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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Claritin-D, Allegra-D 24 Hour, Actifed, Zyrtec-D, Sudafed 12-Hour, Mucinex D, Allegra-D 12 Hour, Vicks Dayquil Daytime Cold/Flu, SudoGest, Show all 1032 »Resperal-DM, Conex, Vanacof, Advil Cold and Sinus, Virtussin DAC, Sudafed 24-Hour, Loratadine-D 24 Hour, Dimetapp Elixir, Entex, Zutripro, Zyrtec-D 12 Hour, Sudafed Congestion, Cheratussin DAC, Tylenol Cold, Drixoral, Semprex-D, Claritin-D 24 Hour, Duomine, Claritin-D 12 Hour, Sinarest, Aprodine, Stahist, Decofed, Chlo Tuss, Allergy & Congestion Relief, Allegra-D 24 Hour Allergy & Congestion, Robitussin Cold Cough and Flu, Bromatane DX, Rescon, Cold Medicine Plus, Theraflu Flu, Cold and Cough Powder, Children's Dimetapp Decongestant Infant, Maxifed, Robitussin Allergy & Cough, AllerClear D-24 Hour, Aleve-D Sinus & Cold, Suphedrine, Capmist DM, Hycofenix, Daytime Cold, Deconamine, Deconamine SR, Dimetane DX, Actifed Cold and Sinus, Brexin LA, Allegra-D 12 Hour Allergy & Congestion, Nexafed, Advil Allergy Sinus, Polyhist NC, Alka-Seltzer Cold and Sinus, Contac Cold, Afrinol, Sinutab Ex-Strength, M-End DMX, Stahist AD, Maldec, Silfedrine, Sudafed Children's Nasal Decongestant, Profen Forte, Disophrol, Suphedrin, Pseudo GG, Drexophed SR, Zephrex, NasOpen, Esocor P, Ryna-C, Dristan Sinus, Congestac, Benadryl Children's Allergy And Sinus, Codimal, Brotapp-DM, Deltuss DMX, Ursinus, Alavert D-12 Hour Allergy and Sinus, Ambenyl-D, Mytussin DAC, Q-Tapp, Duraflu, Mintex, Shellcap, Tekral, Clarinex-D 12 Hour, Bromfenex, Triafed, Klerist-D, Duralex, Orlenta, Histussin D, M-END, Respaire-120 SR, Zaptec PSE, Ambi 80/780, Mucus Relief D, Entex T, Corzall, Sildec, Brofed, Bromaline, Maxifed-G, Touro LA-LD, Guaifenex PSE 120, Wal-Zyr D, Defen-LA, BroveX PSE, Pseudovent, Profen II, Dynex, Versacaps, Kidcare Cough and Cold, Tusnel-DM Pediatric Drops, Pseudogest-DM, Maxifed DM, Despec Drops, Despec DM, Dynahist-ER Pediatric, Suclor, LoHist-D, Tusnel, SuTan, Disobrom, Clarinex-D 24 Hour, Cycofed, Dexaphen SA, Drixoral Cold and Allergy, Ambifed CD, Abatuss DMX, Allerest Maximum Strength, SudoGest Sinus & Allergy, Lortuss LQ, Pancof, Dihydro-CP, Kidkare Cough/Cold, M-End DM, Vanacof DX, Phenylhistine DH, Neotuss D, Coldcough Syrup, Benaphen Plus, VisRx Dose Pack, Novafed A, Anaplex, Coldamine, Xiral SR, Hyphed, Decongestant Cold Formula, Entex PSE, Andehist, Mar-cof BP, Day Relief Cold and Flu, Sudafed 12 Hour Pressure+Pain, Day Time Multi Symptom, Alka-Seltzer Plus Flu/Body, Myfedrine, Drixoral Decongestant Non-Drowsy, Ornex, Pseudoephedrine Sinus, Comtrex Day and Night, Allergy Relief D 24 Hour, Zymine-D, Dimetapp DM, Carbofed DM Syrup, Q-Tapp DM, All-Nite Multi-Symptom Cold/Flu Relief, Vicks Nyquil D Cold and Flu Nighttime Relief, Flutabs, Tripohist D, Bromdex D, Allerphed, Aphedrid, Atrogen, Theraflu (pseudoephedrine) Daytime Severe Cold, Contact Cold and Sore Throat, Benadryl Severe Allergy & Sinus Headache, Singlet, Allerest Sinus, Sinarest Extra Strength, Motrin Cold and Flu, Genacol Maximum Strength, Allerfrim, Kid Kare Drops, Ed A-Hist PSE, Sudodrin, Comtrex