Medication Guide App

Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, NyQuil, Sudafed Nasal Decongestant, Claritin-D, Mucinex D, Vicks Dayquil Daytime Cold/Flu, Sudafed 12-Hour, Resperal-DM, Actifed, Zyrtec-D, Show all 1024 »Allegra-D 24 Hour, Conex, SudoGest, Cheratussin DAC, Vanacof, Allegra-D 12 Hour, Advil Cold and Sinus, Zutripro, Dimetapp Elixir, Aprodine, Tusnel, Tylenol Cold, Nyquil Cold Medicine, Entex, Theraflu Flu, Cold and Cough Powder, Coldcough Syrup, Loratadine-D 24 Hour, Claritin-D 24 Hour, M-End DMX, Sinarest, Rescon, Alka-Seltzer Plus Flu/Body, Advil Allergy Sinus, Maxifed, Zyrtec-D 12 Hour, Children's Dimetapp Decongestant Infant, Zephrex, Tusnel Pediatric, Guaifen DAC, Disophrol, Novafed, Robitussin Allergy & Cough, M-End Max D, Q-Tapp, Bromfenex, Lodrane D, Rezira, Nalex Expectorant, Congestac, Qdall, Rynex PSE, Alavert D-12 Hour Allergy and Sinus, Unifed, Sudafed 24-Hour, Histacol DM Pediatric Syrup, Suphedrine, Semprex-D, Stahist, Biotuss PE, Nacon, Robitussin Cold Cough and Flu, Clarinex-D 24 Hour, Drixoral, Triaminicin, M-END, Mar-cof BP, Tylenol Cold Severe Congestion Daytime, AllerClear D-24 Hour, Cough Formula M Multi-Symptom, Lodrane, Poly-Vent DM, Advil Cold and Sinus Liqui-Gels, Guaiatussin DAC, Actifed Cold and Sinus, Xiral SR, Deconamine, Dimetane DX, Singlet, Rymed, Sinufed, Rescon-DM, Brotapp-DM, Pseudovent, Codimal, Chlor-Trimeton Nasal Decongestant, Notuss, Q-Tapp DM, Tussin-V, Brometane DX, We Mist II LA, We Mist LA, Pancof, Dihydro-CP, Welltuss HC, Contac Cold, Contac Cold and Flu Maximum Strength, B-Vex PD, Z-Tuss 2, Tenar PSE, Aleve-D Sinus & Cold, J-Cof DHC, D-Feda II, Allergy & Congestion Relief, Silfedrine, J-Tan D HC, P-Hist DM Drops, Motrin Cold and Flu, Vanatab DX, NasOpen, Vanacof DX, Wal-Zyr D, Orlenta, Allergy Relief D, Stahist AD, Q-V Tussin, Entex PSE, Nalex CR, Triaminic-D Multi-Symptom Cold, Atuss DS, P-V-Tussin Syrup, M-End DM, D-Amine-SR, Duralex, J-TanD PD, Duratuss GP (old formulation), Lodrane 24D, Bromaline, Bromfenex PD, Ultrabrom, Ambifed CD, JayCof-HC, LoHist-D, Dicel, Dallergy DM, Welltuss EXP, Tussafin, Ultrabrom PD, Z-Tuss E, Alka-Seltzer Cold and Sinus, Z-COF 12, Capmist DM, C-Phed DPD Tann, Dixaphedrine, BromTann/DM Tann/PSE Tann, Sta-D, NyQuil Multi-Symptom, Abatuss DMX, M-End WC, A-Phedrin, Lortuss DM, Dristan Cold Non-Drowsy, Daytime Cold, Contact Cold and Sore Throat, LoHist-12D, Sinus Relief, D-Hist D, Rhinaclear, Mescolor, Nucodine, Shellcap, Contac Severe Cold and Flu Non Drowsy, Tussar SF, Tylenol Sinus Maximum Strength, Phenapap, Sinarest Sinus, Pseudoephedrine Sinus, Sinutab Regular Strength, Allergy DN, Comtrex Non-Drowsy, Anaplex, Nucofed Pediatric Expectorant, Children's Nyquil, Tricode GF, Tussin Pediatric Cold and Cough, Cophene No 2, Actedril, Aphedrid, Allegra-D 12 Hour Allergy & Congestion, Lortuss LQ, Kolephrin, Suclor, Carbodec, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant, Histex, Carboxine-PSE, Rondamine, Carbic-D, Brexin LA, Suphenamine-SR, SuTan, Deltuss DP, Ephed Plus, Bromfed SR, Maldec-DM, Decongestant Cold Formula, Actacin, Histafed, Duotan, Fedahist, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus