Cloxacillin use while Breastfeeding

Drugs containing Cloxacillin: Cloxapen, Tegopen

Cloxacillin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Cloxacillin is acceptable to use during breastfeeding. Limited information indicates that maternal doses of cloxacillin produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels.No studies have reported milk levels after oral cloxacillin. After a single intramuscular dose of 500 mg of cloxacillin in 2 women, milk levels ranged from 0.1 to 0.3 mg/L between 1 and 6 hours after the dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In a telephone follow-up study, 10 nursing mothers reported taking cloxacillin (dosage unspecified). Two mothers reported diarrhea in their infants. No rashes or candidiasis were reported among the exposed infants.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

Cloxacillin Identification

Substance Name

Cloxacillin

CAS Registry Number

61-72-3

Drug Class

Antiinfective Agents

Antibacterial Agents

Penicillins

Administrative Information

LactMed Record Number

74

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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