Cold and Flu Maximum Strength Liquid, Hist-PSE, S-Pak DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Coldmist DM, Relacon-DM, Pediatex TD, Ru-Tuss DM, Aldex GS DM, Respa SA, Efidac, Med-RX DM, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Protuss DM, Tussin Cough and Cold, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Profen Forte DM, Profen II DM, Decofed Liquid, Genac, Allercon, Entuss-D JR, Triposed, ExeFen-DMX, Profen II DM Liquid, ExeClear-DM, Tusnel Pediatric, Pseudo Cough, Viravan-P, Seldane-D, Tussin Pediatric Cold and Cough, Vicks 44D, Drixoral Cough & Congestion Liquid Caps, SudoGest 12 Hour, Dexatrex D, Buckley's DM Decongestant, Balminil DM + Decongestant, Benylin DM-D, Uni-Cof Expectorant, Hydro-Tussin EXP, Pancof EXP, Dristan Cold Maximum Strength, DiHydro-GP, Pedia Relief Infant, Viravan-PDM, Pediatex TDM, Benylin Multi-Symptom, Actifed Allergy Day/Night, Liquicough DM, Benadryl Allergy Sinus, Maxifed DMX, Ambi 40 /400 /20, Z-Cof DM, Relacon-DM NR, Welltuss EXP, Relasin DM, Elixsure Decongestant, Unifed, Pseudo Max DMX, SudaTex-DM, P-Tuss DM, Pseudo DM GG, Tusnel Ped-C, Tavist NightTime Allergy, Z-Cof 12DM, Trikof-D, Touro CC-LD, Rhinosyn-X, Drixomed, 12 Hour Cold, Pharmadrine, Dixaphedrine, Altafed, Dexophed, Desihist SA, Ritifed, Triacin, Histafed, Biofed-PE, Allerfrin, Tannate DMP-DEX, Triptifed, Actagen, Vi-Sudo, Tannate PD-DM, TanaCof DM, SuTan-DM, TanDur DM, C-Phed DPD Tann, DuraTan Forte, Bromatan Plus, Dur-Tann Forte, Actacin, Trisofed, Nucofed, Codar D, EndaCof-DC, Notuss-DC, KG-Fed, Zodryl DEC, Codafed Pediatric, Novagest with Codeine, Suttar SF, Codafed, Suttar-2, Nucodine, Neo AC, Deka, Zymine DXR, Childrens Tylenol Cold Plus Cough, Pseudocot-T, Trip-PSE, Pseudodine C, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Tanafed DMX, Polaramine Expectorant, Benylin DM-D-E, Ambi 600/1000/30, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, TL-Dex DM, Balminil DM + Decongestant + Expectorant, Mardrops-DX, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, Ambifed DM, Tenar DM, Decotuss-HD, Ru-Tuss Expectorant, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Novahistine DMX, Dimacol, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Medent-DMI, Poly-Vent DM, AllerDur, Tanafed DP, Deltuss DP, Hexafed, Nalfrx, Duotan PD, Tri-Sudo, D-Hist D, DuraHist D, Histatab D, Triphed, Lortuss DM, Ridifed, Triofed, Z-Cof 8DM, Entex Pac, Entre-Cough, A-Phedrin, Actedril, LA Nasal Decongestant, Hista-Tabs, Atrofed, Atridine, Suda-Tussin DM, Deconamine CX, Med-RX, Humibid GC, Nasabid SR, Panmist LA, Panmist JR, Uni Tussin PE, Robitussin Severe Congestion, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, H 9600 SR, Pseudovent Ped, We Mist LA, SudaTex-G, Coldmist, Drituss GP, Guiatex II SR, Guiadrine PSE, Guaifenex GP, ExeFen-IR, Durasal II, Miraphen PSE, Tusnel Pediatric Drops, Respaire-30, Guaifenex RX, Ru-Tuss DE, Guaitab, Biotuss PE, Guiatuss PE, Pseudo-G/PSI, Ami-Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Mastussin PE, Mytussin PE, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Sinufed, Tussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, We