NightTime, Triptifed, Carbodex DM Drops, Kidcare Cough and Cold, Claritin-D 12 Hour, Comtrex Cold and Flu Maximum Strength Tablet, Tussin PE, Disobrom, Q-Tussin PE, Medent DM, Bromhist-DM, Sudafed Children's Nasal Decongestant, Suphedrin, Relacon-DM NR, Profen II DM, Zaptec PSE, Guaifenex PSE 120, Decongest II, Demibid II, Guaifed, Nalex, Abletex-PSE, Pseudogest-DM, Fenex-PSE, Aleve-D Sinus & Headache, Ed A-Hist PSE, Sinus & Cold D, Myfedrine, Despec DM, Duraflu, CPM-PSE DM Drops, Drixoral Decongestant Non-Drowsy, Deka, BroveX PSB DM, Tusnel-A, Guaifenesin DAC Liquid, Sudafed Congestion, SudoGest 12 Hour, Actifed Cold & Sinus, Dihistine, Bromatane DX, Anaplex DM, Carbodex DM Syrup, Anatuss DM, Maxichlor PSE DM, Ambenyl-D, ProHist DM, Respa-AR, Maxifed DM, Tanafed DMX, Novahistine DM Expectorant with Decongestant, Profen Forte, Vanex Expectorant, Tussadur-HD, Drixomed, Tussend Expectorant, 12 Hour Cold, Dexaphen SA, Drixoral Cold and Allergy, Pharmadrine, Entuss-D JR, Decotuss-HD, Medtuss HD, Entex HC, Pseudatex HC, Deltuss DMX, Dynex HD, Hydro-Tuss XP, Polaramine Expectorant, TanaCof DM, Tannate PD-DM, Triaminic Flu, Cough & Fever, Tannate DMP-DEX, DuraTan Forte, Bromatan Plus, Dur-Tann Forte, SuTan-DM, TanDur DM, Drituss HD, Hytussin Expectorant, Entuss-D, Hydrotussin HD, Poly-Tussin XP, Deconamine CX, Tussgen Expectorant, SRC Expectorant, KG-Tuss HD, Comtrex Nighttime Flu Therapy, Su-Tuss HD Elixir, Tussafin Liquid, DuraHist D, Vanacon, Histatab D, Spantuss HD, Detussin Expectorant, Buckley's DM Decongestant, Duotan PD, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Tanafed DP, AllerDur, Dorcol Childrens Cough, Comtrex Sinus and Nasal, Nalfrx, Hexafed, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, Med-RX DM, Protuss DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Rhinosyn-X, Ru-Tuss Expectorant, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, Mardrops-DX, Medent-DMI, Z-Cof 8DM, Entex Pac, Entre-Cough, TL-Dex DM, Ambi 600/1000/30, Tenar DM, Donatussin DM Syrup, Dimacol, Novahistine DMX, Ambifed DM, Ambi 60/580/30, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, ExeFen-DMX, Profen II DM Liquid, Benylin DM-D, Pedia Relief Infant, Viravan-PDM, DiHydro-GP, Balminil DM + Decongestant, Vicks 44D, P-Tuss DM, Dexatrex D, Drixoral Cough & Congestion Liquid Caps, Uni-Cof Expectorant, Hydro-Tussin EXP, Benadryl Allergy Sinus, Respa SA, Tekral, Benaphen Plus, Benadryl Children's Allergy And Sinus, Tavist NightTime Allergy, Pancof EXP, Benylin Multi-Symptom, Actifed Allergy Day/Night, SudaTex-DM, Pseudo Max DMX, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Relacon-DM, Aldex GS DM, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Touro CC-LD, Despec Drops, Maxifed DMX, Z-Cof 12DM, Trikof-D, Pseudo DM GG, Liquicough DM, Ambi 40 /400 /20, Pseudo Cough, Relasin DM, Z-Cof DM, Allegra-D 24 Hour Allergy & Congestion, Ambifed, Theraflu Flu & Cough, Allpanto-S, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Co-Apap, Advil Children's Cold, Motrin IB Sinus, Dristan Sinus, Sine-Aid IB, Motrin Childrens