Medication Guide App

Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, NyQuil, Mucinex D, Sudafed Nasal Decongestant, Claritin-D, Actifed, Vicks Dayquil Daytime Cold/Flu, Resperal-DM, Zyrtec-D, Allegra-D 24 Hour, Show all 1028 »Sudafed 12-Hour, SudoGest, Cheratussin DAC, Conex, Allegra-D 12 Hour, Vanacof, Nyquil Cold Medicine, Advil Cold and Sinus, Theraflu Flu, Cold and Cough Powder, Tylenol Cold, Aprodine, Entex, Tusnel, Dimetapp Elixir, Zutripro, Alka-Seltzer Plus Flu/Body, Sinarest, Alka-Seltzer Cold and Sinus, Rezira, Semprex-D, Claritin-D 12 Hour, Robitussin Cold Cough and Flu, M-End DMX, Rymed, Drixoral, Dimetane DX, Disophrol, Brotapp-DM, Claritin-D 24 Hour, Sinufed, Loratadine-D 24 Hour, Sudafed 24-Hour, Daytime Cold, Zephrex, Guaifen DAC, M-End Max D, Actifed Cold and Sinus, Sudafed Children's Nasal Decongestant, Despec DM, Rescon, Duralex, Suphedrine, Wal-Zyr D, Dristan Sinus, NyQuil Multi-Symptom, Poly-Vent DM, Capmist DM, Congestac, Q-Tapp DM, Dixaphedrine, Mar-cof BP, Stahist, Benadryl Children's Allergy And Sinus, Tussin-V, Coldcough Syrup, Benadryl Allergy Sinus, Maxifed, Alavert D-12 Hour Allergy and Sinus, Aleve-D Sinus & Cold, Contac Cold, Silfedrine, Vanacof DX, Nacon, Zyrtec-D 12 Hour, Bromfenex, Stahist AD, Brometane DX, Deconamine, Singlet, Welltuss HC, Pancof, Allergy & Congestion Relief, Decongestant Cold Formula, AllerClear D-24 Hour, Lodrane 24D, Notuss, Cold Medicine Plus, Children's Dimetapp Decongestant Infant, Novafed, Clarinex-D 24 Hour, Deltuss DMX, Sta-D, Suphedrin, Triaminicin, Aleve-D Sinus & Headache, Cough Formula M Multi-Symptom, Respa-AR, Respi-Tann, Q-Tapp, Guaifenex PSE 120, Duratuss GP (old formulation), Rondamine, Qdall, Tussin PE, Robitussin Severe Congestion, Codahistine-DH Elixir, Ambifed CD, Levall G, Pseudovent, Flutabs, Entex PSE, Sinutab Maximum Strength, Suclor, Nucodine, Polyhist NC, Pseudoephedrine Sinus, Bromaline, Sinus Relief, Brexin LA, Allegra-D 24 Hour Allergy & Congestion, Lodrane, Duotan, Coldamine, Orlenta, Kronofed-A-Jr, Maldec-DM, Fedahist, Tussafed, Corzall, Advil Allergy Sinus, Anaplex, Clofera, M-End DM, CPM-PSE DM Drops, Children's Nyquil, Kidcare Cough and Cold, NasOpen, Phenylhistine DH, Phenylhistine DH Expectorant, Neotuss D, Triaminic-D Multi-Symptom Cold, T-Tanna DM, DuraHist, All Day Allergy-D, Mescolor, Mooredec, DryMax, AlleRx Dose Pack, JayCof-HC, Q-V Tussin, P-V-Tussin Syrup, Carbiset, Novahistine DM Expectorant with Decongestant, We Mist II LA, Profen Forte, P-V-Tussin, Histinex D, Motrin Sinus Headache, Pancof HC, Dynex, Tusnel Pediatric Drops, Desal II, Nalex, Tenar PSE, Q-Tussin PE, Robafen PE, Advil Cold and Sinus Liqui-Gels, Childrens Tylenol Cold Plus Cough, Ed A-Hist PSE, Viravan-P, Allerfrim, Aphedrid, Triptifed, Sudafed Congestion, SudoGest 12 Hour, Decofed, Allerx-D, Myfedrine, Unifed, Drixoral Decongestant Non-Drowsy, Contac Cold and Flu Maximum Strength, Tussend Expectorant, Pseudodine C, Triacin C, Clarinex-D 12 Hour, Drexophed SR, Lortuss DM, Novagest with Codeine, Dihistine, Dicel, SudoGest Sinus & Allergy, Deproist with Codeine, Mytussin DAC, Tussar SF, Benylin DM-D-E, Calmylin 