral, Cold Medicine Plus, Sudafed 24-Hour, Nexafed, Robitussin Allergy & Cough, Advil Allergy Sinus, Zutripro, Sudafed Children's Nasal Decongestant, M-End DMX, Coldcough Syrup, Sinarest, Contac Cold, Tusnel, Benadryl Children's Allergy And Sinus, Children's Nyquil, Chlo Tuss, Capmist DM, Claritin-D 24 Hour, Allerfrin, Stahist AD, Stahist, Aleve-D Sinus & Cold, Alka-Seltzer Cold and Sinus, Semprex-D, M-END, Clarinex-D 24 Hour, Notuss-Forte, Sinutab Ex-Strength, Allegra-D 24 Hour Allergy & Congestion, Robitussin Severe Congestion, Tusnel Pediatric, Dicel, Dimetapp DM, Dristan Sinus, Q-Tapp, Mucinex D Maximum Strength, Allerest Maximum Strength, Panatuss PED, Suphedrine, Contac Cold and Flu Maximum Strength, Drixoral Decongestant Non-Drowsy, LoHist-D, Ornex, Deconamine, Rescon, Sildec, Bromadine-DM, Brotapp-DM, Q-Tapp DM, Bromophed-DX, Singlet, Visvex, Advil Cold and Sinus Liqui-Gels, Clarinex-D 12 Hour, Drixoral Non-Drowsy, Duomine, Profen II, Entex T, Contact Cold and Sore Throat, Triacin, Maxifed, Actacin, Bromhist Pediatric, Lodrane, Nalex, Shellcap, Dimacol, Drixoral Cold and Allergy, Mintex, Suclor, Brotapp, Mardrops-DX, Brovex HC, Congestac, Claritin-D 12 Hour, AllerClear D-24 Hour, ExeFen, Medent, Alavert D-12 Hour Allergy and Sinus, Daytime Liquicap, Rezira, Zephrex, Anamine, Despec DM, Dorcol Childrens Cough, Anaplex, Maldec-DM, Benadryl Allergy Sinus, Zotex-D, PCM-LA, Pseudacarb, Coldamine, Pseudo GG, Allegra-D 12 Hour Allergy & Congestion, Pannaz, Maldec, Nacon, Tricof, Pseudovent 400, Pseudovent, Abletex-PSE, Fedahist, Novafed A, Orlenta, Duralex, Up and Up All Day Allergy Relief D, Brexin LA, Stamoist E, KS Aller-Tec D-12, Poly-Tussin XP, Vanex Expectorant, Deconamine SR, Hycofenix, Simplet, Vanatab DX, Bromaline, Benadryl Cold, Abatuss DMX, Tylenol Sinus Day/Night Convenience Pack, Tanafed DP, SuTan, Mar-cof BP, M-End WC, Aleve-D Sinus & Headache, Genacol Maximum Strength, Tavist Allergy/Sinus/Headache, Sinutab Regular Strength, Tusnel C, Ambifed CD, DuraHist D, Drixoral Cold and Flu, Actifed Cold and Sinus, Maxiflu CD, Pediahist DM Syrup, Ru-Tuss, Flutabs, BromTann/DM Tann/PSE Tann, Dixaphedrine, Theraflu Max-D Severe Cold & Flu, Pediatex TD, Acticon, Daytime Cold, Dexophed, Aphedrid, Duraflu, Bromanate DX Cough, Actedril, Lortuss DM, Biofed-PE, Bromphenex DM, Tavist NightTime Allergy, Actifed Allergy Day/Night, Zodryl DEC, Bromatan Plus, Respa SA, Dur-Tann Forte, Lortuss LQ, TanDur DM, Benaphen Plus, Tekral, SuTan-DM, Vicks 44D, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Drixoral Cough & Congestion Liquid Caps, Buckley's DM Decongestant, Deltuss DMX, P-Tuss DM, Tannate PD-DM, Dexatrex D, Benylin DM-D, Pedia Relief Infant, Pancof EXP, Welltuss EXP, Codar D, Codafed Pediatric, Hydro-Tussin EXP, Uni-Cof Expectorant, Viravan-PDM, Pediatex TDM, DiHydro-GP, Benylin Multi-Symptom, DuraTan Forte, Hytussin Expectorant, Drituss HD, Hydro-Tuss XP, Dynex HD, Tussafin Liquid, Suttar-2, Vanacon, Su-Tuss HD Elixir, Drexophed SR, Entex HC, Pseudatex HC, 12 Hour