Acetaminophen use while Breastfeeding

Drugs containing Acetaminophen: Norco, Percocet, Vicodin, Tylenol, Lortab, Fioricet, Paracetamol, Tylenol with Codeine #3, Percocet 5/325, Percocet 10/325, Show all 840 »Endocet, Ultracet, Roxicet, NyQuil, Panadol, Midrin, Excedrin, Percocet 7.5/325, Darvocet-N 100, Darvocet-N 50, Tylox, Tylenol with Codeine, Tylenol Extra Strength, Vicodin ES, Tylenol PM, Excedrin Migraine, Lortab 7.5/500, Lortab 5/500, Vicks Dayquil Daytime Cold/Flu, Tylenol Arthritis Pain, Alka-Seltzer Plus Cold, Esgic, Fioricet with Codeine, Lorcet 10/650, Lortab 10/500, Tylenol with Codeine #4, Mapap, Bupap, Coricidin HBP Cold & Flu, Tylenol Cold, Percocet 10/650, Ofirmev, Vicks Nyquil Cold & Flu Relief, Percogesic, Theraflu Flu, Cold and Cough Powder, Nyquil Cold Medicine, Anexsia, Vicodin HP, Percocet 7.5/500, Dologesic, Talacen, Esgic-Plus, Darvocet A500, Nodolor, Floricet with Codeine, Phrenilin, Q-Pap, Tempra, Perfalgan, Hycet, Trezix, Lorcet Plus, Sinarest, Children's Tylenol, Dolmar, Robitussin Cold Cough and Flu, Mucinex Fast-Max Cold, Flu & Sore Throat, Dafalgan, Flextra, Norel AD, Vicks Dayquil Cold & Flu Relief, Mucinex Fast-Max Severe Congestion & Cold, Midol Maximum Strength Menstrual, Triad, Excedrin Extra Strength, Sudafed PE Severe Cold, Zebutal, Cough & Cold Relief, Tylenol Cold & Flu Severe, Pain Relief PM Extra Strength, Pamprin Cramp Menstrual Pain Relief, Tylenol with Codeine #2, Coricidin D, Tencon, Acephen, Midol PMS, Paracetamol Teva, Panadol Osteo, Trycet, Tylenol Sinus Congestion & Pain Nighttime, Epidrin, Infant's Tylenol, Hedex, NyQuil Multi-Symptom, Prodrin, Dilotab II, Xodol, Cephadyn, Duraflu, Theraflu Nighttime Severe Cold & Cough, Altenol, Q-Pap Extra Strength, Efferalgan, Panamax, Feverall, Dologen, Balacet, Excedrin Tension Headache, Norel SR, Wygesic, Sudafed PE Cold & Cough, Headache Relief, Alka-Seltzer Plus Flu/Body, Tylenol Regular Strength, Pamprin Multi-Symptom Menstrual Relief, Orbivan, Goody's Headache Powders, Painaid, Vicks Dayquil Sinus, Dolorex, Liquicet, Delsym Night Time Cough & Cold, Alvedon, Migralam, Maxidone, Hydrocet, Tylenol Cold Multi-Symptom Severe, XL-3 Cold Medicine, Contac Cold and Flu Maximum Strength, XL-3 Xtra Cold and Cough, Zolvit, Comtrex Cold and Cough Maximum Strength, Sudafed PE Pressure + Pain, Percocet 2.5/325, Vanquish, Actifed Cold and Sinus, Doliprane, Paracetamol Almus, Paracetamol Zydus, Dolgic Plus, Relagesic, Excedrin PM, Daytime Cold, Tylenol Cold Multi-Symptom Daytime, Panadol Extend, Buckley's Complete, Frenadol, Umphamol, Sine-Off Sinus/Cold, Calpol Infant, Tactinal, Mapap Infant Drops, Actamin, Endolor, Panadol ActiFast, Contact Cold and Sore Throat, Benadryl Allergy Plus Cold, Alka-Seltzer Plus Cold and Sinus, Pamprin Maximum Pain, Primlev, Magnacet, Tylenol Sinus Congestion & Pain Severe, Duradrin, Percogesic Extra Strength, Tavist Allergy/Sinus/Headache, Sinutab Regular Strength, Capacet, MigraTen, Ezol, Axocet, Dristan