4, Tussin Pediatric Cold and Cough, SudaTex-DM, Benylin Multi-Symptom, Tekral, Lortuss LQ, Z-Cof DM, Relacon-DM NR, Dimacol, Anatuss DM, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Sudogest Cold & Allergy, Guaifenesin DAC Liquid, J-TanD PD, Drixoral Cold and Flu, Brotapp, Ephed Plus, Shellcap, Ultrabrom PD, Bromdex D, BroveX PSB DM, Sinutab Ex-Strength, Kolephrin, Actifed Cold & Sinus, Dimetapp DM, BroveX PSE DM, Lodrane D, Sudogest Sinus Maximum Strength, J-Cof DHC, M-END, Tylenol Sinus Day/Night Convenience Pack, Daytime Cold and Flu Relief, Ru-Tuss, Contact Cold and Sore Throat, P-Hist DM Drops, ProHist DM, Bromophed-DX, Dallergy DM, Bromfed PD, Bromadine-DM, Robitussin Allergy & Cough, Codimal, Phenapap, Trinalin Repetabs, M-End WC, Tylenol Sinus NightTime, Suphedrin Plus, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Pseudatex HC, Entex HC, Hytussin Expectorant, Drituss HD, Hydro-Tuss XP, Dynex HD, Tylenol Allergy Complete NightTime, Sudafed Sinus Nighttime Plus Pain, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Non-Drowsy, Tylenol Cold Non-Drowsy Gelcaps, Day Relief Cold and Flu, Day Time Multi Symptom, Severe Cold Multi-Symptom, Tussafin Liquid, Contac Day and Night Allergy, Benadryl Cold, Non-Drowsy Super Strength Contac Complete, Genapap Sinus, Tussadur-HD, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Vanex Expectorant, Decotuss-HD, Sinutab Regular Strength, Allegra-D 12 Hour Allergy & Congestion, Tylenol Sinus Severe Congestion Daytime, Entuss-D JR, Nalex Expectorant, Deconamine CX, Spantuss HD, Vanacon, Tylenol Sinus Maximum Strength, Contac Severe Cold and Flu Non Drowsy, Medtuss HD, KG-Tuss HD, Poly-Tussin XP, Entuss-D, Hydrotussin HD, Su-Tuss HD Elixir, Theraflu Flu Cold & Cough, Guaibid D Pediatric, Pseudocot-G, Nasatab LA, Eudal SR, Guaivent PD, Versacaps, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Sudal 60/500, Tuss-LA, Demibid II, Guiadrine II, Iosal II, Guiatex II, Guaifenex PSE 60, D-Feda II, Stamoist E, V-Dec-M, Deconsal LA, Guaibid D, Respaire-120 SR, Mardrops-EX, Zephrex LA, Pan-Mist LA, Poly-Vent IR, Nalex CR, Tusnel-A, Sine-Off Maximum Strength, Sinarest Sinus, Ursinus, Theraflu Flu & Cough, Medent-LDI, Despec-Tab, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Fenex-PSE, Touro LA, Entex T, Guaimax-D, Anatuss LA, Comtrex Non-Drowsy, Dristan Cold Non-Drowsy, Profen II DM Liquid, Sudafed Cough, ExeClear-DM, S-Pak DM, ExeFen-DMX, Profen II DM, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, Ru-Tuss DM, Aldex GS DM, Touro CC-LD, Despec Drops, Pseudo Cough, PanMist DM, Tusnel Pediatric, Ambifed-G DM, Relacon-DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, Ambi 80/780/40, Ambi 600/1000/30, Ru-Tuss Expectorant, Rhinosyn-X, Ambi 60/580/30, Novahistine DMX, Tenar DM, Z-COF 12, Donatussin DM Syrup, Ambenyl-D, Dorcol Childrens Cough, Syn-Rx DM, Medent DM, Daytime Liquicap, Med-RX DM, TL-Dex DM, Tusnel-DM Pediatric Drops, Tusnel Ped-C, Guaifenex DM RX, Suda-Tussin DM, Pseudogest-DM, Relasin DM, Ambi 40 /400 /20, Actifed Allergy Day/Night, Tavist NightTime Allergy, Respa SA, Benaphen Plus, Ambifed, Sinus Maximum