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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Claritin-D, Actifed, Sudafed 12-Hour, Allegra-D 24 Hour, Mucinex D, Sudafed Congestion, Resperal-DM, Zyrtec-D, Allegra-D 12 Hour, Show all 1033 »Conex, Virtussin DAC, SudoGest, Vicks Dayquil Daytime Cold/Flu, Dimetapp Elixir, Advil Cold and Sinus, Claritin-D 24 Hour, Vanacof, Entex, Loratadine-D 24 Hour, Sinarest, Zutripro, Cheratussin DAC, Duomine, Chlo Tuss, Drixoral, Allegra-D 24 Hour Allergy & Congestion, Capmist DM, Sudafed 24-Hour, Semprex-D, Tylenol Cold, Stahist, Robitussin Cold Cough and Flu, Suphedrine, Aprodine, Zyrtec-D 12 Hour, Claritin-D 12 Hour, Cold Medicine Plus, Aleve-D Sinus & Cold, M-End DMX, Maldec, Children's Dimetapp Decongestant Infant, Benadryl Children's Allergy And Sinus, Hycofenix, Aleve-D Sinus & Headache, Robitussin Allergy & Cough, Silfedrine, Nexafed, Shellcap, Mytussin DAC, Tylenol Sinus Day/Night Convenience Pack, Afrinol, Dimetane DX, Actifed Cold and Sinus, Allegra-D 12 Hour Allergy & Congestion, Brexin LA, Deconamine SR, Deconamine, Allergy Relief D 24 Hour, Rescon, Dimacol, Contac Cold, Maxifed, Vicks Nyquil D Cold and Flu Nighttime Relief, Guaifenex PSE 120, Stahist AD, Clorfed, Orlenta, Zephrex, KS Aller-Tec D-12, Duralex, Pseudo GG, Drexophed SR, Theraflu Flu, Cold and Cough Powder, Ursinus, Ambi 80/780, Trinalin Repetabs, Mintex, Tricom, Tekral, Q-Tapp, Lodrane, Decongestant Cold Formula, Sinutab Ex-Strength, Tusnel, AllerClear D-24 Hour, Alavert D-12 Hour Allergy and Sinus, Ryna-C, Suclor, Suphedrin, Panmist JR, Neotuss D, Advil Allergy Sinus, Triafed, Daytime Cold, Ed A-Hist PSE, Dristan Sinus, Sudal SR, Motrin Cold and Flu, Sinarest Extra Strength, Touro LA-LD, Singlet, Anaplex, Lortuss LQ, Sinarest Sinus, Mescolor, Q-Tapp DM, Brofed, Vanacof DX, Ambenyl-D, BroveX PSE, VisRx Dose Pack, Novafed A, Tusnel-DM Pediatric Drops, Bromaline, Rezira, Histussin D, LoHist-D, Corzall, Sildec, Hyphed, NasOpen, LoHist-PD, Coldcough Syrup, Dihydro-CP, Ryna Liquid, Fedahist Gyrocaps, Relasin DM, Despec Drops, SudoGest Sinus & Allergy, Benylin Multi-Symptom, Dynahist-ER Pediatric, Zaptec PSE, Profen II, Carbofed DM Syrup, Day Relief Cold and Flu, All-Nite Multi-Symptom Cold/Flu Relief, Alka-Seltzer Cold and Sinus, Disophrol, Ornex, Nasatab LA, Clarinex-D 12 Hour, Statuss Green, Respaire-120 SR, Drixoral Cold and Allergy, Flutabs, Myfedrine, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, Sudafed Children's Nasal Decongestant, Ridafed, Duraflu, Pseudoephedrine Sinus, Cenafed, Brotapp-DM, Clarinex-D 24 Hour, Ambifed CD, Benadryl Severe Allergy & Sinus Headache, Decongest II, Andehist, Deproist with Codeine, Cycofed, Tussin-V, Day Time Multi Symptom, Entex T, Zymine-D, Entex PSE, Esocor P, Congestac, Kidkare Cough/Cold, Sudafed 12 Hour Pressure+Pain, Mar-cof BP, Atrogen, M-End DM, Z-Cof 12DM, Trikof-D, Z-Cof DM(obs), Despec DM, Relacon-DM NR, Tusnel Pediatric, Pseudo Cough, Pseudo DM GG, Ambifed-G DM, Altarussin CF, Liquicough DM, Ambi 40 /400 /20, Z-Cof DM, Touro CC-LD, Maxifed DMX, Vanex Expectorant, Coldmist DM, Tussadur-HD, Tussend