Cold Maximum Strength, Panlor DC, Panlor SS, Margesic, Pamprin Max Menstrual Pain Relief, Mucinex Sinus-Max Pressure & Pain, Theraflu Flu & Sore Throat, Tylenol Sinus Congestion & Pain Daytime, Robitussin Peak Cold Nasal Relief, Syncol, Menstrual PMS, Lortab 2.5/500, Oxycet, Flextra-650, Vistra, Tylenol Sinus Maximum Strength, Sinus Maximum Strength, Sinus Relief, Dristan Cold Non-Drowsy, Alka-Seltzer Cold and Sinus, Zflex, Ornex, Hy-Phen, Sinus Congestion & Pain, Cold Medicine Plus, Complete Sinus Relief, Diabetic Tussin Night Time Formula, Allergy Multi-Symptom, Pyrroxate, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Allergy Multi-Symptom, Tylenol Cold Multi-Symptom Nighttime Liquid, Alka-Seltzer Plus Severe Sinus Congestion & Cough (Night Formula), Coricidin Night Time Cold Relief, Headache Relief PM, Midol PM, Amidrine, Sudafed PE Pressure+Pain+Cold, Alka-Seltzer Plus Severe Sinus Congestion & Cough (Day Formula), Coricidin HBP Maximum Strength Flu, Simplet, Paracetamol Biogaran, Paracetamol Sandoz, Cetafen, Calpol Paediatric, Atasol, Panamol, Lemsip Max, Lemsip Original, Tylenol 8 Hour, Silapap Childrens, Taminol, Tempol, Theraflu Cold & Sore Throat, KneeRelief, Flextra Plus, Paracetamol Merck, Paracetamol Ranbaxy, Mapap Rapid Release Gelcaps, Dolitabs, Doliprane Sans Sucre, Doliprane Adultes, PMS Relief, Midol PMS Maximum Strength, Claradol, Cipla Genpharm Paracetamol, Mapap Arthritis Pain, Sigma Pain Relief, Setamol, Isocom, Remedol, Miradol, RhinoFlex, Genasec, Calpol Fastmelts, Iso-Acetazone, Migrin-A, Sinus Congestion and Pain Daytime Cool Ice, Bydol, Colrex, DHC Plus, Sinutab Sinus Maximum Strength, Diacetazone, LarkaDrin, Sinapils, Panadol Soluble, Abenol, CVS Allergy & Cold, Vopac, Phenaphen with Codeine, Onset Forte, Benadryl Allergy Plus Sinus Headache, Zydone, Zamicet, Capital w/Codeine, Cocet, Singlet, Allerest Sinus, Alka-Seltzer Plus Severe Allergy Sinus Congestion & Headache, Theraflu Flu & Chest Congestion, Benadryl Cold, Mucinex Sinus-Max Severe Congestion Relief, Sinulin, Lorcet HD, Panacet, Staflex, BF-Paradac, Night Time Cold & Flu, Valorin, Codral Cold and Flu + Cough Day and Night, Narvox, Roxilox, Coricidin HBP Nighttime Multi-Symptom Cold, Unisom PM Pain, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Dolacet, Respa C&C, Non-Aspirin PM Extra Strength, Pain Reliever PM, Contac Day and Night Cold and Flu, Xolox, Benylin Sore Throat, Phrenilin Forte, Sedapap, Duraxin, Anabar, Tempra Quicklets, Dolgic, Prominol, Contac Severe Cold and Flu Non Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Tycolene, Promacet, Butex Forte, Genapap Extra Strength, Dologesic DF, Comtrex Cold & Cough, Supac, Theraflu Warming Relief Daytime Severe Cough & Cold, Robitussin Peak Cold Daytime Cold + Flu, Sudafed PE Pressure+Pain+Cough, Goody's Extra Strength, Flutabs, Levacet, Genebs, Panadol Childrens, Genapap, Propacet 100, Severe Cold Multi-Symptom, Apra, Nonbac, Minotal, Mucinex