Strength, Pancof EXP, Welltuss EXP, Ornex Maximum Strength, Suphedrin Sinus, Medent-DMI, Entre-Cough, Sudafed Triple Action, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ambifed DM, Ornex, Tavist Sinus, Entex Pac, Z-Cof 8DM, Comtrex Day and Night, Hydro-Tussin EXP, Uni-Cof Expectorant, Pseudo DM GG, Pseudo Max DMX, P-Tuss DM, Benadryl Allergy Sinus Headache, Trikof-D, Z-Cof 12DM, Liquicough DM, Maxifed DMX, Maxifed DM, Mardrops-DX, Allerest No Drowsiness, Dexatrex D, Pedia Relief Infant, Viravan-PDM, Pediatex TDM, DiHydro-GP, Benylin DM-D, Balminil DM + Decongestant, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Contac Sinus, Guiadrine PSE 120, Allergy Sinus Maximum Strength, Tavist Allergy/Sinus/Headache, Sinutab Maximum Strength Caplets, Sinarest Extra Strength, Allerest Headache Strength, Maxiflu CD, Maxiflu CDX, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Quadra-Hist D, Drixoral Cold/Flu, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, nasofed, Comtrex Sinus and Nasal, Drixoral Non-Drowsy, ElixSure Congestion, Allermed, Comtrex Nighttime Flu Therapy, Simplet, Tylenol Allergy Sinus, Allerest Sinus, Comtrex Allergy Sinus, Tricom, Sinus & Cold D, Complete Sinus Relief, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Allpanto-S, Contac Day and Night Cold and Flu, Hexaflu, Multi-Symptom Nighttime, Advil Children's Cold, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Drixoral Sinus, Clear-Atadine-D, Amdry-D, Extendryl PSE, Respivent-D, Sinadrin Plus, AlleRx Dose Pack (AM Dose), Sudatrate, Allergy Relief D12, Leader Allergy Relief D-24, Allergy Relief D 24 Hour, Drixoral Allergy Sinus, Cenafed, Genaphed, Ridifed, LA Nasal Decongestant, Tri-Sudo, Triphed, Vi-Sudo, Hista-Tabs, Atrogen, A-Phedrin, Actedril, Atridine, Atrofed, Actagen, Allerfrin, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Biofed-PE, Histafed, Triacin, Triofed, Allerphed, Efidac, Decofed Liquid, Kid Kare Drops, Sudodrin, Elixsure Decongestant, Afrinol, Chlor-Trimeton Nasal Decongestant, Ridafed, Seudotabs, Sudrine, Superfed, Nexafed, Seldane-D, Allercon, Genac, Triafed, Triposed, Pediatex TD, Zymine-D, Dristan Cold Maximum Strength, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D, Hist-PSE, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Sinutab Non Drying, Sudafed Non Drying Sinus, Uni Tussin PE, Humibid GC, Med-RX, S-Pack, Altarussin PE, Venbid TR, Degen II, Guaivent (Ethex), Respaire-30, Nasabid SR, Panmist LA, Miraphen PSE, Durasal II, Guiadrine PSE, Guiatex II SR, We Mist LA, Profen II, ExeFen-IR, Panmist JR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Tusscidin PE, T-Tussin PE, Hi Tex PSE, Guai-Vent/PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Abletex-PSE, Guaifed-PSE, Defen-LA, Decongest II, Deco-D, GP 500, Iotex PSE, Ami-Tex PSE, Guiatuss PE, Mastussin PE, Mytussin PE, Robichem PE, Biotuss PE, Guaitab, Pseudo-G/PSI, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, SudaTex-G, Coldmist, Theraflu Max-D Severe Cold & Flu, Duraflu, Balminil Cough and Flu Sugar Free, Tussafin, Tussgen, Maxiflu DM, Procof D, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, Protuss-D, Hytussin, Iotussin