Mist II LA, Panmist-S, Procof D, Protuss-D, Rezira, Tussafin, Tussgen, Aquatab D Dose Pack, Mucinex D Maximum Strength, ExeFen, Ambi 60/1000, Motrin IB Sinus, Ambi 60/580, P-V-Tussin, Hytussin, SymTan, Liquituss HD, Detussin, Zymine HC, Pancof HC, ColdCough HCM, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, Ru-Tuss Jr., Pseudo GG TR, Levall G, Guaifenex PSE 80, Medent, Pseudatex, Ambifed-G, Pseudovent 400, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Clear-Atadine-D, Advil Children's Cold, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Despec-SR, Aldex GS, Advil Cold and Sinus Liqui-Gels, Motrin Sinus Headache, Motrin Childrens Cold, Sine-Aid IB, Hi Tex PSE, Guai-Vent/PSE, ElixSure Congestion, Allermed, Drixoral Non-Drowsy, nasofed, Quadra-Hist D, Novafed, Comtrex Cold and Flu Maximum Strength Tablet, Cenafed, Dynex HD, Entex HC, Pseudatex HC, Quadra-Hist D Pediatric, Aleve-D Sinus & Headache, Sudatrate, Leader Allergy Relief D-24, Allergy Relief D12, Nalex CR, AlleRx Dose Pack (AM Dose), Amdry-D, Sinus & Cold D, Allerx-D, Respivent-D, Extendryl PSE, Genaphed, Hydro-Tuss XP, Poly-Tussin XP, Cough Formula M Multi-Symptom, Entuss-D, Hydrotussin HD, Chlor-Trimeton Nasal Decongestant, Nalex Expectorant, SRC Expectorant, Tussadur-HD, Tussend Expectorant, Detussin Expectorant, Tussgen Expectorant, Superfed, Sudrine, Su-Tuss HD Elixir, Tussafin Liquid, Hytussin Expectorant, Drituss HD, Vanacon, Spantuss HD, Seudotabs, Ridafed, KG-Tuss HD, Medtuss HD, Mardrops-EX, Zephrex LA, Guaifenex PSE 60, D-Feda II, Demibid II, Guiadrine II, Iosal II, Deconsal LA, Duratuss GP (old formulation), Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Respa-1st, Guiatex II, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Tenar PSE, Deco-D, Ambifed, Guiadrine II SR, Decongest II, Desal II, Eudal SR, Nasatab LA, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Anatuss LA, Guaimax-D, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Respaire-60 SR, Nasabid, Guaivent PD, Guaifenesin DAC Liquid, Guaibid D Pediatric, Pseudocot-G, Sinufed Timecelles, G-Phed- PD, G-Phed, Guaibid D, Guaifed, Nalex Jr, Vanex Expectorant, Ambifed CDX, Allent, Touro A&H, Shellcap PD, Lodrane LD, Respahist, Nalfed PD, Endafed, Bromhist Pediatric, Lodrane D, Rynex PSE, BroveX PD, BroveX PSB, B-Vex PD, Iofed PD, Ultrabrom PD, Nalfed, Lodrane Liquid, Touro Allergy, Andehist NR Syrup, Bromhist Pediatric Drops, Bromaxefed RF Syrup, Pseubrom, Iofed, Bromfenex PD, Pseubrom-PD, Histex SR, M-Hist TD, Ultrabrom, Lodrane 12D, Bidhist-D, ProHist DM, Brom Tann, P-Hist DM Drops, Carbodex DM Syrup, J-Cof DHC, Sildec DM, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Drocon-CS, Anaplex HD, Lodrane, J-Tan D HC, LoHist PSB, Bromfed PD, Bromfed SR, SymTan A, Brovex HC, Bromph HD, Bromplex HD, Visvex, Bromcomp HC, Endacof HC, AccuHist Pediatric, Unit-Tex 10/120 ER, Mintex DM, Pseudo Carb DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine 12 DM, Carboxine DM, Cordron-DM NR, Pediatex-DM, Cydec-DM Drops, Dura-Ron DM, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Carb PSE 12 DM, PSE Allergy DM, Pannaz, Nacon, Biohist