Children's Multi-Symptom Cold & Fever, Cold Multi-Symptom Severe, Tylenol Cold Head Congestion Severe, Cold Head Congestion, Repan, G-1, Femcet, Alagesic LQ, Isocet, Tylenol Allergy Multi-Symptom Nighttime, Tylenol Plus Children's Cold & Cough, Children's Tylenol Plus Cold And Allergy, Benadryl Severe Allergy Plus Sinus Headache, Theraflu Multi-Symptom Severe Cold, Sudafed PE Nighttime Cold, Flu & Severe Cold & Cough Daytime Powder, Medinol Paediatric, Counteract PM Extra Strength, Wal-Nadol PM Extra Strength, Percogesic Original Strength, Night Time Pain, Acetaminophen PM Extra Strength, Headache Formula PM, Acetadryl, Paldesic, Alka-Seltzer Plus Day & Night Cold Formula (Day Cold) Liquid Gels, Medinol Under 6, ConRx PM, Theraflu Warming Relief Caplets Daytime Multi-Symptom Cold, Theraflu Warming Relief Nighttime Severe Cold & Cough, Benadryl Severe Allergy & Sinus Headache, Contac Day and Night Allergy, Silapap Infants, Theraflu Flu Cold & Cough, Robitussin Multi-Symptom Cold Night Time, Sudafed Sinus Nighttime Plus Pain, Parmol, Contac Complete Cough, Cold & Flu Extra Strength, Neocitran Non Drowsy Extra Strength Cold and Flu, Tylenol Cold Head Congestion Daytime, Tylenol Allergy Complete NightTime, Daytime Non-Drowsy, Severe Allergy and Sinus Headache, Suphedrine PE Severe Cold, Tylenol Plus Children's Cold & Allergy, Theraflu Warming Relief Flu & Sore Throat, Alka-Seltzer Plus Multi-Symptom Cold & Flu (Day Formula), Mapap Cold Formula, Theraflu Warming Relief Sinus & Cold, Robitussin Peak Cold Nighttime Multi-Symptom Cold, CounterAct Night, CVS Allergy & Sinus Headache, Equate Allergy & Sinus Headache, Robitussin Night Time Cough, Cold & Flu, Alka-Seltzer Plus Day Non-Drowsy Cold Formula Liquid Gels, Febridol, Migrex, Midchlor, IDA, Day Relief Cold and Flu, Alidrin, Panamax 240, Migragesic IDA, Migrazone, Anadin Paracetamol, Mandanol, Migquin, Vicks Nyquil Sinus, Cuprofen for Children, Non-Drowsy Super Strength Contac Complete, Day Time Multi Symptom, Migrapap, Mandanol Infant, Migratine, Lemsip Childrens Cold & Flu, Mandanol 6+, Mitride, Comtrex Non Drowsy Liquigel, Robitussin Cold + Flu (Daytime), Tylenol Sore Throat Nighttime, Anacin P.M. Aspirin Free, Legatrin PM, Sominex Pain Relief Formula, Aceta-Gesic, Tylenol Severe Allergy, Day Time Multi-Symptom Cold/Flu Relief, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Comtrex Non-Drowsy, Mapap PM, Genapap PM, Medinol Over 6, Paracets, Multi Symptom Cold (Day Formula), Cold Multi-Symptom (Daytime), Calpol Six Plus, Lemsip Pharmacy Non-Decongestant Formula, Pharbetol PM, Parahexal, Paralgin, Day Relief PE, Q-Nol, Myophen, BP Poly-650, Lagesic, Acuflex, D-Time Sinus, Day Relief Sinus PE, Major-gesic, Phenylgesic, Uni-Perr, Vitoxapap, Q-Gesic, Phenagesic, Apagesic, Duogesic, Contac Cold + Flu (Day Formula), Tylenol Plus Children's Cold & Stuffy Nose, Premsyn PMS, PMS Formula Multi-Symptom, Lurline PMS, PainAid Premenstrual Formula, Tylenol Women's