Estradiol Cypionate use while Breastfeeding

Drugs containing Estradiol Cypionate: Estrace, Vagifem, Vivelle-Dot, Estrace Vaginal Cream, Climara, Activella, Vivelle, Minivelle, Estring, CombiPatch, Show all 106 »Natazia, Estrogen Patches, Mimvey, Estradiol Patch, Divigel, Alora, Estrogel, Progynova, Femring, Evamist, Climara Pro, Angeliq, Elestrin, Estrofem, Delestrogen, Depo-Estradiol, Estraderm, Ena, Evorel, Mimvey Lo, Menostar, Prefest, Lunelle, Oestrogel, Esclim, Elleste Solo, Estradot, Oesclim, Systen, Nuvelle TS Phase I, Estrapatch, Climaval, Oestradiol Implants, Climodien, Organon Oestradiol, Provames, Estradiol G GAM, Estro-Cyp, Menaval-20, Oestrogel Pump-Pack, Progynova TS, Delidose, Estro-LA, Estra-C, Valergen, Depogen, Dioval 40, Zumenon, Sandrena, Estrasorb, FemSeven Sequi Phase I, Thaissept, Femtrace, Ortho-Prefest, Thais, Oromone, Menorest, Oestrodose, Duratestrin, Dura-Dumone, Estra-Testrin, Delatestadiol, Dep Androgyn, Valertest No 1, Duo-Cyp, Depo-Testadiol, Femsept, Depotestogen, Dioval XX, Fempatch, Dura-Estrin, Estragyn LA 5, Clinagen LA 40, Estradot 37.5, Medidiol 10, Estro-Span 40, Gynogen LA 20, Dep Gynogen, Duragen, Estra-V 40, Gynodiol, Estradot 50, Estradot 75, Femtran, FemTab, Primogyn Depot, Bedol, Dermestril Septem, Menorest Patch, Fematrix, Dermestril, Estradot 100, FemSeven, Aerodiol, Adgyn Estro, Estreva

Estradiol Cypionate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Estradiol cypionate has not been studied during breastfeeding. However, the similar drug, estradiol valerate, has been used to suppress lactation, usually in combination with testosterone. Generally, estradiol cypionate should be avoided in mothers wishing to breastfeed.

Drug Levels

Maternal Levels. Relevant published information on estradiol cypionate was not found as of the revision date. However, estradiol appears in breastmilk in small amounts after administration by other routes.[1][2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Another injection ester form of estradiol, estradiol valerate was previously used therapeutically to suppress lactation, usually in combination with testosterone.[3][4][5]

A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.[6]

Alternate Drugs to Consider

Ethinyl Estradiol

References

1. Nilsson S, Nygren KG, Johansson ED. Transfer of estradiol in human milk. Am J Obstet Gynecol. 1978;132:653-7 . PMID: 717472

2. Perheentupa A, Critchley HO, Illingworth PJ, McNeilley AS. Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab. 2000;85:4280-6. PMID: 11095468

3. Louviere RL, Upton RT. Evaluation of Deladumone OB in the suppression of postpartum lactation. Am J Obstet Gynecol. 1975;121:641-2. PMID: 1090174

4. Morris JA, Creasy RK, Hohe PT. Inhibition of puerperal lactation. Double-blind comparison of chlorotrianesene, testosterone enanthate with estradiol valerate and placebo. Obstet Gynecol. 1970;36:107-14. PMID: 4912251

5. Iliya FA, Safon L, O'Leary JA. Testosterone enanthate (180 mg.) and estradiol valerate (8 mg.) for suppression of lactation: a double-blind evaluation. Obstet Gynecol. 1966;27:643-5. PMID: 5949195

6. Jordan HL, Bruinsma FJ, Thomson RJ et al. Adolescent exposure to high-dose estrogen and subsequent effects on lactation. Reprod Toxicol. 2007;24:397-402. PMID: 17531440

Estradiol Cypionate Identification

Substance Name

Estradiol Cypionate

CAS Registry Number

313-06-4

Drug Class

Estrogens

Hormones

Administrative Information

LactMed Record Number

852

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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