Cold, Disophrol, Disobrom, Dexaphen SA, Drixomed, Comtrex Cold and Flu Maximum Strength Tablet, Pharmadrine, Codafed, Spantuss HD, Medtuss HD, Decotuss-HD, Tussadur-HD, Tussend Expectorant, Desgen DM (with pseudoephedrine), Entuss-D JR, Tannate DMP-DEX, Comtrex Cold and Flu Maximum Strength Liquid, Desihist SA, C-Phed DPD Tann, Detussin Expectorant, Suttar SF, Entuss-D, Hydrotussin HD, KG-Tuss HD, Deconamine CX, Nalex Expectorant, Deka, Tussgen Expectorant, SRC Expectorant, Childrens Tylenol Cold Plus Cough, Maxifed DMX, Donatussin DM Syrup, Deltuss DP, Anatuss DM, AllerDur, Z-COF 12, Novahistine DM Expectorant with Decongestant, Calmylin 4, Ambi 60/580/30, Ambifed DM, Tenar DM, Triacin C, Ambenyl-D, Suda-Tussin DM, Pseudogest-DM, Tusnel Ped-C, Duotan PD, Guaifenex DM RX, Syn-Rx DM, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Ambi 80/780/40, Benylin DM-D-E, Polyhist NC, Z-Cof 8DM, Entex Pac, Entre-Cough, EndaCof-DC, Notuss-DC, Cycofed, Nucodine, Neo AC, Poly-Vent DM, Medent-DMI, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Sudafed Cough, PanMist DM, Nalfrx, Hexafed, Maxifed DM, Tusnel-DM Pediatric Drops, Medent DM, Touro CC-LD, Relacon-DM NR, Despec Drops, Pseudo Cough, Ambifed-G DM, Z-Cof DM(obs), Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Relasin DM, Z-Cof DM, TanaCof DM, Pseudo DM GG, Pseudo Max DMX, SudaTex-DM, Trikof-D, Z-Cof 12DM, Ambi 40 /400 /20, Liquicough DM, KG-Fed, Tanafed DMX, Polaramine Expectorant, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, Profen II DM, Tussafed-LA, Med-RX DM, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, ExeFen-DMX, Profen II DM Liquid, Trifed C, Pseudodine C, Histatab D, D-Hist D, Triafed & Codeine, Allerfrin with Codeine, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Nucofed, Deconsal LA, Motrin Childrens Cold, Motrin Cold and Flu, Motrin Sinus Headache, Advil Children's Cold, Clear-Atadine-D, Comtrex Day and Night, Sine-Aid IB, Motrin IB Sinus, Detussin, Liquituss HD, Histussin D, Zymine HC, Cough Formula M Multi-Symptom, Allergy Relief D12, Leader Allergy Relief D-24, Sinus & Cold D, Allerx-D, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Quadra-Hist D, Respivent-D, Extendryl PSE, Allergy Relief D 24 Hour, Allergy & Congestion Relief, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, SymTan, Pancof HC, Pseudo GG TR, Maxifed-G, Ru-Tuss Jr., Mucus Relief D, Ambi 60/1000, Nomuc-PE, Poly-Vent, Jr., Aldex GS, Touro LA-LD, Despec-SR, Guaifenex PSE 85, Poly-Vent, Ambi 60/580, Ambi 80/780, Histinex D, Iotussin D Liquid, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Hytussin, P-V-Tussin, Protuss-D, Aquatab D Dose Pack, Procof D, Tussafin, Tussgen, nasofed, Silfedrine, Atridine, A-Phedrin, Atrofed, Atrogen, LA Nasal Decongestant, Hista-Tabs, Triofed, Allerphed, Allercon, Zymine-D, Genac, Triafed, Triposed, Ridifed, Tri-Sudo, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Ritifed, Histafed, Vi-Sudo, Triphed, Triptifed, Actagen, Altafed, Allerfrim, Ed A-Hist