Menstrual Relief, Backaid Max, Theraflu Sinus & Cold, Excedrin Sinus Headache, Non-Pseudo Sinus Pain & Pressure, Suphedrine PE Sinus Headache, Mapap Sinus Congestion and Pain, Sudafed PE Sinus Headache, Congespirin Aspirin Free, Flextra-DS, Alpain, Suphedrin Sinus, Ornex Maximum Strength, Sinutab Maximum Strength, Sinarest Sinus, Phenapap, Pseudoephedrine Sinus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Panritis Forte, Tramapap, Ephed Plus, Sinutab Maximum Strength Non Drowsy, Benadryl Allergy Sinus Headache, Tavist Sinus, Suphedrin Plus, Genapap Sinus, Zgesic, Q Flex, Ali-Flex, RhinoFlex 650, Hyflex-650, Hyflex-DS, BeFlex, Ed-Flex, Contac Sinus, Sine-Off Maximum Strength, Be-Flex Plus, By-Ache, Lobac, Midol Maximum Strength Teen Formula, Panadol Menstrual Relief, Infadrops, Elixsure Fever/Pain, Sudafed Triple Action, Tylenol Sinus Severe Congestion Daytime, ConRx Sinus, Sudafed PE Pressure+Pain+Mucus, Jr. Tylenol, Acetaminophen-odan, Liquiprin, St. Joseph Aspirin-Free, Adprin B, Bromo Seltzer, Pharbetol, Atasol Forte, Mucinex Fast-Max Cold & Sinus, Emagrin Forte, Disprol Paracetamol, Disprol Soluble Paracetamol, Galpamol, Comtrex Deep Chest Cold, Tylenol Sinus Day/Night Convenience Pack, Tylenol Chest Congestion, Theraflu Warming Relief Cold and Chest Congestion, Beechams All-in-One, Coldonyl, Histenol-Forte II, Sudafed PE Triple Action, LuSonex Plus, Duratuss-A, Ed-APAP, Dolono Infant, Aceta, Children's ElixSure, Panadol Jr, Tempra 2, T-Gesic, Tempra 3, Infantaire Drops, Cetafen Extra, Perloxx, Xartemis XR, Tylophen, Mapap Children's, Febrol Solution, Children's Silapap, Margesic H, Hydrogesic, Conacetol, Anacin Aspirin Free, Dolono, Redutemp, Uniserts, Pain-Eze, Daytime Cold & Flu, Dolagesic, Duocet, Duradyne DHC, Co-Gesic, Theracodophen Low 90, Stagesic, Tylenol Sinus NightTime, ConRx Cold, Durabac, Combiflex, Paralgin Paracetamol Tabsules, Cafgesic, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Cafgesic Forte, Combiflex ES, Saleto-D, Menstrual Complete, Menstrual Relief, Colrex Compound, Herron Paracetamol Tabsules, Vicks Formula 44 Custom Care Cough & Cold PM, Cotabflu, Congestant, Rid-A-Pain Compound, Panadol Rapid Handipak, Durabac Forte, Arthriten, Paineze Paracetamol, Valorin Extra, Excedrin Quick Tab, Dolko, Phrenilin with Caffeine and Codeine, Dolotec, Dolko Enfants, Hycomine Compound, Flu Strength Hot Lemon Powders, Alpha First Aid Supplies Paracetamol, Pharmacy Health Colour Free Childrens Paracetamol, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Emagrin Forte (old formulation), Zerlor, Accidental First Aid Supplies Paracetamol, Rex Paracetamol, Mapap Cough & Sinus Formula, Tylenol Plus Children's Cough & Runny Nose, Comtrex Maximum Strength Cold Relief, Comtrex Cold and Flu Maximum Strength, Contac Severe Cold and Flu Maximum Stength, Cold Multi-Symptom (Nighttime), Multi Symptom Cold Relief, Dimetapp Children's Multi-Symptom Cold & Flu, Multi Symptom Cold (Night