Expectorant, Detussin Expectorant, Decotuss-HD, Entuss-D JR, Benaphen Plus, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Tussgen Expectorant, SRC Expectorant, KG-Tuss HD, Medtuss HD, Spantuss HD, Vanacon, Hydrotussin HD, Entuss-D, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Respa SA, Benadryl Allergy Sinus, Vicks 44D, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Drixoral Cough & Congestion Liquid Caps, Buckley's DM Decongestant, SudaTex-DM, P-Tuss DM, Dexatrex D, Pedia Relief Infant, Viravan-PDM, Welltuss EXP, Actifed Allergy Day/Night, Tavist NightTime Allergy, Pancof EXP, Hydro-Tussin EXP, Pediatex TDM, DiHydro-GP, Uni-Cof Expectorant, Pseudo Max DMX, Ambi 60/580/30, Bromatan Plus, DuraTan Forte, Dur-Tann Forte, TanDur DM, SuTan-DM, C-Phed DPD Tann, Tannate DMP-DEX, Dexaphen SA, 12 Hour Cold, Drixomed, Pharmadrine, Dixaphedrine, Tannate PD-DM, Deltuss DMX, Duotan PD, Histatab D, Tanafed DP, AllerDur, SuTan, DuraHist D, D-Hist D, Abatuss DMX, TanaCof DM, Tanafed DMX, Polaramine Expectorant, Disobrom, Dexophed, Zodryl DEC, Codafed Pediatric, Codar D, Nucofed, EndaCof-DC, Suttar-2, Codafed, Codahistine Expectorant, Gua PC, Guaifenesin DAC Liquid, Novagest with Codeine, Suttar SF, Notuss-DC, KG-Fed, Pseudodine C, Trifed C, Deka, Genacol Maximum Strength, Desihist SA, Triafed & Codeine, Allerfrin with Codeine, Nucodine, Neo AC, Polyhist NC, Triacin C, Deltuss DP, Hexafed, Medent DM, Tusnel Ped-C, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Pseudogest-DM, Suda-Tussin DM, Rhinosyn-X, Ru-Tuss Expectorant, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Protuss DM, Med-RX DM, ExeClear-DM, Profen II DM Liquid, S-Pak DM, Ru-Tuss DM, Aldex GS DM, ExeFen-DMX, Profen II DM, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, Novahistine DMX, Anatuss DM, Mardrops-DX, Medent-DMI, Maxifed DM, PanMist DM, Sudafed Cough, Poly-Vent DM, Entre-Cough, Nalfrx, Lortuss DM, Z-Cof 8DM, Entex Pac, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, Tenar DM, Ambifed DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Su-Tuss HD Elixir, Calmylin 4, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Relacon-DM, Sinufed Timecelles, Detussin, Liquituss HD, Zymine HC, Motrin IB Sinus, Motrin Childrens Cold, Sine-Aid IB, SymTan, Pancof HC, Histinex D, Iotussin D Liquid, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Amdry-D, AlleRx Dose Pack (AM Dose), Extendryl PSE, Respivent-D, Allerx-D, Sudatrate, Allergy & Congestion Relief, Comtrex Day and Night, Advil Children's Cold, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Hytussin, P-V-Tussin, Despec-SR, Aldex GS, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Pseudatex, Medent, Pseudovent 400, Pseudo Max, Ambifed-G, Levall G, Guaifenex PSE 80, Nomuc-PE, Maxifed-G, Protuss-D, Aquatab D Dose Pack, Procof D, Tussafin, Tussgen, Mucinex D Maximum Strength, Ambi 60/580, Ru-Tuss Jr., Pseudo GG TR, ExeFen, Mucus Relief D, Ambi 60/1000, Sinus & Cold D, Quadra-Hist D Pediatric, Ridifed, LA Nasal