Gadoxetate use while Breastfeeding

Drugs containing Gadoxetate: Eovist

Gadoxetate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although early investigators recommended withholding breastfeeding following administration of gadolinium contrast agents, a more recent and much larger study on another agent, gadopentetate, indicated that the amounts of gadolinium excreted into breastmilk are less than 1% of the amount allowed to be given to infants. In addition, because gadolinium contrast agents are poorly absorbed orally, none is likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a gadolinium-containing contrast medium.[1][2][3] However, because there is no published experience with gadoxetate during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant. The manufacturer states that mothers with normal kidney function can resume nursing 10 hours or more after administration with minimal risk to the infant.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Gadopentetate

References

1. American College of Radiology Committee on Drugs and Contrast Media. Administration of contrast media to breast-feeding mothers. In, ACR manual on contrast media. 2012;Version 8:79-80.

2. Webb JA, Thomsen HS, Morcos SK, Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR). The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol. 2005;15:1234-40. PMID: 15609057

3. Chen MM, Coakley FV, Kaimal A, Laros RK Jr. Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol. 2008;112:333-40. PMID: 18669732

Gadoxetate Identification

Substance Name

Gadoxetate

CAS Registry Number

135326-11-3

Drug Class

Contrast Media

Diagnostic Agents

Administrative Information

LactMed Record Number

794

Last Revision Date

20130907

Disclaimer

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