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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Claritin-D, Vicks Dayquil Daytime Cold/Flu, Mucinex D, Actifed, Allegra-D 24 Hour, SudoGest, Virtussin DAC, Vicks Nyquil D Cold and Flu Nighttime Relief, Show all 1037 »Sudafed 12-Hour, Zyrtec-D, M-End DM, Advil Cold and Sinus, Allegra-D 12 Hour, Aprodine, Dimetapp Elixir, Drixoral, Cheratussin DAC, Tusnel, Tylenol Cold, Theraflu Flu, Cold and Cough Powder, Entex, Loratadine-D 24 Hour, Allerfrin, Conex, Zyrtec-D 12 Hour, Sudafed 24-Hour, Alka-Seltzer Cold and Sinus, Robitussin Cold Cough and Flu, Vanacof, Mucinex D Maximum Strength, Claritin-D 24 Hour, Clarinex-D 12 Hour, Dimetapp DM, Duomine, Despec DM, Resperal-DM, Deconamine, Chlo Tuss, Sudafed Children's Nasal Decongestant, Coldcough Syrup, Sinarest, Semprex-D, Dimetane DX, Disophrol, Zutripro, Vanacof DX, Bromaline, Advil Allergy Sinus, Stahist, Suphedrine, Contac Cold, Tylenol Sinus Maximum Strength, Comtrex Cold and Flu Maximum Strength Tablet, Efidac, Aleve-D Sinus & Cold, Dristan Sinus, M-END, Alavert D-12 Hour Allergy and Sinus, Capmist DM, Dixaphedrine, Brotapp-DM, Zephrex, Pseudovent, Nexafed, Maxifed, AccuHist DM Pediatric Drops, BromTann/DM Tann/PSE Tann, Benadryl Cold, Nacon, Tavist Allergy/Sinus/Headache, Clarinex-D 24 Hour, Theraflu (pseudoephedrine) Daytime Severe Cold, Tanafed, Dicel, Sudafed Cough Syrup, Contac Cold and Flu Maximum Strength, Alka-Seltzer Plus Flu/Body, Robitussin Allergy & Cough, Bromadine-DM, Fenex-PSE, Sinus & Cold D, Actifed Cold and Sinus, Flutabs, Dristan Cold Maximum Strength, Robitussin Cough & Cold D, BroveX PSB DM, Hydro-Tussin DHC, ScopoHist, Pseubrom, Pseubrom-PD, LoHist-D, Allerest Maximum Strength, Decongestant Cold Formula, Isophen-DF, Shellcap, Lodrane, Nucodine, Pancof, Visvex, Allegra-D 12 Hour Allergy & Congestion, Pannaz, Lortuss LQ, Claritin-D 12 Hour, Cough Formula M Multi-Symptom, Abatuss DMX, Drixoral Non-Drowsy, Triofed, Panatuss PED, Cold Medicine Plus, M-End DMX, Wal-Zyr D, Drixoral Decongestant Non-Drowsy, Ambifed-G, Medent, Notuss-NXD, Entre-S, ExeFen, Pseudo Max, Nalex, Drixoral Cold and Flu, Lodrane 24D, Bromhist Pediatric, Lodrane D, Maldec, Notuss, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Hydrotussin HD, Hycofenix, Dihydro-CP, Stahist AD, Singlet, Kidkare Cough/Cold, Brovex HC, Cetiri D, Benadryl Allergy Sinus, Benadryl Children's Allergy And Sinus, Actacin, Triacin, Novafed A, Fedahist, Chlordrine SR, Pediatex TD, Daytime Cold, Contact Cold and Sore Throat, Benylin DM-D, Cycofed, Tylenol Cold Non-Drowsy Gelcaps, Brexin LA, Anaplex, DryMax, Deka, AlleRx Dose Pack, Ambifed, PCM-LA, Amdry-C, Anamine, De-Congestine, Qdall, Coldamine, Desal II, NyCair, Ornex, Robitussin Severe Congestion, Drixoral Cold and Allergy, Pseudoephedrine Sinus, Bromhist-DM, Poly-Vent DM, Myfedrine, Genaphed, AllerClear D-24 Hour, Lortuss DM, Bromophed-DX, SuTan, Drexophed SR, Tanafed DP, Sinutab Ex-Strength, Advil Cold and Sinus Liqui-Gels, Neo DM Syrup, Entex PSE, Rescon, Aleve-D Sinus & Headache, Allerfrim, Zephrex LA, Tylenol Cold Severe Congestion Daytime, Mytussin DAC, Abletex-PSE, Ru-Tuss, Congestac, ExeFen-IR, Daytime