LA, Coldec D, Coldec, Pseudox M, Pannaz S, Pediatex 12 DM, Cordron-12 DM, Tri-Vent HC, Histex HC, Mintex HC, Cydec-DM Syrup, Maldec-DM, LoHist-12D, LoHist-PD, J-TanD PD, Exall-D, Respi-Tann Pd, Re-Tann, Lodrane 24D, Dimaphen, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brotapp, Brovex SR, Carb Pseudo-Tan, Respi-Tann, Dynatuss, Cordron-DM, Tussafed, Biodec DM, Rondamine DM, Carbodex DM Drops, Andehist DM NR, Allres D, Allres Pd, Pseudacarb, Zotex-D, Corzall Plus, Uni-Hist DM Pediatric Drops, Bromaline DM, Comtrex Non-Drowsy, Theraflu Flu Cold & Cough, Contac Severe Cold and Flu Non Drowsy, Non-Drowsy Super Strength Contac Complete, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Alka-Seltzer Plus-D, Tusnel-A, Phlemgesic, Tylenol Cold Severe Congestion Daytime, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Maxiflu DM, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Sudafed Triple Action, Tylenol Sinus Severe Congestion Daytime, Sinus Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus NightTime, Contac Day and Night Allergy, Benadryl Cold, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, NyCair, Multi-Symptom Nighttime, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Allerest Headache Strength, Triaminicin, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Tylenol Allergy Sinus, Kolephrin, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Simplet, Tricom, Comtrex Allergy Sinus, Actifed Cold & Sinus, Tavist Allergy/Sinus/Headache, Hexaflu, Drixoral Sinus, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Drixoral Cold and Flu, Drixoral Allergy Sinus, Maxiflu CDX, Maxiflu CD, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, PBM Allergy, BroveX PSE DM, BroveX PSB DM, Anaplex DMX, Neo DM Syrup, BromTann/DM Tann/PSE Tann, BroveX PSE DM Tablets, PediaHist DM, Co-Apap, Histacol DM Pediatric Syrup, Allpanto-S, EndaCof PD Drops, AccuHist DM Pediatric Drops, Dallergy DM, Myphetane DX, Andehist DM NR Syrup, Bromphenex DM, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Anaplex DM, Bromadine-DM, Myphetane DX Cough, Bromanate DX Cough, Bromophed-DX, Liquiphed DM, Brometane DX, Pediahist DM Syrup, Bromhist-DM, Sine-Off Maximum Strength, Contac Sinus, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Suphedrin Plus, Genapap Sinus, Dristan Cold Non-Drowsy, Sinus Relief, Tavist Sinus, Benadryl Allergy Sinus Headache, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Phenapap, Sinarest Sinus, Rydex, M-End WC, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, SymPak II, Dicel CD, Ru-Tuss, Sinutab Maximum Strength, Respa-AR, Sta-D, Trinalin Repetabs, Carbodec, Pediatex 12D, Histafed LA, Chlorafed, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Neutrahist Drops, Sudogest Plus, Curaler, Clorfed II, Cophene No 2, Pseudochlor, Anamine, Codimal-LA Half, Fedahist Gyrocaps, Ryna Liquid, Sudogest Cold & Allergy, Re2+30, Histade, Sudal-12, Pediox Chewable, De-Congestine, C-Phed Tannate, CP-Tannic, Tavist-DA, Hayfebrol Liquid, Genaphed Plus, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Rescon-Ed, Chlorafed Timecelles, Tanafed, Fedahist, Chlorafed HS