D Liquid, Histussin D, Zymine HC, Phlemgesic, Tylenol Cold Severe Congestion Daytime, Detussin, Liquituss HD, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, SymTan, Ambi 60/1000, Mucus Relief D, Pseudovent 400, Pseudo Max, Ambifed-G, Guaifenex PSE 80, Medent, Sudal SR, Coldmist Jr, Drituss GP, Panmist-S, Pseudo GG, Coldmist LA, Pseudatex, Touro LA-LD, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Nomuc-PE, Poly-Vent, Jr., Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Guiadrine II SR, Histatab D, Co-Histine DH, Novadyne DH, Ryna-C, Bromplex HD, Anaplex HD, Codehist DH, Decohistine DH, Bromph HD, Dihistine DH, Tricode AR, Zodryl DAC, Drocon-CS, Sildec DM, Tanafed-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Rescon-DM, Creomulsion Pediatric, Carbodex DM Syrup, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Visvex, Bromcomp HC, Mintex PSE, PSE Allergy, Palgic DS, Comtrex Cold and Flu Maximum Strength Tablet, Up and Up All Day Allergy Relief D, Carboxine-D, Pseudo Carb, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Allergy Relief D, Cetiri D, Notuss-NXD, Statuss Green, Brovex HC, Endacof HC, SymTan A, Certuss-D, Biclora-D, Chlo Tuss (Reformulated), J-Tan D HC, Vanatab DX, Atuss DS, Entre-S, Hydrotuss HC, KG-Tussin, Hydron PCS, Hydrocof-HC, Cordron-HC, A-G Tussin, Hyphed, Histinex PV, Pediatex HC, Tussend, Hexatussin, Cordron-HC NR, Atuss HD, Bromtapp-DM, Andehist DM NR Syrup, Xiral SR, RelCof DN PSE, Bromaxefed DM RF Syrup, PSE Brom DM, Atuss HS, Carbofed DM Syrup, Advil Children's Allergy Sinus, Bromaline DM, Detuss, Notuss-Forte, Duotan DM, Allres DS, Brom Tann, Histacol BD Drops, Tricof, Mesehist DM, Esocor P, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, Hydro-Tussin DHC, Dihydro-CP, Pediahist DM Drops, Bromhist-DM Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromph DM, Uni-Hist PDX Drops, Uni-Cof, Z-Tuss 2, Lemohist Plus, Allanhist PDX Drops, Carboxine-PSE, Hydro-Tussin CBX, Dimaphen, Brovex SR, LoHist-PD, LoHist-12D, Exall-D, Bromhist-NR, Di-Bromm, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Rynex PSE, Lodrane 12D, Zotex-D, Corzall Plus, Bidhist-D, Bromfed SR, Pseudacarb, Allres D, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Allres Pd, Sildec, Bromaxefed RF Syrup, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Respahist, Touro A&H, Endafed, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Iofed PD, Pseubrom-PD, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Pseubrom, Iofed, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Andehist DM NR, Carbodex DM Drops, Coldec, Coldec D, Carbodec, Pediatex 12D, Carboxine 12D, Biohist LA, LoHist PSB, Brofed, Pannaz S, Pseudox M, Pannaz, Cydec, Palgic-DC, Dura-Ron, Ex-Dec-TR, Coldec-TR, Andehist, Carbic-D, Andec-TR, Andec, Cardec-S, Maldec, Palgic-D, Mintex HC, Histex HC, Carbaxef-DM, Cydec-DM Drops, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Dura-Ron DM, Cydec-DM Syrup, Cordron-DM, Dynatuss, Biodec DM, Rondamine DM, Cordron-DM NR, Pseudo Carb DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Carb PSE 12 DM, Carboxine 