Liquicap, Afrinol, Dihistine Expectorant with Codeine, Dimacol, M-End WC, Nucodine Expectorant, Donatussin DM Syrup, Children's Nyquil, SudaTex-DM, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Desgen DM (with pseudoephedrine), Vicks 44D, Tussin Pediatric Cold and Cough, Pseudo Max DMX, Spantuss HD, Medtuss HD, Balminil DM + Decongestant, KG-Tuss HD, Dexatrex D, Pseudo DM GG, Entuss-D, P-Tuss DM, Vanacon, Deconamine CX, Hydro-Tuss XP, Nalex Expectorant, Allegra-D 24 Hour Allergy & Congestion, Hytussin Expectorant, Genacol Maximum Strength, Drituss HD, SRC Expectorant, Entuss-D JR, Detussin Expectorant, Tussgen Expectorant, Tussend Expectorant, Tussadur-HD, Decotuss-HD, Vanex Expectorant, Childrens Tylenol Cold Plus Cough, Benaphen Plus, Hydro-Tussin EXP, Pancof EXP, Welltuss EXP, Uni-Cof Expectorant, DiHydro-GP, Viravan-PDM, Pediatex TDM, Benylin Multi-Symptom, Actifed Allergy Day/Night, Tussafin Liquid, Poly-Tussin XP, Su-Tuss HD Elixir, Tekral, Tavist NightTime Allergy, Respa SA, Pedia Relief Infant, Novahistine DMX, DuraHist D, D-Hist D, Histatab D, Duotan PD, AllerDur, Polaramine Expectorant, Tanafed DMX, SuTan-DM, TanDur DM, Tannate PD-DM, Deltuss DMX, TanaCof DM, Deltuss DP, Hexafed, PanMist DM, Maxifed DM, Sudafed Cough, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Mardrops-DX, Medent-DMI, Nalfrx, Z-Cof 8DM, Entex Pac, Entre-Cough, Dur-Tann Forte, Bromatan Plus, Triacin C, Polyhist NC, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Neo AC, KG-Fed, Codar D, Nucofed, EndaCof-DC, Notuss-DC, Pseudodine C, Theraflu Flu & Cough, Pharmadrine, Drixomed, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Dexaphen SA, 12 Hour Cold, Desihist SA, Dexophed, Disobrom, Acticon, Ambi 600/1000/30, Benylin DM-D-E, Aldex GS DM, Ru-Tuss DM, Relacon-DM, Coldmist DM, Altarussin CF, S-Pak DM, ExeClear-DM, Profen Forte DM, Profen II DM, ExeFen-DMX, Profen II DM Liquid, Z-Cof DM(obs), Ambifed-G DM, Ambi 40 /400 /20, Z-Cof DM, Liquicough DM, Maxifed DMX, Z-Cof 12DM, Relasin DM, Pseudo Cough, Tusnel Pediatric, Touro CC-LD, Relacon-DM NR, Despec Drops, Touro CC, Tussafed-LA, Anatuss DM, Z-COF 12, Ambenyl-D, Dynex HD, Ru-Tuss Expectorant, Novahistine DM Expectorant with Decongestant, Tenar DM, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Ambifed DM, Rhinosyn-X, Dorcol Childrens Cough, Multi Symptom Cough and Cold, Medent DM, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tusnel-DM Pediatric Drops, Tusnel Ped-C, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Pseudogest-DM, Trikof-D, Sudal 60/500, Sine-Aid IB, Motrin IB Sinus, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Comtrex Day and Night, Zymine HC, SymTan, Pancof HC, Liquituss HD, Detussin, Histussin D, Advil Children's Cold, Clear-Atadine-D, Respivent-D, Extendryl PSE, Allerx-D, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Amdry-D, AlleRx Dose Pack (AM Dose), Leader Allergy Relief D-24, Allergy Relief D12, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, ColdCough HCM, H-C Tussive D, Maxifed-G, Nomuc-PE, Pseudo GG TR, Ru-Tuss Jr., Mucus Relief D, Poly-Vent, Jr., Poly-Vent, Touro LA-LD, Pseudatex, Aldex GS, Despec-SR, Guaifenex