Cold, Motrin Sinus Headache, Allergy Relief D 24 Hour, Sudatrate, Quadra-Hist D, Quadra-Hist D Pediatric, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Sudafed 12 Hour Pressure+Pain, Allerx-D, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Alka-Seltzer Plus-D, Zymine HC, Ambi 80/780, Ambi 60/580, Aquatab D Dose Pack, Protuss-D, Procof D, Ambi 60/1000, Mucus Relief D, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Tussgen, P-V-Tussin, SymTan, Pancof HC, Liquituss HD, Detussin, Histussin D, ColdCough HCM, H-C Tussive D, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, Comtrex Day and Night, nasofed, Hista-Tabs, Atrogen, LA Nasal Decongestant, Ridifed, Tri-Sudo, Atrofed, Atridine, Triafed, Triposed, Allerphed, Triofed, Triphed, Vi-Sudo, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Ritifed, Triacin, Actagen, Allerfrin, Altafed, Biofed-PE, Genac, Allercon, Sudrine, Seudotabs, Superfed, Afrinol, Decofed Liquid, Ridafed, Genaphed, Drixoral Non-Drowsy, ElixSure Congestion, Allermed, Cenafed, Efidac, Decofed, Hist-PSE, Dristan Cold Maximum Strength, Allerfrim, Zymine-D, Pediatex TD, Seldane-D, Viravan-P, Kid Kare Drops, Sudodrin, Elixsure Decongestant, Nexafed, Nomuc-PE, Poly-Vent, Jr., Defen-LA, Guiadrine II SR, Desal II, Deco-D, GP 500, Dexophed, Guiatex II, Deconsal LA, V-Dec-M, Guaifenex PSE 60, Guiadrine II, Iosal II, Guaifed-PSE, Guiadrine PSE 120, Pseudo-G/PSI, Ami-Tex PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Iotex PSE, Guaipax PSE, Guai-Vent/PSE, Hi Tex PSE, Guiatex PSE, Guai Sudo, Stamoist E, Tuss-LA, Touro LA, Anatuss LA, Syn-Rx, Respaire-60 SR, Nasabid, Guaimax-D, Entex T, Zephrex LA, Poly-Vent IR, Medent-LDI, Despec-Tab, G-Phed, Respaire-120 SR, Pseudocot-G, Guaibid D Pediatric, Nasatab LA, Eudal SR, Sudal 60/500, Guaivent PD, Versacaps, Guaibid D, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Guiatuss PE, Mastussin PE, Drituss GP, Coldmist, Panmist-S, Pseudo GG, Coldmist LA, SudaTex-G, Guiatex II SR, Profen II, Durasal II, Miraphen PSE, Guiadrine PSE, Coldmist Jr, Sudal SR, Aldex GS, Touro LA-LD, Despec-SR, Guaifenex PSE 85, Poly-Vent, Pseudatex, Guaifenex PSE 80, Pseudo Max, Pseudovent 400, Ambifed-G, Levall G, ExeFen-IR, Dynex, Guaivent (Ethex), Robafen PE, Respaire-30, Tusnel Pediatric Drops, Altarussin PE, Degen II, Venbid TR, Mytussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, S-Pack, Sudafed Non Drying Sinus, Panmist JR, Panmist LA, H 9600 SR, Pseudovent Ped, Guaifenex GP, Nasabid SR, Med-RX, Sinutab Non Drying, Robitussin Severe Congestion, Uni Tussin PE, Humibid GC, Mardrops-EX, Medent C, Exall-D, LoHist-PD, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Dimaphen, Brovex SR, Unit-Hist Drops, Unit-Tex 10/120 ER, Di-Bromm, Bromhist-NR, Brotapp, Respi-Tann, Corzall, Dynatuss, Cordron-DM, Tussafed, Biodec DM, Rondamine DM, Andehist DM NR, Corzall Plus, Allres Pd, Allres D, Pseudacarb, Zotex-D, AccuHist Pediatric, Bromhist Pediatric Drops, Allent, Touro A&H, Shellcap PD, Lodrane LD, Nalfed PD, Endafed, Bromhist Pediatric, Lodrane 12D, Bidhist-D, BroveX PSE, BroveX PD, BroveX PSB, Respahist, Iofed PD, Touro