Decongestant, Tri-Sudo, Triphed, Vi-Sudo, Hista-Tabs, Atrofed, Aphedrid, Triofed, A-Phedrin, Actedril, Atridine, Triptifed, Actagen, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Allerfrin, Biofed-PE, Histafed, Triacin, Allerphed, Triposed, Sudrine, Seudotabs, Superfed, Chlor-Trimeton Nasal Decongestant, Decofed Liquid, Genaphed, Novafed, nasofed, Quadra-Hist D, Drixoral Non-Drowsy, ElixSure Congestion, Allermed, Efidac, Decofed, Allerfrim, Hist-PSE, Pediatex TD, Allercon, Genac, Dristan Cold Maximum Strength, Seldane-D, Sudodrin, Kid Kare Drops, Elixsure Decongestant, Unifed, Viravan-P, Coldmist Jr, Coldmist LA, V-Dec-M, Stamoist E, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Tuss-LA, Sudal 60/500, Guaivent PD, Versacaps, Guaibid D Pediatric, Pseudocot-G, Eudal SR, Guaifenex PSE 60, Demibid II, Deco-D, Desal II, Tenar PSE, GP 500, Guaifed-PSE, Defen-LA, Guiadrine II SR, Iosal II, Guiadrine II, Respa-1st, Guiatex II, Ambifed, Dihistine, G-Phed- PD, Mardrops-EX, Nalex CR, Zephrex LA, Pan-Mist LA, Poly-Vent IR, Cough Formula M Multi-Symptom, Pseudatex HC, Drituss HD, Hytussin Expectorant, Hydro-Tuss XP, Dynex HD, Entex HC, Medent-LDI, Despec-Tab, G-Phed, Nasabid, Guaibid D, Guaifed, Nalex Jr, Respaire-60 SR, Syn-Rx, Anatuss LA, Guaimax-D, Touro LA, Fenex-PSE, Nalex, Abletex-PSE, Guiadrine PSE 120, Panmist LA, Nasabid SR, H 9600 SR, Pseudovent, Pseudovent Ped, Med-RX, Humibid GC, Sudafed Non Drying Sinus, S-Pack, Sinutab Non Drying, Robitussin Severe Congestion, Uni Tussin PE, Guaifenex GP, Dynex, Coldmist, SudaTex-G, Drituss GP, We Mist II LA, Panmist-S, We Mist LA, Guiatex II SR, Profen Forte, ExeFen-IR, Durasal II, Miraphen PSE, Guiadrine PSE, Altarussin PE, Tusnel Pediatric Drops, Ru-Tuss DE, Pseudo-G/PSI, Guaifenex RX, Guaitab, Biotuss PE, Ami-Tex PSE, Iotex PSE, Hi Tex PSE, Guai-Vent/PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Guiatuss PE, Mastussin PE, Degen II, Venbid TR, Robafen PE, Guaivent (Ethex), Respaire-30, Sinufed, Tussin PE, Q-Tussin PE, Mytussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussafin Liquid, Tusnel C, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Touro A&H, Endafed, Lodrane D, Rynex PSE, Bromfed PD, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, Allent, Shellcap PD, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Bromfenex, Pseubrom-PD, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Ultrabrom PD, J-Tan D HC, SymTan A, Bromph DM, Pediahist DM Drops, Uni-Hist PDX Drops, Allanhist PDX Drops, Brom Tann, Histacol BD Drops, Bromhist-DM Drops, Bromplex DM, Bromaxefed DM RF Syrup, Bromtapp-DM, PSE Brom DM, Bromaline DM, Uni-Hist DM Pediatric Drops, ProHist DM, P-Hist DM Drops, Visvex, Bromph HD, Bromcomp HC, Endacof HC, Brovex HC, Bromplex HD, Anaplex HD, Sildec DM, Carbodex DM Syrup, J-Cof DHC, M-END, Drocon-CS, Lodrane Liquid, Nalfed, Carbofed DM Drops, Carbaxef-DM, Decahist-DM, Pediatex-DM, Pseudo Carb DM, Cordron-DM NR, Cydec-DM Drops, Dura-Ron DM, Biodec DM, Tussafed, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Mintex DM, PSE Carbinoxamine DM, Histex HC, Tri-Vent HC, Mintex HC, Pannaz S, Nacon, Pseudox M, Pediatex 12 DM, Cordron-12 DM, Carboxine DM, PSE Carb DM