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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Claritin-D, Sudafed Congestion, Mucinex D, Allegra-D 24 Hour, Vicks Dayquil Daytime Cold/Flu, SudoGest, Actifed, Drixoral, Virtussin DAC, Show all 1037 »Vicks Nyquil D Cold and Flu Nighttime Relief, Zyrtec-D, Dimetapp Elixir, Sudafed 12-Hour, Advil Cold and Sinus, Allegra-D 12 Hour, Theraflu Flu, Cold and Cough Powder, Claritin-D 24 Hour, Tusnel, Semprex-D, Allerfrin, Clarinex-D 12 Hour, Entex, Tylenol Cold, Loratadine-D 24 Hour, Resperal-DM, Conex, Sudafed Children's Nasal Decongestant, Sudafed 24-Hour, Aprodine, Mucinex D Maximum Strength, Zyrtec-D 12 Hour, Alka-Seltzer Cold and Sinus, Robitussin Cold Cough and Flu, Despec DM, Capmist DM, Alavert D-12 Hour Allergy and Sinus, Duomine, Deconamine, Vanacof, Dimetapp DM, Zutripro, Tylenol Sinus Maximum Strength, Wal-Zyr D, Cheratussin DAC, Sinarest, Bromaline, Disophrol, Sinutab Ex-Strength, Brotapp-DM, Advil Allergy Sinus, Vanacof DX, Benadryl Cold, Coldcough Syrup, Comtrex Cold and Flu Maximum Strength Tablet, Efidac, Dristan Sinus, Dixaphedrine, Stahist, Theraflu (pseudoephedrine) Daytime Severe Cold, Zephrex, Triofed, Clarinex-D 24 Hour, AlleRx Dose Pack, Claritin-D 12 Hour, Nucodine Expectorant, Nexafed, Advil Cold and Sinus Liqui-Gels, Sudafed Cough Syrup, Tanafed, Maldec, AccuHist DM Pediatric Drops, Nucodine, Alka-Seltzer Plus Flu/Body, Decongestant Cold Formula, Suphedrine, Chlo Tuss, Dimetane DX, Pseubrom-PD, Panatuss PED, Pseubrom, Lodrane 24D, Lodrane, Allegra-D 12 Hour Allergy & Congestion, Contac Cold, Bromadine-DM, BromTann/DM Tann/PSE Tann, BroveX PSB DM, AllerClear D-24 Hour, Dristan Cold Maximum Strength, Sinus & Cold D, Hydro-Tussin DHC, Allermed, Tavist Allergy/Sinus/Headache, M-END, Robitussin Cough & Cold D, Drixoral Decongestant Non-Drowsy, Congestac, Afrinol, Myfedrine, Pancof, Fenex-PSE, Lortuss LQ, Cardec-S, Stahist AD, Maxifed, Nacon, LoHist-D, Isophen-DF, ScopoHist, Pseudovent, Mooredec, Respaire-60 SR, Cough Formula M Multi-Symptom, Sinutab Maximum Strength Non Drowsy, Benylin DM-D, Maldec-DM, Chlordrine SR, Duralex, Fedahist, Aleve-D Sinus & Cold, Histalet, De-Congestine, Orlenta, Brexin LA, Qdall, Hexatussin, Dihistine Expectorant with Codeine, Novafed A, Sudogest Cold & Allergy, Mytussin DAC, Pseudochlor, Notuss, Dicel, AllePak, Pediatex-D, Allegra-D 24 Hour Allergy & Congestion, Poly-Tussin XP, Tusnel Pediatric Drops, Brotapp, Aleve-D Sinus & Headache, Bromhist Pediatric, Shellcap, Hydrotussin HD, Pannaz, Coldamine, Benaphen Plus, Benadryl Allergy Sinus, Lodrane D, Amdry-C, Su-Tuss HD Elixir, DryMax, Benadryl Children's Allergy And Sinus, Ambenyl-D, Nalex, Abatuss DMX, Zephrex LA, Entex PSE, Ambifed, Desal II, Ambifed-G, Medent, Zaptec PSE, Codahistine-DH Elixir, Tricode AR, Triacin, Allerfrim, Seldane-D, Notuss-NXD, Ephed Plus, NasOpen, Tylenol Sinus Severe Congestion Daytime, Drixoral Sinus, Pseudo Max, Kidcare Cough and Cold, Entre-S, Children's Nyquil, Tylenol Cold Severe Congestion Daytime, Kidkare Cough/Cold, M-End DMX, ExeFen-IR, Deka, NyCair, Theraflu Max-D Severe Cold & Flu, Flutabs, Contact Cold and Sore Throat, Tylenol Cold Non-Drowsy Gelcaps, Drixoral