Allergy, Nalfed, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Lodrane Liquid, Pseubrom, Pseubrom-PD, Histex SR, M-Hist TD, Iofed, Cydec-DM Syrup, Dura-Ron DM, Andec-TR, Palgic-D, Dura-Ron, Ex-Dec-TR, Coldec-TR, Maldec, Cardec-S, Cydec, Carbiset, Palgic-DC, Andec, Mooredec, Andehist, Hydro-Tussin CBX, Mintex PSE, PSE Allergy, Palgic DS, Sinutab Maximum Strength Caplets, Sinarest Extra Strength, Carboxine-D, Pseudo Carb, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Carboxine 12D, Pediatex 12D, PSE Carbinoxamine DM, Mintex DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Pseudo Carb DM, Cordron-DM NR, Carbaxef-DM, Cydec-DM Drops, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Carb PSE 12 DM, PSE Allergy DM, Pannaz, Pseudox M, Biohist LA, Coldec D, Coldec, Pannaz S, Mintex HC, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Histex HC, Bromfed PD, Brofed, Sinus Maximum Strength, Sudafed Triple Action, Suphedrin Sinus, Ornex Maximum Strength, Allerest No Drowsiness, Tylenol Sinus Severe Congestion Daytime, Actifed Sinus Day and Night, Contac Day and Night Allergy, Benadryl Cold, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Suphedrin Plus, Genapap Sinus, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Sine-Off Maximum Strength, Contac Sinus, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Severe Cold Multi-Symptom, Theraflu (pseudoephedrine) Daytime Severe Cold, Multi-Symptom Nighttime, Tylenol Severe Cold & Flu Night Time, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Phlemgesic, All-Nite Cold, Complete Sinus Relief, Drixoral Sinus, Drixoral Cold and Flu, Hexaflu, Contac Day and Night Cold and Flu, Sinadrin Plus, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Day Relief Cold and Flu, Non-Drowsy Super Strength Contac Complete, Tylenol Cold Non-Drowsy Gelcaps, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Day Time Multi Symptom, Theraflu Flu Cold & Cough, Flutabs, Maxiflu DM, Drixoral Cold/Flu, Maxiflu CDX, Trinalin Repetabs, Dicel CD, Bromph DM, Pediahist DM Drops, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Bromhist-DM Drops, Bromplex DM, PSE Brom DM, Bromaxefed DM RF Syrup, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Brom Tann, Sildec DM, Brovex HC, Endacof HC, SymTan A, Allergy Sinus Maximum Strength, LoHist PSB, Bromcomp HC, Visvex, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Bromtapp-DM, Andehist DM NR Syrup, Dimetapp DM, Cold Medicine Plus, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, Tavist Allergy/Sinus/Headache, Maxiflu CD, SymPak II, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, BroveX PSE DM Tablets, BroveX PSE DM, Bromophed-DX, Myphetane DX Cough, Liquiphed DM, Bromadine-DM, Bromphenex DM, Bromanate DX Cough, Myphetane DX, PBM Allergy, Anaplex DMX, Bromdex D, Neo DM Syrup, Up and Up All Day Allergy Relief D, All Day Allergy-D, Comtrex Acute Head Cold, Dynahist ER, Tylenol Allergy Sinus, Allerest Sinus, Lortuss EX, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, Sudal-12 Chewable, De-Congestine, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), Tusnel C, Ambifed