Formula), Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Tylenol Cold Plus Cough, Theraflu Flu & Cough, Allpanto-S, Genacol Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Childrens Panadol 1 - 5 Years Colourfree, Comtrex Day and Night, Alka-Seltzer Plus Flu Formula, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Childrens Panadol 5 - 12 Years, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Febridol Clear Effervescent, Coricidin HBP Multi-Symptom Cold (Night), Triaminic Multi-Symptom Fever, Flu Relief BP, Dimetapp Children's Nighttime Flu, Tylenol Cold Multi-Symptom Nighttime, Comtrex Nighttime Cold & Cough, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Alka-Seltzer Plus Cold & Cough Formula Liquid, Tylenol Cold Head Congestion Day and Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Americet, Alagesic, Excedrin Menstrual Complete, CVS Extra Strength Headache Relief, Medique Pain-Off, Goody's Extra-Strength Headache Powders, Anacin Advanced Headache Formula, Conney Aspirin-Free, Mapap Extra Strength Rapid Burst, Genace, PainAid Extra-Strength Formula, Backaid Inflammatory Pain Formula, Exaprin, Rhinocaps, Tylenol GoTabs, Saleto, Topcare 8 Hour Pain Relief, ConRx Pain Reliever, Arthriten Inflammatory Pain Formula, Aminofen, Masophen, DG Health Pain Reliever, Triaminic Fever Reducer Pain Reliever, Triaminic Infant Drops, Topcare Arthritis Pain Relief, Equaline Pain Relief, Leader 8 Hour Pain Reliever, Little Fevers, Tylenol Cool Caplet Extra Strength, Actimol Children's, Excedrin Back & Body, UN-Aspirin Extra Strength, Nortemp Children's, Goody's Body Pain, ConRx Extra Strength, Tylenol Cold Sore Throat, Help I Have A Headache, Comtrex Acute Head Cold, Vitapap, Pharmagesic, Anoquan, Two-Dyne, Arcet, Dolgic LQ, Efferalganodis, Efferalgan Pediatrique, Tenake, Anolor 300, Medigesic, Mygracet, Pacaps, Ide-cet, Fiorpap, Geone, Tencet, Expandox, Geluprane, Triaprin, Bucet, Marten-Tab, Perfalgan Nourrissons Et Enfants, Mapap Rapid Tabs, Vicks Formula 44 Custom Care Body Aches, Medi-Tabs, Orbivan CF, Paralyoc, Paracetamol Ivax, Paracetamol EG, Paracetamol Arrow, Paracetamol Qualimed, Paracetamol RPG, Paracetamol Winthrop, Paracetamol Sandoz Conseil, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D, Pacimol Caplets, Panadol Gel Caps, Alka-Seltzer Plus Night Cold Formula Liquid Gels, Robitussin Cold + Flu (Nighttime), Robitussin Peak Cold Nighttime Cold + Flu, Contac Cold + Flu (Night) Cooling Relief Liquid, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Alka-Seltzer Plus Day & Night Cold Formula (Night Cold) Liquid Gels, Alka-Seltzer Plus Night Cold Formula Liquid, Pharmacist Advice Paracetamol, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Paracare, Priceline Paracetamol, Delsym Night Time Multi-Symptom, Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula), Tylenol Cold & Cough Nighttime, Vicks Nyquil Cold & Flu Symptom Relief Plus Vitamin C, Tylenol Plus Children's Cough & Sore Throat, Children's Triacting, Triaminic Cough & Sore Throat, Triaminic Softchews Cough & Sore Throat, Tylenol Cough and Sore Throat Daytime, Hexaflu, Drixoral Cough/Sore Throat, Tylenol Cold & Cough Daytime, Topcare Cough and Sore Throat, Clear Cough PM Multi-Symptom, Vicks NyQuil Multi-Symptom, Tylenol Cough & Sore Throat Nightime, Pharmore Paracetamol, Pain Clear Paracetamol, Paraspen Drops, Respa C&C IR, All-Nite Multi-Symptom Cold/Flu Relief, Multi-Symptom Nighttime, Tusnel-A, Maxiflu DM, Balminil Cough and Flu Sugar Free, Febridol Syrup for Children, Guardian Childrens Paracetamol, Alka-Seltzer Plus Severe Cold, Mucus & Congestion, Anatuss, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Fennings Childrens Cooling, Theraflu Daytime Severe Cold & Cough, Little Colds Multi-Symptom, Duatrol SR, Tylenol Sore Throat Daytime, Theraflu Max-D Severe Cold & Flu, Mapap Meltaway, Actimol Infant, Mucinex Children's Cold, Cough & Sore Throat, Panadol Gel Tabs, Promax, Dymadon, Panadol Mini Caps, Pharmacy Health Paracetamol, NyCair, Pharmacist Paracetamol, Paraspen, Tylenol Cough & Severe Congestion Daytime, Cold & Cough PE Multi-Symptom, Suphedrine PE Cold & Cough, CounterAct Day, Mucus Relief Plus, Mucus Relief Complete, Non-Pseudo Cold Relief, Phenflu DM, Drixoral Sinus, Drixoral Cold and Flu, Tylenol Sinus Congestion and Pain Cool Burst Day Night, ConRx Allergy Sinus, Hybrid CF, GNP Cold Relief Plus, Allergy Sinus PE Pain Relief, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Allergy Pain Relief, Covangesic, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Duadacin, Alumadrine, Sigma Paracetamol, Chlor-Trimeton Sinus, Pharmacy Health Paracetamol Colour Free Childrens, Trital SR, Rhinogesic, Robitussin Peak Cold Nighttime Nasal Relief, Contac Cold + Flu (Night Formula), Lemsip Headcold, Accidental Rapatabs, Febridol Infant Drops, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chem Mart Chemadol, Gelpirin-CCF, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Pharmacy Health Own Name Paracetamol for Children, Lemsip Cold and Flu Liquid Capsule, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Dristan Cold Multi Symptom Formula, Gendecon, Dryphen, Protid, Paracetamol Soluble, Hexal Comfarol, Capital with Codeine Suspension, Cocet Plus, Codrix, EZ III, Aceta w/ Codeine, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmacist Paracetamol Infant Drops Colour Free, Phenflu CD, Phenflu CDX, Drixoral Cold/Flu, Sinadrin Plus, Drixoral Allergy Sinus, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Maxiflu CD, Maxiflu CDX, Pharmaction Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Codimal, Kolephrin, Tylenol Allergy Sinus, Comtrex Allergy Sinus, Tricom, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Pharmacist Advice Paracetamol Infant Drops, Triaminicin, Sinarest Extra Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Vicks Dayquil Cold & Flu Symptom Relief Plus Vitamin C