Cold and Allergy, Contac Severe Cold and Flu Non Drowsy, Drexophed SR, Duraflu, Cycofed, Codar D, Kolephrin, Pseudoephedrine Sinus, Bromhist-DM, SudoGest 12 Hour, Poly-Vent DM, Allerest Maximum Strength, Donatussin DM Syrup, Contac Cold and Flu Maximum Strength, Silfedrine, Neo DM Syrup, Robitussin Allergy & Cough, M-End WC, Genaphed, Dihydro-CP, Cetiri D, Actifed Cold and Sinus, Pseudogest-DM, Lortuss DM, Dimacol, Deconamine CX, Nalex Expectorant, Viravan-PDM, DiHydro-GP, Pediatex TDM, Entuss-D, Pedia Relief Infant, Medtuss HD, Spantuss HD, Uni-Cof Expectorant, Vanacon, Tussafin Liquid, KG-Tuss HD, Drituss HD, Tussgen Expectorant, Hydro-Tuss XP, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Dynex HD, Hytussin Expectorant, Pseudatex HC, Entex HC, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Tussadur-HD, Tussend Expectorant, Hycofenix, SRC Expectorant, Welltuss EXP, Pancof EXP, Detussin Expectorant, Benylin Multi-Symptom, Tekral, Respa SA, Tavist NightTime Allergy, Actifed Allergy Day/Night, Hydro-Tussin EXP, Daytime Liquicap, Simplet, Tricom, Singlet, Z-Cof 8DM, Entex Pac, Nalfrx, Hexafed, AllerDur, Tanafed DP, SuTan, Deltuss DP, Rescon, Entre-Cough, Medent-DMI, Ambi 80/780/40, Benylin DM-D-E, Calmylin 4, Ambi 60/580/30, Ambifed DM, Ambi 600/1000/30, TL-Dex DM, Maxifed DM, Mardrops-DX, PanMist DM, Sudafed Cough, Balminil DM + Decongestant + Expectorant, Duotan PD, Histatab D, 12 Hour Cold, Acticon, Dexaphen SA, Drixomed, Pharmadrine, Disobrom, Dexophed, Allerest Sinus, Tylenol Allergy Sinus, Codimal, Comtrex Allergy Sinus, Desihist SA, Tannate DMP-DEX, C-Phed DPD Tann, Tanafed DMX, TanaCof DM, Polaramine Expectorant, D-Hist D, DuraHist D, Deltuss DMX, Tannate PD-DM, Bromatan Plus, DuraTan Forte, Dur-Tann Forte, TanDur DM, SuTan-DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Pseudo Cough, Despec Drops, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Relacon-DM NR, Touro CC-LD, Altarussin CF, Coldmist DM, Z-Cof DM(obs), Ambifed-G DM, Tusnel Pediatric, Liquicough DM, Maxifed DMX, Buckley's DM Decongestant, Dexatrex D, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Tussin Pediatric Cold and Cough, P-Tuss DM, Desgen DM (with pseudoephedrine), Trikof-D, Z-Cof 12DM, Pseudo DM GG, Pseudo Max DMX, SudaTex-DM, Relacon-DM, Aldex GS DM, Suda-Tussin DM, Guaifenex DM RX, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Syn-Rx DM, Dorcol Childrens Cough, Anatuss DM, Z-COF 12, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Multi Symptom Cough and Cold, Tussin Cough and Cold, Profen II DM Liquid, ExeFen-DMX, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Profen II DM, Profen Forte DM, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Balminil DM + Decongestant, Stamoist E, Triaminic Flu, Cough & Fever, Advil Children's Cold, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Co-Apap, Clear-Atadine-D, Allpanto-S, Motrin Sinus Headache, Motrin Childrens Cold, Zymine HC, Histussin D, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Allergy Relief D12, Leader Allergy Relief D-24, Sudafed 12 Hour Pressure+Pain, Allerx-D, Quadra-Hist D Pediatric, Quadra-Hist D, Theraflu Flu & Cough, Respivent-D, Extendryl PSE, Allergy