PSE, Seudotabs, Ridafed, Sudrine, Superfed, Chlor-Trimeton Nasal Decongestant, Genaphed, Cenafed, ElixSure Congestion, Suphedrin, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Afrinol, Decofed Liquid, Viravan-P, SudoGest 12 Hour, Seldane-D, Dristan Cold Maximum Strength, Hist-PSE, Unifed, Elixsure Decongestant, Decofed, Efidac, Kid Kare Drops, Myfedrine, Sudodrin, Pseudatex, Guaifenex PSE 80, Iosal II, Guiadrine II, Respa-1st, Guiatex II, Guiadrine II SR, Ambifed, Demibid II, Guaifenex PSE 60, V-Dec-M, Tuss-LA, Duratuss GP (old formulation), Novagest with Codeine, D-Feda II, Defen-LA, Decongest II, Hi Tex PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Guai-Vent/PSE, Guiadrine PSE 120, Deco-D, Desal II, Tenar PSE, GP 500, Guaifed-PSE, Sudal 60/500, Eudal SR, Anatuss LA, Guaimax-D, Touro LA, Fenex-PSE, Syn-Rx, Despec-Tab, Medent-LDI, Mardrops-EX, Nalex CR, Zephrex LA, Pan-Mist LA, Poly-Vent IR, Respaire-60 SR, Nasabid, Guaivent PD, Versacaps, Guaibid D Pediatric, Pseudocot-G, Nasatab LA, Sinufed Timecelles, G-Phed- PD, Respaire-120 SR, G-Phed, Guaibid D, Guaifed, Nalex Jr, Iotex PSE, Ami-Tex PSE, ExeFen-IR, Dynex, Profen Forte, Durasal II, Miraphen PSE, Guaifenex GP, Pseudovent Ped, Nasabid SR, Med-RX, Panmist LA, Panmist JR, H 9600 SR, Guiadrine PSE, Guiatex II SR, Sudal SR, Coldmist Jr, Pseudo Max, Ambifed-G, Levall G, Coldmist LA, Panmist-S, SudaTex-G, We Mist LA, Coldmist, Drituss GP, We Mist II LA, Humibid GC, Uni Tussin PE, Mastussin PE, Guiatuss PE, Mytussin PE, Q-Tussin PE, Robichem PE, Biotuss PE, Guaitab, Mucus D, Pseudo-G/PSI, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, T-Tussin PE, Tusscidin PE, Altarussin PE, Tusnel Pediatric Drops, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Respaire-30, Guaivent (Ethex), Sinufed, Tussin PE, Venbid TR, Degen II, Robafen PE, Entex PSE, Maxifed CD, Ultrabrom PD, Iofed PD, Pseubrom-PD, Bromfenex, Histex SR, Bromfenex PD, Respahist, Nalfed PD, Touro A&H, Endafed, Allent, Shellcap PD, Lodrane LD, M-Hist TD, Ultrabrom, AccuHist Pediatric, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, Unit-Hist Drops, Bromhist-NR, Di-Bromm, Bromaxefed RF Syrup, Andehist NR Syrup, Pseubrom, Iofed, Lodrane Liquid, Nalfed, Touro Allergy, B-Vex PD, BroveX PSB, Drocon-CS, J-Cof DHC, Anaplex HD, Bromplex HD, Bromcomp HC, Bromph HD, Sildec DM, Carbodex DM Syrup, Histacol BD Drops, Allanhist PDX Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Endacof HC, SymTan A, Rynex PSE, Lodrane 12D, Lodrane D, BroveX PSE, BroveX PD, Bidhist-D, Bromfed SR, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, J-Tan D HC, LoHist PSB, Brofed, Bromfed PD, Brovex SR, Dimaphen, Pediatex 12 DM, Cordron-12 DM, Tri-Vent HC, Histex HC, Pannaz S, Mintex HC, PSE Allergy DM, Carb PSE 12 DM, PSE Carbinoxamine DM, Mintex DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Pseudox M, Biohist LA, Andec, Palgic-DC, Mooredec, Rondamine, Cardec-S, Cydec, Carbiset, Coldec, Coldec D, Carbodec, Pediatex 12D, Carboxine 12D, Pseudo Carb DM, Cordron-DM