PSE 85, Ambi 60/1000, Ambi 60/580, Hytussin, P-V-Tussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, Tussgen, Tussafin, Aquatab D Dose Pack, Ambi 80/780, Protuss-D, Procof D, Rezira, Quadra-Hist D, nasofed, Atrogen, Atrofed, Hista-Tabs, LA Nasal Decongestant, Ridifed, Atridine, Actedril, Triposed, Triafed, Allerphed, Aphedrid, A-Phedrin, Tri-Sudo, Triphed, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Ritifed, Histafed, Triptifed, Vi-Sudo, Actagen, Altafed, Biofed-PE, Genac, Allercon, Seudotabs, Ridafed, Sudrine, Superfed, Chlor-Trimeton Nasal Decongestant, Cenafed, Novafed, Suphedrin, Silfedrine, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Decofed Liquid, Decofed, Comtrex Acute Head Cold, Seldane-D, Hist-PSE, Ed A-Hist PSE, Zymine-D, Viravan-P, SudoGest 12 Hour, Kid Kare Drops, Sudodrin, Elixsure Decongestant, Unifed, Guaifenex PSE 80, Levall G, Guiadrine II, Demibid II, Iosal II, Respa-1st, Guiatex II, Guaifenex PSE 60, D-Feda II, Stamoist E, Tuss-LA, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, Guiadrine II SR, Defen-LA, Hi Tex PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Guai-Vent/PSE, Guiadrine PSE 120, Deco-D, Decongest II, Tenar PSE, GP 500, Guaifed-PSE, Eudal SR, Nasatab LA, Entex T, Despec-Tab, Guaimax-D, Anatuss LA, Touro LA, Medent-LDI, Poly-Vent IR, Comtrex Cold and Flu Maximum Strength Liquid, Pseudatex HC, Nalex CR, Mardrops-EX, Pan-Mist LA, Syn-Rx, Respaire-60 SR, Versacaps, Sinufed Timecelles, Guaivent PD, Guaibid D Pediatric, Pseudocot-G, G-Phed- PD, Nalex Jr, G-Phed, Nasabid, Respaire-120 SR, Guaibid D, Guaifed, Iotex PSE, Ami-Tex PSE, Dynex, Guaifenex GP, Profen II, Profen Forte, Durasal II, Pseudovent Ped, H 9600 SR, Med-RX, Humibid GC, Nasabid SR, Panmist LA, Panmist JR, Miraphen PSE, Guiadrine PSE, Coldmist LA, Pseudo GG, Coldmist Jr, Sudal SR, Pseudovent 400, Panmist-S, We Mist II LA, We Mist LA, Guiatex II SR, SudaTex-G, Coldmist, Drituss GP, Uni Tussin PE, Sinutab Non Drying, Mastussin PE, Guiatuss PE, Mytussin PE, Q-Tussin PE, Robichem PE, Biotuss PE, Guaitab, Mucus D, Pseudo-G/PSI, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, T-Tussin PE, Tusscidin PE, Tusnel Pediatric Drops, Respaire-30, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Guaivent (Ethex), Robafen PE, Tussin PE, Sinufed, Venbid TR, Degen II, Entex HC, Ambifed CDX, Bromfenex PD, Bromfenex, Histex SR, M-Hist TD, Iofed, Ultrabrom, Ultrabrom PD, Iofed PD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Respahist, Lodrane Liquid, Nalfed, Unit-Hist Drops, Unit-Tex 10/120 ER, Di-Bromm, Bromhist-NR, Brotapp, AccuHist Pediatric, Bromhist Pediatric Drops, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Sildec, Q-Tapp, Touro A&H, Endafed, Anaplex HD, Drocon-CS, Bromplex HD, Bromph HD, Endacof HC, Bromcomp HC, J-Cof DHC, Sildec DM, Brom Tann, Histacol BD Drops, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, SymTan A, J-Tan D HC, BroveX PSE, Rynex PSE, BroveX PD, BroveX PSB, B-Vex PD, Lodrane 12D, Bidhist-D, LoHist PSB, Triaminic Flu, Cough & Fever, Brofed, Bromfed PD, Bromfed SR, Brovex SR, Dimaphen, PSE Allergy DM, Carb PSE 12 DM, Cordron-12 DM, Pediatex 12 DM, Histex HC, Tri-Vent