Relief D 24 Hour, Allergy & Congestion Relief, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Detussin, Liquituss HD, Ambi 60/1000, Mucus Relief D, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, ExeFen, Ru-Tuss Jr., Poly-Vent, Jr., Poly-Vent, Nomuc-PE, Maxifed-G, Pseudo GG TR, Protuss-D, Procof D, H-C Tussive D, Entuss-D Liquid, ColdCough HCM, Pancof HC, SymTan, Histinex D, Iotussin D Liquid, Tussafin, Rezira, Tussgen, P-V-Tussin, Hytussin, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Atrogen, Atrofed, Hista-Tabs, LA Nasal Decongestant, Tri-Sudo, Ridifed, Atridine, Actedril, Triposed, Triafed, Allerphed, Aphedrid, A-Phedrin, Triphed, Vi-Sudo, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Actagen, Triptifed, Altafed, Biofed-PE, Histafed, Genac, Allercon, Cenafed, Novafed, Ridafed, Seudotabs, Sudrine, Children's Dimetapp Decongestant Infant, ElixSure Congestion, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, nasofed, Suphedrin, Drixoral Non-Drowsy, Superfed, Chlor-Trimeton Nasal Decongestant, Hist-PSE, Comtrex Acute Head Cold, Ed A-Hist PSE, Zymine-D, Pediatex TD, Viravan-P, Unifed, Decofed, Decofed Liquid, Kid Kare Drops, Sudodrin, Elixsure Decongestant, Guaifenex PSE 85, Despec-SR, Guiatex II, Respa-1st, Guiadrine II SR, Defen-LA, Deco-D, Decongest II, Iosal II, Guiadrine II, Deconsal LA, Duratuss GP (old formulation), D-Feda II, Guaifenex PSE 60, Demibid II, Tenar PSE, GP 500, Guaipax PSE, Guai Sudo, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Guiatex PSE, Hi Tex PSE, Abletex-PSE, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, V-Dec-M, Pseudodine C, Touro LA, Anatuss LA, Syn-Rx, Nasabid, G-Phed, Guaimax-D, Entex T, Pan-Mist LA, Mardrops-EX, Poly-Vent IR, Medent-LDI, Despec-Tab, Respaire-120 SR, Guaibid D, Nasatab LA, Pseudocot-G, Eudal SR, Sudal 60/500, Tuss-LA, Guaibid D Pediatric, Guaivent PD, Nalex Jr, Guaifed, G-Phed- PD, Sinufed Timecelles, Versacaps, Mucus D, Ru-Tuss DE, Guiadrine PSE, Miraphen PSE, Guiatex II SR, We Mist LA, SudaTex-G, Durasal II, Profen Forte, Pseudovent Ped, H 9600 SR, Guaifenex GP, Dynex, Profen II, Coldmist, Drituss GP, Guaifenex PSE 80, Levall G, Pseudatex, Touro LA-LD, Aldex GS, Pseudovent 400, Sudal SR, Panmist-S, We Mist II LA, Pseudo GG, Coldmist LA, Coldmist Jr, Panmist JR, Panmist LA, T-Tussin PE, Robichem PE, Tusscidin PE, Tussin PE, Sinufed, Q-Tussin PE, Mytussin PE, Guaitab, Guaifenex RX, Biotuss PE, Guiatuss PE, Mastussin PE, Venbid TR, Degen II, Uni Tussin PE, Robitussin Severe Congestion, Humibid GC, Med-RX, Nasabid SR, Sinutab Non Drying, Sudafed Non Drying Sinus, Guaivent (Ethex), Robafen PE, Respaire-30, Altarussin PE, S-Pack, Nalex CR, Deproist with Codeine, Q-Tapp, Sildec, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Hist Drops, Unit-Tex 10/120 ER, Bromaxefed RF Syrup, Andehist NR Syrup, Iofed, Ultrabrom, Lodrane Liquid, Nalfed, Touro Allergy, Di-Bromm, Bromhist-NR, Carb Pseudo-Tan, Respi-Tann Pd, Respi-Tann, Corzall, Allres Pd, Re-Tann, Exall-D, Dimaphen, Brovex SR, LoHist-PD, LoHist-12D, J-TanD PD, M-Hist TD, Histex SR, Bidhist-D, Bromfed SR, Lodrane 12D, Rynex PSE, BroveX PSE, Bromfed PD, Brofed, SymTan A, Brovex HC, J-Tan D HC, Cold Medicine