CDX, Ryna-CX, Robitussin-DAC, Drixoral Allergy Sinus, Novahistine Expectorant, Nucofed Expectorant, Maxifed-G CDX, Maxifed-G CD, Ambifed-G CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, C-Phed Tannate, Pediox Chewable, Sudogest Plus, Aller-Chlor Decongestant, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Histafed LA, Chlorafed, Codimal-LA Half, Klerist-D, Fedahist Gyrocaps, Clorfed II, Curaler, Genaphed Plus, SudoGest Sinus & Allergy, Histade, CP-Tannic, Mintex, Re2+30, Sudal-12, Dynahist-ER Pediatric, Tavist-DA, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tussar-2, Deproist with Codeine, EndaCof-DC, Nucofed, Notuss-DC, KG-Fed, Cycofed, Codar D, Zodryl DEC, Suttar SF, Novagest with Codeine, Codafed, Suttar-2, Codafed Pediatric, Neo AC, Polyhist NC, Tricom, Comtrex Allergy Sinus, Simplet, Drexophed SR, Desihist SA, Clarinex-D 12 Hour, Pseudodine C, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Codahistine Expectorant, Gua PC, Nucochem Pediatric Expectorant, Novadyne Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Halotussin DAC, Phenhist Expectorant, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Cycofed Expectorant, KG-Fed Expectorant, Biotussin DAC, KG-Fed Pediatric Expectorant, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Cycofed Pediatric Expectorant, Guiatussin DAC, Nucodine Expectorant, Deconsal C Expectorant, Guiatuss DAC, Mytussin DAC, Anamine, Pseudochlor, T-Tanna DM, Duotan DM, Comtrex Allergy Sinus Night and Day, Tricof, Hydro-Tussin DHC, Allres DS, Mesehist DM, Kidkare Cough/Cold, Entre-S, Neutrahist PDX Drops, AccuHist PDX Drops, Esocor P, Uni-Cof, Lemohist Plus, Hyphed, Hexatussin, A-G Tussin, KG-Tussin, Hydrotuss HC, Tussend, Pediatex HC, Comtrex Allergy Sinus Maximum Strength, Notuss-Forte, Detuss, Histinex PV, Dicel DM, Atuss-12 DM, Dihistine DH, Statuss Green, Tricode AR, Zodryl DAC, Phenylhistine DH, Notuss-NXD, Clofera, Biclora-D, Cetiri D, Chlo Tuss (Reformulated), Allerest Headache Strength, Certuss-D, Decohistine DH, Codehist DH, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Creomulsion Pediatric, Tanafed-DM, C-Phed DM, Rhinosyn-DM, Codahistine-DH Elixir, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Ryna-C, Hydron PCS, Hydrocof-HC, Codimal-LA, Chlorafed HS Timecelles, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Tanafed, Histalet, Deconamine SR, Biohist LA (old formulation), Novafed A, Duratuss DA, Clorfed, Chlorphedrin SR, Colfed-A, Anamine TD, Chlordrine SR, Time-Hist, Chlorafed Timecelles, Rescon-Ed, ND Clear, Kronofed-A, Deconomed SR, Pseudocot-C, Rinade-BID, Isophen-DF, Durafed, Chlor-Trimeton Decongestant, DryMax, AlleRx Dose Pack, DuraHist, RelCof DN PSE, Dallergy PSE, Advil Children's Allergy Sinus, Sinutab Ex-Strength, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Relcof PSE, Hista-Vent PSE, Allergy AM-PM Dose Pack, ScopoHist, VisRx Dose Pack, Histatab, Histade CR, Coldamine, Pseudo CM TR, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Duomine

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

Disclaimer

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