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Estradiol Cypionate use while Breastfeeding

Drugs containing Estradiol Cypionate: Estrace, Vagifem, Estrace Vaginal Cream, Vivelle-Dot, Estring, Minivelle, Climara, Activella, Estrogel, CombiPatch, Show all 107 »Divigel, Vivelle, Estradiol Patch, Estrogen Patches, Natazia, Evamist, Angeliq, Alora, Mimvey, Femring, Estraderm, Progynova, Lopreeza, Delestrogen, Estrasorb, Elestrin, Depo-Estradiol, Progynova TS, Gynodiol, Climara Pro, Estrofem, Esclim, Mimvey Lo, Ena, Prefest, Depogen, Lunelle, Femtrace, Menostar, Estrapatch, Evorel, Oestrodose, Estradot, Depo-Testadiol, Sandrena, Organon Oestradiol, Delidose, Estreva, Zumenon, Estradot 100, Dioval 40, Estro-Cyp, Estradot 37.5, Valergen, Systen, Femsept, Estradiol G GAM, Dermestril Septem, Menorest, Thaissept, Provames, Oromone, Oestrogel, Thais, Oestradiol Implants, Dep Androgyn, Delatestadiol, Estra-Testrin, Depotestogen, Duo-Cyp, Duratestrin, Dura-Dumone, Ortho-Prefest, Valertest No 1, Oesclim, Estragyn LA 5, Fempatch, Dura-Estrin, Clinagen LA 40, Estro-LA, Estradot 50, Menaval-20, Medidiol 10, Estro-Span 40, Gynogen LA 20, Dep Gynogen, Dioval XX, Duragen, Estra-V 40, Estra-C, Estradot 75, Oestrogel Pump-Pack, Climaval, Nuvelle TS Phase I, FemTab, Femtran, Climodien, Primogyn Depot, Menorest Patch, FemSeven Sequi Phase I, FemSeven, Dermestril, Aerodiol, Elleste Solo, Fematrix, Adgyn Estro, Bedol

Estradiol Cypionate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Estradiol cypionate has not been studied during breastfeeding. However, the similar drug, estradiol valerate, has been used to suppress lactation, usually in combination with testosterone. Generally, estradiol cypionate should be avoided in mothers wishing to breastfeed.

Drug Levels

Maternal Levels. Relevant published information on estradiol cypionate was not found as of the revision date. However, estradiol appears in breastmilk in small amounts after administration by other routes.[1][2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Another injection ester form of estradiol, estradiol valerate was previously used therapeutically to suppress lactation, usually in combination with testosterone.[3][4][5]

A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.[6]

Alternate Drugs to Consider

Ethinyl Estradiol


1. Nilsson S, Nygren KG, Johansson ED. Transfer of estradiol in human milk. Am J Obstet Gynecol. 1978;132:653-7 . PMID: 717472

2. Perheentupa A, Critchley HO, Illingworth PJ, McNeilley AS. Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab. 2000;85:4280-6. PMID: 11095468

3. Louviere RL, Upton RT. Evaluation of Deladumone OB in the suppression of postpartum lactation. Am J Obstet Gynecol. 1975;121:641-2. PMID: 1090174

4. Morris JA, Creasy RK, Hohe PT. Inhibition of puerperal lactation. Double-blind comparison of chlorotrianesene, testosterone enanthate with estradiol valerate and placebo. Obstet Gynecol. 1970;36:107-14. PMID: 4912251

5. Iliya FA, Safon L, O'Leary JA. Testosterone enanthate (180 mg.) and estradiol valerate (8 mg.) for suppression of lactation: a double-blind evaluation. Obstet Gynecol. 1966;27:643-5. PMID: 5949195

6. Jordan HL, Bruinsma FJ, Thomson RJ et al. Adolescent exposure to high-dose estrogen and subsequent effects on lactation. Reprod Toxicol. 2007;24:397-402. PMID: 17531440

Estradiol Cypionate Identification

Substance Name

Estradiol Cypionate

CAS Registry Number


Drug Class



Administrative Information

LactMed Record Number


Last Revision Date



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