Plus, LoHist PSB, BroveX PD, BroveX PSB, Iofed PD, Respahist, Ultrabrom PD, Bromfenex, Bromfenex PD, Nalfed PD, Lodrane LD, Endafed, B-Vex PD, Touro A&H, Allent, Shellcap PD, Allres D, Pseudacarb, Pediatex 12D, Carbodec, Carboxine 12D, Carbiset, Cydec, Coldec, Coldec D, Mintex HC, Histex HC, Pannaz S, Pseudox M, Biohist LA, Palgic-DC, Andec, Hydro-Tussin CBX, Andehist, Carboxine-PSE, Cordron-D, Cordron-D NR, Coldec-TR, Ex-Dec-TR, Palgic-D, Rondamine, Andec-TR, Carbic-D, Dura-Ron, Tri-Vent HC, Pediatex 12 DM, Rondamine DM, Biodec DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Tussafed, Dynatuss, Corzall Plus, Zotex-D, Andehist DM NR, Carbodex DM Drops, Cordron-DM, Carbaxef-DM, Carbofed DM Drops, Carboxine 12 DM, Carboxine DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, PSE Carb DM Drops, PSE Carbinoxamine DM, Pediatex-DM, Decahist-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, Endacof HC, Bromcomp HC, Benadryl Allergy Sinus Headache, Sudogest Sinus Maximum Strength, Tavist Sinus, Ornex, Bayer Select Sinus Pain Formula, Allerest No Drowsiness, Ornex Maximum Strength, Sudafed Triple Action, Tylenol Sinus Day/Night Convenience Pack, Drixoral Cold/Flu, Sinus Maximum Strength, Suphedrin Sinus, Sinus Relief, Dristan Cold Non-Drowsy, Maxiflu CDX, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Respa-AR, Sinarest Sinus, Phenapap, Sine-Off Maximum Strength, Contac Sinus, Sinutab Regular Strength, Genapap Sinus, Suphedrin Plus, Tylenol Sinus NightTime, Actifed Sinus Day and Night, Phlemgesic, Sinadrin Plus, Balminil Cough and Flu Sugar Free, Maxiflu DM, Tusnel-A, All-Nite Multi-Symptom Cold/Flu Relief, Multi-Symptom Nighttime, Contac Day and Night Cold and Flu, Hexaflu, Drixoral Allergy Sinus, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Complete Sinus Relief, Theraflu Flu Cold & Cough, Contac Day and Night Allergy, Daytime Cold, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Severe Cold Multi-Symptom, Daytime Non-Drowsy, Day Time Multi Symptom, Comtrex Non-Drowsy, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Daytime Cold and Flu Relief, Sta-D, Trinalin Repetabs, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromtapp-DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Anaplex HD, Drocon-CS, Bromplex HD, Bromph HD, Visvex, J-Cof DHC, Sildec DM, Brom Tann, Histacol BD Drops, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Bromphenex DM, Anaplex DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Maxiflu CD, Actifed Cold & Sinus, EndaCof PD Drops, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, SymPak II, Dicel CD, Mar-cof BP, Rydex, Mesehist WC, PediaHist DM, BroveX PSE DM Tablets, Myphetane DX Cough, Bromatane DX, Bromophed-DX, Liquiphed DM, Brometane DX, Bromanate DX Cough, Myphetane DX, PBM Allergy, BroveX PSE DM, Anaplex DMX, Bromdex D, Dallergy DM, Cordron-12 D, Pseudo Carb, Pediox Chewable, Sudal-12, C-Phed Tannate, Sudal-12 Chewable, Sudal-12 Tannate, Re2+30, Suclor, Dynahist-ER Pediatric, Tavist-DA, CP-Tannic, Histade, Mintex, SudaHist, AccuHist Drops (old formulation), Tricode GF, Z-Tuss E, Ambifed CD, Ambifed CDX, Ambifed-G CD, Tusnel C, Lortuss EX, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, Dynahist