HC, Carboxine 12 DM, Carboxine DM, Pseudo Carb DM, Cordron-DM NR, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Mintex HC, Pannaz S, Cydec, Carbiset, Palgic-DC, Andec, Mooredec, Carboxine 12D, Pediatex 12D, Biohist LA, Pseudox M, Coldec D, Coldec, Carbodec, Pediatex-DM, Decahist-DM, Corzall, Respi-Tann, Allres Pd, Allres D, Zotex-D, Pseudacarb, Carb Pseudo-Tan, Respi-Tann Pd, LoHist-12D, LoHist-PD, J-TanD PD, Exall-D, Re-Tann, Corzall Plus, Andehist DM NR, Dura-Ron DM, Cydec-DM Syrup, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Maldec-DM, Rondamine DM, Cordron-DM, Carbodex DM Drops, Dynatuss, Tussafed, Biodec DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Comtrex Non-Drowsy, Theraflu Flu Cold & Cough, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Day Relief Cold and Flu, Non-Drowsy Super Strength Contac Complete, Tusnel-A, Maxiflu DM, Phlemgesic, All-Nite Multi-Symptom Cold/Flu Relief, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Duraflu, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Sinus Maximum Strength, Sudafed Triple Action, Suphedrin Sinus, Ornex Maximum Strength, Allerest No Drowsiness, Tylenol Sinus NightTime, Actifed Sinus Day and Night, Contac Day and Night Allergy, Severe Cold Multi-Symptom, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Multi-Symptom Nighttime, Tylenol Severe Cold & Flu Night Time, Tylenol Allergy Sinus, Allerest Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Sinarest Extra Strength, Allerest Headache Strength, Kolephrin, Codimal, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Simplet, Tricom, Comtrex Allergy Sinus, Triaminicin, Sinutab Maximum Strength Caplets, Drixoral Sinus, Drixoral Allergy Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Sinadrin Plus, Complete Sinus Relief, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, Maxiflu CD, Maxiflu CDX, Drixoral Cold/Flu, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Bromanate DX Cough, Myphetane DX, Bromatane DX, Myphetane DX Cough, Brometane DX, Liquiphed DM, Dallergy DM, Bromdex D, BroveX PSE DM Tablets, PediaHist DM, BroveX PSE DM, PBM Allergy, Anaplex DMX, Anaplex DM, Bromphenex DM, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromtapp-DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, EndaCof PD Drops, Histacol DM Pediatric Syrup, Sinutab Regular Strength, Sine-Off Maximum Strength, Genapap Sinus, Suphedrin Plus, Phenapap, Contac Sinus, Dristan Cold Non-Drowsy, Sinutab Maximum Strength Non Drowsy, Tavist Sinus, Bayer Select Sinus Pain Formula, Ephed Plus, Sinus Relief, Sinarest Sinus, Sinutab Maximum Strength, Mesehist WC, Rydex, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Mar-cof BP, SymPak II, Respa-AR, Ursinus, Sta-D, Trinalin Repetabs, Dicel CD, Rondamine, Cardec-S, SudoGest Sinus & Allergy, Genaphed Plus, Hayfebrol Liquid, Suphedrine Plus, Chlor-Trimeton Allergy Decongestant SR, Atrohist Pediatric Capsule, Sudogest Cold & Allergy, Ryna Liquid, Chlor-Trimeton Allergy Decongestant, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Tavist-DA, Dynahist-ER Pediatric, Sudal-12 Chewable, C-Phed Tannate, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), Pediox