NR, Respi-Tann, Carb Pseudo-Tan, Corzall, Allres Pd, Corzall Plus, Allres D, Respi-Tann Pd, Re-Tann, LoHist-PD, Lodrane 24D, LoHist-12D, J-TanD PD, Exall-D, Andehist DM NR, Carbodex DM Drops, Carbaxef-DM, Cydec-DM Drops, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Dura-Ron DM, Cydec-DM Syrup, Dynatuss, Cordron-DM, Tussafed, Biodec DM, Rondamine DM, Uni-Hist PDX Drops, Bromph DM, Contac Severe Cold and Flu Non Drowsy, Comtrex Non-Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Tylenol Cold Non-Drowsy Gelcaps, Day Relief Cold and Flu, Alka-Seltzer Plus Flu/Body, Theraflu Flu Cold & Cough, Phlemgesic, Tylenol Cold Severe Congestion Daytime, Balminil Cough and Flu Sugar Free, Maxiflu DM, Tusnel-A, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Tylenol Sinus Severe Congestion Daytime, Tylenol Sinus NightTime, Sudafed Triple Action, Sinus Maximum Strength, Ornex Maximum Strength, Suphedrin Sinus, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Severe Cold Multi-Symptom, Theraflu (pseudoephedrine) Daytime Severe Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, All-Nite Multi-Symptom Cold/Flu Relief, NyCair, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Triaminicin, Sinarest Extra Strength, Allerest Sinus, Kolephrin, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Tricom, Comtrex Allergy Sinus, Codimal, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Contac Day and Night Cold and Flu, Hexaflu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, Drixoral Sinus, Drixoral Allergy Sinus, Maxiflu CDX, Actifed Cold & Sinus, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Bromdex D, Anaplex DMX, Neo DM Syrup, Dallergy DM, Bromatane DX, Myphetane DX, BroveX PSB DM, PBM Allergy, AccuHist DM Pediatric Drops, EndaCof PD Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, Myphetane DX Cough, Liquiphed DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Bromaline DM, PSE Brom DM, Anaplex DM, Brometane DX, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, Triaminic Flu, Cough & Fever, Histacol DM Pediatric Syrup, Sine-Off Maximum Strength, Contac Sinus, Tylenol Sinus Maximum Strength, Genapap Sinus, Phenapap, Suphedrin Plus, Dristan Cold Non-Drowsy, Sinus Relief, Tavist Sinus, Benadryl Allergy Sinus Headache, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Pseudoephedrine Sinus, Sinarest Sinus, Mesehist WC, Rydex, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, SymPak II, Dicel CD, Ursinus, Sinutab Maximum Strength, Respa-AR, Sta-D, Trinalin Repetabs, Palgic-D, Andec-TR, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Sudogest Plus, Neutrahist Drops, Sudogest Cold & Allergy, Ryna Liquid, Histafed LA, Chlorafed, Codimal-LA Half, Klerist-D, Fedahist Gyrocaps, Clorfed II, Curaler, Genaphed Plus, SudoGest Sinus & Allergy, Re2+30, Histade, Sudal-12, Pediox Chewable, De-Congestine, C-Phed Tannate, CP-Tannic, Dynahist-ER Pediatric, Suphedrine Plus, Hayfebrol Liquid, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Cophene No 