Timecelles, Codimal-LA, Dura-Tap/PD, Kronofed-A-Jr, Histalet, Clorfed, Duotan, Chlor-Trimeton Decongestant, Durafed, Biohist LA (old formulation), Duratuss DA, Fedahist Timecaps, Chlorphedrin SR, ND Clear, Kronofed-A, Chlordrine SR, Anamine TD, Time-Hist, Isophen-DF, Suphenamine-SR, D-Amine-SR, Colfed-A, Deconomed SR, Pseudocot-C, Rinade-BID, Sudal-12 Chewable, Dicel, Nucodine Pediatric, Nuco-Tuss Pediatric Expectorant, Cycofed Expectorant, KG-Fed Expectorant, Deconsal C Expectorant, Nucodine Expectorant, Nucochem Expectorant, Nucochem Pediatric Expectorant, Dihistine Expectorant, Dihistine Expectorant with Codeine, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Guaiatussin DAC, Guiatuss DAC, Nucochem, Nuco-Tuss Expectorant, Guaifen DAC, Dihistine, Gua PC, Phenylhistine Expectorant, Biotussin DAC, Cycofed Pediatric Expectorant, Guiatussin DAC, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Decohistine Expectorant, Co-Histine Expectorant, Comtrex Acute Head Cold, M-End Max D, Lortuss EX, Tusnel C, Tricode GF, Z-Tuss E, Dynahist ER, Qdall, SudaHist, Sudal-12 Tannate, AccuHist Drops (old formulation), Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Triaminic Flu, Cough & Fever, Ambifed-G CD, Novahistine Expectorant, Medent C, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Ryna-CX, Robitussin-DAC, Maxifed CD, Ambifed-G CDX, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Histade CR, Histatab, Poly-Tussin D, Clofera, Notuss-NXD, Statuss Green, Tricode AR, Dihistine DH, Certuss-D, Vanatab DX, Cetiri D, Allergy Relief D, Biclora-D, Contac Cold and Flu Maximum Strength, Panatuss PED, Zodryl DAC, Decohistine DH, Creomulsion Pediatric, Creomulsion Cough/Cold/Allergy, Children's Nyquil, Rescon-DM, Tanafed-DM, Vicks 44M Pediatric, Rhinosyn-DM, Phenylhistine DH Expectorant, Codehist DH, Novadyne DH, Co-Histine DH, Codahistine-DH Elixir, All Day Allergy-D, Up and Up All Day Allergy Relief D, Palgic-D, Cardec-S, Andec-TR, Carbic-D, Ex-Dec-TR, Dura-Ron, Rondamine, Mooredec, Carbiset, Carboxine 12D, Cydec, Palgic-DC, Andec, Coldec-TR, Hydro-Tussin CBX, Mintex PSE, PSE Allergy, Palgic DS, Theraflu Flu & Cough, KS Aller-Tec D-12, Carboxine-D, Pseudo Carb, Cordron-D, Carboxine-PSE, Pediatex-D, Cordron-D NR, Cordron-12 D, C-Phed DM, Atuss-12 DM, Atuss HS, Atuss HD, Advil Children's Allergy Sinus, AlleRx Dose Pack, DuraHist, DryMax, Cordron-HC NR, Cordron-HC, P-V-Tussin Syrup, KG-Tussin, Hydrotuss HC, Hydron PCS, Hydrocof-HC, RelCof DN PSE, Dallergy PSE, Allergy DN, Rhinaclear, Pseudo CM TR, ScopoHist, Allergy AM-PM Dose Pack, AllePak, Time-Hist QD, Mescolor, Relcof PSE, Hista-Vent PSE, PCM-LA, Amdry-C, A-G Tussin, Q-V Tussin, Triaminic-D Multi-Symptom Cold, Mesehist DM, Allres DS, Duotan DM, Tricof, T-Tanna DM, CPM-PSE DM Drops, AccuHist PDX Drops, Atuss DS, Dicel DM, Entre-S, Maxichlor PSE DM, Neutrahist PDX Drops, Hydro-Tussin DHC, Uni-Cof, Tussend, Pediatex HC, Welltuss HC, Hexatussin, Tussin-V, JayCof-HC, Histinex PV, Lemohist Plus, Z-Tuss 2, Notuss-Forte, Notuss, Detuss, Codahistine Expectorant

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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