12 DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Dallergy PSE, Relcof PSE, Guiatussin DAC, Guiatuss DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Guaiatussin DAC, Deconsal C Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Biotussin DAC, Phenylhistine Expectorant, Suttar-2, Codafed Pediatric, Zodryl DEC, Codar D, Codafed, Suttar SF, Nuco-Tuss Expectorant, Nucochem, Gua PC, Codahistine Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Maxifed-G CD, Maxifed CDX, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Maxifed CD, Ambifed-G CDX, Z-Tuss E, Tricode GF, Ambifed CDX, Ambifed-G CD, Medent C, Novahistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Dihistine Expectorant, Dihistine Expectorant with Codeine, Nucofed Expectorant, Tussar-2, Co-Histine Expectorant, Decohistine Expectorant, Nucofed, EndaCof-DC, Tannate PD-DM, SuTan-DM, Abatuss DMX, TanaCof DM, Tanafed DMX, TanDur DM, Dur-Tann Forte, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Bromatan Plus, Polaramine Expectorant, D-Hist D, SuTan, Deltuss DP, Hexafed, Nalfrx, AllerDur, Tanafed DP, DuraHist D, BroveX PSE, SymPak II, Duotan PD, Pharmadrine, Drixoral Cold and Allergy, Comtrex Cold and Flu Maximum Strength Liquid, Trifed C, Genacol Maximum Strength, Deka, Histacol DM Pediatric Syrup, Triafed & Codeine, Allerfrin with Codeine, Notuss-DC, KG-Fed, Cycofed, Neo AC, Pediahist DM Syrup, Bromhist-DM, Disobrom, 12 Hour Cold, Dexaphen SA, Drixomed, Dexophed, Duomine, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Mesehist WC, Desihist SA, Tusnel C, Lortuss EX, Clorfed, Duratuss DA, Histalet, Tanafed, Chlorafed HS Timecelles, Novafed A, Deconamine SR, Histade CR, Chlor-Trimeton Decongestant, Durafed, Biohist LA (old formulation), Codimal-LA, Dura-Tap/PD, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Pseudocot-C, Deconomed SR, Fedahist Timecaps, Chlorphedrin SR, Colfed-A, D-Amine-SR, PediaHist DM, BroveX PSE DM Tablets, Pseudo CM TR, Allergy DN, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Rhinaclear, AllePak, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, Histatab, Bromphenex DM, Neo DM Syrup, BromTann/DM Tann/PSE Tann, Anaplex DMX, PBM Allergy, Myphetane DX, Bromanate DX Cough, Anaplex DM, Liquiphed DM, Myphetane DX Cough, Bromatane DX, ND Clear, Chlordrine SR, Sudal-12, Re2+30, Pediox Chewable, C-Phed Tannate, De-Congestine, Mintex, Histade, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Sudal-12 Chewable, Sudal-12 Tannate, AccuHist DM Pediatric Drops, Comtrex Acute Head Cold, EndaCof PD Drops, Co-Apap, Dynahist ER, Pseudoephedrine Plus, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Allerest Maximum Strength, Atrohist Pediatric Capsule, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Cophene No 2, Pseudochlor, Anamine TD, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Clorfed II, Curaler, Ryna Liquid, Genaphed Plus, Hayfebrol Liquid, Suphedrine Plus, Neutrahist Drops, Sudogest Plus, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Dicel CD

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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