Cloxacillin Side Effects

Brand Names: Cloxapen

Please note - some side effects for Cloxacillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Gastrointestinal

Common gastrointestinal complaints include nausea, vomiting, and diarrhea. Rarely the use of cloxacillin has been associated with pseudomembranous colitis.

Hematologic

Hematologic adverse effects include neutropenia, leukopenia, and thrombocytopenia. Neutropenia has occurred in 17% of patients and occurs most commonly with higher doses and longer durations of therapy. Neutropenia occurs most often after 14 days of therapy and is reversible upon discontinuation.

Hepatic

Hepatic side effects include transient increases in serum transaminases and the development of cholestatic hepatitis. Liver transaminases may take several weeks to return to normal following discontinuation of therapy. Frequent monitoring of liver function tests is recommended in patients with liver disease.

Hypersensitivity

Hypersensitivity reactions include rash, fever, eosinophilia, pruritus, fever, chills, and myalgias.

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