2, Pseudochlor, Codimal-LA, Chlorafed HS Timecelles, Kronofed-A-Jr, Dura-Tap/PD, Chlorphedrin SR, Fedahist Timecaps, Tanafed, Histalet, Durafed, Duotan, Biohist LA (old formulation), Duratuss DA, Clorfed, Colfed-A, D-Amine-SR, Anamine TD, Chlordrine SR, Time-Hist, Chlorafed Timecelles, Rescon-Ed, ND Clear, Kronofed-A, Pseudocot-C, Deconomed SR, Rinade-BID, Suphenamine-SR, Isophen-DF, Sudal-12 Chewable, Sudal-12 Tannate, KG-Fed Expectorant, Cycofed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guiatuss DAC, Guaiatussin DAC, Nucodine Pediatric, Nuco-Tuss Pediatric Expectorant, Halotussin DAC, Phenhist Expectorant, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Mytussin DAC, Guiatussin DAC, Guaifen DAC, Nucochem, Dihistine, Gua PC, Codahistine Expectorant, Nuco-Tuss Expectorant, Phenylhistine Expectorant, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Biotussin DAC, Dihistine Expectorant, Dihistine Expectorant with Codeine, Comtrex Acute Head Cold, Theraflu Flu & Cough, Lortuss EX, Z-Tuss E, Ambifed CDX, Tricode GF, M-End Max D, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Ambifed-G CD, Ambifed-G CDX, Tussar-2, Nucofed Expectorant, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Novahistine Expectorant, Medent C, Maxifed-G CD, Maxifed CDX, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Chlor-Trimeton Decongestant, Histade CR, Phenylhistine DH Expectorant, Codehist DH, Novadyne DH, Co-Histine DH, Codahistine-DH Elixir, Ryna-C, Decohistine DH, Phenylhistine DH, NasOpen, Statuss Green, Dihistine DH, Tricode AR, Zodryl DAC, Neotuss D, Allpanto-S, Atuss-12 DM, C-Phed DM, Dicel DM, Atuss DS, Entre-S, Tanafed-DM, Rescon-DM, Vicks 44M Pediatric, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Notuss-NXD, Poly-Tussin D, Pediatex-D, Cordron-D, Cordron-D NR, Cordron-12 D, Carboxine-D, Pseudo Carb, Carboxine-PSE, Hydro-Tussin CBX, Dura-Ron, Carbic-D, Ex-Dec-TR, Coldec-TR, Andehist, PSE Allergy, Mintex PSE, Panatuss PED Drops, Biclora-D, Vanacof DX, Certuss-D, Clofera, Wal-Zyr D, Cetiri D, Co-Apap, Palgic DS, Allergy D-12, All Day Allergy-D, Allergy Relief D, Maxichlor PSE DM, Kidkare Cough/Cold, AlleRx Dose Pack, Advil Children's Allergy Sinus, DryMax, DuraHist, RelCof DN PSE, Xiral SR, Atuss HS, Atuss HD, Hydron PCS, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Dallergy PSE, Relcof PSE, ScopoHist, Pseudo CM TR, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Allergy DN, Rhinaclear, Hista-Vent PSE, Mescolor, Amdry-C, Time-Hist QD, AllePak, P-V-Tussin Syrup, KG-Tussin, T-Tanna DM, Duotan DM, Pancof, Hydro-Tussin DHC, Uni-Cof, Dihydro-CP, Allres DS, Triaminic-D Multi-Symptom Cold, AccuHist PDX Drops, Neutrahist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Z-Tuss 2, Lemohist Plus, Hyphed, Hexatussin, Tussin-V, Q-V Tussin, A-G Tussin, Welltuss HC, Tussend, Detuss, Notuss, Histinex PV, JayCof-HC, Pediatex HC, Guaifenesin DAC Liquid

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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