Drops, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Dynatuss, Cordron-DM, Bromhist-NR, Di-Bromm, Brotapp, Brovex SR, Lodrane 24D, Dimaphen, Unit-Hist Drops, Unit-Tex 10/120 ER, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Bromhist Pediatric Drops, AccuHist Pediatric, LoHist-12D, J-TanD PD, Zotex-D, Pseudacarb, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Allres D, Allres Pd, Re-Tann, Exall-D, Respi-Tann Pd, Carb Pseudo-Tan, Respi-Tann, Andehist DM NR Syrup, Bromphenex DM, Maxiflu DM, Theraflu Max-D Severe Cold & Flu, Tusnel-A, Theraflu Flu Cold & Cough, Comtrex Non-Drowsy, Alka-Seltzer Plus Flu/Body, Balminil Cough and Flu Sugar Free, Phlemgesic, Tylenol Severe Cold & Flu Night Time, All-Nite Cold, Multi-Symptom Nighttime, NyCair, Tylenol Cold Severe Congestion Daytime, Contac Severe Cold and Flu Non Drowsy, Non-Drowsy Super Strength Contac Complete, Sudafed Sinus Nighttime Plus Pain, Contac Day and Night Allergy, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Tylenol Sinus Severe Congestion Daytime, Tylenol Sinus NightTime, Benadryl Cold, Severe Cold Multi-Symptom, Tylenol Cold Non-Drowsy Gelcaps, Contact Cold and Sore Throat, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Contac Day and Night Cold and Flu, Hexaflu, Kolephrin, Codimal, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus, Simplet, Alka-Seltzer Plus-D, Co-Apap, Triaminic Flu, Cough & Fever, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Allerest Headache Strength, Triaminicin, Sinadrin Plus, Complete Sinus Relief, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Drixoral Cold/Flu, Maxiflu CDX, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Actifed Cold & Sinus, Tavist Allergy/Sinus/Headache, Maxiflu CD, Sudafed Triple Action, Sinus Maximum Strength, PediaHist DM, AccuHist DM Pediatric Drops, BroveX PSE DM Tablets, BroveX PSE DM, BroveX PSB DM, PBM Allergy, EndaCof PD Drops, Dimetapp DM, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Theraflu Flu & Cough, Contac Cold and Flu Maximum Strength, Anaplex DMX, BromTann/DM Tann/PSE Tann, Liquiphed DM, Bromophed-DX, Brometane DX, Bromadine-DM, Anaplex DM, Myphetane DX Cough, Bromatane DX, Neo DM Syrup, Bromdex D, Dallergy DM, Myphetane DX, Bromanate DX Cough, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Ephed Plus, Bayer Select Sinus Pain Formula, Sinus Relief, Dristan Cold Non-Drowsy, Sine-Off Maximum Strength, Contac Sinus, Sinutab Maximum Strength Non Drowsy, Tavist Sinus, Ornex Maximum Strength, Suphedrin Sinus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, SymPak II, Dicel CD, M-End WC, Rydex, Mesehist WC, Sta-D, Respa-AR, Suphedrin Plus, Genapap Sinus, Phenapap, Sinutab Maximum Strength, Ru-Tuss, Pannaz, Biohist LA, Codimal-LA Half, Klerist-D, Clorfed II, Curaler, Histafed LA, Chlorafed, Anamine, Cophene No 2, Time-Hist, Anamine TD, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant SR, Allerest Maximum Strength, Tavist-DA, CP-Tannic, Re2+30, Histade, Atrohist Pediatric Capsule, Suphedrine Plus, Neutrahist Drops, Sudogest Plus, Sudogest Cold & Allergy, Genaphed Plus, Hayfebrol Liquid, Chlordrine SR, ND