Miconazole use while Breastfeeding

Drugs containing Miconazole: Monistat, Monistat 7-Day Combination Pack, Monistat 3-Day Combination Pack, Vusion, Aloe Vesta, Micatin, Lotrimin AF Athlete's Foot Powder, Monistat 3-Day Ovule Combination Pack, Mitrazol, Monistat-Derm, Show all 58 »Zeasorb-AF, Lotrimin AF Athlete's Foot Spray, Baza Antifungal, Monistat 1-Day Ovule Combination Pack, Azolen, Monistat 1-Day or Night Combination Pack, Vagistat-3, DermaFungal, Lotrimin AF Jock Itch Powder Spray, Miranel AF, Micaderm, Zeasorb-AF Lotion/Powder, Breezee Mist Antifungal, Triple Paste AF, Desenex Antifungal Foot Cream, Micon 7, Fungoid, Micatin Jock Itch, Yeast-X Int, Micatin Foot Powder, Absorbine Antifungal Foot Powder, Critic-Aid Clear AF, Desenex Antifungal Atheletes Foot Spray Liquid, Secura Antifungal Extra Thick, Dermagran AF, Zeasorb-AF Drying Gel, Desenex AF, Daktozin, Rash Relief Antifungal, Secura Antifungal, Soothe & Cool Inzo, Remedy Antifungal with Olivamine, NuZole, Aloe Vesta 2 in 1 Antifungal, Desenex Prescription Strength, Micatin Foot Powder Deodorant, Micatin Liquid Foot, Desenex Antifungal Liquid Spray, Oravig, Tetterine, Fungoid Kit, Ony-Clear, Desenex Jock Itch, M-Zole 3, Micatin Cooling Action, Cruex Prescription Strength, M-Zole Dual Pack, Micro-Guard

Miconazole Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because miconazole has poor oral bioavailability, it is unlikely to adversely affect the breastfed infant, including topical application to the nipples. However, miconazole ointment appears to have no advantage over lanolin for treating sore nipples during breastfeeding[1] and a survey of members of the Academy of Breastfeeding Medicine found topical miconazole is rarely prescribed to nursing mothers to treat thrush.[2] Any excess cream or ointment should be removed from the nipples before nursing. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

In a randomized, double-bind trial, lanolin was compared to an all-purpose nipple ointment containing mupirocin 1%, betamethasone 0.05%, and miconazole 2% for painful nipples while nursing in the first 2 weeks postpartum. The two treatments were equally effective in reducing nipple pain, nipple healing time, breastfeeding duration, breastfeeding exclusivity rate, mastitis and nipple symptoms, side effects or maternal satisfaction with treatment.[1]

Alternate Drugs to Consider

Clotrimazole, Fluconazole, Nystatin

References

1. Dennis CL, Schottle N, Hodnett E, McQueen K. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: A randomized controlled trial. Breastfeed Med. 2012;7:473-9. PMID: 22428572

2. Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001;40:503-6. PMID: 11583049

3. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. PMID: 14623482

Miconazole Identification

Substance Name

Miconazole

CAS Registry Number

22916-47-8

Drug Class

  • Antifungal Agents
  • Dermatologic Agents

Administrative Information

LactMed Record Number

368

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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