Cloxacillin Side Effects

Some side effects of cloxacillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to cloxacillin: oral capsule, oral powder for reconstitution

If you experience any of the following serious side effects, stop taking cloxacillin and seek emergency medical attention:

  • an allergic reaction (shortness of breath; closing of your throat; hives; swelling of your lips, face, or tongue; rash; or fainting);

  • seizures;

  • severe watery diarrhea and abdominal cramps; or

  • unusual bleeding or bruising.

Other, less serious side effects maybe more likely to occur. Continue to take cloxacillin and talk to your doctor if you experience

  • mild nausea, vomiting, diarrhea, or abdominal pain;

  • white patches on the tongue (thrush/yeast infection);

  • itching or discharge of the vagina (vaginal yeast infection); or

  • black, "hairy" tongue or sore mouth or tongue.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to cloxacillin: oral capsule, oral powder for reconstitution

Gastrointestinal

Common gastrointestinal complaints include nausea, vomiting, and diarrhea. Rarely the use of cloxacillin has been associated with pseudomembranous colitis.

Hematologic

Hematologic adverse effects include neutropenia, leukopenia, and thrombocytopenia. Neutropenia has occurred in 17% of patients and occurs most commonly with higher doses and longer durations of therapy. Neutropenia occurs most often after 14 days of therapy and is reversible upon discontinuation.

Hepatic

Hepatic side effects include transient increases in serum transaminases and the development of cholestatic hepatitis. Liver transaminases may take several weeks to return to normal following discontinuation of therapy. Frequent monitoring of liver function tests is recommended in patients with liver disease.

Hypersensitivity

Hypersensitivity reactions include rash, fever, eosinophilia, pruritus, fever, chills, and myalgias.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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