Acetaminophen Levels and Effects while Breastfeeding

Summary of Use during Lactation

Acetaminophen is a good choice for analgesia, and fever reduction in nursing mothers. Amounts in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare.

Drug Levels

Maternal Levels. A single oral dose of 650 mg of acetaminophen was given to 12 nursing mothers who were 2 to 22 months postpartum. Peak milk levels of 10 to 15 mg/L occurred between 1 and 2 hours after the dose in all patients. Acetaminophen was undetectable (<0.5 mg/L) in all mothers 12 hours after the dose. The authors calculated that an infant who ingested 90 mL of breastmilk every 3 hours would receive an average of 0.88 mg of acetaminophen or 0.14% (range 0.04 to 0.23%) of the mother's absolute dosage.[1] Using data from this study, an infant would receive a maximum of about 2% of the maternal weight-adjusted dosage.

Three women took a single 500 mg dose of acetaminophen. Peak milk levels averaging 4.2 mg/L occurred within 2 hours after the dose.[2] Using data from this study, an infant would receive a maximum of about 3.6% of the maternal weight-adjusted dosage.

Four women who were 2 to 8 months postpartum were given a single 1 gram dose of acetaminophen. Peak milk levels occurred between 1 and 2.5 hours after the dose. The authors estimated that a breastfed infant would receive an average of 1.1% and a maximum of 1.8% of the maternal weight-adjusted dosage. This dose is about 0.5% of the lowest recommended infant dose of acetaminophen.[3]

Infant Levels. No acetaminophen was detected in the urine of 12 breastfed infants aged 2 to 22 months after maternal ingestion of 650 mg of acetaminophen.[1]

Urine was collected for 1 to 3.5 hours after nursing in 6 infants aged 2 to 6 days whose mothers received 1 to 2 grams of acetaminophen 2 to 4 hours before nursing their infant. Infants excreted an average of 401 mcg of acetaminophen and its metabolites in urine during the collection interval. These neonates excreted a greater percentage of drug as acetaminophen and much less as the sulfate metabolite than adults.[3]

Effects in Breastfed Infants

A maculopapular rash on the upper trunk and face of a 2-month-old infant was probably caused by acetaminophen in breastmilk. The rash occurred after 2 days of therapy in the mother at a dose of 1 gram at bedtime. It subsided when the drug was discontinued and recurred 2 weeks later after another acetaminophen dose of 1 gram was taken by the mother.[4]

Two papers report 14 women who breastfed after taking acetaminophen or its prodrug phenacetin with no adverse effects to their infants.[1][5]

In a telephone follow-up study, mothers reported no side effects among 43 infants exposed to acetaminophen in breastmilk.[6]

Two clinicians speculated that breastmilk exposure to acetaminophen during breastfeeding might be a risk factor for asthma and wheezing in the breastfed infants based on their personal observations.[7] However, these observations were uncontrolled and cannot be considered to be valid proof of an association.[8]

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Ibuprofen

References

1. Berlin CM Jr, Yaffe SJ, Ragni M. Disposition of acetaminophen in milk, saliva and plasma of lactating women. Pediatr Pharmacol. 1980;1:135-41. PMID: 7202185

2. Bitzen PO, Gustafsson B, Jostell KG et al. Excretion of paracetamol in human breast milk. Eur J Clin Pharmacol. 1981;20:123-5. PMID: 7262173

3. Notarianni LJ, Oldham HG, Bennett PN. Passage of paracetamol into breast milk and its subsequent metabolism by the neonate. Br J Clin Pharmacol. 1987;24:63-7. PMID: 3620287

4. Matheson I, Lunde PKM, Notarianni L. Infant rash caused by paracetamol in breast milk? Pediatrics. 1985;76:651-2. Letter. PMID: 2931668

5. Findlay JWA, DeAngelis RL et al. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981;29:625-33. PMID: 6529531

6. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

7. Nadal-Amat J , Verd S. Paracetamol and asthma and lactation. Acta Paediatr. 2011;100:e2-3. PMID: 21244486

8. Bakkeheim E, Carlsen KH, Lodrup Carlsen KC. Paracetamol exposure during breastfeeding and risk of allergic disease. Acta Paediatr. 2011;100:e3. PMID: 21535130

Acetaminophen Identification

Substance Name

Acetaminophen

CAS Registry Number

103-90-2

Drug Class

  • Analgesics, Non-Narcotic

Administrative Information

LactMed Record Number

330

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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