Clear, Biohist LA (old formulation), Durafed, Duratuss DA, Histalet, Tanafed, Fedahist, Duotan, Chlor-Trimeton Decongestant, ScopoHist, Coldamine, Allergy AM-PM Dose Pack, Histatab, Histade CR, Chlorafed HS Timecelles, Codimal-LA, Rinade-BID, Pseudocot-C, Suphenamine-SR, Isophen-DF, Kronofed-A, Deconomed SR, D-Amine-SR, Dura-Tap/PD, Kronofed-A-Jr, Fedahist Timecaps, Chlorphedrin SR, Colfed-A, Sudal-12, Pediox Chewable, Nucochem Pediatric Expectorant, Novadyne Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Cycofed Expectorant, Nucodine Pediatric, Halotussin DAC, Phenhist Expectorant, Co-Histine Expectorant, Tussar-2, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Biotussin DAC, Tussar SF, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Nucofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Guaiatussin DAC, Deconsal C Expectorant, Guiatuss DAC, Guiatussin DAC, Cycofed Pediatric Expectorant, Nucofed Expectorant, Novahistine Expectorant, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, Comtrex Acute Head Cold, M-End Max D, AccuHist Drops (old formulation), SudaHist, De-Congestine, C-Phed Tannate, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Lortuss EX, Allpanto-S, Maxifed-G CDX, Maxifed-G CD, Robitussin-DAC, Ryna-CX, Medent C, Maxifed CDX, Maxifed CD, Tricode GF, Z-Tuss E, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Pseudo CM TR, Allergy DN, Panatuss PED, Panatuss PED Drops, Vanatab DX, Certuss-D, Poly-Tussin D, Clofera, Biclora-D, Wal-Zyr D, Up and Up All Day Allergy Relief D, Childrens Tylenol Cold Plus Cough, All Day Allergy-D, Allergy Relief D, Cetiri D, Notuss-NXD, Dihistine DH, Codahistine-DH Elixir, Co-Histine DH, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Pediatric, Creomulsion Cough/Cold/Allergy, Novadyne DH, Phenylhistine DH Expectorant, Zodryl DAC, Tricode AR, Phenylhistine DH, Decohistine DH, Codehist DH, Palgic DS, Mintex PSE, Andec, Palgic-DC, Mooredec, Rondamine, Palgic-D, Cardec-S, Cydec, Carbiset, Coldec, Coldec D, Carbodec, Pediatex 12D, Carboxine 12D, Andec-TR, Carbic-D, Cordron-12 D, Cordron-D NR, Pseudo Carb, Carboxine-D, PSE Allergy, Pediatex-D, Cordron-D, Ex-Dec-TR, Dura-Ron, Coldec-TR, Hydro-Tussin CBX, Carboxine-PSE, Kidcare Cough and Cold, Children's Nyquil, Hydrocof-HC, Hydron PCS, Cordron-HC, Cordron-HC NR, Atuss HS, Atuss HD, Hydrotuss HC, P-V-Tussin Syrup, Hexatussin, Welltuss HC, Q-V Tussin, A-G Tussin, KG-Tussin, Advil Children's Allergy Sinus, AlleRx Dose Pack, Amdry-C, PCM-LA, Time-Hist QD, AllePak, Rhinaclear, Hista-Vent PSE, Relcof PSE, DuraHist, DryMax, Xiral SR, RelCof DN PSE, Dallergy PSE, Tussend, Pediatex HC, Neutrahist PDX Drops, Maxichlor PSE DM, AccuHist PDX Drops, CPM-PSE DM Drops, Triaminic-D Multi-Symptom Cold, Mesehist DM, Entre-S, Atuss DS, Tanafed-DM, Rescon-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Allres DS, Duotan DM, Notuss, Notuss-Forte, Detuss, Histinex PV, JayCof-HC, Lemohist Plus, Z-Tuss 2, Pancof, T-Tanna DM, Tricof, Hydro-Tussin DHC, Uni-Cof, Guaifen DAC

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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