Chewable, Sudal-12, Histade, CP-Tannic, Mintex, Suclor, Re2+30, Chlorafed, Curaler, Colfed-A, Chlorphedrin SR, D-Amine-SR, Deconomed SR, Duralex, Pseudocot-C, Orlenta, Fedahist Timecaps, Chlorafed HS Timecelles, Histalet, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Rinade-BID, Suphenamine-SR, Klerist-D, Cophene No 2, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Pseudochlor, Rescon-Ed, ND Clear, Kronofed-A, Anamine TD, Time-Hist, Chlorafed Timecelles, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Guiatussin DAC, Guiatuss DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Tussar SF, Nucofed Pediatric Expectorant, Guaiatussin DAC, Deconsal C Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Biotussin DAC, Phenylhistine Expectorant, Suttar SF, Novagest with Codeine, Codafed, Suttar-2, Codafed Pediatric, Guaifenesin DAC Liquid, Codahistine Expectorant, Nucochem, Nuco-Tuss Expectorant, Guaifen DAC, Dihistine, Gua PC, Nucochem Pediatric Expectorant, Novadyne Expectorant, Ambifed-G CD, Ambifed CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Tricode GF, Z-Tuss E, M-End Max D, Dynahist ER, Allpanto-S, Lortuss EX, Tusnel C, Maxifed-G CD, Maxifed-G CDX, Decohistine Expectorant, Co-Histine Expectorant, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Deproist with Codeine, Tussar-2, Ryna-CX, Robitussin-DAC, Medent C, Novahistine Expectorant, Nucofed Expectorant, Clorfed, Duratuss DA, Codehist DH, Decohistine DH, Phenylhistine DH Expectorant, Novadyne DH, Ryna-C, Co-Histine DH, Phenylhistine DH, Zodryl DAC, Statuss Green, Poly-Tussin D, NasOpen, Dihistine DH, Tricode AR, Codahistine-DH Elixir, Neotuss D, C-Phed DM, Tanafed-DM, Atuss-12 DM, Dicel DM, Atuss DS, Rescon-DM, Kidcare Cough and Cold, Rhinosyn-DM, Co-Apap, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Clofera, Certuss-D, Carboxine-PSE, Hydro-Tussin CBX, Cordron-D, Pediatex-D, Cordron-12 D, Cordron-D NR, Andehist, Coldec-TR, Andec-TR, Palgic-D, Carbic-D, Dura-Ron, Ex-Dec-TR, Pseudo Carb, Carboxine-D, Allergy Relief D, All Day Allergy-D, Biclora-D, Panatuss PED Drops, Vanatab DX, Up and Up All Day Allergy Relief D, KS Aller-Tec D-12, Mintex PSE, PSE Allergy, Palgic DS, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Allergy D-12, Maxichlor PSE DM, Neutrahist PDX Drops, RelCof DN PSE, Xiral SR, Dallergy PSE, Relcof PSE, Hista-Vent PSE, Mescolor, DuraHist, Advil Children's Allergy Sinus, Cordron-HC, Hydrocof-HC, Cordron-HC NR, Atuss HD, Atuss HS, Time-Hist QD, AllePak, Duotan, Chlor-Trimeton Decongestant, Durafed, Biohist LA (old formulation), Deconamine SR, Histade CR, Histatab, Allergy DN, Rhinaclear, Pseudo CM TR, Allergy AM-PM Dose Pack, VisRx Dose Pack, Hydron PCS, Hydrotuss HC, Tricof, T-Tanna DM, Uni-Cof, Z-Tuss 2, Lemohist Plus, Duotan DM, Allres DS, CPM-PSE DM Drops, AccuHist PDX Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Notuss-Forte, Detuss, Q-V Tussin, Tussin-V, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hyphed, Hexatussin, JayCof-HC, Histinex PV, Pediatex HC, Tussend, Welltuss HC, Zodryl DEC

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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