ER, M-End Max D, Comtrex Allergy Sinus Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Atrohist Pediatric Capsule, Anaplex, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Rescon-Ed, Chlorafed Timecelles, Kronofed-A, Suphenamine-SR, ND Clear, Anamine TD, Time-Hist, Fedahist Gyrocaps, Clorfed II, Genaphed Plus, Ryna Liquid, SudoGest Sinus & Allergy, Hayfebrol Liquid, Suphedrine Plus, Neutrahist Drops, Sudogest Plus, Chlorafed, Curaler, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Ambifed-G CDX, Maxifed CD, Gua PC, Dihistine, Codahistine Expectorant, Guaifenesin DAC Liquid, Novagest with Codeine, Guaifen DAC, Nucochem, Tussar SF, Nucofed Pediatric Expectorant, Biotussin DAC, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Suttar SF, Codafed, Polyhist NC, Neo AC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, KG-Fed, Notuss-DC, Codafed Pediatric, Suttar-2, Zodryl DEC, Nucofed, EndaCof-DC, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Tussar-2, Nucofed Expectorant, Drixoral Cold and Flu, Co-Histine Expectorant, Decohistine Expectorant, Novahistine Expectorant, Medent C, Maxifed-G CD, Maxifed CDX, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Dihistine Expectorant, Phenhist Expectorant, Deconsal C Expectorant, KG-Fed Expectorant, Guaiatussin DAC, Guiatuss DAC, Guiatussin DAC, Cycofed Expectorant, Nucodine Pediatric, Novadyne Expectorant, Halotussin DAC, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Rinade-BID, Pseudocot-C, C-Phed DM, Tanafed-DM, M-End DM, Atuss-12 DM, Dicel DM, Rescon-DM, Creomulsion Pediatric, Neotuss D, Ryna-C, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Atuss DS, Maxichlor PSE DM, T-Tanna DM, Duotan DM, Tricof, Uni-Cof, Z-Tuss 2, Allres DS, Triaminic-D Multi-Symptom Cold, AccuHist PDX Drops, Neutrahist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Co-Histine DH, Novadyne DH, KS Aller-Tec D-12, Allergy D-12, Up and Up All Day Allergy Relief D, All Day Allergy-D, Allergy Relief D, Triaminicin, Sinutab Maximum Strength Caplets, PSE Allergy, Carboxine-D, Mintex PSE, Palgic DS, Allergy Sinus Maximum Strength, Biclora-D, Sinarest Extra Strength, Phenylhistine DH, Zodryl DAC, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Dihistine DH, Statuss Green, Vanatab DX, Panatuss PED Drops, Certuss-D, Clofera, Poly-Tussin D, Lemohist Plus, Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, VisRx Dose Pack, Allergy AM-PM Dose Pack, Time-Hist QD, PCM-LA, Rhinaclear, Allergy DN, Pseudo CM TR, Durafed, Biohist LA (old formulation), Chlorphedrin SR, Fedahist Timecaps, Colfed-A, D-Amine-SR, Deconomed SR, Dura-Tap/PD, Kronofed-A-Jr, Duratuss DA, Deconamine SR, Clorfed, Chlorafed HS Timecelles, Codimal-LA, Hista-Vent PSE, Mescolor, Tussin-V, Hyphed, Q-V Tussin, A-G Tussin, KG-Tussin, Welltuss HC, Tussend, Detuss, Notuss-Forte, Histinex PV, JayCof-HC, Pediatex HC, P-V-Tussin Syrup, Hydrotuss HC, Xiral SR, DuraHist, RelCof DN PSE, Dallergy PSE, Relcof PSE, Advil Children's Allergy Sinus, Atuss HS, Hydrocof-HC, Hydron PCS, Cordron-HC, Cordron-HC NR, Atuss HD, Trifed C

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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